springer basel nov 2010 (6 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The complexity of Information Technology (IT) systems has been steadily incre- ing in the past decades. In October 2001, IBM released the 'Autonomic Computing Manifesto' observing that current applications have reached the size of millions of lines of code, while physical infrastructures include thousands of heterogeneous servers requiring skilled IT professionals to install, con gure, tune, and maintain. System complexity has been recognized as the main obstacle to the further advan- ment of IT technology. The basic idea of Autonomic Computing is to develop IT systems that are able to manage themselves, as the human autonomic nervous system governs basic body functions such as heart rate or body temperature, thus freeing the conscious brain- IT administrators-from the burden of dealing with low-level vital functions. Autonomic Computing systems can be implemented by introducing autonomic controllers which continuously monitor, analyze, plan, and execute (the famous MAPE cycle) recon guration actions on the system components. Monitoring acti- ties are deployed to measure the workload and performance metrics of each running component so as to identify system faults. The goal of the analysis activities is to determine the status of components from the monitoring data, and to forecast - ture conditions based on historical observations. Finally, plan and execute activities aim at deciding and actuating the next system con guration, for example, deciding whether to accept or reject new requests, determining the best application to servers assignment, in order to the achieve the self-optimization goals. 184 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Filtering is the science of nding the law of a process given a partial observation of it. The main objects we study here are di usion processes. These are naturally associated with second-order linear di erential operators which are semi-elliptic and so introduce a possibly degenerate Riemannian structure on the state space. In fact, much of what we discuss is simply about two such operators intertwined by a smooth map, the projection from the state space to the observations space', and does not involve any stochastic analysis. From the point of view of stochastic processes, our purpose is to present and to study the underlying geometric structure which allows us to perform the ltering in a Markovian framework with the resulting conditional law being that of a Markov process which is time inhomogeneous in general. This geometry is determined by the symbol of the operator on the state space which projects to a symbol on the observation space. The projectible symbol induces a (possibly non-linear and partially de ned) connection which lifts the observation process to the state space and gives a decomposition of the operator on the state space and of the noise. As is standard we can recover the classical ltering theory in which the observations are not usually Markovian by application of the Girsanov- Maruyama-Cameron-Martin Theorem. This structure we have is examined in relation to a number of geometrical topics. 184 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Increasing size and complexity of software and hardware systems makes it harder to ensure their reliability. At the same time, the issues of autonomous computing become more critical as we more and more rely on software systems in our daily life. Such complexity is getting even more critical with the ubiquitous computing of embedded devices and other pervasive systems. These trends ask for techniques and tools for developing reliable and autonomous software which can support software engineers in their efforts. This book summarizes the state of the art of research in the diverse fields concerned, including novel designs, case studies and experimental as well as theoretical results. 428 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways.This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry. 188 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines. 464 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 464 pp. Englisch.