Humana jul 1995 (5 risultati)

Taschenbuch. Condizione: Neu. Neuware - Antibodies are the instraments of immune defense and attack. They can bind small atomic arrays as well as large epitopes with high affinity. Antibody Engineering Protocols presents advanced protocols in the field of antibody engineering, reviews of basic principles and methodology, and a historical perspective on the development of cur rently held beliefs about antibody structure-function relationships. The topics cover analysis of antibody sequences, three-dimensional structure, delineation of antibody characteristics in polyclonal mixtures, phage display of natural and synthetic antibodies, and antibody catalysis. Ligand recognition by antibodies occurs primarily at a subset of amino acid residues located in the complementarity determining regions (CDRs) found in the light (L) and heavy (H) chain subunits. Specific antibodies are developed by immunization with molecules identical to or related in structure to the target ligand. The immune repertoire from nonimmunized individuals also contains pre-existing specificities that can be selected by screening libraries composed of hybridoma cells or phage particles displaying F domains or indi vidual variable domains of the light (VJ and heavy (V^^) chains. Ran dom or site-directed mutagenesis in vitro can be used to refine the pre-existing specificities or produce new specificities de novo. Another level at which new specificities may be generated in vitro is V^ and V^ domain-swapping and CDR-swapping. The former procedure embodies a variation of natural mechanisms of generating antibody diversity. The latter procedure produces new intramolecular CDR combinations not found in nature.…

Buch. Condizione: Neu. Neuware - It has been established that neuroglia are involved in early neu ronal growth, differentiation, and migration; these issues are well discussed in the companion volume entitled Neuron-Glia Interrela tions During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells. The present volume, Neuron-Glia Interrelations During Phylogeny: II. Plas ticity and Regeneration, focuses on two aspects: (1) neuron-glia inter relations as they relate to the physiological and metabolic homeostasis of neurons; and (2) the role of neuroglia and neuronal plasticity in regeneration and aging. Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration begins with the unique presentation, 'Neuron-Glia In teractions in the Human Fetal Brain,' by Sogos et al. The interesting issue discussed in this chapter is the immunocompetence of the CNS, a field that is now rising. The chapter by Oland et al. , 'Glial Cells Playa Key Role in the Construction of Insect Olfactory Glomeruli,' discusses a unique role of glial cells as intermediates in afferent axon induction of substructure with the CNS. The chapter by Vanhems, 'Insect Glial Cells and Their Relationships with Neurons,' compliments the information presented in the companion volume by Fredieu and Mahowald and, in this volume, the chapter by Tobert and Oland. The chapter by Tsacopoulos and Poitry, 'Metabolite Exchanges and Signal Trafficking Between Glial Cells and Neurons in the Insect Retina,' provides evidence of the nutritive functions of glial cells and the important role of alanine supplied by glial cells to photoreceptors, a clear neuron-glia interaction.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite its short history, wavelet theory has found applications in a remarkable diversity of disciplines: mathematics, physics, numerical analysis, signal processing, probability theory and statistics. The abundance of intriguing and useful features enjoyed by wavelet and wavelet packed transforms has led to their application to a wide range of statistical and signal processing problems. On November 16-18, 1994, a conference on Wavelets and Statistics was held at Villard de Lans, France, organized by the Institute IMAG-LMC, Grenoble, France. The meeting was the 15th in the series of the Rencontres Pranco-Belges des 8tatisticiens and was attended by 74 mathematicians from 12 different countries. Following tradition, both theoretical statistical results and practical contributions of this active field of statistical research were presented. The editors and the local organizers hope that this volume reflects the broad spectrum of the conference. as it includes 21 articles contributed by specialists in various areas in this field. The material compiled is fairly wide in scope and ranges from the development of new tools for non parametric curve estimation to applied problems, such as detection of transients in signal processing and image segmentation. The articles are arranged in alphabetical order by author rather than subject matter. However, to help the reader, a subjective classification of the articles is provided at the end of the book. Several articles of this volume are directly or indirectly concerned with several as pects of wavelet-based function estimation and signal denoising. 420 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It is now established that neuroglia are the intimate partners of neurons and that neuronal function is a result of neuron-glia interrelations at several levels of organization. The literature shows that the study of phylogeny has contributed a deeper understand ing of the complex functions of the neuroglia and the neuron-glia unit. It is the purpose of Neuron-Glia Interrelations During Phylog eny: I. Phylogeny and Ontogeny of Glial Cells, as well as its compan ion volume Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration, to present to the scientific community a broad spectrum of information on neuroglia through phylog eny and ontogeny, the focus of this volume. In view of the role of neuroglia in plasticity and regeneration, the companion volume will cover this aspect of neuroglia during phylogeny. Neuron-Glia Interrelations During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells begins with the elegant chapter 'Glial Types, Gliogenesis, and Extracellular Matrix in Mammalian CNS' by Amico Bignami, to whom this volume is dedicated. He was one of the pioneers in describing gliogenesis and this chapter brings together everything we know today on this critical topic. It also includes the latest views of Bignami on the role of extracellular matrix in gliogenesis and glial functions. 'Evolution of Astrocytes in the Vertebrate CNS' by Suarez et al. complements and extends the information in Bignami's chapter by including ependymal astrocytes. 296 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It is now established that neuroglia are the intimate partners of neurons and that neuronal function is a result of neuron-glia interrelations at several levels of organization. The literature shows that the study of phylogeny has contributed a deeper understand ing of the complex functions of the neuroglia and the neuron-glia unit. It is the purpose of Neuron-Glia Interrelations During Phylog eny: I. Phylogeny and Ontogeny of Glial Cells, as well as its compan ion volume Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration, to present to the scientific community a broad spectrum of information on neuroglia through phylog eny and ontogeny, the focus of this volume. In view of the role of neuroglia in plasticity and regeneration, the companion volume will cover this aspect of neuroglia during phylogeny. Neuron-Glia Interrelations During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells begins with the elegant chapter 'Glial Types, Gliogenesis, and Extracellular Matrix in Mammalian CNS' by Amico Bignami, to whom this volume is dedicated. He was one of the pioneers in describing gliogenesis and this chapter brings together everything we know today on this critical topic. It also includes the latest views of Bignami on the role of extracellular matrix in gliogenesis and glial functions. 'Evolution of Astrocytes in the Vertebrate CNS' by Suarez et al. complements and extends the information in Bignami's chapter by including ependymal astrocytes.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 296 pp. Englisch.…