Rsc publishing dez 2020 (7 risultati)

Buch. Condizione: Neu. Neuware - Understanding how simple molecules have given rise to the complex biochemical systems and processes of contemporary biology is widely regarded as one of chemistry's great unsolved questions. There are numerous theories as to the origins of life, the majority of which draw on the idea that DNA and nucleic acids are the central dogma of biology. This book takes a systems-based approach to the origin and evolution of complex life. Readers will gain a novel understanding of physiologic evolution and the limits to our current understanding, as well as offering new opportunities for understanding relationships between physics and biology in the origins of biological life at the cellular-molecular level.…

Buch. Condizione: Neu. Neuware - Molecular interations, protein-protein interactions play a crucial role in regulating many cellular functions. In many diseases, abberant forms of these interactions play central roles. Thus, they have emerged as critical drug targets. This book includes a survey of recent advances in the structural understanding of protein-protein interactions, as well as recent developments in modulator discovery.…

Buch. Condizione: Neu. Neuware - Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens From the most recent examples, what were the factors enabling target identification and validation This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.…

Buch. Condizione: Neu. Neuware - As analysis, in terms of detection limits and technological innovation, in chemical and biological fields has developed so computational techniques have advanced enabling greater understanding of the data. Indeed, it is now possible to simulate spectral data to an excellent level of accuracy, allowing chemists and biologists access to robust and reliable analytical methodologies both experimentally and theoretically. This work will serve as a definitive overview of the field of computational simulation as applied to analytical chemistry and biology, drawing on recent advances as well as describing essential, established theory. Computational approaches provide additional depth to biochemical problems, as well as offering alternative explanations to atomic scale phenomena. Highlighting the innovative and wide-ranging breakthroughs made by leaders in computational spectrum prediction and the application of computational methodologies to analytical science, this book is for graduates and postgraduate researchers showing how computational analytical methods have become accessible across disciplines. Contributed chapters originate from a group of internationally-recognised leaders in the field, each applying computational techniques to develop our understanding of and supplement the data obtained from experimental analytical science.…

Buch. Condizione: Neu. Neuware - Breaking down large biomolecules into fragments in a controlled manner is key to modern biomolecular mass spectrometry. This book is a high-level introduction - as well as a reference work for experienced users - to ECD, ETD, EDD, NETD, UVPD, SID, and other advanced fragmentation methods. It provides a comprehensive overview of their history, mechanisms, instrumentation, and key applications. With contributions from leading experts, this book will act as an authoritative guide to these methods. Aimed at postgraduate and professional researchers mainly in academia, but also in industry, it could be used as supplementary reading for advanced students on mass spectrometry or analytical (bio)chemistry courses.…

Buch. Condizione: Neu. Neuware - Endocrine disruptors are chemicals that can interfere with the endocrine systems (hormone systems) at certain dosages and are known to affect the development of numerous diseases. They are an increasing concern given the number of known EDCs in household products and the environment. This book will cover the pathology of EDCs across the spectrum of disease as well as risk assessment and government and legal regulation to provide a hollistic view of the current issues and cutting-edge research.…

Buch. Condizione: Neu. Neuware - Building on decades of 'host-guest' research, recent years have seen a surge of activity in water-soluble supramolecular receptors for protein recognition and assembly. Progress has been particularly rich in the area of calixarenes, cucurbiturils and molecular tweezers. Emerging applications include controlled protein assembly in solution, crystal engineering, supramolecular control of catalysis (both in vitro and in vivo), as well as novel mechanisms of protein-interaction inhibition with relevance to amyloids and disease. One challenge at the interface of supramolecular chemistry and protein science is to increase interaction and collaboration between chemists and biochemists/structural biologists.This book addresses the exciting interface of supramolecular chemistry and protein science. Chapters cover supramolecular approaches to protein recognition, assembly and regulation. Principles outlined will highlight the opportunities that are readily accessible to collaborating chemists and biochemists, enriching the breadth and scope of this multidisciplinary field. Supramolecular Protein Chemistry will be of particular interest to graduate students and researchers working in supramolecular chemistry, protein science, self-assembly, biomaterials, biomedicine and biotechnology.…