humana aug 2012 (100 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The protection of agricultural crops, forest, and man and his domestic animals from annoyance and damage by various kinds of pests remains a chronic problem. As we endeavor to improve pro duction processes and to develop more effective and acceptable tactics for achieving this protection, we must give high priority to all potentially useful techniques for the control and management of insects. Pest control is recognized as an acceptable and necessary part of modern agriculture. Methods employed vary greatly and tend to reflect compromises involving 3 determining factors: technological capability, economic feasibility, and social acceptability. How ever, these factors are also subject to change with time since each involves value judgments that are based on available information, cost, benefit considerations, the seriousness of the pest problem, and the political climate. Whatever method is chosen, energy resources continue to dwindle under the impact of increasing popu lation, and it is inevitable that greater reliance must be placed upon renewable resources in pest management. One alternative is the use of a pest management method that uses the energy of the pest's own biomass to fuel a self-perpetuating control system. The use of biological control agents for the control of pests has long been an integral part of the pest management strategy in crop production and forestry and in the protection of man and animals. The importance and unique advantages of the method are well recognized; numerous treatises deal with accomplishments and methodologies. 496 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Strategies of treatment involving therapeutic proteins, irnrnune immune cells, or cel lular protein targets are those of greatest potential for further reducing mortality from melanoma. Therapeutic proteins or cells may inhibit melanoma cell growth either by augmentation of immune cell function or by inhibition of angiogenesis. Cytokines and melanoma antigens may be used either in vivo as a vaccine to stimulate irnrnune immune cell cell function or ex vivo to stimulate or proliferate cells for infusion. Alternatively, alteration in melanoma cell growth can occur through inhibition of protein signal transduction pathways within melanoma cells or in the endothelial cells constituting the necessary angiogenic support for tumor growth. The great promise of these therapies and their cellular targets constitutes the basis for Melanoma: Biologically Targeted Therapeutics. THE CLINlCAL PROBLEM More than four million people will be diagnosed with melanoma in the first decade of the 21st century. Half of those who will die will be individuals who would otherwise have had a life expectancy of another 25 years or more. These individuals will die of systemic systernic metastases, which are present at the time of primary surgery. Despite use of sunscreens, incidence continues to increase in developed countries worldwide. To reduce mortality, there must continue to be a focus on prevention and earlier detection through public education. Early interventions are always preferable to treatment of disseminated metastatic disease. 416 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Much of current programming practice is basically empirical and ad hoc in approach. Each problem is tackled without relation to those that have gone before; experiences are made and stored as a series of fragments. Now, under the pressure of events, this unsatisfactory state of affairs is coming to an end. Programming is becoming a technology, a theory known as structured programming is developing. The purpose of a theory is to categorise and explain existing practice, thus enabling it to be improved through the development of new and sharper techniques. The resulting experiences have then to be fed back into the theory so that the process of enrichment may continue. This dialectical relationship between theory and practice is essential to a healthy programming technology. The lack of such a relationship in the 1950s and 60s and the accompanying software crisis certainly confirm the converse of this proposition. My aim in writing this book has been to explain the current state of the theory of structured programming, so that it may be used to improve the reader's practice. The book deals with two facets of programming - how to design a program in terms of abstract data structures and how to represent the data structures on real and bounded computers. The separation between program design and data structure representation leads to more reliable and flexible programs. 236 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The international Workshop on 'Data Analysis in Astronomy' was in tended to give a presentation of experiences that have been acqui red in data analysis and image processing, developments and appli cations that are steadly growing up in Astronomy. The quality and the quantity of ground and satellite observations require more so phisticated data analysis methods and better computational tools. The Workshop has reviewed the present state of the art, explored new methods and discussed a wide range of applications. The topics which have been selected have covered the main fields of interest for data analysis in Astronomy. The Workshop has been focused on the methods used and their significant applications. Results which gave a major contribution to the physical interpre tation of the data have been stressed in the presentations. Atten tion has been devoted to the description of operational system for data analysis in astronomy. The success of the meeting has been the results of the coordinated effort of several people from the organizers to those who presen ted a contribution and/or took part in the discussion. We wish to thank the members of the Workshop scientific committee Prof. M. Ca paccioli, Prof. G.De Biase, Prof. G.Sedmak, Prof. A.Zichichi and of the local organizing committee Dr.R.Buccheri and Dr. M.C.Macca rone together with Miss P.Savalli and Dr. A.Gabriele of the E.Majo rana Center for their support and the unvaluable part in arranging the Workshop. 556 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Phonological Processes and Brain Mechanisms reviews selective neurolinguistic research relating brain structures to phonology. The studies in the volume report on a number of timely and important topics, such as a neuronal model for processing segmental phonology, the role of the thalamus and basal ganglia in language processing, and oral reading in dyslexia. Increasingly, phonology is considered a cognitive module whose brain correlates may be independently investigated. Given the modular nature of the phonological system and its direct linkage with peripheral components of the nervous system, research on phonology and the brain will undoubtedly flourish in the future. The chapters in this volume give substance to this future. 200 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Classic telescopes are of interest to amateur astronomers for a variety of reasons. There are the dedicated collectors, but there are also many amateurs who love the nostalgia they inspire. These telescopes 'feel' different from any contemporary telescope and perhaps have a unique ability to reconnect the owner to a bygone age of craftmanship. This book takes a look at traditional telescopes built by the great instrument makers of the 18th and 19th centuries, particularly the dynastic telescope makers, including Dollond, Alvan Clark, Thomas Cooke & Sons, and Carl Zeiss. Also included are lesser luminaries such as John Brashear, John Calver, William Wray, Henry Fitz, and William Henry Mogey.'Classic Telescopes' covers the key features of the telescopes designed by these manufacturers, and shows how a heady combination of market trends, instrument condition, and pedigree will dictate their prices at auction. 'Classic Telescopes' also shows the reader how to find real bargains! Interviews with top classic telescope collectors (and users) provide the best tips of prospecting for a genuine acquisition.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 256 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -¿¿E-Commerce Strategy: Text and Cases provides the fundamental literature required for graduate students and practitioners to understand electronic commerce. Each chapter provides clearly designed learning objectives and review questions to highlight the major topics and goals. This book covers many of the new innovations and technologies that have been established for e-commerce site development. Unlike similar books, topics such as e-channel adoption, factors affecting e-commerce adoption, and strategy design are reviewed in greater depth. Additionally, the book examines areas not normally covered like open source, online research, and peer-to-peer systems.E-Commerce Strategy: Text and Cases is divided into two parts. Part 1 examines the evolution of e-commerce, analyzes different sectors such as B2B and m-Commerce, and explores the challenges they face. Case studies of well known companies reinforce the concepts learned to demonstrate both successes and failures in the field. Part 2 deals with developing strategies in e-Commerce and looks at future trends including Web 2.0. Overall,the useful guidelines provided should prove valuable to students and researchers in the field.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 280 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The problem of range and motion segmentation is of major importance in computer vision, image procession, and intelligent robotics. This edited volume explores several issues relating to parametric segmentation emphasizing robust techniques and model selection. With contributions from leading scientists and engineers in the field, this book is a valuable resource for researchers and graduate students working in computer vision, pattern recognition, image processing and robotics.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 232 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Reviews in Fluorescence 2004, the first book of a new book series from Springer, is a collection of current trends and emerging hot topics in the field of Fluorescence.This annual review series differs from Springer's current Topics in Fluorescence series in that it is more specialized and includes reviews of an individual's own work or scientific perspective. Reviews in Fluorescence will therefore complement the other fluorescence titles published by Springer, whilst feeding the requirement from the fluorescence community for annual informative updates and developments.Key features: Reviews in Fluorescence will be citable, indexed, and available both in print and online. Reviews in Fluorescence will be published annually. Reviews in Fluorescence will comprise invited review articles that summarize the yearly progress in fluorescence. Alternate years will publish the Invited Papers from the Methods and Applications in Fluorescence conference series (MAFS).Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book analyzes conventional fixed-bed reactors such as trickle-bed, bubble (packed) column, and multitubular reactors with regard to process efficiency, design and safety. It is shown that these reactors do not possess any substantial potential for improving industrial processes.Modern concepts in mass transfer, kinetics and process design are applied to process development. In light of the given analysis, new approaches to the development of technologies based on innovative principles are elucidated. For the first time, first-hand knowledge about Two-Zone Model, Oscillation Theory, map of the energy dissipation is presented in full.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 124 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Strategies of treatment involving therapeutic proteins, irnrnune immune cells, or cel lular protein targets are those of greatest potential for further reducing mortality from melanoma. Therapeutic proteins or cells may inhibit melanoma cell growth either by augmentation of immune cell function or by inhibition of angiogenesis. Cytokines and melanoma antigens may be used either in vivo as a vaccine to stimulate irnrnune immune cell cell function or ex vivo to stimulate or proliferate cells for infusion. Alternatively, alteration in melanoma cell growth can occur through inhibition of protein signal transduction pathways within melanoma cells or in the endothelial cells constituting the necessary angiogenic support for tumor growth. The great promise of these therapies and their cellular targets constitutes the basis for Melanoma: Biologically Targeted Therapeutics. THE CLINlCAL PROBLEM More than four million people will be diagnosed with melanoma in the first decade of the 21st century. Half of those who will die will be individuals who would otherwise have had a life expectancy of another 25 years or more. These individuals will die of systemic systernic metastases, which are present at the time of primary surgery. Despite use of sunscreens, incidence continues to increase in developed countries worldwide. To reduce mortality, there must continue to be a focus on prevention and earlier detection through public education. Early interventions are always preferable to treatment of disseminated metastatic disease.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come. 340 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cancer is a devastating disease that affects millions of people in the world. Our the- pies for tumors have mostly been based on classical chemotherapy and antiproliferative treatments. More recently, directed therapies against a causative oncogene have led to prominent reduction in tumor rates for some cancers. For instance, chronic myelogenous leukemia that is due to a BCR-ABL translocation can be targeted with Gleevec. Despite these advances in individual tumors, a number of patients are treated for their primary tumors and ultimately relapse. Relapsing tumors can be due to resistance to chemotherapy or to antioncogene drugs. Another hypothesis is that heterogeneity in the tumor leads to an inability of classical chemotherapy to completely eradicate all cells of the tumor. This concept of heterogeneity has led some investigators to propose a cancer stem cell model. As patients are treated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells that remain after classical chemotherapy or the cells that can remake the tumor among the heterogeneous population, this information would have a huge impact on our treatment of cancer. 300 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Progenitor cells have become important in regenerative medicine therapies, due to their potential to differentiate into many cell types. This capability, and understanding how to regulate the cells, will provide the basis for future cell therapies aimed at correcting tissue and organ dysfunction as a result of disease or injury. In, Progenitor Cells: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to investigate progenitor cells. These include methods and techniques of the manipulation of physical forces that shape progenitor cell behavior, studying progenitor cells in vivo, using non-mammalian and mammalian model systems, and investigating human progenitor cells, including their isolation, characterization and application in cell-based therapies. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Progenitor Cells : Methods and Protocols seeks to aid scientists in the further study progenitor cells and how they are studied across multiple systems. 424 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Several years ago, two of us published a full-length textbook entitled Nutrition and Immunology: Principles and Practice. The book was aca demically successful and well received by our peers. Our colleagues commented that while the book was eminently suitable for a library, there was still an intellectual need for a more concise volume on nutrition and immunology for health care providers and scientists working at the inter face of delivering therapeutic and/or preventive health care. We agreed and decided that a book focused on issues relevant to laboratory workers and to developing countries would be valuable. We invited well-known experts in their fields to contribute a chapter each and asked that they err on the short rather than the long side and update cited review articles rather than original papers wherever possible. The Handbook of Nutrition and Immunity is the culmination of that process. Our intention is that the book will grow over time and new editions will fill identified voids that meet the changing needs of health care providers and scientists interested in the practical aspects related to evaluating nutrition and immunology in the field. The Handbook of Nutrition and Immunity is for those people working in both adult and child nutrition throughout the world. It is also of relevance to those in the pharmaceutical and the food industry who are interested in developing ways to evaluate both the efficacy and effective ness of their products. 380 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in methodologies and experimental models are pivotal to furthering our understanding of central nervous system (CNS) functions in mammals. Isolated Central Nervous System Circuits examines the application a variety of technologies to mostly active in vitro preparations from basically different CNS regions with a diversity of functions. From patch-clamp, multiphoton imaging, live fluorescent protein expression, or immunohistochemistry techniques to acute or 'organotypic' slices and en bloc preparations, this detailed volume features key protocols and examples for exciting results from the labs of renowned experts. Written for the popular Neuromethods series, chapters include the kind of thorough implementation advice that is vital for achieving successful results. Comprehensive and cutting-edge, Isolated Central Nervous System Circuits will greatly aid scientists to further improve models and to develop corresponding models of not yet intensively studied structures such as nucleus ruber, superior colliculus, or basal ganglia. 484 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A concise, up-to-date review of the many new therapies available for the treatment of benign prostatic hypertrophy (BPH). The authors concisely evaluate the latest minimally invasive therapies, as well as time-tested surgical treatments, and review the medical therapies for BPH, namely a-adrenergic antagonists, 5-a reductase inhibitors, and their therapeutic combinations. Additional chapters examine the pathophysiology and natural history of BPH, its epidemiology, and the urodynamic evaluation of lower urinary tract symptoms. A perfect reference source for the practicing urologist seeking sound guidance on the best approach to his patients. 280 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Soil salinity is destroying several hectares of arable land every minute. Because remedial land management cannot completely solve the problem, salt tolerant crops or plant species able to remove excessive salt from the soil could contribute significantly to managing the salinity problem. The key to engineering crops for salt tolerance lies in a thorough understanding of the physiological mechanisms underlying the adaptive responses of plants to salinity. Plant Salt Tolerance: Methods and Protocols describes recent advances and techniques employed by researchers to understand the molecular and ionic basis of salinity tolerance and to investigate the mechanisms of salt stress perception and signalling in plants. With chapters written by leading international scientists, this book covers nearly 30 different methods, such as microelectrode and molecular methods, imaging techniques, as well as various biochemical assays. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Plant Salt Tolerance: Methods and Protocols serves as an essential read for every student or researcher tackling various aspects of the salinity problem. 448 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Genomic imprinting, the process by which the non-equivalence of the paternal and maternal genomes is established, has been fascinating us for over three decades and has provided many emerging scientists with the chance to hit their stride in a frontier posing many unexpected questions and even more surprising answers. In Genomic Imprinting: Methods and Protocols, experts in the field provide a survey of the technologies that are being applied to advance the study of imprinting. This detailed volume features new technologies that are accelerating the pace of discovery of imprinted genes and characterization of their epigenetic profile, bioinformatic procedures for prediction and comparative analyses of imprinted genes, as well as methods in embryology and basic molecular biology that have been employed for many years, some appearing in new versions for small cell numbers. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Genomic Imprinting: Methods and Protocols will aid scientists in unveiling both much awaited answers and all-new questions to keep this vital field busy for many exciting years to come. 312 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A team of expert investigators and clinical researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for today's researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases. 272 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today. 408 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stem cell mobilization represents a transient increase in the levels of circulating stem and progenitor cells. In Stem Cell Mobilization: Methods in Protocols, expert researchers in the field detail cell mobilization methodology and recent developments in the field for basic and biomedical research community. Specifically clinical hematopoietic progenitor cell mobilization protocols, frontiers in mobilization and analysis of non-hematopoietic progenitors, mesenchymal progenitor cells, monocyte-derived fibroblast progenitors, and very small embryonic like cells. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Mobilization: Methods and Protocols seeks to aid scientists in the further study of this important stem cell research. 268 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The liver is responsible for a wide range of critical functions essential to life, and is composed of several different cell types. In Liver Proteomics: Methods and Protocols, expert researchers in the field detail many of the methods that are used to study the live. These methods include the most up-to-date strategies being used to characterize the liver proteome at the global, cellular, subcellular, post translational and functional level.Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Liver Proteomics: Methods and Protocols seeks to aid scientists in the further study of this crucially important organ. 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease. The second edition of Autoimmunity: Methods and Protocols researchers in the field detail many of the most up-to-date methods which are now commonly used to study autoimmunity. The first half the book focuses on methods and protocols used to assess immunological and biochemical pathways of diseases pathogenesis in human subjects. While the second half investigates treatment of inflammatory arthritis, experimental allergic encephalomyelitis (EAE), IDDM, scleroderma, and uveitis in animal models and assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases. Written in the highly successful Methods in Molecular Biology(tm) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Through and intuitive, Autoimmunity: Methods and Protocols, Second Edition seeks to aid scientists in the autoimmunity field to extract new meaning of old models and developing new ones. 520 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Psychoneuroimmunology (PNI) has developed rapidly in the last four decades. As a multidisciplinary area, PNI may provide a scientific basis for mind-body relationships toward the development of personalized and systems medicine. In Psychoneuroimmunology:Methods and Protocols, expert researchers in the field detail methods and protocols geared toward the development of integrative and individualized therapeutics in multiple dimensions from drugs to behaviors. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Psychoneuroimmunology:Methods and Protocols aids scientists in continuing to study holistic views for the translation of psychoneuroimmunology into better preventive and personalized medical practice. 420 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the last decade, several different optical imaging techniques, either based on various voltage or calcium dyes, or more recently on modified fluorescent or bioluminescent proteins (genetically encoded) that are sensitive to calcium, have been developed to study neuronal activity, and especially groups of neurons, with the goal of mapping and deciphering the neural code underlying major neurophysiological functions. Genetically Encoded Functional Indicators brings together expert contributors to present the development of recent genetic techniques that allow for generating genetically encoded activity sensors in order to investigate neuronal activity. Each chapter describes a specific sensor and its utilization to study neuronal activity in a particular way. Written in the Neuromethods series style, chapters contain the kind of key description and implementation advice that guarantees successful results. Helpful and easy to use, Genetically Encoded Functional Indicators aims to inspire students and researchers and to serve as a useful guide to those who wish to start using these different brain imaging techniques and require a bit of guidance in how best to choose a technique to match the goal of their study. 184 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Genetic approaches to understanding plant growth and development have always benefitted from screens that are simple, quantitative and rapid. Visual screens and morphometric analysis have yielded a plethora of interesting mutants and traits that have provided insight into complex regulatory pathways, and yet many genes within any given plant genome remain undefined. The premise underlying High Throughput Phenotyping in Plants: Methods and Protocols is that the higher the resolution of the phenotype analysis the more likely that new genes and complex interactions will be revealed. The methods described in this volume can be generally classified as quantitative profiling of cellular components, ranging from ions to small molecule metabolites and nuclear DNA, or image capture that ranges in resolution from chlorophyll fluorescence from leaves and time-lapse images of seedling shoots and roots to individual plants within a population at a field site. Written in the successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, High Throughput Phenotyping in Plants: Methods and Protocols serves as an invaluable guide to plant researchers and all scientists who wish to better understand plant growth and development. 380 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is an introductory graduate-level textbook on the theory of smooth manifolds. Its goal is to familiarize students with the tools they will need in order to use manifolds in mathematical or scientific research--- smooth structures, tangent vectors and covectors, vector bundles, immersed and embedded submanifolds, tensors, differential forms, de Rham cohomology, vector fields, flows, foliations, Lie derivatives, Lie groups, Lie algebras, and more. The approach is as concrete as possible, with pictures and intuitive discussions of how one should think geometrically about the abstract concepts, while making full use of the powerful tools that modern mathematics has to offer.This second edition has been extensively revised and clarified, and the topics have been substantially rearranged. The book now introduces the two most important analytic tools, the rank theorem and the fundamental theorem on flows, much earlier so that they can be used throughout the book. A fewnew topics have been added, notably Sard¿s theorem and transversality, a proof that infinitesimal Lie group actions generate global group actions, a more thorough study of first-order partial differential equations, a brief treatment of degree theory for smooth maps between compact manifolds, and an introduction to contact structures.Prerequisites include a solid acquaintance with general topology, the fundamental group, and covering spaces, as well as basic undergraduate linear algebra and real analysis.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 724 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -MicroRNAs constitute a particularly important class of small RNAs given their abundance, broad phylogenetic conservation and strong regulatory effects, with plant miRNAs uniquely divulging their ancient evolutionary origins and their strong post-transcriptional regulatory effects. In Plant MicroRNAs: Methods and Protocols, experts in the field present chapters that focus on the identification, validation, and characterization of the miRNA class of RNAs, and address important aspects about heterochromatic small interfering RNAs. In addition, the methods contained in this volume emphasize miRNA analyses, but also include ways to distinguish one class of small RNAs from another. As a volume in the highly successful Methods in Molecular Biology(TM) series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easy to use, Plant MicroRNAs: Methods and Protocols provides the research community with a set of protocols that will help advance vital miRNA research for all plant species, both in typical model species and non-model species alike. 280 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since its first systematic application during the 1970s, bioremediation, or the exploitation of a biological system's degradative potential to combat toxic pollutants such as heavy metals, polyaromatic hydrocarbons (PAH), cyanides, and radioactive material, has proven itself over time, and the many advances in molecular techniques have only amplified its utility. In Bioremediation: Methods and Protocols, experts in the field explore imaginative and ambitious multidisciplinary techniques that will enable more predictable removal of pollutants from a variety of environments. The easy-to-follow volume addresses some of the broader issues such as the effect of the environment in determining the availability and fate of organic and inorganic compounds and how choices around the most appropriate bioremediation process can be arrived at, as well as detailed complementary techniques that support the effective deployment and monitoring of a bioremediation approach. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Bioremediation: Methods and Protocols offers researchers a series of invaluable techniques certain to enhance their work with environmental contamination. 296 pp. Englisch.