springer chapman and hall crc okt 2011 (174 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -vitro methodology for the cultivation of erythroid The purpose of In Vitro Aspects of Erythropoiesis is to broaden our understanding of the regulation of stem cells. The second series of papers treats cellular normal and neoplastic hematopoietic cells by means and soluble factors which affect erythroid stem cell of a synthesis of different techniques, divergent no differentiation. Hormonal modulation of in vitro menclature as well as a closer standardization of re erythropoiesis is the theme of the third session fol agents and methods which had heretofore produced lowed by a series of papers in the fourth which fo vagaries of results among different laboratories. cuses on erythropoiesis after transformation by ei Hence the papers, discussions and appendices pre ther Friend or Rauscher viruses. The fifth session deals with serum inhibitors to erythropoiesis and the sented in this volume will be of value and interest to investigators and clinicians as well as to students and role of the macrophage in red blood cell production. teachers of hematology. Finally, the sixth session concentrates on the biogen In Vitro Aspects of Erythropoiesis is comprised of esis of erythropoietin in vivo and in vitro. thirty papers delivered by twenty invited contribu Each of the six sections is followed by a discus tors at a three day conference which was held in sion which was transcribed and initially edited at the Capri, Italy in October of 1977. The contributors meeting. 304 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This report originated in a request to me from the Board of Trustees of the Ford Foundation in the summer of 1975. The trustees, aware that there would be a change of leadership at the Foundation be fore 1980, wanted to make a running start in the process of plan ning for the future. Their first step was to make a study of the great national and international needs that might lie ahead in the next decade and a half, and where and how the Foundation might ad dress them. They sought advice both within the Foundation and outside it, and they engaged in long discussions of their own. Although the exercise was directed toward planning for the future, the trustees also wished to review our past, not exhaus tively but at least well enough to have a clear sense of what the Foundation had been up to in the quarter century of its existence as a national and international institution. In this connection, the chairman of our board, Alexander Heard, asked for /I a canvass of the Ford Foundation's experiences, successes, and failures during the last twenty-five years . . . [focused] on the broad objectives sought, the means pursued to achieve them, and the results. 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Intercellular communication in multicellular organisms enables cells to respond to environmental changes. Intercellular signal transduction transmitters include hormones, peptide growth factors, neurotransmitters as well as some lipid-soluble mediators. Once signalling molecules are bound to their cell surface receptors, one or more intracellular signals are generated which alter the Qehavior of the target cell. The IXth International Washington Spring Symposium at the George Washington University in Washington, D.C. was organized to assess the current status of the field of signal transduction processes and regulatory mechanisms. The symposium was held on May 8-'.2, 1989 and was attended by more than 1000 scientists from 30 countries. Most of the papers presented at the plenary sessions have been collected in this volume. The first section of this book details the action and regulation of receptors such as ,B-pdr.'nergic receptors and receptors for EGF, insulin, leukotrienes, phosphoinositides and prostaglandins. Section two focuses on the family of guanine nucleotide regulatory proteins (G proteins). These G proteins are known to mediate the coupling of receptor-mediated signals to several intracellular effector systems. Papers are presented describing the intracellular localization of G proteins, the utilization of G protein antibodies, the interaction of G proteins with tubulin and the involvement of G proteins in the regulation of ion channels, adenylate cy~lase and in the activation of neutrophils and T cells. In the third section, several papers describe the second messenger role of phosphoinositides as well as the regulation of phosphoinositide production. 432 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume represents the findings of the six-year NATO CCMS pilot study on the use of remote sensing for the control of marine pollution, a joint study conducted by countries confronted by the problems that arise from the prevention of, and the fight against, deliberate and accidental oil spills. In 1976, when I submitted to the Committee on the Challenges of Modern Society the draft of this pilot study, the use of remote sensing in the area covered by the project was still at the experimental research stage. Two years later, the Amoco Cadiz disaster occurring on the Brittany Coast gave ~he opportunity to demonstrate the important role that remote sensing could play in the fight against major oil spills. At the same time, many countries engaged in the fight against the deliberate discharge of oil from ships became aware of the po tential of remote sensing to help combat this type of illegal activity. Compiling this volume has afforded me the opportunity to re-read the papers that were presented at the workshops in Washington, D.C. and Paris, which were held April 1979 and October 1982, respectively. Not only is the material still of current interest, but also some recommendations expressed by the experts have already received international recognition. This applies, in particular, to the Isowake experiments, which were originated by the United States (U.S. Coast Guard) and the United Kingdom (Warren Spring Laboratory). 484 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thermoelectric and related transport properties of metals have been a source of information and, also, exasperation to physicists for over a century. Perhaps the principal reasons for interest in these phenomena are their sensitivity to composition, structure and external fields and, until fairly recently, the distressing fact that often even gross experimental features such as the sign of the thermopower eluded theoretical understanding. During the past two decades many of the previously perplexing aspects of thermoelectricity have yielded to more sophisticated theoretical treat ment. As a result of this effort and concomitant experimental work using advanced measurement techniques, there is now good reason to believe that thermoelectric phenomena can shed much light on the interactions between electrons and phonons, impurities, and other defects. The last few years have witnessed new and fascinating developments that promise to stimulate new activity in this field. In contrast to the more conventional transport properties, second-and high-order contributions in electron scattering theory appear to play a profound role in thermoelectricity-the controversy surrounding ordinary and 'phony' phonon drag is far from resolved; the startlingly large effect of magnetic fields on the thermopower of metals appears to be linked intimately to scattering anisotropy; quantum oscillations of thermopower are orders of magnitude larger than corresponding oscillations of the magnetoresistance; a new approach to thermoelectric studies allows extension of thermopower measurements into the millikelvin region of temperature; finally, the advent of superconducting detection devices permits the precise measurement of extremely small voltages, an essential requirement in this field. 284 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents plenary lectures and invited papers that Were delivered during the Fourth Australian Conference on Electro chemistry held at The Flinders University of South Australia, 16-20th February 1976. EZeat~oahemi8try fo~ a Futu~e Soaiety was selected as the Conference theme since the organising committee were mindful of the rapid change in technological perspective which the world now faces. We no longer have a prospect of uncontrolled spontaneous expansion and change as the result of technological enterprise. Rather, we face the task of attempting to reach a state of very restricted growth. In the next few decades special accent must be placed on minimizing pollution and maximizing the efficient utilization of all available energy sources. With this in mind, the Conference organisers considered that a conventional electrochemistry symposium, with its divisions into the various academic aspects, would be less relevant than a meeting devoted to aspects of electrochemistry which may underlie parts of the new and necessary technology for the future state of affairs. What has actually been achieved by the Conference organisers is a balance between the ideals expressed and the resulting response from electrochemists. This response has a bias which reflects the dominance of certain resources, e.g. metallic minerals, within Australia. Consequently, the papers included in T~ends in EZeat~o ahemist~ cover subjects which are of both global and local concern. 424 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -At the present time there are renewed global efforts to control the major tropical infections and to stem the tide of malnutrition, the two serious, often intertwined, problems that contribute to much of the morbidity and mortality in under privileged populations. Many international organizations have joined hands with national governments and with the private sector to search for new approaches to problems that beset much of the developing world, including countries in the tropical region. This volume continues the tradition of the previous publication in the Series. A variety of fare is offered to readers: explanations of the activities and achievements of the UNDP/World Bank/WHO Special Programme for Re search and Training in Tropical Diseases; and studies of infant mortality, schistosomiasis, trypanosomiasis, helminths, lactase deficiency, oral rehydration therapy, functional consequences of iron deficiency, and fertility control. Au thoritative state-of-the-art reviews provide a critical analysis of recent data. I hope the Series will continue to prove useful to all those working in the tropics and to those in the industrialized countries whose awareness of physical health problems of the Third World is relatively limited. R. K. Chandra St. John's, Newfoundland VlI Contents Chapter 1. The Special Programme for Research and Training in Tropical Diseases . . . . . . . . . . . . . . . . . . . DAVID S. ROWE 1. Origins, Objectives, and Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Modus Operandi of the Programme. . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Scientific Working Groups. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Research Strengthening Group. . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 3. TheScientific and Technical Advisory Committee. . . . . . . . . 7 2. 4. Joint Coordinating Board. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The effects of drugs on behavior are of inherent interest and psycho pharmacology has provided a focus for research activity for many years. Until recently, however, it could be claimed that the contribution of pharmacology was more obvious than that of psychology in the de velopment of what should surely prove to be a matter for interdis ciplinary endeavor. Pharmacological analyses of drug action have frequently been expressed in terms of dose-response functions, for ex ample, with the dependent variable taking the form of patterns of be havior whose controlling influences were but poorly understood. The introduction of operant conditioning techniques has transformed psy chopharmacology in this respect. Operant analyses have traditionally emphasized the environmental determinants of behavior and have ex plored the behavioral outcomes of many different experimental ar rangements. These different behavioral repertoires have quickly proved to be of great importance in influencing the behavioral effects of drugs, and so psychologists have begun to playa role which better balances that of the pharmacologist in experimental psychophar macology. To reflect the development of these interdisciplinary studies, several excellent books have been published in recent years. These 1 have included introductory texts, collections of important experi mental reports which had appeared in learnedjournals,2 and authorita 3 tive handbooks which survey the current scene. 524 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is a result of the summary and synthesis of data collected in the Grassland Biome Program, which is part of the American contribution to the International Biological Program (IBP). The purpose of this volume is to present a summary of quantitative ecological investigations of North American grass lands and to present a set of broad comparisons of their characteristics and functions as well as the results of some models and experiments that lead to practical considerations of the management of grasslands. Synthesis is a continuing activity in science. Early in the Grassland Biome Program there was a synthesis of literature data on grasslands, edited by R. L. Dix and R. G. Beidleman (1969). Results of the first year of field data collection under this program were synthesized in a volume edited by N. R. French (1971). Development of the large-scale model constructed to depict the processes and the dynamics of state variables in grassland ecosystems was presented by Innis (1978). Soon to appear will be two volumes integrating studies of American grasslands with IBP studies in other grasslands of the world (Coupland, in press) and the application of systems analysis to understanding grassland function and utilization (Breymeyer and Van Dyne, in press). The present volume presents current results and comparisons of field investigations and experimental studies that were conducted under this program. 224 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume constitutes the Proceedings of a Symposium on the Plastic Deformation of Ceramic Materials, held at The Pennsylvania State University, University Park, Pennsylvania, July 17, 18, and 19, 1974. The theme of this conference focused on single crystal and polycrystalline deformation processes in ceramic materials. The 31 contributed papers by 52 authors, present a current understand ing of the theory and application of deformation processes to the study and utilization of ceramic materials. The program chairmen gratefully acknowledge the financial assistance for the Symposium provided by the United States Atomic Energy Commission, The National Science Foundation, and The College of Earth and Mineral Sciences of The Pennsylvania State University. Special acknowledgment is extended to Drs. Louis C. Ianniello and Paul K. Predecki of the AEC and NSF, respectively. Of course, the proceedings would not have been possible without the excellent cooperation of the authors in preparing their manuscripts. Special appreciation is extended to the professional organi zation services provided by the J. Orvis Keller Conference Center of The Pennsylvania State University. In particular, Mrs. Patricia Ewing should be acknowledged for her excellent program organization and planning. Finally, we also wish to thank our secretaries for the patience and help in bringing these Proceedings to press. 588 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains papers presented at a NATO Advanced Research Institute, sponsored by their Eco-Sciences Panel, on 'The effects of acid precipitation on vegetation and soils,' held at Toronto, Canada from May 22-26, 1978. The organizing expenses and greater part of the expenses of the speakers and chair~en were provided by N.A.T.O. The scientific programme was planned by T. C. Hutchinson together with an international planning committee of G. Abrahamsen (Norway), G. Likens (U.S.A.), F.E. Last (U.K.), C.O. Tamm (Sweden) and B. Ulrich (W. Germany). Many of the dimensions of the 'acid rain' problem are common to countries of northern Europe and North America. The developing awareness over the past ten years of the international nature of the acid rain phenomenon has lead to studies documenting damaging effects on susceptible freshwater bodies. Large areas of the Canadian Pre-Cambrian Shield, with its extension into the United States, and the granitic areas of southern Norwayand Sweden contain lakes which are in the process of acidification. The biological resources of these affected areas are of considerable national concern. However, while clearly damaging effects of acidification on freshwater systems have been well documented, the impact of acid precipitation on terrestrial systems has not been so well understood. 672 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is the second in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is de voted to a description of depressive illness from many vantage points including that of the patient as well as the psychiatrist. Epidemiological, nosological, and developmental aspects are included together with specific descriptions of major subtypes of depressive illness. It is only after an illness is fully described that an attempt should be made to generate models with ex planatory and predictive properties. This second volume is that next step. The major models of depressive illness are described. The limited progress that has been made in integrating these models is discussed, but with further knowledge, this will change. Each model has different advantages and may apply more directly to different subtypes of depressive illness. Such refinements also await the results of future studies. However, the heuristic and clinical usefulness of the models described is considerable and will inform the reader about the current state of knowledge regarding the etiology and pathogenesis of de pressive illness and directions of future research. J. John Mann, M.D. New York vii ACKNOWLEDGMENTS This volume would not have been possible without the support of my wife and children who permitted me the time to work on it. Ms. Renee Azima-Heller assisted greatly in the organi zation of the material for the book. A career scientist award from the Irma T. HirschI Trust provided support for this work. 200 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -John Maynard Keynes is credited with the aphorism that the long-term view in economics must be taken in the light that 'in the long-term we are aU dead'. It is not in any spirit of gloom however that we invite our readers of the sixteenth volume in the review series, Advances in Nuclear Science and Technology, to take a long view. The two principal roles of nuclear energy lie in the military sphere - not addressed as such in this serie- in the sphere of the centralised production of power, and chiefly electricity generation. The immediate need for this latter has receded in the current era of restricted economies, vanishing growth rates and occasional surpluses of oil on the spot markets of the world. Nuclear energy has its most important role as an insurance against the hard times to come. But will the demand come at a time when the current reactors with their heavy use of natural uranium feed stocks are to be used or in an era where other aspects of the fuel supply must be exploited The time scale is sufficiently uncertain and the duration of the demand so unascertainable that a sensible forward policy must anticipate that by the time the major demand comes, the reasonably available natural uranium may have been largely consumed in the poor convertors of the current thermal fission programme. 592 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Historically, the development of biological science has proceeded from the anatomy to the physiology of particular systems. Knowledge about neurotransmitters in the brain has evolved from the discovery of the compounds per set through the elucidation of their biosynthetic and degradative pathways, and finally to the current focus, the regulation of these processes. Regulation in a biological system implies the capacity to respond to perturbations. The introduction of standard and speci fiable disturbances in a biological system followed by examination of the mechanisms involved in response, i.e. that dampen and/or cancel the induced changes, has proved to be a successful way to elucidate regulatory mechanisms. Psychotropic drugs have been most useful to students of regula tory mechanisms in that calvarial prisoner, the brain, for they allow prospective manipulation of variables like dosage and time. Those of us interested in the biological substrata of behavior are especially excited that disturbance induced by drugs leaves the organism intact and behaving, and we can observe behavioral correlates. The pharmacological strategy is, of course, not unique to brain scientists. The relationship between psychotropic drugs and our emerging knowledge of neurotransmitter regulation is, for example, akin to the development of anticancer agents in company with the uncovering of many mysteries of molecular biology. 332 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -That a close relationship exists between the specialties of peripheral vascular diseases and of orthopedic and general surgery has frequently been brought sharply into focus for both of us during many years of clinical experience in our respective fields of endeavor. Frequently, trauma to musculoskeletal struc tures has also been responsible for the production of a seriously compromised local blood flow, thus requiring a combined therapeutic approach to the solution of the problem. Improper utilization of appliances and conventional surgical procedures for common orthopedic conditions has on occasion likewise been followed by disastrous vascular complications. The fact that these possibilities exist in clinical practice has been the prime motivation for the development of this monograph. The purpose of the volume is first to make readily available to the orthopedic or the general surgeon information that will allow him to determine whether a limb which he is treating is also suffering from an underlying impairment of arterial, venous, or lymphatic circulation. On the basis of such data, he should be in a better position to institute an appropriate and safe therapeutic program. Second, the subject matter should acquaint him with the necessary steps for early recognition of vascular complications of musculoskeletal disorders pro duced by trauma, with their differential diagnosis, and with their management. Finally, it should make him aware of the fact that a relatively large number of clinical entities possess both vascular and orthopedic components, and that it is essential to distinguish one from the other. 416 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -SIDNEY CALLAHAN AND DANIEL CALLAHAN This book, like many other things to do with abortion, is a product of long controversy. Though carried out with cooperation, it was conceived in conflict. The conflict between the coeditors has per sisted for years-in fact, for at least half of their thirty-year marriage. One, Sidney, is prolife; the other, Daniel, is prochoice. Ever since the topic of abortion became of professional interest to us, in the 1960s, we have disagreed. At one time, while Daniel was writing a book on the subject, Abortion: Law, Choice and Morality (1970), we talked about the subject every day for the four years of the book's gestation. On many occasions during the 1970s, prolife articles writ ten by Sidney were passed out at Daniel's lectures in order to refute his pro choice views. Over the years, every argument, every statistic, every historical example cited in the literature has been discussed by the two of us. As Eliza Doolittle says about 'words' in My Fair Lady, 'There's nota one I haven't heard. ' And yet we still disagree. How can it be, we ask ourselves, that intelligent people of goodwill who know all the same facts and all the same arguments still come down on different sides of the con troversy As we well know, it is possible to agree about many things and have great love and respect for an opponent, and still differ. 364 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country. 872 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We are proud to present Volume 3 of Biological Magnetic Resonance, a series that has met with praise from the scientific community. This volume covers the new applications of various multiple irradia tion techniques to the NMR of biomolecules; the chapter of Keller and Wuthrich describes much of the technique and its applications to hemo proteins. The ESR of some hemoproteins in the single crystal is described by Chien and Dickinson, who also include discussions of techniques and methods for single-crystal ESR of paramagnetically intrinsic and spin labeled protein crystals. Mims and Peisach describe the latest applications and results in electron spin echo spectroscopy of several metalloproteins. Two ESR spin probe techniques are reviewed. Chasteen describes the methods and applications of vanadyl(JV) to several systems. Ohnishi and Tokutomi describe studies of phase separations in mixed and model mem branes by the nitroxide spin probe technique. We have been successful in continuing to provide topics that are timely and experimentally informative with a heavy emphasis on biolo gically relevant applications. We thank our colleagues in the scientific com munity for their suggestions on future coverage-we will remain receptive to future suggestions and comments on this series. A tentative topic list for forthcoming volumes is given on the following pages. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Direct methods of crystal structure determination are usually associated with techniques in which phases for a set of structure factors are determined from the corresponding experimental amplitudes by probabilistic calcula tions. It is thus implied that such ab initio phase calculations do not require a knowledge of atomic positions, and this basis distinguishes direct methods from other techniques for structure determination. An acceptably wider interpretation of the term direct methods leads to other important applica tions involving, inter alia, the use of heavy atoms, resolution-limited phase data for large molecules, rotation functions, and Fourier series. These topics are discussed in the later chapters of this book. Although some earlier theoretical investigations were made by Harker and Kaspar, direct methods may be considered to have begun around the year 1950. Important landmarks in the development of the subject include the book by Hauptmann and Karle, The Centrosymmetric Crystal (1953), the definitive paper by Karle and Karle in Acta Crystallographica (1966), and the recent (1978) sophisticated program package MULTAN 78 produced mainly by Germain, Main, and Woolfson. Woolfson's book, Direct Methods in Crystallography, was published in 1961, but because of the rapid progress in direct methods, much of it soon became outmoded. It is interesting to note that direct methods nearly came into being many years earlier. Certainly the E2 relationship was used implicitly by Lonsdale in 1928 in determining the crystal structure of hexamethylbenzene. 436 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -reached full definition in the 1940s by Kempner diet. The important role of adrenal aldosterone and associates in demonstrating the beneficial ef secretion in supporting human hypertension is now fects of a low salt rice diet for treating hypertensive well recognized as are the beneficial effects of patients. It became apparent that the value of rice blockade, especially in low-renin patients who ex was wholly related to its sodium content. A rice hibit inappropriate or absolute excesses of aldoste diet, or any other stringent low sodium diet, rone secretion. Further definition of the more sub greatly improves or completely corrects the hyper tle participation of aldosterone and of the factors tension of about ~ or so of all patients with essen that control aldosterone secretion in hypertensive subjects are promising areas for further research. tial hypertension. However, what is often forgotten is that little or no benefit accrues to the remaining THE NERVOUS SYSTEM majority of patients. Parallel studies of animal models has demon Besides the endocrine and excretory functions of strated the amplifying effect of a high sodium diet the kidney and the influence of dietary sodium on blood pressure and vice versa. Strains of rats and of aldosterone secretion, there has been long were developed which are especially sensitive to standing agreement about the important role of the pressor effects of a high sodium diet. In a way, the nervous system in blood pressure control. 672 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Tension' is an internationally recognized word. Its omnI presence in our public media--in our newspapers, on TV, in magazines, and on radio--as well as in our everyday conversations indicate that we are well aware of the problems of over-tenseness. Pulp news papers and magazines increase their sales with promises of quick relief for tension problems. Business executives complain at the end of the day of being 'uptight', and often accept a hotel chain's invitation to 'unwind' at their bar. Soap operas attract large audiences, in part capitalizing on tension problems--irritable ar guments between husband_ and wife seem interminable! Indeed, the entire world is aware of the need to control ten sions. Such widespread needs invite varied 'solutions', with the most attractive appearing ones offering promises of quick and easy cures. The market for tension reduction has been exploited in numer ous ingenious ways for centuries but I think never more than today. People with serious tension disorders often eagerly seize promises of easy relief, regardless of cost. Those who suffer headaches, spastic colon, essential hypertension, back pains, phobias and general anxiety are especially sensitized to tension disorders and potential cures. The American Association for the Advancement of Tension Control is dedicated to the elimination of tension problems through a two pronged attack: through the immediate technological application of tension control principles that now exist, and by encouraging scientific research to further develop our methods. 336 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this work we present the basic principles of metabolic control which we hope will serve as a foundation for the vast array of factual matter which the biochemist and the physician engaged in metabolic research must accumulate. Accordingly, we attempt to set forth these principles, along with sufficient explanation, so that the reader may apply them to the ever-expanding literature of biochemistry. If we are successful, this will provide a theoretical approach which can be applied to any given set of metabolic reactions. It is impossible to enumerate each and every biochemical reaction and pathway since such a work would be too unwieldy for efficient use. Rather, we hope our presentation of the principles of metabolic control will be sufficiently basic to be of lasting usefulness no matter how detailed biochemistry may become. We would like to be able to con dense biochemistry into a theoretical biology that will not only allow for the general treatment of any given reaction but will enable predic tions to be made as to the existence of necessary pathways and the con sequences of altered control. Such is not possible today, but this may be accomplished in the future. We believe it is now possible to institute the beginnings of such a theoretical biology. 692 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The skin allograft has been used as the test tool since the beginning of investiga tions of the fate of skin transplanted between two individuals of ordinary genetic diversity. This monograph is designed to furnish the transplantation work er with a review of the significant papers in which skin allografts and xeno grafts, applied to experimental animals and man, have played a role in acquiring a body of knowledge concerning the behavior and fate of these transplants and the reaction of the body to their presence. Skin, an essential organ for survival, a barrier between the 'milieu inte rieur' of Claude Bernard and the 'milieu exterieur,' will remain the most frequently used transplant in transplantation research. Because it is highly antigenic, the final solution of the problem of acceptance of allografts of various tissues and organs will probably depend upon the achievement of a permanent survival of skin allografts. My personal interest in transplantation, which originated during my surgi cal training, was rekindled when I met Peter Medawar (today Sir Peter) in England during World War II. I had joined, in 1940, an American Volunteer Surgical Unit (The American Hospital in Britain), organized and headed by Dr. 216 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Advanced Research Institute on 'Health Services Systems' was held under the auspices of the NATO Special Programme Panel on Systems Science as a part of the NATO Science Committee's continuous effort to promote the advancement of science through international cooperation. A special word is said in this respect supra by Pro fessor Checkland, Chairman of the Systems Science Panel. The Advanced Research Institute (ARI) was organized for the purpose of bringing together senior scientists to seek a consensus on the assessment of the present state of knowledge on the specific topic of 'health services systems' and to present views and recom mendations for future health services research directions, which should be of value to both the scientific community and the people in charge of reorienting health services. The conference was structured so as to permit the assembly of a variety of complementary viewpoints through intensive group discussions to be the basis of this final report. Invitees were selected from allover Europe and North America, including observers from the major international organizations involved in health ser vices research, to provide the experience and expertise necessary to make the issue of 'health services systems' val id and significant. 392 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ever since the beginning of the plastics and rubber industry, it was realized that useful products could be produced only if cer tain additives were incorporated into polymers. With the help of these additives, when physically dispersed in a polymer matrix, it has been possible to improve stability against thermal, oxidative, UV, hydrolytic and biological degradation, mechanical properties, flammability, cost, and processibility of plastics. The enormous growth of the volume of plastics consumed by modern society, and new application areas for plastics, have created a demand for new, better additives and better understanding of their functions in polymer systems. As a result of these trends there is a need for sharing of information on progress achieved in the area of polymer additives among engineers and scientists of the plastics industry and academia. This book is based on expanded and updated papers originally presented at the International Symposium on Polymer Additives, which was held in Las Vegas, Nevada, and was sponsored by the American Chemical Society, Division of Polymeric Materials Science and Engi neering. The book is divided into five parts which cover advances in various areas of polymer additives. The first part is devoted to the progress in understanding of UV degradation and stabilization of various polymers. Oxidation degradation and stabilization of plastic materials is covered in the second part. New developments in the stabilization of PVC are presented in the third part. 424 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests. 352 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in Solar Energy, now in its fifth year, is continuing with topics of the main field of solar energy conversion. However, because of the increasing interest in a solar systems approach, we have decided to include the article of Bockris et al., on Hydrogen Technology, which offers interesting aspects of transport and storage of solar energy, as well as the potential for a versatile fuel. The other articles cover the field of photovoltaics, solar energy-related mate rials, wind conversion, solar retrofitting of existing buildings, and new architectural designs in harmony with climate and the comfort of all occupants. These articles give a critical assessment of the present state of the art, and provide a long list of literature for further in-depth studies. I greatly appreciate the assistance of the Editors and referees of the articles for their many constructive suggestions. My special thanks go to Ms. Martha Hobbs for her dedicated work in typesetting the manuscript in the University of Delaware's Publication Office, and to the University of Delaware for their continued support. The accommodating help from Plenum Press and its production staff deserves our grateful acknowledgement. 472 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Acquired immune deficiency syndrome (AIDS) poses a health threat unparalleled in modem times. Identified just a few years ago, AIDS and the human inunlmodeficiency virus (IDV) responsible for it affect millions of persons worldwide. AIDS has already become the leading cause of death among persons under 40 in some large American cities. From the beginning. it has been evident that AIDS carries unique psychological and social ramifications. In spite of its lethality, new cases of HIV infection are preventable if individuals can be assisted to make behavior changes to lessen or eliminate viral transmission. To the extent that we can develop effective primary prevention interventions, it will be possible to keep larger numbers of people from becoming infected with the mv virus. Psychological and social risk behavior change interventions, whether at the level of individual clients, groups, or entire communities, can playa key role-in fact, the only available role-in disease prevention. Patients with any life-threatening illness have psychological, social, and support needs. However, these needs are more pronounced and, often, less easily addressed for persons affected by AIDS. People in good clinical health but with HIV infection face years of worry concerning whether they will develop AIDS. Nearly 2 million Americans are currently in this precarious position; by 1991, 50 to 100 million persons worldwide are expected to share the same uncertainty. 224 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The title of amorphous magnetism was conceived to en compass the study of the magnetic properties of dilute ran dom substitutional alloys, amorphous metallic alloys, amor phous magnetic semiconductors and the conventional glasses, including cha1cogenide, organic and inorganic glasses. These materials have heretofore been considered to be quite different because of the differences in their atomic struc tures. However, when the magnetic behavior of these mater ials is carefully examined it becomes clear that these materials exhibit certain similarities. For the first time at the International Symposium on Amorphous Magnetism held at Wayne State University in Detroit, Michigan on August 17 and 18, 1972, scientists working in these areas were assembled to examine the similarities of these systems. This volume contains a summary of the 9 invited talks, 23 delivered, contributed papers and an additional 12 contri buted papers whcih were not presented because of insuffic ient time in the program. This volume presents for the first time a collection of the most current theoretical and experimental studies in the area of amorphous magnetism. We wish to thank the authors of these papers for their outstanding cooperation in preparing their manuscripts and for editing our transcriptions from tape recordings of the discussions which followed their presentations. In addition, we wish to thank the participants at this conference whose enthusiasm and interest made the conference so successful. 460 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Fourth American Physical Society Topical Conference on Shock Waves in Condensed Matter was held in Spokane, Washington, July 22-25, 1985. Two hundred and fifty scientists and engineers representing thirteen countries registered at the conference. The countries represented included the United States of America, Australia, Canada, The People's Repub lic of China, France, India, Israel, Japan, Republic of China (Taiwan), United Kingdom, U. S. S. R, Switzerland and West Germany. One hundred and sixty-two technical papers, cov ering recent developments in shock wave and high pressure physics, were presented. All of the abstracts have been published in the September 1985 issue of the Bulletin of the American Physical Society. The topical conferences, held every two years since 1979, have become the principal forum for shock wave studies in condensed materials. Both formal and informal technical discussions regarding recent developments conveyed a sense of excitement. Consistent with the past conferences, the purpose of this conference was to bring together scientists and engineers studying the response of condensed matter to dynamic high pressures and temperatures. Papers covering experimental, theoretical, and numerical studies of con densed matter properties were presented. A noteworthy feature of this conference was the participation by several leading scientists engaged in static high pressure research. Donald Curran served as the Master of Ceremonies at the conference banquet, which was at tended by two hundred and seventy-five conference participants and guests including Dr. Samuel Smith, the new President of Washington State University. Dr. 972 pp. Englisch.