Humana jan 2013 (147 risultati)

Taschenbuch. Condizione: Neu. Neuware - The present fifth conference in this series - counting the 1956 conference in Mainz the same way as the 'zeroth' symphonies of Beethoven and Bruckner - was held in conjunction with the centennial of the 'Convention du Metre' which was signed May 20, 1875 in Paris, Because of this occasion, an extensive honorary committee was appointed: Honorary Committee; Chairman A. Kastler R. C. Barber(M) W. H. Johnson(M) K. Ogata(M) u. Bonse E. R. Cohen(M) Y. Sakurai A. H. Cook J. H. Sanders(M) P, Dean H. H. Staub(M) R. D, Deslattes U. Stille(M) J. V. Dunworth J, Terrien(M) V. I. Goldanskii(M) M. A. Thompson P. Grivet A. H. Wapstra(M) The members (marked M) of the Commission on Atomic Masses and Fundamental Constants of the International Union of Pure and Applied Physics belonged ex officio to this Committee, The Organizing Committee; chairman A, Horsfield H. Capptuller J . E. Faller J . L. Hall B. W. Petley B. N. Taylor was helped by the following two committees: v vi PREFACE Program Committee; chairman A. H. Wapstra c. Audoin W. H. Johnson W. Benenson R. Klapisch E. R. Cohen A. Rytz P. Giacomo J. H. Sanders Local Committee; chairman P. Grivet c. Audoin R. Klapisch N. Elnekave Y. Le Gallic s. Gerstenkorn P. Petit F. Hartmann M.…

Taschenbuch. Condizione: Neu. Neuware -During the course of the developnent of most areas of scien tific research certain events occur that serve to bring a particular area into focus. We feel that this symposilHll volume serves that role with regard to the study of the reproductive biology of amphib ians. The collection of vnrks contained in this volume provides an excellent review of a diversity of past contributions to this field of investigation and brings together in one volume the major ap proaches that have been utilized to study amphibian reproductive biology. The work emphasizes recently-completed studies and therefore can be considered to be an up-to-date account of the field. Equally signif icant, however, the contributors to this volume have excelled in pointing out directions for future research that will be of im mense value in integrating the component parts of reproductive bi ology, i.e., genetics, developnental biology, physiology, behavior, and ecology, into an eVOlutionary framework. 488 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A 'Festschrift' volume fulfils a more far-reaching purpose than the laudatory one. It shows how science develops as a result of the activities - scientific and organizational - of an individual person. Scientific achievement cannot be subjected to the very refined measurement techniques of science itself, but there is a continuous mutual evaluation among scientists which manifests itself through refereeing, literature citation and dedicatory volumes like the present one. Near and distant associates of Per-Olov Lowdin were enthusiastic about the idea of a tribute to him in the form of a collection of scientific papers on the occasion of his sixtieth birthday. Monographs and journals have fairly well-defined readerships. This book is directed to a wider group of scientists. It presents reviews of areas where Lowdin's work has influenced the development as well as research papers with original results. We feel that it can serve as a source on the current status of the quantum theory of matter for scientists in neighbouring fields. It might also provide stimulus for renewed scientific efforts among scientists turned administrators and will certainly be relevant for teachers and students of quantum theory. 608 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Frequently attempts to design experiments utilizing the methodology de scribed in articles in trade journals can be frustrating. Description of procedures, because of space constraints, are not always complete. The present volume attempts to bring together in one reference source many of the techniques which are utilized in the study of the kidney. It provides a thorough compendium of research tools, framed by the critical analysis of the theoretical background of renal physiology, biochemistry, and pharmacology discussed in Volume 4A. Some areas previously dealt with are not covered from a methodological point of view since adequate information does exist elsewhere (e.g., methods of whole kidney ATPase isolation). Since drugs acting on the kidney may alter not only functional but anatomical integrity, a chapter on the preparation of tissue for morphological studies has been included. The important developments in analy sis of minute (ultramicro) quantities of tissue and biological fluids, as well as methodological advances in studies of the isolated kidney, are thoroughly covered. It is my hope that investigators, research fellows, and graduate students will benefit from the information contained in this volume and that, together with its companion tome, it will be a ready reference for the renal physiologist, the renal pharmacologist, and the nephrologist. The contributors have provided painstaking descriptions and, when re quired, mathematical analyses of the techniques described herein. I wish to thank all of them for their enthusiasm and the excellence of their contributions. 416 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In less than 40 years teratology has grown from a little known discipline concerned with studies on the effects of a few physical and chemical stresses on developing fish, amphibians, and birds, to a discipline embracing a vast accumulation of literature on experimental studies in many animal forms and the results of intensive scrutiny of human development under varied conditions, as well. Emphasis has shifted from preoccupation with descrip tions of anatomical defects to concern about subtle and interacting causative factors, to searches for the early reactions to these at the cellular and subcellu lar levels, and to identification of abnormality in the chemical, the functional, and the ultrastructural realms. These changes in orientation have quite naturally made necessary the recruitment of concepts, methods, and expertise from other disciplines. Hence the foundations of teratology, which once were largely morphological, have extended into genetics, biochemistry, molecular biology, reproductive physiology, epidemiology, and several aspects of veteri nary and clinical medicine. It is not surprising that a student or new investigator approaching the field of teratology may feel some dismay when confronted with the confusing array of cross-disciplinary concepts and principles it encompasses today. One of the aims of this work is to introduce what the editors believe is a logical thread of continuity into a field that may be regarded by some as a welter of disordered information. 492 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Are there ways to intervene early in a child's life that might reduce, at a reasonable cost, the probability of his becoming a serious delinquent The results of some small-scale social experiments have been published suggesting that certain kinds of preschool education and parent training might have desirable and lasting effects. In addition, there is growing evidence that some kinds of medical intervention and certain forms of school organization and ethos could help reduce the rate of misconduct. The authors provide a full-scale assessment of the evidence that might lead to the design of new research and action efforts. 356 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biomedical Ethics Reviews is an annual publication designed to review and update the literature on issues of central importance in bioethics today. Ordinarily, more than one topic is discussed in each volume of Biomedical Ethics Reviews. This year, however, we have decided to devote the entire volume of Biomedical Ethics Reviews: 1988 to disussion of one topic, namely, AIDS. The ra tionale for this decision should be clear: AIDS is arguably the most serious public health threat facing our nation today, and the char acter of the disease is such that it creates special problems for ethicists, philosophers, theologians, educators, jurists, health care professionals, and politicians. Indeed, the questions that AIDS gives rise to are so numerous and complex that no one text could hope to treat them exhaustively. Still, if it is impossible, in anyone text, to deal with all of the perplexing difficulties that AIDS generates, it nevertheless remains true that each addition to the AIDS literature contributes to our collective knowledge, and in so doing, brings us one step closer to resolving at least some of the problems associated with the disease. We believe that the articles included in the present volume of Biomedical Ethics Reviews serve this purpose admirably, and we hope the reader will agree. James M. Humber Robert F. Almeder vii Contributors Ronald Carson - Medical Humanities Institute, University of Texas Medical Branch, Galveston, Texas David J. 184 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The series of volumes entitled Biological Responses in Cancer provides information on approaches through which the interaction between neoplas tic and normal cells may be modified. Topics discussed in various volumes include immunological and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. This volume is specifically concerned with various aspects of cell interactions and regulation within heterogeneous tumor cell populations, and their role in tumor progression and metastasis. Knowledge in this area is likely to provide new leads toward the exploitation of novel cellular sites and mech anisms in the development of new types of therapies of cancer. Several topics are discussed within these general areas of consideration. The possibly unique characteristics and mechanisms of tumor vascularization and the potential sites of interference with angiogenesis that might have therapeutic impli cations are critically evaluated. Tumor cell-normal tissue interactions in volved in different phases of the growth and metastatic processes are dis cussed in two chapters dealing with mechanisms of tumor invasion and with the role of collagen in mammary tumor growth; here again potential leads are identified that may be exploited toward the development of new thera peutic approaches. The evolution of phenotypic diversity as a phenomenon complicating the biology of tumor metastasis and consequently affecting the opportunities offered by chemotherapy is also critically considered. 276 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An overall view of the cancer problem and development of cancer chemothera 231 peutic biosynthetic products to February 1976 was presented in Volume 1. In the short time that has elapsed since the preparation of Volume 1, several very stimulating advances in application of biosynthetic cancer chemotherapeutic drugs in cancer treatment have been reported. At the May 1976 meeting (in Toronto) of the American Association for Cancer Research, a Sloan-Kettering research group summarized an improved treatment of human neuroblastoma using a combination of vincristine, cytoxan, trifluorothymidine, and papaverine. In the same period other clinical groups described significant advances in the cancer chemotherapeutic treatment of human breast cancer and oat cell carcinoma of the lung. Each of these newer advances in cancer treatment was based on combinations of biosynthetic and synthetic cancer chemotherapeutic drugs. Certainly, further examination of the antineoplastic biosynthetic agents summarized in this volume and the vast number yet to be discovered will eventually provide the means for controllil).g and/or curing the various types of human cancer. 164 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The short period since the publication of Volume 1 of Methods in Membrane Biology has been a time of momentous progress. Calorimetry, electron spin and nuclear magnetic resonance, X-ray diffraction, and freeze-cleavage electron microscopy, reinforced by biochemical analyses and enzymatic studies, have led to universal acceptance of a generalized membrane model. All membrane biologists would agree that a major element of all biological membranes is a bilayer of phospholipids which, in some instances, also contains other lipids, notably sterols and glycolipids. The fatty acid com position of the lipids of most membranes is such that the lipids are above their transition temperatures in their normal environment so that the bilayer is fluid. The microviscosity of the fatty acyl groups decreases pro gressively down the chain so that, at the hydrocarbon interior of the bilayer, the lipid phase has a viscosity approximating that of olive oil at room temperature. As a consequence of this membrane fluidity, a phospholipid molecule is very mobile within the plane of the membrane (moving a distance of about 1-2 fLm in 1 s) but the movement of a phospholipid molecule from one side of the membrane bilayer to the other (flip-flop) is very slow. The lipid bilayer is an essentially inert and rather impermeable struc ture, as shown by many studies with model systems. Proteins, of course, provide the catalytic components of the membranes. as well as playing a significant structural role. 324 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Electronic Prope~ties Information Cente~ has developed the Data Table as a compilation of the most ~eliable info~mation available fo~ the physical, c~ystallog~aphic, mechanical, thermal, elect~onic, magnetic and optical p~ope~ties of a given mate~ial. Data Tables forme~ly se~ved as an int~oduction to the g~aphic data compilations on the mate~ial published by the Elect~onic ~ope~ties Information Cente~, EPIC, as Data Sheets. Although the Data Sheets we~e p~incipally concerned, according to the scope of the Cente~, with electronic and optical data, it is believed that data cove~ing the complete p~ope~ty spect~um, is of the f~st impo~tance to eve~y scientist and engineer, whateve~ his information requi~ements. The enthusiastic ~eception of these Data Tables has confi~med this opinion and increasing requests fo~ this highly selective type of information ~esulted in the publication of volume 2 in this se~ies, 'III-V Semiconducting Compounds' in 1971 and 'G~oup IV Semiconducting Compounds', also in 1971. Recent inte~est in the device applications of the te~n~y semiconducto~s, led to the compilation of these Data Tables on the III-V Te~n~y Semiconducting Compounds. The majo~ problem in this type of selective data compilation on a semiconducting mate~ial, lies in the mate~ial specifications. Prope~ties may va~y so widely with doping, c~stallinity, defects, geometric forms and the othe~ pa~amete~s of p~epa~ation, that any attempts at comparison normally fail. On this basis, we have consistently attempted to give the p~epa~ation methods, ca~rier concent~ations, and physical form. 68 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume, the second in the Methods in Pharmacology series, contains some of the physical methods which either have been or could be applied to pharmaco logical problems. A major emphasis has been placed on spectroscopic techniques, particularly those, such as optical rotatory dispersion and circular dichroism, fluorescence spectroscopy, magnetic resonance spectroscopy, ultraviolet absorption spectroscopy, stopped flow and relaxation spectrometry, Mossbauer spectroscopy, light scatter and x-ray crystallography, that can be used to study drug interactions with biological systems at a molecular level. Although phosphorescence spectro scopy and oscillographic polarography can also be used to study drug interactions, their main usefulness is in the detection and estimation of drugs and their meta bolities in body tissues and fluids. Mass spectrometry is a powerful tool for study ing the metabolism of drugs as well as for detecting abnormal endogenous metabolites in the body. Finally, heatburst microcalorimetry is a non spectroscopic technique that can be used to study how drugs and other ligands interact with biological macromolecules. Each chapter contains a brief introduction to the theoretical basis for each technique as well as a description of the instrumentation involved. This is followed by a section describing the application of the technique to pharmacological prob lems. Where these are not available, examples have been drawn from the other life sciences. In a final section, some further applications of each technique to problems in pharmacology are suggested. 512 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As the nature of the field of environment-behavior relations is interdis ciplinary, the collaboration of three persons of diverse professional backgrounds in writing this book is therefore not surprising. This col laboration started in 1972 with the offering of a graduate seminar 'Envi ronment, Behavior, and Design Evaluation' at the University of Massa chusetts. Several research projects dealing with design evaluation which have been conducted at the University are also included as case studies in this book (Chapter III): the ELEMR study and the Visitor Center study. Two of the authors have worked as part of the instructional team in the seminar, and all of the authors have participated in varying degrees in the ELEMR Project. The authors' backgrounds in design, psychology, and landscape architecture suggest, by example, that professionals with diverse backgrounds but a common interest in environment-behavior problems can indeed learn to communicate and to collaborate. Since design evaluation is a new field and very little specific litera ture on the subject exists to date, we hope this book fills a current need. 236 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume V deals with the problems of turnover in the nervous system. 'Turnover' is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here 'turnover' in dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. 'Turnover' is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery. 480 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In Reproduction, Technology, and Rights, philosophers and ethicists debate the central moral issues and problems raised by today's revolution in reproductive technology. Leading issues discussed include the ethics of paternal obligations to children, the place of in vitro fertilization in the allocation of health care resources, and the ethical implications of such new technologies as blastomere separation and cloning. Also considered are how parents and society should respond to knowledge gained from prenatal testing and whether or not the right to abort should relieve men of the duty to support unwanted children. Reproduction, Technology, and Rights illuminates the moral and ethical choices that our society faces because of advances in reproductive technology and helps to make those decisions better informed. 172 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -(Written for the original Russian edition) Out of all the functional groups of protein molecules that be long to the side chains of amino acid residues, the sulfhydryl or thiol (SH) groups of cysteine residues and the disulfide (S-S) groups of cystine have for long attracted particular attention from chemists and biochemists. This is due, on the one hand, to the high chemical reactivity of these groups, which enter into many, and often very characteristic and selective, reactions with several types of compound. On the other hand, this attention is connected with the great significance of SH and S-S groups for the specific functions of a number of enzymes, hormones, and other biological ly active proteins, and consequently for the normal course of many physiological processes. The varied functions of sulfhydryl and disulfide groups in en zymes are particularly interesting; their role can consist of bind ing substrates and cofactors, in direct participation in the catalytic act, or in maintaining (in ways not so far sufficiently studied) the native, catalytically active conformation of the protein. It is entirely natural that the detailed study of the chemical behavior and biological role of these sulfur-containing groups in proteins (and in such low-molecular cofactors as glutathione, co enzyme A, lipoiC acid, etc. ) has, in addition to its academic, gen eral biological interest, great Significance for many applied branches of medicine and biology (toxicology, radiobiology, diagnostics and therapeutics, biochemical engineering, plant growing, etc. ). 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Fifth International Cryogenic Materials Conference (ICMC) was held in Colorado Springs, Colorado in collaboration with the Cryogenic Engineering Conference (CEC) on August 15-19, 1983. The growth and success of the joint conferences is a result of their complementary program and close cooperation. Materials remain a challenge in the application of cryogenic technology and sometimes, as in the case of superconductors, are the driving force for the technology. The association of materials and cryogenic engineers increases their awareness of recent research in their respective fi. elds and influences the course of future research and applications. Many contributed to the success of the 1983 conference: E. W. Collings of Battelle Memorial Institute was the ICMC Confer ence Chairman; M. Suenaga of Brookhaven National Laboratories, the ICMC Program Chairman; and L. L. Sparks of the National Bureau of Standards, the ICMC Local Arrangements Chairman. J. M. Wells and A. I. Braginski of Westinghouse R & D Center, G. Hartwig of the Nuclear Research Center of Karlsruhe, and K. T. Hartwig of the University of Wisconsin assisted the Program Chairman in metallic metals, superconducting materials, nonmetallic materials, and cryo physical properties, respectively. Excellent conference management was provided by Centennial Conferences. We especially thank M. Stieg, who coordinated the preparation of the papers for this volume. The CEC Board, especially their conference chairman, C. D. Henning of Lawrence Livermore National Laboratories, contributed very substan tially to conference planning and implementation. 1024 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Section III: Initiating Mechanisms and Early Pathogenesis.- 1 Gene Expression and Its Regulation.- 2 Developmental Genetics.- 3 Numerical and Structural Chromosome Abnormalities.- 4 Cell Death and Reduced Proliferative Rate.- 5 Altered Biosynthesis.- 6 Embryonic Intermediary Metabolism under Normal and Pathological Conditions.- 7 Altered Electrolyte and Fluid Balance.- 8 Abnormal Cellular and Tissue Interactions.- 9 Cell Morphogenetic Movements.- 10 Alterations in the Metabolism of Glycosaminoglycans and Collagen.- 11 Time-Position Relationships, with Particular Reference to Cleft Lip and Cleft Palate.- 12 Teratogenesis and Oncogenesis.- Section IV: Examples of Abnormal Organogenesis.- 13 Abnormal Organogenesis in the Eye.- 14 Abnormal Organogenesis in the Cardiovascular System.- 15 Abnormal Organogenesis in the Urinary Tract.- 16 Abnormal Organogenesis in the Reproductive System.- 17 Abnormal Organogenesis of Facial Structures.- 18 Abnormal Organogenesis in the Limbs. 504 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In Biotechnology for Fuels and Chemicals: The Twenty-Fifth Symposium, leading American and international researchers from academia, industry, and government present the latest research and breakthroughs on how biotechnology is being used to produce economically competitive fuels and chemicals in a sustainable and environmentally responsible manner. The contributors discuss both fundamental science discoveries and the progress that has been made in commercialization efforts. Special attention is given to biofeedstock (plant genomics, production, and pretreatment), bioprocessing, direct production in plants, and the use of molecular biology and genomics to create new biocatalysts. The field continues to expand, and the ideas and techniques described here will play important roles in developing new biological processes for producing fuels and chemicals on a large scale, as well as for reducing pollution and waste disposal problems and their adverse impacts on global climate change. Cutting-edge and authoritative, Biotechnology for Fuels and Chemicals: The Twenty-Fifth Symposium provides an excellent overview of current research and development in the production of commodity fuels and chemicals via biological transformation. 1268 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Section VIII: Research Procedures and Data Analysis.- 1 Techniques for Cytogenetic Analysis.- 2 Mutation Testing Systems.- 3 Cell, Tissue, and Organ Culture as Teratologic Tools.- 4 Whole Embryo Explants and Transplants.- 5 Survey of in Vitro Systems: Their Potential Use in Teratogenicity Screening.- 6 The Structure and Uses of Genetically Homogeneous Lines of Animals.- 7 Multigeneration Reproduction Studies.- 8 The Design of Subprimate Animal Studies.- 9 Feasibility and Design of Subhuman Primate Studies.- 10 Uterine Vascular Interruption and Combined Radiation and Surgical Procedures.- 11 Analytical Techniques for the Study of Teratogenic Mechanisms.- 12 Immunological Aspects of Development.- 13 Behavioral Teratology.- 14 Methods and Concepts of Biometrics Applied to Teratology.- of the Complete Handbook (Volumes 1-4).Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 472 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Continuum Mechanics of Anisotropic Materials(CMAM) presents an entirely new and unique development of material anisotropy in the context of an appropriate selection and organization of continuum mechanics topics. These features will distinguish this continuum mechanics book from other books on this subject. Textbooks on continuum mechanics are widely employed in engineering education, however, none of them deal specifically with anisotropy in materials. For the audience of Biomedical, Chemical and Civil Engineering students, these materials will be dealt with more frequently and greater accuracy in their analysis will be desired. Continuum Mechanics of Anisotropic Materials' author has beena leaderin the field of developing new approaches for the understanding of anisotropic materials.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 440 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Immunochemistry, recently rechristened molecular immunology, has been pre occupied throughout its long history with the structure and function of antibodies and the specificity of antibody-antigen reactions. With the recent X-ray diffrac of several crystallized immunoglobulin (Ig) fragments and a whole tion analyses Ig molecule, the three-dimensional structure of antibodies and their ligand combining sites has been realized, marking the concluding stages of a phase of immunological research that can be traced back at least 75 years. At the same time chemically minded immunologists have been moving in new directions. A substantial beginning in one direction has been made with the purification of messenger RNAs (mRNAs) for Ig chains. Hybridization of these RNAs (or their DNA copies made with the enzyme reverse transcriptase) to cell DNA is beginning to provide convincing estimates of the number of germ-line Ig genes. And some hybridization studies have already yielded suggestive evidence for translocation of V and C genes from separate to contiguous positions in DNA isolated from cells at different stages of differentiation. Moreover, in vitro trans lation of Ig mRNAs has revealed a remarkably hydrophobic stretch of about 20 amino acids at the N-terminus of the nascent Ig chain. This extra piece is absent in the Ig extracted from or secreted by plasma cells, presumably because it is rapidly cleaved from the 'preimmunoglobulin' chain within the cell, but the extra piece probably plays a key role in directing the synthesis of prelg to the cell's secretory pathway.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 256 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Those who are familiar with the two volumes of The Year in Endocrinology may, at first glance, fail to recognize their relationship to the present volume, Contemporary Endocrinology. The name is different and the cover design different, but nonetheless the admonition against judging a book by its cover is very well taken in this instance. In fact, Contemporary Endocrinology is not only the direct linear descendant of The Year in Endocrinology, it is a purposeful clone thereof-the topics are unchanged, the talented group of authors is unchanged, and most importantly, both the objective of the work and the manner in which that objective is approached are unchanged. The objective is, of course, to assist the reader in maintaining currency with respect to important developments, both basic and clinical, in the major areas of endocrinology. We are all much too familiar, unfortunately, with the difficulty of maintaining currency these days. Our approach to dealing with the informational inflation that we are suffering is similar to that used by economists in dealing with monetary inflation, that is, to increase interest. This we have attempted to do by providing for the reader an easy-to-read group of essays in which advances in individual areas of endocrinology are re viewed broadly, synthesized, and placed into perspective by a group of authors who are authorities in their individual fields. They serve, not as guest artists, but as members of a stable Editorial Board that provides continuity by contributing to successive volumes.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 420 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -recipients and acceptance of allografts can be made. The authors have the experi ence and ability to bridge the entire field of transplantation and their article encompasses both clinical and immunochemical data in this area. Their data show clearly that matches for the DR antigens are more important than those at the ABC loci in determination of graft survival. Additional relevant factors, in cluding autoimmunity and other B-cell antigens, are discussed and correlated with graft survival. The authors also present pathology data concerning the distribution of HLA-DR antigens in various tissues. These data indicate a fruitful area for future investigations on the chemical aspects of the various antigens encoded within the human MHC. Do changes in the structure of lymphocyte surface glycoproteins, especially changes in their carbohydrate portions, occur during normal lymphoid differen tiation Information about this question is limited, and pertinent data are avail able for only a few proteins. Three of the proteins are major glycoprotein con stituents of rodent thymocyte membranes: the Thy-! antigen, a glycosylated leukocyte sialoglycoprotein called W3/13, and a high-molecular-weight glycopro tein known as the leukocyte-common antigen. In his contribution, Pink thor oughly characterizes these glycoproteins and discusses the evidence that the structures change when a thymocyte differentiates into a mature, peripheral T cell. A comparison is drawn between lymphocyte glycoprotein changes and those that occur during red blood cell differentiation. The reader will find Pink's discourse informative and provocative. Mast cells, basophils, and related tumor lines bind IgE with very high affinity.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 264 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The distinction between molecular immunology and immunobiology is neces sarily arbitrary. The most rapid progress is usually made in the blurred area between the two, when the chemist is aware of the full significance of the biological problems, and the biologist is alert to the contribution that a knowl edge of molecular structure can be made to their solution. The range of scientific disciplines able to contribute to research in immunology, which this approach brings, is reflected in the present volume. Protein chemists worked out the arrangement of the polypeptide chains and the amino acid sequences of antibodies and X-ray crystallographers the three dimensional structure, but more precise definition of the amino acid side chain positions in the combining site is required for an understanding of the subtleties of antibody specificity. That this can be achieved with physical techniques such as nuclear magnetic resonance has been shown by R. A. Dwek, and in his chapter he summarizes these results with a minimum of technical detail. The immune response has been shown to be dependent on complex cellular interactions and further progress will be facilitated by investigation of the molecular basis of these interactions. This necessitates study of the structure and organization of the molecules in the surfaces of lymphocytes and other cells.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 272 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Coronaviruses represent a major group of viruses of both molecular biological interest and clinical significance in animals and humans. During the past two decades, coronavirus research has been an expanding field and, since 1980, an international symposium was held every 3 years. We organized the yth symposium for providing an opportunity to assess important progresses made since the last symposium in Cambridge (U. K. ) and to suggest areas for future investigations. The symposium, held in September 1992, in Chantilly, France, was attended by 120 participants representing the majOlity of the laboratories engaged in the field. The present volume collects 75 papers which were presented during the yth symposium, thus providing a comprehensive view of the state of the art ofCoronavirology. The book is divided into 7 chapters. The first chapters gather reports dealing with genome organization, gene expression and structure-function relationships of the viral polypeptides. New sequence data about as yet poorly studied coronaviruses - canine coronavirus CCY and porcine epidemic diarrhoea virus PEDY - are presented. Increasing efforts appear to be devoted to the characterization of products of unknown function, encoded by various open reading frames present in the coronavirus genomes or delived from the processing of the large polymerase polyprotein. Due to the extreme size of their genome, the genetic engineering ofcoronavi'uses through the production of full length cDNA clones is presently viewed as an unachievahle task.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 492 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This series was originally entitled Contemporary Topics in Immunochemistry, and Volume 1 bearing that name was published. Upon its editorial review and while charting the development of future volumes, the editors began to sense that the word 'Immunochemistry' was somewhat restrictive according to its present interpretation. Accompanying the expansion of knowledge in immuno biology is a demand for explanations in molecular terms. Since the intent of the series is to focus attention on research at the molecular level in any aspect of immunology, the editors and publisher felt the term 'Immunochemistry' should be replaced with 'Molecular Immunology.' Thus, the series now bears a revised appellation, Contemporary Topics in Molecular Immunology. The editors feel this more accurately reflects the intended breath of the series. An apology is offered to writers, librarians, and other catalogers for the inconvenience this change will cause. F. P. Inman General Editor Athens, Georgia March,1973 vii Preface The earliest explorers into immunology were at once confronted by myriad molecular riddles which became increasingly complex as immunochemical tech niques resolved one question only to raise scores of others. Even as our knowledge of cellular immunology was growing remarkably fast, during the past two decades exciting experiments delineated the molecular structure of immuno globulins. These joint advances not only shaped the Gestalt of present-day immunology, but paved the way for an incisive molecular approach to the challenges of research.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 296 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -When discussion began four years aga about launehing the American Association for the Study of Mental Imagery there was still a great deal of skepticism on the part of many academic and clinical psychologists. They held to the gradually diminishing view that mental imagery was too idiosyncratic a subject for intensive study. However, there were sufficient visionaries to recognize the undeniable importance of imagery for the functioning of life in memory and the transmission of information. Through the valiant efforts of these pioneers in psychology, art and movement therapy, and others in the field of human relations the organization has grown and flourished. Even more important is the burgeoning of knowledge about the ubiquitous nature of imagery and its impact on life. The third annual meeting of AASMI was held in 1981 at Yale University under the sponsorship of president-elect Jerome L. Singer. Sixty-five persons presented papers, workshops and theoretical studies. This volume represents the broad array of topics and approaches offered at the conference. While it is informative and stimulating to read and study the articles in this volume they can convey only a fraction of the excitement and the knowledge available to those who attended the conference. The reader will reap a two-fold benefit from this volume, for not only does it cover a vast array of topics related to imagery, but it also offers the strong possibility that the results of these works can be included in one's daily work as a clinician and/or researcher.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 448 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The publication explores the ways in which archaeological research can inform us about the manner and motives of European involvement in the development of a sovereign United States. The five chapters focus on different archaeological sites (four terrestrial sites) and each consider the special ways in which archaeology can contribute to our understanding of the cultural dynamics that set the historic course of events in motion that culminated in United States sovereignty. An introduction and conclusion examine how the material culture that is the central focus of archaeological research should be preserved, managed, and interpreted.While much is known through historical documents,this volumeseeks to enrich, modify, and challenge the written record by attention to the archaeological remains. The scale of analysis ranges from the artifact through the site to the landscape. Chapters address the changing relationships between specific European countries and the United States as indicated by the presence of artifacts or types of artifacts (e.g., weapons, domestic, architectural) made or traded by other countries during different time periods; an analysis of ¿space syntax¿ seen at battlefields or fortifications; the importance of conceptually reconstructing terrain crossed by troops or at battlefields. The Archaeology of Interdependence: European Involvement in the Development of a Sovereign United States presents innovative investigations of what material culture at all scales might tell us about the political, economic, or ideological relationships among cultures that corroborates, contradicts, or enriches the historic record.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 116 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Electronic funds transfer (EFT) systems include a wide range of computer-based payment systems and sources that substitute electronic and digital transfers for movements of cash and paper checks. A few years ago some people were predict ing that EFT would replace paper money and coins entirely and that we would soon be a 'checkless' and' 'cashless' society. Such sweeping changes have not occurred, but a slower evolution is clearly underway. Although checks, cur rency, and coin are likely to be here for many years to come, EFT is becoming an established part of our worldwide payment transfer system, and the implications and consequences of this technology are real. They include: ¿ Alterations in personal finance and in the process of purchasing and paying for consumer goods and services. ¿ Changes in the structure of financial and retail organizations and their mode of interaction in the marketplace. ¿ Modifications in the flow of funds in our society and in the interactions among economic institutions. ¿ Alterations in the prospects for invasion of personal privacy, perpetration of fraud and theft, and violation of antitrust regulations. ¿ Changes in the regulatory and competitive balance among the numerous financial institutions in the United States. Such alterations foretell important impacts on people and society. Benefits are forthcoming, but the costs will also be real.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 328 pp. Englisch.…