Springer nature apr 2013 (121 risultati)

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - That residues of pestidde and other 'foreign' chemicals in foodstufts are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying en thusiasm, sincerity, and effons shown by all the individuals from whom manuscripts have been solidted. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that pers ist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly developed ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemi cal, food technological, medical, pharmacological, and toxicological dis ciplines.…

Taschenbuch. Condizione: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, tOxicolOgists, and changing pest-control requirements in progressive food-prodUCing economies. These matters are of' genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these -chemicals per sisting 'into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and tOXicological disciplines.…

Taschenbuch. Condizione: Neu. Neuware - The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.…

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - This volume is the fourth in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de scription of depressive illness from a variety of perspectives that include that of the patient, the clinician, and the psychiatric researcher. It de scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysio logic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clini cally overlapping features such as anxiety disorders or eating disor ders. The effects on biology of comorbid conditions such as anxiety, personality disorders, alcoholism, and eating disorders are reviewed.…

Taschenbuch. Condizione: Neu. Neuware - That residues of pesticide and other contaminants in the total environment are of concern to everyone everywhere is attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are of genuine concern to increasing numbers of governmental agencies and legislative bodies around the' wprld, for some of these chemicals have resulted in a few mishilps from improper use. Adequate safety-in-use evaluations of any of these chemicals per sisting into our foodstuHs are not simple matters, and they incorporate theconsidered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and toxicological disciplines.…

Taschenbuch. Condizione: Neu. Neuware - Worldwide concern in scientific, industrial, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmentaI contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.…

Taschenbuch. Condizione: Neu. Neuware - The concept of a blood~retinal barrier is still relatively new in the ophthalmic literature. ~fuereas work on the blood-brain barrier was initiated in the first decade of this century, the blood retinal barrier has only recently been defined. Information accu mulated during the last 10 years has shown that the function of the blood-ocular barriers may be better understood if two main barrier systems are considered to exist in the eye. The blood-aqueous barrier regulates the exchanges between the blood and the intraocu lar fluids, and the blood-retinal barrier separates the neural tissue from the blood. Recent studies have shown that the blood-retinal barrier plays a fundamental role in controlling the microenvironment of the retina. Similarly, the significance of the blood-retinal barrier in retinal disease has become increasingly clear. Fluorescein angiography has demonstrated an intricate series of relationships between altera tions of the blood-retinal barrier and diverse retinal diseases, particularly vascular retinopathies and pigment epitheliopathies. Finally, in the past few years, vitreous fluorophotometry has pro vided a new and accurate index of the alteration of the blood-retinal barrier.…

Taschenbuch. Condizione: Neu. Neuware - H. J. BEYER AND H. KLEINPOPPEN During the preparation of Parts A and B of Progress in Atomic Spectros copy a few years ago, it soon became obvious that a comprehensive review and description of this field of modern atomic physics could not be achieved within the limitations of a two-volume book. While it was possible to include a large variety of spectroscopic methods, inevitably some fields had to be cut short or left out altogether. Other fields have developed so rapidly that they demand full cover in an additional volume. One of the major problems, already encountered during the prepar ation of the first volumes, was to keep track of new developments and approaches which result in spectroscopic data. We have to look far beyond the area of traditional atomic spectroscopy since methods of atomic and ion collision physics, nuclear physics, and even particle physics all make important contributions to our knowledge of the static and dynamical state of atoms and ions, and thereby greatly add to the continuing fascination of a field of research which has given us so much fundamental knowledge since the middle of the last century. In this volume, we have tried to strike a balance between contribu tions belonging to the more established fields of atomic structure and spectroscopy and those fields where atomic spectroscopy overlaps with other areas.…

Taschenbuch. Condizione: Neu. Neuware - As we enter the last decade of the twentieth century, the AIDS epidemic looms ever larger and threatening. The specter of upwards of a million deaths in the United States and perhaps many millions worldwide from a sexually transmitted virus shakes our belief in modem medical science, while challenging the foundations of democratic society. Almost ten years into the epidemic, and with an enormous body of basic science research on the Human Immunodeficiency Virus (HIV), we still do not know why AIDS emerged when it did or how to stop its spread. A very humbling experience for scientists, clinicians, public health experts, politicians, and the general public. Yet there are signs that a well coordinated multidisciplinary research program can conquer the epidemic and, perhaps, provide the basis for preventing future epidemics. The HIV family of viruses is now better understood, both in terms of structure and function, than any other virus. Genetically engineered peptides and nucleic acids are being tested as specific treatments or vaccines against HIV infection/disease. Most prom ising are the strides which have been made in understanding those aspects of human behavior which have contributed to the spread of HIV infection and which must be substantially modified if AIDS is to be controlled and eventually eradicated. The basis of that understanding has roots in a diverse set of disciplines which have converged in the work presented in this book.…

Taschenbuch. Condizione: Neu. Neuware - After the appearance of the four-book series Human Nutrition: A Compre hensive Treatise, it became apparent to the editors that an important area of nutrition had been overlooked, namely, behavioral aspects of nutrition. There are two areas in which nutrition and behavior interact. On the one hand, mal nutrition may play a major role in determining behavior; alternatively, often aspects of behavior influence the eating habits of populations and individuals and thus affect their nutritional status. Volume 5 of this series speaks eloquently to both features of this important topic. Various aspects of the influence of behavior modification and nutrition have been explored by a number of qualified investigators. It is hoped that this volume will prove a valuable addition to the subjects covered in the other volumes. Roslyn B. Alfin-Slater David Kritchevsky Los Angeles and Philadelphia ix Contents Introduction: The Challenge of Nutrition and Environment as Determinants of Behavioral Development . . Janina R. Galler References . 5 Part I - Nutritional Deficiencies or Excesses Modifying Behavioral Outcome Chapter 1 Methological Requirements for Conceptually Valid Research Studies on the Behavioral Effects of Malnutrition David E. Barrett 1. Introduction . 9 2. Statistical-Conclusion Validity. . . . . . . . . . . . . . . . . . . . . 11 . . . . . . . 3. Internal Validity . 14 4. External Validity . 16 5. Construct Validity of Putative Causes and Effects . . . . . . . . . . . . 19 6. Conclusions and Recommendations . . . . . . . . . . . . . . . . . . . 28 . . . .…

Taschenbuch. Condizione: Neu. Neuware - When the 13 founders of the American Psychiatric Association came together in 1844, hospitals were small, and the administrative aspects of a superinten dent's job were relatively minor compared with their size and complexity today. Since the turn of the century, administration-the art and the sci ence-has become a specialty of great importance, particularly in big business and government. Business recognizes fully that the success of organizational endeavors depends to a great extent on the talents and energies of top lead ers. As a result, industry spends huge sums of money to train promising young executives and offers generous salaries and benefits to entice them. Anyone who wants to invest in a business first asks: 'Who manages this organization, and is this management competitive in today's marketplace ' Although health is today a great industry, emphasis on the executive role has lagged behind that in the general business field. In mental health circles, the strong emphasis on one-to-one therapy has delayed a full appreciation of the influence of organization per se on patient care and treatment. Yet there 1 are now many signs of change. The popularization of behavioral science and the rise of social and community psychiatry have brought organizational con siderations forward. We are increasingly concerned with the human side of enterprise, with worker satisfaction, group dynamics, and organizational morale. Other flags have been unfurled.…

Taschenbuch. Condizione: Neu. Neuware - The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.…

Taschenbuch. Condizione: Neu. Neuware - 1 The Lethal Osteochondrodysplasias.- 2 Mutations in Type I Procollagen Genes That Cause Osteogenesis Imperfecta.- 3 Structural Defects in Inherited and Giant Platelet Disorders.- 4 Genetic Aspects of Immunoglobulin A Deficiency.- 5 Oxidative Phosphorylation Diseases: Disorders of Two Genomes.- Addendum.…

Taschenbuch. Condizione: Neu. Neuware - This volume is an up-to-date treatise of chemosensory vertebrate research performed by over 200 scientists from 22 countries. Importantly, data from over 25 taxa of vertebrates are presented, including those from human beings. Unlike other volumes on this topic, a significant nurober of the contributions come from leading workers in the former Soviet Union and reflect studies within a wide variety of disciplines, including behavior, biochemistry, ecology, endocrinology, genetics, psychophysics, and morphol ogy. Most of the studies described in this volume were presented at the Chemical Signals in Vertbrates VI (CSV VI) symposium held at the University of Pennsylvania in the summer of 1991. This international symposium was the largest and the most recent of a series of six such symposia, the first of which was held in Saratoga Springe, New York (June 6-9, 1976) and the last in Oxford, England (August 8-10, 1988). Unlike the previous symposia, Chemical Signals in Vertabrates VI lasted a full week, reflecting the increased number of participants and the desire of many to present their research findings orally to the group as a whole.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using case studies, this book explores the publishing of African literature, addressing the construction of literary value, relationships between African writers and British publishers, and importance of the African market. It analyses the historical, political and economic conditions framing the emergence of postcolonial literature. 255 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A fresh look at the greatest poet of early eighteenth-century England, this highly readable book focuses on Pope's religious thinking and major poems. G. Douglas Atkins extends the argument that the Roman Catholic poet was no Deist, 'closet' or otherwise. 69 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Today, extensive interconnected global processes provide non-state actors with a degree of agency that a 'System of States' paradigm cannot account for alone. Using Russia-Latin America relations as a case study and applying a Complex Adaptive Systems perspective, this work explores alternative international mechanisms of order and organization. 129 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book adopts an explicitly postmodernist perspective of the digital revolution. While exploring issues relating to the re-creation of social life in the digital world, its main focus is on the political economy and in particular the extent to which the paradigms of capitalism and socialism can be mapped as postcapitalism onto this new world. 81 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -By using information collected from numerous American Economic Review publications from the last 100 years, Torgler and Piatti examine the top publishing institutions to determine their most renowned AER papers based on citation success. 154 pp. Englisch.…