humana aug 2013 (245 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The development of neurophysiology, the study of the activity of living nervous tissue, has relied heavily on the techniques of electrophysiology. This emphasis is revealed in volumes 14 and 15 of this series, which show how electrophysiological techniques can be applied to research topics ranging from ion channels to human behavior. Kitai and Park show how cellular neurophysiology can be related to classical neuroanatomy, an important basis for any type of functional analysis. Wonderlin, French, Arispe, and Jones describe new (single channel) and more traditional (whole cell) techniques for studying the role of ion channels in cellular pr- esses, a field that is currently developing very rapidly. An exciting nontraditional approach to the study of cellular electrophysiology is discussed by Hopp, Wu, Xiao, Rioult, London, Zecevic, and Cohen in their paper on optic measurement of membrane pot- tials. Humphrey and Schmidt offer a thoughtful review of the uses and limitations of the technique of recording extracellular unit potentials in the brain. Hoffer presents an introduction to a field that is of great interest but is technically very difficult-the reco- ing from cells and axons in the spinal cord and peripheral nervous system in freely moving animals. An electrophysiological approach to the analysis of the neural mechanisms of normal behavior is presented by Halgren in a wide-ranging review of the field of evoked potentials in humans. 392 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The identification of hepatitis C virus by Michael Houghton and his c- leagues at the Chiron Corporation nearly years ago represented a technical tour de force of modern molecular medicine. This breakthrough not only unearthed the causative agent of non-A non-B hepatitis that had eluded the best of scientists for more than 20 years, but also was symbolic of another chapter in the changing paradigm of modern science and medicine. The re- lutionary concept of identifying a pathogen without actually visualizing or detecting it will forever redefine the way we approach pathogenesis of d- eases whose cause is unknown. It is benefitting that this discovery treads on the heels of the human immunodeficiency pandemic, and parallels the ala- ing emergence of various microbial pestilences in the world. Despite the rapid advances in our understanding of the virus, there is much remaining to learn about it. This book highlights some of the important areas yet to be unraveled. As illustrated in this book, the marriage between basic science and clinical medicine is essential in our quest for these unknowns. The last decade has focused on the fundamentals of the virus; the next decade must underscore translational research, bridging clinical medicine and basic science with re- ization of fundamental knowledge to improve prevention, diagnosis, and tre- ment of viral hepatitis C. 644 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stem Cell Nanotechnology: Methods and Protocols gathers several representative protocols related to the emerging interest in nanotechnology as it relates to stem cell biology. The detailed chapters presented within have been validated for reproducibility and are described in an easy to follow, step-by-step fashion so as to be valuable for not only experts but also novices in the stem cell field. As with other volumes in the highly successful Methods in Molecular Biology series, chapters conclude with a Notes section, which provides tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Nanotechnology: Methods and Protocols provides both a flavor of the field as it currently is and a source to stimulate new approaches and methodologies by those interested in nanotechnological applications. 196 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The ability to introduce macromolecules into animal cells, includ ing DNA, RNA, proteins, and other bioactive compounds has facili tated a broad range of biological studies, from biochemistry and biophysics to molecular biology, cell biology, and whole animal stud ies. Gene transfer technology in particular will continue to play an essential role in studies aimed at improving our understanding of the relationships between the gene structure and function, and it has impor tant practical applications in both biotechnology and biomedicine, as evidenced by the current intense interest in gene therapy. Although DNA and other macromolecules may be introduced into cells by a variety of methods, including chemical treatments and microinjection, el- troporation has proven to be simpler to perform, more efficient, and effective with a wider variety of cell types than other techniques. The early and broad success of electric field-mediated DNA transfer soon prompted researchers to investigate electroporation for transferring other types of molecules into cells, including RNA, enzymes, antibodies, and analytic dyes. Animal Cell Electroporation and Electrofusion Protocols begins with three chapters that describe the theoretical and practical aspects of electroporation, including a review of the commercially available instrumentation. These introductory chapters will be of particular inter est to those new to electric field technologies and to those developing protocols for as yet untested species or cell types. Nineteen chapters follow that present well-tested protocols for electroporation of proteins and DNA into insect, fish, and mammalian cells. 392 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The optimal function of the placenta and thus fetal well being largely depends upon the integrity of both the fetal and maternal circulations of the placenta. Intense basic research concerned with placental vascularization and blood flow has been performed for the past 30 years, beginning with the classical morphological descriptions of the placental vessels by Boe (1953) and Arts (1961), as well as with the radioangiographic studies of maternal placental circulation in the human by Borell (1958) and in the rhesus monkey by Ramsey (1962). The scientific framework presented by these investigators has been filled and completed by numerous investigators, leading to more morphological details, functional considerations, and pathological understanding. For an extended period of time, this research has been of primarily academic interest by increasing our insights into one important system of the placenta, yet having nearly no practical importance. Recently, this situation has changed dramatically: in vitro studies of the isolated, dually perfused human placenta and in vivo studies of placental circulation for diagnostic purposes have raised an enormous interest in basic research data. New methods like Doppler Ultrasound and NMR became available. These technics have enabled the obstetrician to study fetal and placental hemodynamics in vivo. Meanwhile, such methods are becoming incorporated into the daily obstetrical routine, to some degree without an adequate background knowledge of placental vascularization and blood flow, since such experience is currently available to only a small group of experts. 384 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of this book is a discussion, at the introductory level, of some applications of solid state physics. The book evolved from notes written for a course offered three times in the Department of Physics of the University of California at Berkeley. The objects of the course were (a) to broaden the knowledge of graduate students in physics, especially those in solid state physics; (b) to provide a useful course covering the physics of a variety of solid state devices for students in several areas of physics; (c) to indicate some areas of research in applied solid state physics. To achieve these ends, this book is designed to be a survey of the physics of a number of solid state devices. As the italics indicate, the key words in this description are physics and survey. Physics is a key word because the book stresses the basic qualitative physics of the applications, in enough depth to explain the essentials of how a device works but not deeply enough to allow the reader to design one. The question emphasized is how the solid state physics of the application results in the basic useful property of the device. An example is how the physics of the tunnel diode results in a negative dynamic resistance. Specific circuit applications of devices are mentioned, but not emphasized, since expositions are available in the elec trical engineering textbooks given as references. 348 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A NATO Advanced Studies Institute was held June 12-23, 1978, at the University of Wisconsin in Madison, Wisconsin. It was a topical Institute in theoretical nuclear physics and had the some what novel feature of focussing not on a single topic but on two closely allied ones: pion-nucleus and heavy-ion physics. These two fields. both dedicated to the investigation of short-wave length properties of nuclei, have many techniques and concepts in cornmon, and essentially become one in the topic of relativistic heavy-ion physics. The purpose of including both in a single Institute was to encourage the practitioners in each of these fields to learn from those in the other; to judge from the liveli ness of the questioning which ensued, the purpose was well-served indeed. Because the Institute was viewed as one which served both educational and research ends, the lecturers took particular pains to develop their subjects in a careful, coherent sequence. The result is a compendium of advanced techniques and current results in these two rapidly-expanding fields of nuclear theory which should serve interested physicists as an ideal introduction to the fields. In addition to the support provided by the Scientific Affairs Division of NATO, substantial financial assistance was provided by the U. S. National Science Foundation and the Graduate School of the University of Wisconsin. 764 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the last decade, changes in the scale of operations required to find and transport oil have led to a pollution problem of major proportions: oil on the sea. These changes occurred slowly, and the change in magnitude of the possi bilities for . pollution went unrecognized until a series of dramatic accidents recently gave the problem wide-spread public notice. The Torrey Canyon and Santa Barbara episodes are discussed in this volume. The changes in the scale of oil operations stem from an ever increasing demand for energy. In response to this demand, oil drilling from offshore rigs on the continental shelf has been rapidly developed. To inexpensively trans port oil to the consumers of energy, huge supertankers, of ever increasing size, are being constructed. These ships effect economic savings at the expense of being relatively underpowered, and less maneuverable. Having very deep draft, they are constrained to operate on the high seas and the few deep harbors of the world. Every year there is more oil pumped from the sea floor. Every year more oil is trans ported over the sea. Approximately one tenth of one per cent of this oil each year is spilled on the sea. The purpose of the present volume is to provide a summary of our current understanding of the problem of oil on the sea. Before describing in detail the topics presented, it seems well to point out . 128 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Imaging and Tracking Stem Cells: Methods and Protocols gathers representative protocols related to the vital techniques of stem cell imaging and lineage tracing, including that of live cells, both in vivo and in vitro. The detailed chapters presented within have been validated for reproducibility and are described in an easy to follow, step-by-step fashion so as to be valuable for not only experts but also novices in the stem cell field. As with other volumes in the highly successful Methods in Molecular Biology series, chapters conclude with a Notes section, which provides tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Imaging and Tracking Stem Cells: Methods and Protocols provides both a flavor of the field as it currently is and a source to stimulate new approaches and methodologies by those interested in tracking stem cells and their progeny. 232 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Along with many small improvements, this revised edition contains van Yzeren's new proof of Pascal's theorem (1.7) and, in Chapter 2, an improved treatment of order and sense. The Sylvester-Gallai theorem, instead of being introduced as a curiosity, is now used as an essential step in the theory of harmonic separation (3.34). This makes the logi cal development self-contained: the footnotes involving the References (pp. 214-216) are for comparison with earlier treatments, and to give credit where it is due, not to fill gaps in the argument. H.S.M.C. November 1992 v Preface to the Second Edition Why should one study the real plane To this question, put by those who advocate the complex plane, or geometry over a general field, I would reply that the real plane is an easy first step. Most of the prop erties are closely analogous, and the real field has the advantage of intuitive accessibility. Moreover, real geometry is exactly what is needed for the projective approach to non-Euclidean geometry. Instead of introducing the affine and Euclidean metrics as in Chapters 8 and 9, we could just as well take the locus of 'points at infinity' to be a conic, or replace the absolute involution by an absolute polarity. 240 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many toxicologists have for some time been unhappy with the quantity (often a result of unnecessary duplication), the reliability, and the ethical circumstances of much animal experimentation. It is hoped that the present book, In Vitro Toxicity Testing Protocols, will play some part in enabling and encouraging the more widespread use of in vitro techniques. Since in vitro toxicity testing methodology is evolving at such a rapid rate, this book can of necessity provide only a 'snapshot' of the major techniques in use at the present time. As with the other publications in Humana Press' Methods in Molecular Biology series, the aim has been to supply information on the fundamental requirements for the establishment of new techniques within working laboratories and to describe a variety of basic in vitro methodologies. Certain of the techniques detailed here could more accurately be described as ex vivo rather than truly in vitro. No apology is made for the inclusion of these techniques. 360 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in bioscience research usually arise as a result of the continu ing refinement of existing technologies. However, there are a number of occa sions v^rhere newly developed methodologies have a profound effect on nearly all areas of research. Frequently these are techniques that are elegantly simple in concept and require minimal technical manipulation. Two of these revolu tionary techniques are the focus ofPCR Sequencing Protocols. The first such technique is enzymatic chain termination sequencing developed by Sanger and his co-workers in Cambridge and reported in 1977. This essentially brought the possibility of deriving nucleotide sequence information in a very short time scale and has been widely accepted in many laboratories as a routine molecular biological research tool. Furthermore, it has not only led to the sequencing of many genes and gene fragments, but has also allowed the tech nical means of sequencing the human genome. The second technique that has found widespread acceptance in basic applied research and many routine applications is the polymerase chain reac tion. This technique, first reported in 1985 by MuUis and his colleagues, pro vides the means to amplify nucleic acid sequence, which immediately proved invaluable in nearly all fields of biological laboratory research. Here, as with enzymatic DNA sequencing, is a very simple concept that relies on minimal information to prepare short oligonucleotide primers that direct the synthesis of a specified fi-agment o f DNA in the presence of a thermostable DNA polymerase. 236 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Gene transfer is an essential technology for improving our under standing of gene structure and function. Although there are many meth ods by which DNA may be introduced into cells-including heat and chemical treatments, and microinjection-electroporation has been found to be the most versatile gene transfer technique. Electroporation is effective with a wide variety of cell types, including those that are difficult to transform by other means. For many cell types, electroporation is either the most efficient or the only means known to effect gene transfer. The early and broad success of electric field-medi ated DNA transfer soon prompted researchers to investigate electroporation for transferring other types of molecules into cells, in cluding RNA, enzymes, antibodies, and analytic dyes. The first section of Plant Cell Electroporation and Electrofusion Protocols includes two chapters that serve as a guide to theoretical and practical aspects of electroporation, and will be of particular interest to those developing protocols for as yet untested species or cell types, and a third chapter that describes commercially available electroporation instruments. The remaining chapters describe well-tested protocols for DNA electrotransfection, electroporation of other biomolecules, or cell electrofusion. These chapters also include brief discussions of alterna tives to electric field-based methods, citing the advantages and limita tions of the various methods for achieving specific goals. 224 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The development of recombinant DNA technology and methods for transferring recombinant genes into plants has brought about significant advances in plant science. First, it has allowed investigation, using reporter genes, into the transcriptional regulation of plant genes-a key to the under standing of the biochemical basis of growth and development in plants. Second, gene transfer technology has facilitated the molecular cloning, by tagging genomic sequences, of important genes (e. g. , homeotic genes) whose gene products control the normal pattern of growth and differentia tion of plants. Third, overproducing foreign or endogenous proteins in plants can often lead to a better understanding of biochemical and physiological processes. Fourth, gene transfer technology has allowed the improvement of plant agricultural productivity. For example, plants have been engineered with improved viral resistance or the ability to withstand herbicide attack, therefore allowing a more effective use of herbicides to kill weeds. Fifth, there have been recent successes that demonstrate the potential use of plants as biotechnological chemical factories. For example, it is possible to use plants in the production of human antibodies and antigens of medical importance. It has been demonstrated recently that plants can be engineered to produce modified oils and even plastics! This paves the way to redirect agriculture from the production of surplus foods to the production of bio technological products of industrial importance. 500 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Neurobiologists are bound to differ in their perceptions of what the discipline of molecular neurobiology should encompass. We have taken the view that molecular neurobiology should cover any aspect of brain science that uses the techniques of modern molecular biology, though we accept the fact that classification of a technique as a 'biochemical\* or 'molecular biological\* one is in itself somewhat arbitrary. Each chapter of this volume sets out to identify a clear problem in neurobiology and to place it in its context within the literatu- i.e., indicating how the solution of the problem will advance knowledge in the field. The core of the chapter then details the approaches taken to solve the problem, in sufficient detail that the reader can appre- ate exactly why a specific strategy was adopted and how it was executed. Each chapter also includes detailed protocols providing all the inf- mation necessary to reproduce the technique and its results in any appropriately equipped laboratory. 392 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Imaging and Tracking Stem Cells: Methods and Protocols gathers representative protocols related to the vital techniques of stem cell imaging and lineage tracing, including that of live cells, both in vivo and in vitro. The detailed chapters presented within have been validated for reproducibility and are described in an easy to follow, step-by-step fashion so as to be valuable for not only experts but also novices in the stem cell field. As with other volumes in the highly successful Methods in Molecular Biology series, chapters conclude with a Notes section, which provides tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Imaging and Tracking Stem Cells: Methods and Protocols provides both a flavor of the field as it currently is and a source to stimulate new approaches and methodologies by those interested in tracking stem cells and their progeny.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Computational Fluid Dynamics (CFD) has been applied extensively to great benefit in the food processing sector. Its numerous applications include:predicting the gas flow pattern and particle histories, such as temperature, velocity, residence time, and impact position during spray drying;modeling of ovens to provide information about temperature and airflow pattern throughout the baking chamber to enhance heat transfer and in turn final product quality; designing hybrid heating ovens, such as microwave-infrared, infrared-electrical or microwave-electrical ovens for rapid baking; model the dynamics of gastrointestinal contents during digestion based on the motor response of the GI tract and the physicochemical properties of luminal contents; retort processing of canned solid and liquid foods for understanding and optimization of the heat transfer processes. This Brief will recapitulate the various applications of CFD modeling, discuss the recent developments in this field, and identify the strengths and weaknesses of CFD when applied in the food industry.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 100 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The rate at which geospatial data is being generated exceeds our computational capabilities to extract patterns for the understanding of a dynamically changing world. Geoinformatics and data mining focuses on the development and implementation of computational algorithms to solve these problems.This unique volume contains a collection of chapters on state-of-the-art data mining techniques applied to geoinformatic problems of high complexity and important societal value.Data Mining for Geoinformatics addresses current concerns and developments relating to spatio-temporal data mining issues in remotely-sensed data, problems in meteorological data such as tornado formation, estimation of radiation from the Fukushima nuclear power plant, simulations of traffic data using OpenStreetMap, real time traffic applications of data stream mining, visual analytics of traffic and weather data and the exploratory visualization of collective, mobile objects such as the flocking behavior of wild chickens.This book is designed for researchers and advanced-level students focused on computer science, earth science and geography as a reference or secondary text book. Practitioners working in the areas of data mining and geoscience will also find this book to be a valuable reference.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 180 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Dynamic secrets are constantly generated and updated from messages exchanged between two communication users. When dynamic secrets are used as a complement to existing secure communication systems, a stolen key or password can be quickly and automatically reverted to its secret status without disrupting communication.'Dynamic Secrets in Communication Security' presents unique security properties and application studies for this technology. Password theft and key theft no longer pose serious security threats when parties frequently use dynamic secrets. This book also illustrates that a dynamic secret based security scheme guarantees impersonation attacks are detected even if an adversary steals a user¿s password or their key is lost.Practitioners and researchers working in network security or wireless communications will find this book a must-have reference. 'Dynamic Secrets in Communication Security' is also a valuable secondary text for advanced-level students in computer science and electrical engineering.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 148 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The identification of hepatitis C virus by Michael Houghton and his c- leagues at the Chiron Corporation nearly years ago represented a technical tour de force of modern molecular medicine. This breakthrough not only unearthed the causative agent of non-A non-B hepatitis that had eluded the best of scientists for more than 20 years, but also was symbolic of another chapter in the changing paradigm of modern science and medicine. The re- lutionary concept of identifying a pathogen without actually visualizing or detecting it will forever redefine the way we approach pathogenesis of d- eases whose cause is unknown. It is benefitting that this discovery treads on the heels of the human immunodeficiency pandemic, and parallels the ala- ing emergence of various microbial pestilences in the world. Despite the rapid advances in our understanding of the virus, there is much remaining to learn about it. This book highlights some of the important areas yet to be unraveled. As illustrated in this book, the marriage between basic science and clinical medicine is essential in our quest for these unknowns. The last decade has focused on the fundamentals of the virus; the next decade must underscore translational research, bridging clinical medicine and basic science with re- ization of fundamental knowledge to improve prevention, diagnosis, and tre- ment of viral hepatitis C.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 644 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The ability to introduce macromolecules into animal cells, includ ing DNA, RNA, proteins, and other bioactive compounds has facili tated a broad range of biological studies, from biochemistry and biophysics to molecular biology, cell biology, and whole animal stud ies. Gene transfer technology in particular will continue to play an essential role in studies aimed at improving our understanding of the relationships between the gene structure and function, and it has impor tant practical applications in both biotechnology and biomedicine, as evidenced by the current intense interest in gene therapy. Although DNA and other macromolecules may be introduced into cells by a variety of methods, including chemical treatments and microinjection, el- troporation has proven to be simpler to perform, more efficient, and effective with a wider variety of cell types than other techniques. The early and broad success of electric field-mediated DNA transfer soon prompted researchers to investigate electroporation for transferring other types of molecules into cells, including RNA, enzymes, antibodies, and analytic dyes. Animal Cell Electroporation and Electrofusion Protocols begins with three chapters that describe the theoretical and practical aspects of electroporation, including a review of the commercially available instrumentation. These introductory chapters will be of particular inter est to those new to electric field technologies and to those developing protocols for as yet untested species or cell types. Nineteen chapters follow that present well-tested protocols for electroporation of proteins and DNA into insect, fish, and mammalian cells.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The development of neurophysiology, the study of the activity of living nervous tissue, has relied heavily on the techniques of electrophysiology. This emphasis is revealed in volumes 14 and 15 of this series, which show how electrophysiological techniques can be applied to research topics ranging from ion channels to human behavior. Kitai and Park show how cellular neurophysiology can be related to classical neuroanatomy, an important basis for any type of functional analysis. Wonderlin, French, Arispe, and Jones describe new (single channel) and more traditional (whole cell) techniques for studying the role of ion channels in cellular pr- esses, a field that is currently developing very rapidly. An exciting nontraditional approach to the study of cellular electrophysiology is discussed by Hopp, Wu, Xiao, Rioult, London, Zecevic, and Cohen in their paper on optic measurement of membrane pot- tials. Humphrey and Schmidt offer a thoughtful review of the uses and limitations of the technique of recording extracellular unit potentials in the brain. Hoffer presents an introduction to a field that is of great interest but is technically very difficult-the reco- ing from cells and axons in the spinal cord and peripheral nervous system in freely moving animals. An electrophysiological approach to the analysis of the neural mechanisms of normal behavior is presented by Halgren in a wide-ranging review of the field of evoked potentials in humans.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Five years ago, a new system of classification of the various types of diabetes was proposed. This publication provides an inte grated picture of the latest information on the similarities and dissimilarites of two types of diabetes. It contains contributions from morphologists, physiologists, biochemists, immunologists, pathologists, geneticists, clinicians and epidemiologists. In the first section, the basis for the present classification and its limitations are discussed. In addition, there is a discussion of gestational diabetes and heterogeneity of some sub-classes of diabetes. The next section deals with genetics and immunology. The third section discusses abnormalities of insulin secretion and act ion on both the receptor and post . . . receptor levels. The role of gastrointestinal peptides in Type I and Type II diabetes is also considered. In the last section, both types of diabetes are compared with respect to diabetic complications. The closing sec tion summarizes the present status and offers a stimulating view of future development. We hope that this book will be a useful source of information for both researchers and practicing clinicians. M. Vranic G. steiner C. H. Hollenberg v ACKNOWLEDGEMENTS The symposium from which this volume arose (June 28-29, 1984) was organized by the Banting and Best Diabetes Centre, University of Toronto. We would like to express our appreciation to the following sponsors: Ames Educational Institute, Ayerst Laboratories, Becton Dickinson Canada Inc. , Canadian Soft Drink Association, Connaught Laboratories Limited, Connaught Novo Ltd. , Eli Lilly Canada Inc.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 364 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is intended to provide the conceptual basis for a comprehen sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process gener ates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 384 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Colloidal dispersions play a very important role in nature, industry, and daily life. Sometimes, long-term stability is observed or desired as in ferrotluids (composed of very small magnetic particles with radii of ~ 10 nm), which must be stable even in external fields. On the other hand, only short-term stable dispersions may be necessary during actual processing operations, for example, dispersions of magnetite particles during tape manufacture. The stability of dispersions and many of their physical properties are related to the interaction between the particles in the dispersion medium, which may contain surfactants or macromolecular species. If the net interparticle interaction forces are attractive, then aggregation may occur. Two general types of aggregation behavior may be distinguished: coagulation and flocculation. These two terms are frequently used synonymously but IUPAC has recommended the following definitions: Coagulation implies formation of compact aggregates, leading to the macroscopic separation. Flocculation implies the formation of a loose or open network, floc, which may or may not separate macroscopically. Flocculation brought about by the simultaneous coadsorption of polymer molecules on two (or more) particles is referred to as bridging flocculation. If coagulation results in the merging of two particles into one, as may occur with liquid droplets in emulsions, this process is referred to as coalescence.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 192 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It was seven years ago this month when I had the pleasure of writing the Foreword to the Proceedings of the Eighth Conference on Thermal Conductivity hosted by TPRC/ Purdue University in 1968. Since then this Conference has developed to the point where one can say it has just entered a new phase. At its meeting in June 1975, the Board of Governors of the International Thermal Conductivity Conferences passed a resolution which formalizes two main policies that were felt to be desirable for a number of years, A key item of the resolution was for CINDAS/Purdue University to become the permanent Sponsor of the Conferences and in this capacity assist the Conferences in all matters which will result in the effective implementation of its goals and mission. In short, CINDAS will serve as a home base for the Conferences thus providing continuity and a permanent point of contact. CINDAS/Purdue University is pleased to accept this respons ibility as it is well within its mission to promote the advancement and dissemination of knowledge on thermophysica! properties of matter. A second important aspect of the Conference resolution was the establishment of a policy to publish the Proceedings of future conferences on a continuing and uniform basis effective with this, the Fourteenth Conference.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 584 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Stem Cell Nanotechnology: Methods and Protocols gathers several representative protocols related to the emerging interest in nanotechnology as it relates to stem cell biology. The detailed chapters presented within have been validated for reproducibility and are described in an easy to follow, step-by-step fashion so as to be valuable for not only experts but also novices in the stem cell field. As with other volumes in the highly successful Methods in Molecular Biology series, chapters conclude with a Notes section, which provides tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Stem Cell Nanotechnology: Methods and Protocols provides both a flavor of the field as it currently is and a source to stimulate new approaches and methodologies by those interested in nanotechnological applications.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 196 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Much of the progress in the diagnosis, classification, and treatment of childhood hematological disorders has come from a partnership between clinicians and scientists. Indeed, access to molecular techniques is now an integral part of the practice of modern pediatric hematology. The aim of Pediatric Hematology: Methods and Protocols is to provide a collection of scientific protocols that cover the major aspects of the discipline. Most clinicians will be familiar with the difficulties inherent in establishing the underlying diagnosis in genetic marrow failure syndromes. A particular concern is failure to diagnose those associated with DNA repair defects. In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. Molecular diagnosis is also important in children with congenital pure red cell aplasia, owing to the highly variable phenotype of this condition. In Chapter 2, Ball describes relevant protocols for the investigation of Diamond-Blackfan anemia. Hereditary hemoglobinopathy is a major cause of death and morbidity throughout the world. This area has seen great advances in screening and antenatal diagnosis. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy. High-quality, accurate molecular testing on small amounts of material has been fundamental to progress in antenatal diagnostics. The introduction to his comprehensive chapter includes a discussion of the general principles that underpin these studies. In contrast to hemoglobinopathy, severe hemophilia is uncommon. 288 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Along with many small improvements, this revised edition contains van Yzeren's new proof of Pascal's theorem ( 1.7) and, in Chapter 2, an improved treatment of order and sense. The Sylvester-Gallai theorem, instead of being introduced as a curiosity, is now used as an essential step in the theory of harmonic separation ( 3.34). This makes the logi cal development self-contained: the footnotes involving the References (pp. 214-216) are for comparison with earlier treatments, and to give credit where it is due, not to fill gaps in the argument. H.S.M.C. November 1992 v Preface to the Second Edition Why should one study the real plane To this question, put by those who advocate the complex plane, or geometry over a general field, I would reply that the real plane is an easy first step. Most of the prop erties are closely analogous, and the real field has the advantage of intuitive accessibility. Moreover, real geometry is exactly what is needed for the projective approach to non-Euclidean geometry. Instead of introducing the affine and Euclidean metrics as in Chapters 8 and 9, we could just as well take the locus of 'points at infinity' to be a conic, or replace the absolute involution by an absolute polarity.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 240 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Philip H. Howe and a group of well-versed experimentalists present the first major volume a collection of indispensable classic and cutting-edge TGFß assays. Described in great detail to ensure robust and successful results, these readily reproducible techniques range from the growth inhibition assay for TGFß to methods for monitoring its interactions with the mediating proteins. Extensive notes discuss potential pitfalls and provide tips on how to avoid failures, and throughout, emphasis is given to detailing those technical steps critical for experimental success that are often omitted in the primary literature. Concise and highly practical, Transforming Growth Factor-Beta Protocols provides today's molecular and cell biologists-both expert and novice-with time-tested methods for the identification and analysis of the signal transduction pathways by which TGFß induces and modulates physiological behavior. 188 pp. Englisch.