springer nature apr 2013 (126 risultati)

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - That residues of pestidde and other 'foreign' chemicals in foodstufts are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying en thusiasm, sincerity, and effons shown by all the individuals from whom manuscripts have been solidted. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that pers ist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly developed ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemi cal, food technological, medical, pharmacological, and toxicological dis ciplines.

Taschenbuch. Condizione: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, tOxicolOgists, and changing pest-control requirements in progressive food-prodUCing economies. These matters are of' genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these -chemicals per sisting 'into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and tOXicological disciplines.

Taschenbuch. Condizione: Neu. Neuware - The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.

Taschenbuch. Condizione: Neu. Neuware - Worldwide concern in scientific, industrial, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmentaI contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.

Taschenbuch. Condizione: Neu. Neuware - This volume is the fourth in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de scription of depressive illness from a variety of perspectives that include that of the patient, the clinician, and the psychiatric researcher. It de scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysio logic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clini cally overlapping features such as anxiety disorders or eating disor ders. The effects on biology of comorbid conditions such as anxiety, personality disorders, alcoholism, and eating disorders are reviewed.

Taschenbuch. Condizione: Neu. Neuware - The emergence of a new scientific book series requires some explanation regarding how it hopes to compensate the reader for the discomforts it undoubtedly produces both in the realms of informational input-overload and in the financial strain on personal and institutional budgets. This series recognizes that investigators who have entered neurochemistry from the biochemical tradition have a rather specialized view of the brain. Too often, interdisciplinary offerings are initially attractive but turn out to recite basic biochemical considerations. We have come to believe that there are now sufficiently large numbers of neurochemists to support a specialized venture such as the present one. We have begun with consideration of traditional areas of neurochemistry which show considerable scientific activity. We hope they will serve the neurochemist both for general reading and for specialized information. The reader will also have the opportunity to reftect on the unbridled speculation that results from the disinhibiting effects on the author who has been invited to write a chapter. We plan occasionally also to offer reviews of areas not completely in the domain of neurochemistry which we nevertheless feel to be sufficiently timely to be called to the attention of all who use chemical principles and tools in an effort to better understand the brain. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 POSSIBLE ROLES OF PROSTAGLANDINS IN THE NERVOUS SYSTEM LEONHARD S. WOLFE 1. Introduction 1 1. 1. Background 1 Names and Structures 1. 2. 4 1. 3. Biosynthesis 4 1. 4.

Taschenbuch. Condizione: Neu. Neuware - All around us, in this age of consumerism, are expressions of public expectations regarding the quality of medical care. Among the responses of the medical profession to this growing public demand has been a cre scendo of interest in continuing education. Continuing education is not a new concern for the physician. Most major professional organizations were founded to increase the exchange of information among members. But something new is in the wind. Both inside and outside the profes sion, the question is becoming more and more insistent: What does at tendance at meetings or exposure to other types of prepared materials have to do with the quality of care that is provided Recertification, reexamination, and peer review of outcomes of practice-subjects only recently unmentionable-have become common issues before specialty boards, legislatures, hospital boards, insurance carriers, and even medical societies. As of October of 1979, all 22 of the member boards of the American Board of Medical Specialties had made commitments to the principle of periodic recertification of their members. Most boards have explicitly acknowledged that the cognitive skills measured in the objective examination do not assure clinical competence. An assumption behind information-assessing recertification efforts is that, though mastery of the current knowledge upon which clinical decisions should be made does not guarantee competent practice, the lack of it probably impairs competent practice.

Taschenbuch. Condizione: Neu. Neuware - As in any field of clinical or scientific endeavor, a cataloguing of the techniques and findings of behavioral pediatrics must follow shortly after the first few years of systematic work. This book has been designed to serve this initial summary function for the field. It represents a first attempt to bring together in one place the definition and scope of be havioral pediatrics and to outline current research and treatment ap proaches to various organic disorders, clinical settings, and problem areas in which a sufficient body of knowledge has accrued for author itative statement. As the first text in a rapidly expanding area, our decisions regarding the topics to be covered and the contributors to this volume were guided by our desire to represent what we would consider to exemplify the field in its early development: pragmatic and thorough study of signif icant problems from a base of sound scientific inquiry. Each of the topics addressed in the present volume develops, in a preliminary fashion, an epistemology for current practice and future study. All of the contrib uting authors have been involved in the development of their specialty areas through their research and, importantly, through their clinical work in the hospitals affiliated with the medical schools in which they hold appointments.

Taschenbuch. Condizione: Neu. Neuware - 'Like a Bridge over Troubled Waters' The surge of current interest in the interface between clinical and social psychology is well illustrated by the publication of a number of general texts and journals in this area, and the growing emphasis in graduate programs on providing training in both disciplines. Although the bene fits of an integrated clinical-social approach have been recognized for a number of years, the recent work in this area has advanced from the oretical extrapolations of social psychological models to clinical issues to theory and research that is based on social principles and conducted in clinical domains. It is becoming increasingly common to find social psy chologists pursuing research with clinical populations and clinical psy chologists investigating variables that have traditionally been in the realm of social psychology. A major area of interface between the two disciplines is in research and theory concerned with how individuals respond to negative events. In addition to the trend toward an integrated clinical-social approach, the growing body of literature in this area reflects the explosion of cur rent interest in the area of health psychology; work by clinical and social psychologists on the topics of stress and coping has been one of the major facets of this burgeoning field. The purpose of the present volume is to provide a common forum for recent advances in the clinical and social literature on responses to negative life outcomes.

Taschenbuch. Condizione: Neu. Neuware - The concept of a blood~retinal barrier is still relatively new in the ophthalmic literature. ~fuereas work on the blood-brain barrier was initiated in the first decade of this century, the blood retinal barrier has only recently been defined. Information accu mulated during the last 10 years has shown that the function of the blood-ocular barriers may be better understood if two main barrier systems are considered to exist in the eye. The blood-aqueous barrier regulates the exchanges between the blood and the intraocu lar fluids, and the blood-retinal barrier separates the neural tissue from the blood. Recent studies have shown that the blood-retinal barrier plays a fundamental role in controlling the microenvironment of the retina. Similarly, the significance of the blood-retinal barrier in retinal disease has become increasingly clear. Fluorescein angiography has demonstrated an intricate series of relationships between altera tions of the blood-retinal barrier and diverse retinal diseases, particularly vascular retinopathies and pigment epitheliopathies. Finally, in the past few years, vitreous fluorophotometry has pro vided a new and accurate index of the alteration of the blood-retinal barrier.

Taschenbuch. Condizione: Neu. Neuware - As we enter the last decade of the twentieth century, the AIDS epidemic looms ever larger and threatening. The specter of upwards of a million deaths in the United States and perhaps many millions worldwide from a sexually transmitted virus shakes our belief in modem medical science, while challenging the foundations of democratic society. Almost ten years into the epidemic, and with an enormous body of basic science research on the Human Immunodeficiency Virus (HIV), we still do not know why AIDS emerged when it did or how to stop its spread. A very humbling experience for scientists, clinicians, public health experts, politicians, and the general public. Yet there are signs that a well coordinated multidisciplinary research program can conquer the epidemic and, perhaps, provide the basis for preventing future epidemics. The HIV family of viruses is now better understood, both in terms of structure and function, than any other virus. Genetically engineered peptides and nucleic acids are being tested as specific treatments or vaccines against HIV infection/disease. Most prom ising are the strides which have been made in understanding those aspects of human behavior which have contributed to the spread of HIV infection and which must be substantially modified if AIDS is to be controlled and eventually eradicated. The basis of that understanding has roots in a diverse set of disciplines which have converged in the work presented in this book.

Taschenbuch. Condizione: Neu. Neuware - In observing the development of modern scientific knowledge, many indivi duals have expressed concern over the rapid growth of information in various specialized disciplines. Over 100 years ago the first Secretary of the Smith sonian Institution, and more recently Dr. Vannevar Bush while proposing the modern expansion of the National Institutes of Health, both noted prob lems that prevented the proper utilization of information by individuals in medical and related scientific fields. These observations, tagether with con comitant implications of future difficulty, are particularly pertinent to the field of oncology. The rapid evolution of the latter discipline has largely been aided by the incorporation of concepts and methods developed over a long period of time, and drawn from a wide variety of other scientific fields. The large body of discoveries that have contributed to our current understanding of neoplasia, however, cannot be viewed as being made up of equal parts. They bring to mind Claude Bernard's view 'des determinismes simples et complexes' in the physiological and biochemical regulation of bod ily functions. He was able to observe that the most important and basic of physiologic processes were destined to be fewer in number than those of less fundamental and more highly specialized purpose. He understood that in the future development of medical science, sturlies of the lauer would occupy much of the time and attention of investigators, and were likely to contribute much to scientific literature.

Taschenbuch. Condizione: Neu. Neuware - When the 13 founders of the American Psychiatric Association came together in 1844, hospitals were small, and the administrative aspects of a superinten dent's job were relatively minor compared with their size and complexity today. Since the turn of the century, administration-the art and the sci ence-has become a specialty of great importance, particularly in big business and government. Business recognizes fully that the success of organizational endeavors depends to a great extent on the talents and energies of top lead ers. As a result, industry spends huge sums of money to train promising young executives and offers generous salaries and benefits to entice them. Anyone who wants to invest in a business first asks: 'Who manages this organization, and is this management competitive in today's marketplace ' Although health is today a great industry, emphasis on the executive role has lagged behind that in the general business field. In mental health circles, the strong emphasis on one-to-one therapy has delayed a full appreciation of the influence of organization per se on patient care and treatment. Yet there 1 are now many signs of change. The popularization of behavioral science and the rise of social and community psychiatry have brought organizational con siderations forward. We are increasingly concerned with the human side of enterprise, with worker satisfaction, group dynamics, and organizational morale. Other flags have been unfurled.

Taschenbuch. Condizione: Neu. Neuware - The papers contained in this book were presented at a NATO Advanced Research Workshop (ARW) held at Cape Sounion, Athens, Greece, 19-24 May, 1991. The twenty-eight more comprehensive papers represent the key subjects of the ARW covered by invited speakers. The thirty-four short papers pre sented in a research format are contributions of those invited to participate in the ARW. There was a total of 70 participants from 21 countries. The objectives of the ARW were as follows: to review current knowledge of biological control of plant diseases and plant parasitic nematodes, with emphasis on mechanisms at the molecular, cellular, organismal, and ecosystem level; to examine and expand on current concepts and synthesize new concepts; to identify and prioritize limitations in the use of biological control for plant diseases and nematodes and the scientific research needed to overcome these limitations; and to develop strategies for biological control through management of resident agents or introduction of natural or modified agents.

Taschenbuch. Condizione: Neu. Neuware - Applications of Cryogenic Technology, Vol. 10, is the proceedings from the portion of the conference CRYO-90 sponsored by the Cryogenic Society of America (CSA). CRYO-90, held on the campus of the State University of New York, Binghamton, New York, was an unusual interdisciplinary event, drawing from the life sciences as well as the physical science and engineering areas of the low temperature community. Co-sponsoring CRYO-90 with CSA were the Society for Cryobiology and the Symposium on Invertebrate and Plant Cold Hardiness. These latter two organizations brought an exciting developing field to the conference, a field whose exploration will lead to the betterment of all mankind through improved cryosurgical and organ preservation techniques in addition to improved agricultural and herd yields under extreme conditions. Specific goals of the cryobiological community are cryopreservation, the arrest and recovery of living processes of cells, tissues and organs; and cryosurgery - the local cryodestruction of diseased cells while preserving the healthy surrounding tissue. These goals present great technological challenges. The technological requirements of the cryobiologist include the ability to cool tissues 6 at rates of 10 degrees per second (vitrification), to thaw frozen tissue without damaging the delicate cells, to freeze dry tissue using molecular distillation (vacuum) drying, to supercool cell structures below O°C without freezing, and to successfully store the preserved tissues and organs for any required length of time.

Taschenbuch. Condizione: Neu. Neuware - 1 The Lethal Osteochondrodysplasias.- 2 Mutations in Type I Procollagen Genes That Cause Osteogenesis Imperfecta.- 3 Structural Defects in Inherited and Giant Platelet Disorders.- 4 Genetic Aspects of Immunoglobulin A Deficiency.- 5 Oxidative Phosphorylation Diseases: Disorders of Two Genomes.- Addendum.

Taschenbuch. Condizione: Neu. Neuware - The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.

Taschenbuch. Condizione: Neu. Neuware - This volume is an up-to-date treatise of chemosensory vertebrate research performed by over 200 scientists from 22 countries. Importantly, data from over 25 taxa of vertebrates are presented, including those from human beings. Unlike other volumes on this topic, a significant nurober of the contributions come from leading workers in the former Soviet Union and reflect studies within a wide variety of disciplines, including behavior, biochemistry, ecology, endocrinology, genetics, psychophysics, and morphol ogy. Most of the studies described in this volume were presented at the Chemical Signals in Vertbrates VI (CSV VI) symposium held at the University of Pennsylvania in the summer of 1991. This international symposium was the largest and the most recent of a series of six such symposia, the first of which was held in Saratoga Springe, New York (June 6-9, 1976) and the last in Oxford, England (August 8-10, 1988). Unlike the previous symposia, Chemical Signals in Vertabrates VI lasted a full week, reflecting the increased number of participants and the desire of many to present their research findings orally to the group as a whole.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using case studies, this book explores the publishing of African literature, addressing the construction of literary value, relationships between African writers and British publishers, and importance of the African market. It analyses the historical, political and economic conditions framing the emergence of postcolonial literature. 255 pp. Englisch.