Humana okt 1997 (13 risultati)

Buch. Condizione: Neu. Neuware - Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.…

Buch. Condizione: Neu. Neuware - A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This IMA Volume in Mathematics and its Applications RANDOM SETS: THEORY AND APPLICATIONS is based on the proceedings of a very successful 1996 three-day Summer Program on 'Application and Theory of Random Sets.' We would like to thank the scientific organizers: John Goutsias (Johns Hopkins University), Ronald P.S. Mahler (Lockheed Martin), and Hung T. Nguyen (New Mexico State University) for their excellent work as organizers of the meeting and for editing the proceedings. We also take this opportunity to thank the Army Research Office (ARO), the Office ofNaval Research (0NR), and the Eagan, MinnesotaEngineering Center ofLockheed Martin Tactical Defense Systems, whose financial support made the summer program possible. Avner Friedman Robert Gulliver v PREFACE 'Later generations will regard set theory as a disease from which one has recovered. ' - Henri Poincare Random set theory was independently conceived by D.G. Kendall and G. Matheron in connection with stochastic geometry. It was however G. 436 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -David Morgan brings together in Polyamine Protocols a unique collection of hands-on enzyme assay techniques for the study of polyamines and their biological functions. The techniques range from assay methods for enzymes of polyamine biosynthesis and catabolism to measurements of polyamines, polyamine transport, and polyamine effects on cell growth. All methods are presented by active researchers who have developed them to a high degree of perfection in their own laboratories, and include clear, step-by-step instructions with numerous hints and tips to ensure readily reproducible results. Polyamine Protocols is the only compilation of methods currently available for use in studies involving polyamines. The collection offers both novice and experienced researchers across many fields-including cell and molecular biology, pharmacology, oncology, physiology, laboratory medicine, and clinical pathology-all the tools needed to elucidate the biological roles played by these ubiquitous substances. 200 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Polyamines: An Introduction.- Assay Methods for Enzymes of Polyamine Biosynthesis.- Determination of Ornithine Decarboxylase Activity Using [3H]Omithine.- Assay of Mammalian Ornithine Decarboxylase Activity Using [14C]Ornithine.- Assay of Mammalian S-Adenosylmethionine Decarboxylase Activity.- Assay of Spermidine and Spermine Synthases.- Measurement of Spermidine/Spermine N 1-Acetyltransferase Activity.- Assay of Spermidine N 8-Acetyltransferase.- Assay Methods for Enzymes of Polyamine Catabolism.- Assay of N 8-Acetylspermidine Deacetylase.- Hydrogen Peroxide Assay for Amine Oxidase Activity.- Radiochemical Assay of Diamine Oxidase.- Radiochemical Estimation of Polyamine Oxidase.- Measurement of Aldehyde Formation as an Assay for Polyamine Oxidase Activity.- Measurement of Polyamines.- Determination of Polyamines as Their Benzoylated Derivatives by HPLC.- A Dansyl Chloride-HPLC Method for the Determination of Polyamines.- The Determination of Polyamines and Amino Acids by a Fluorescamine-HPLC Method.- Thin-Layer Chromatographic Method for Assaying Polyamines.- Measurement of Polyamine Transport.- Measurement of Polyamine Transport: Adherent Cells.- Measurement of Polyamine Transport: Cells in Suspension.- Measurement of Polyamine Efflux from Cells in Culture.- Measurement of Polyamine Effects on Cell Growth.- Leucine Incorporation and Thymidine Incorporation.- Tetrazolium (MTT) Assay for Cellular Viability and Activity.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 200 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is based on several courses taught during the years 1985-1989 at the City College of the City University of New York and at Fudan Univer sity, Shanghai, China, in the summer of 1986. It was originally our intention to present to a mixed audience of electrical engineers, mathematicians and computer scientists at the graduate level a collection of algorithms that would serve to represent the vast array of algorithms designed over the last twenty years for computing the finite Fourier transform (FFT) and finite convolution. However, it was soon apparent that the scope of the course had to be greatly expanded. For researchers interested in the design of new algorithms, a deeper understanding of the basic mathematical concepts underlying algorithm design was essential. At the same time, a large gap remained between the statement of an algorithm and the implementation of the algorithm. The main goal of this text is to describe tools that can serve both of these needs. In fact, it is our belief that certain mathematical ideas provide a natural language and culture for understanding, unifying and implementing a wide range of digital signal processing (DSP) algo rithms. This belief is reinforced by the complex and time-consuming effort required to write code for recently available parallel and vector machines. A significant part of this text is devoted to establishing rules and procedures that reduce and at times automate this task.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The great advantage of coincidence measurements is that by suitable choice of the kinematical and geometrical arrangement one may probe delicate physical effects which would be swamped in less differential experiments. The measurement of the triple dif ferential and higher-order cross sections presents enormous technical difficulties, but refined experiments of this type provide an insight into the subtleties of the scattering process and offer a welcome, if severe, test of the available theoretical models. The last few years have been an exciting time to work in the field and much has been learned. Profound insights have been gleaned into the basic Coulomb few body problem in atomic physics: the experimental study of the fundamental (e,2e) processes on hydrogen and helium targets continues to add to our knowledge and indeed to challenge the best of our theoretical models; significant advances have been made in the understanding of the 'double excitation problem,' that is the study of ionization processes with two active target electrons: important measurements of (e,3e), (,),2e), excitation-ionization and excitation autoionization have been reported and strides have been made in their theoretical description; the longstanding discrepancies between theory and experiment for relativistic (e,2e) processes were resolved, spin dependent effects predicted and ob served and the first successful coincidence experiments on surfaces and thin films were announced. Theory and experiment have advanced in close consort. The papers pre sented here cover the whole gambit of research in the field. Much has been achieved but much remains to be done.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals.Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals.Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies. 360 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders. 476 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders. 476 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Synchronization is a critical function in digital communications; its failures may have catastrophic effects on the transmission system performance. Furthermore, synchronization circuits comprehend such a large part of the receiver hardware that their implementation has a substantial impact on the overall costs. For these reasons design engineers are particularly concerned with the development of new and more efficient synchronization structures. Unfortunately, the advent of digital VLSI technology has radically affected modem design rules, to a point that most analog techniques employed so far have become totally obsolete. Although digital synchronization methods are well established by now in the literature, they only appear in the form of technical papers, often concentrating on specific performance or implementation issues. As a consequence they are hardly useful to give a unified view of an otherwise seemingly heterogeneous field. It is widely recognized that a fundamental understanding of digital synchronization can only be reached by providing the designer with a solid theoretical framework, or else he will not know where to adjust his methods when he attempts to apply them to new situations. The task of the present book is just to develop such a framework. 540 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Synchronization is a critical function in digital communications; its failures may have catastrophic effects on the transmission system performance. Furthermore, synchronization circuits comprehend such a large part of the receiver hardware that their implementation has a substantial impact on the overall costs. For these reasons design engineers are particularly concerned with the development of new and more efficient synchronization structures. Unfortunately, the advent of digital VLSI technology has radically affected modem design rules, to a point that most analog techniques employed so far have become totally obsolete. Although digital synchronization methods are well established by now in the literature, they only appear in the form of technical papers, often concentrating on specific performance or implementation issues. As a consequence they are hardly useful to give a unified view of an otherwise seemingly heterogeneous field. It is widely recognized that a fundamental understanding of digital synchronization can only be reached by providing the designer with a solid theoretical framework, or else he will not know where to adjust his methods when he attempts to apply them to new situations. The task of the present book is just to develop such a framework.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 540 pp. Englisch.…