springer copernicus jul 2009 (8 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book aims to give a user friendly tutorial of an interdisciplinary research topic (fronts or interfaces in random media) to senior undergraduates and beginning grad uate students with basic knowledge of partial differential equations (PDE) and prob ability. The approach taken is semiformal, using elementary methods to introduce ideas and motivate results as much as possible, then outlining how to pursue rigor ous theorems, with details to be found in the references section. Since the topic concerns both differential equations and probability, and proba bility is traditionally a quite technical subject with a heavy measure theoretic com ponent, the book strives to develop a simplistic approach so that students can grasp the essentials of fronts and random media and their applications in a self contained tutorial. The book introduces three fundamental PDEs (the Burgers equation, Hamilton¿ Jacobi equations, and reaction¿diffusion equations), analysis of their formulas and front solutions, and related stochastic processes. It builds up tools gradually, so that students are brought to the frontiers of research at a steady pace. A moderate number of exercises are provided to consolidate the concepts and ideas. The main methods are representation formulas of solutions, Laplace meth ods, homogenization, ergodic theory, central limit theorems, large deviation princi ples, variational principles, maximum principles, and Harnack inequalities, among others. These methods are normally covered in separate books on either differential equations or probability. It is my hope that this tutorial will help to illustrate how to combine these tools in solving concrete problems.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 172 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Terrestrial carbon balance is uncertain at the regional and global scale. A significant source of variability in mid-latitude ecosystems is related to the timing and duration of phenological phases. Spring phenology, in particular, has disproportionate effects on the annual carbon balance. However, the traditional phenological indices that are based on leaf-out and flowering times of select indicator species are not universally amenable for predicting the temporal dynamics of ecosystem carbon and water exchange.Phenology of Ecosystem Processes evaluates current applications of traditional phenology in carbon and H2O cycle research, as well as the potential to identify phenological signals in ecosystem processes themselves. The book summarizes recent progress in the understanding of the seasonal dynamics of ecosystem carbon and H2O fluxes, the novel use of various methods (stable isotopes, time-series, forward and inverse modeling), and the implications for remote sensing and global carbon cycle modeling.Each chapter includes a literature review, in order to present the state-of-the-science in the field and enhance the book¿s usability as an educational aid, as well as a case study to exemplify the use and applicability of various methods. Chapters that apply a specific methodology summarize the successes and challenges of particular methods for quantifying the seasonal changes in ecosystem carbon, water and energy fluxes. The book will benefit global change researchers, modelers, and advanced students.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Starting in 1995 numerical modeling of the Earth¿s dynamo has ourished with remarkable success. Direct numerical simulation of convection-driven MHD- ow in a rotating spherical shell show magnetic elds that resemble the geomagnetic eld in many respects: they are dominated by the axial dipole of approximately the right strength, they show spatial power spectra similar to that of Earth, and the magnetic eld morphology and the temporal var- tion of the eld resembles that of the geomagnetic eld (Christensen and Wicht 2007). Some models show stochastic dipole reversals whose details agree with what has been inferred from paleomagnetic data (Glatzmaier and Roberts 1995; Kutzner and Christensen 2002; Wicht 2005). While these models represent direct numerical simulations of the fundamental MHD equations without parameterized induction effects, they do not match actual pla- tary conditions in a number of respects. Speci cally, they rotate too slowly, are much less turbulent, and use a viscosity and thermal diffusivity that is far too large in comparison to magnetic diffusivity. Because of these discrepancies, the success of geodynamo models may seem surprising. In order to better understand the extent to which the models are applicable to planetary dynamos, scaling laws that relate basic properties of the dynamo to the fundamental control parameters play an important role. In recent years rst attempts have been made to derive such scaling laws from a set of numerical simulations that span the accessible parameter space (Christensen and Tilgner 2004; Christensen and Aubert 2006).Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book consists of a number of papers regarding the thermodynamics and structure of multicomponent systems that we have published during the last decade. Even though they involve different topics and different systems, they have something in common which can be considered as the ¿signature¿ of the present book. First, these papers are concerned with ¿difficult¿ or very nonideal systems, i. e. systems with very strong interactions (e. g. , hyd- gen bonding) between components or systems with large differences in the partial molar v- umes of the components (e. g. , the aqueous solutions of proteins), or systems that are far from ¿normal¿ conditions (e. g. , critical or near-critical mixtures). Second, the conventional th- modynamic methods are not sufficient for the accurate treatment of these mixtures. Last but not least, these systems are of interest for the pharmaceutical, biomedical, and related ind- tries. In order to meet the thermodynamic challenges involved in these complex mixtures, we employed a variety of traditional methods but also new methods, such as the fluctuation t- ory of Kirkwood and Buff and ab initio quantum mechanical techniques. The Kirkwood-Buff (KB) theory is a rigorous formalism which is free of any of the - proximations usually used in the thermodynamic treatment of multicomponent systems. This theory appears to be very fruitful when applied to the above mentioned ¿difficult¿ systems.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 712 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 508 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 468 pp. Englisch.