springer copernicus dez 2009 (15 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Algorithms and Programming is primarily intended for use in a first-year undergraduate course in programming. It is structured in a problem-solution format that requires the student to think through the programming process, thus developing an understanding of the underlying theory. The book is easily readable by a student taking a basic introductory course in computer science as well as useful for a graduate-level course in the analysis of algorithms and/or compiler construction.Each self-contained chapter presents classical and well-known problems supplemented by clear and in-depth explanations. The material covered includes such topics as combinatorics, sorting, searching, queues, grammar and parsing, selected well-known algorithms and much more. Students and teachers will find this both an excellent text for learning programming and a source of problems for a variety of courses.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 288 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This textbook presents models and solutions in inventory management. It begins with a 'must-read' chapter discussing basic terminology, concepts, taxonomy, and tenets of inventory system and common mathematical assumptions underlying the models. With a systematic organization, it then presents various models such as the EOQ model, lot-sizing models, Newsvendor model, periodic review models with variable and fixed ordering cost, and a continuous time model. Additionally, it discusses methods in multiechelon systems. In summary it tries to establish relationships between the dicussed models and real situations and discusses some examples in detail. Not directly competitive with other textbooks in this field, (more mathematical than some, less than others) this graduate textbook will appeal to senior and first year graduate students in operations research, industrial engineering, and quantitative MBA programs and can also serve as a reference to persons in the industry.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Algorithms and Programming is primarily intended for use in a first-year undergraduate course in programming. It is structured in a problem-solution format that requires the student to think through the programming process, thus developing an understanding of the underlying theory. The book is easily readable by a student taking a basic introductory course in computer science as well as useful for a graduate-level course in the analysis of algorithms and/or compiler construction.Each self-contained chapter presents classical and well-known problems supplemented by clear and in-depth explanations. The material covered includes such topics as combinatorics, sorting, searching, queues, grammar and parsing, selected well-known algorithms and much more. Students and teachers will find this both an excellent text for learning programming and a source of problems for a variety of courses.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 288 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Juvenile Delinquency in Europe and Beyond: Results of the Second International Self-Report Delinquency Study presents the status of juvenile crime and delinquency and its backgrounds in many of the European Union member states as well as in the United States, Canada, Venezuela and Surinam. The book includes information on key issues in juvenile delinquency such as victimization of young people, alcohol and drug use and its relation to juvenile crime, involvement in youth gangs, immigration, family and school and neighborhood situations. It provides insight into different views on what can be considered juvenile crime; what acts are subsumed in its definition and when we can speak about structural delinquent behavior.These insights are based on self-reported information systematically and simultaneously collected from about 70,000 12-15 year old youths in 28 countries. Until recently, the self-report methodology has not been applied on such a large scale in an international context. The results of this survey provide new and unexpected data about those young people who structurally commit criminal acts, as well as on the frequency of the behavior and the conditions that have an impact on offending.The wealth of descriptions and insights in delinquency of all these countries will be of great interest to scholars, students and practitioners because of the special character of the publication; it is a book of reference to everyone interested in the backgrounds of juvenile delinquency.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 452 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 328 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these molecules in the CNS physiology and pathology is now apparent, these issues are still matter of debate, and further research is required to design effective pharmacological agents that specifically target the brain chemokine system without major side effects.To this end, specific topics have been selected and are reviewed by international experts within the basic science/medical community. This book encourages investigation in the most controversial areas and fosters interaction between clinicians and basic scientists. The book also increases awareness about differences in disease progression among different parts of the world as well as selected patient populations, which may also help identifying novel therapeutic strategies.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The future of surgery is intrinsically linked to the future of computational sciences: the medical act will be computer assisted at every single step, from planning to post-surgery recovery and through the surgical procedure itself. Looking back at the history of surgery, surgery practice has changed drama- cally with the extensive use of revolutionary techniques, such as medical imaging, laparoscopy, endoscopy, sensors and actuators, and robots. This trend is dependent on the use of computer processing, computational method, and virtualization. Computational surgery will not only improve the ef ciency and quality of surgery, but will also give new access to very complex operations that require extreme precision and minimum intrusion. Such examples are today¿s inoperable cancer tumors that have invaded critical tissues or nervous centers. In order for this milestone to be reached quicker and more ef ciently, surgeons will have to become very familiar with computing methods, such as image analysis, augmented re- ity, and/or robotics. It will be critical for surgeons to assimilate computers in their training, understand how computers work, understand the limitations/advantages of these computer tools, and be able to interpret computer imaging and simulations.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Motion processing is an essential piece of the complex brain machinery that allows us to reconstruct the 3D layout of objects in the environment, to break camouflage, to perform scene segmentation, to estimate the ego movement, and to control our action. Although motion perception and its neural basis have been a topic of intensive research and modeling the last two decades, recent experimental evidences have stressed the dynamical aspects of motion integration and segmentation. This book presents the most recent approaches that have changed our view of biological motion processing. These new experimental evidences call for new models emphasizing the collective dynamics of large population of neurons rather than the properties of separate individual filters. Chapters will stress how the dynamics of motion processing can be used as a general approach to understand the brain dynamics itself.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 396 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver¿s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch¿s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasäs labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS¿RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau¿s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Squamous cell carcinoma of the oral cavity (SCCOC) is one of the most prevalent tumors of the head and neck region. Despite improvements in treatment, the survival of patients with SCCOC has not significantly improved over the past several decades. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas improves, SCCOC treatment failures more commonly occur as distant metastasis. The presence of cervical lymph node metastasis is the most reliable adverse prognostic factor in patients with SCCOC, and extracapsular spread (ECS) of cervical lymph nodes metastasis is a particularly reliable predictor of regional and distant recurrence and death from disease. Decisions regarding elective and therapeutic management of cervical lymph node metastases are made mainly on clinical grounds as we cannot always predict cervical lymph node metastasis from the size and extent of invasion of the primary tumors. Therefore the treatment of the neck disease in the management of SCCOC remains controversial. The promise of using biomarker-based treatment decisions has yet to be fully realized due to our poor understanding of the mechanisms of regional and distant metastases of SCCOC. We will summarize the current status of investigations into SCCOC metastases and potential of these studies to impact basic research investigators and clinicians confronting SCCOC in the future.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -European integration is one of the most ambitious and socially far-reaching developments in world politics and in world economics. Against growing opposition and despite increasing social heterogeneity, the European Union continues to expand and to acquire new competences. But to what extent is the self-proclaimed 'ever closer union among the peoples of Europe' a social reality In which ways is the political European project anchored in social developments How does social change impinge upon political integration Societal trends in multi-cultural, multi-ethnic, multi-lingual and socially diverse Europe have never been studied systematically. Handbook of European Societies: Social Transformations in the 21st Centurysets to rectify this neglect of societal developments in Europe, providing a groundwork for the sociology of European integration. The book portrays social life and social relations in the enlarged Europe, and gives a perspective on the European Union as an evolving social entity.Handbook of European Societies is a pioneering source book analyzing the current social patterns on the continent. It covers a representative selection of major topics of social concern and sociological relevance, such as Collective Action, Consumption, Identity, Power Structure, Sexuality, Stratification and Well-being. Each contribution probes key developments in a strictly comparative manner. The Handbook thus offers a detailed look into the intricacies of the national societies of Europe and into the prospect of an emerging European society.The Editors have enlisted leading researchers to synthesize existing knowledge and to make use of many different data sources in a straight-forward style. The contributions stay away from jargon, simple labeling and sweeping assertions. Instead, they provide solid and accessible information on a wide variety of social trends and processes within and across European societies.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 720 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment.Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk.Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI¿s stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project.This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ¿80s-early ¿90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are ¿soft-wired¿, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 512 pp. Englisch.