Springer nature dez 1996 (22 risultati)

Buch. Condizione: Neu. Neuware - Preface. 1. The History of Anti-Inflammatory Drugs and Their Mechanism of Action; J.R. Vane, R.M. Botting. 2. Structure of Prostaglandin H2synthase-1 (COX-1) and its NSAID Binding Sites; P.J. Loll. 3. Differential Inhibition of Cyclooxygenases 1 and 2 by NSAIDs; M. Pairet, et al. 4. Blockade of Inflammatory Hyperalgesia and Cyclooxygenase-2; S.H. Ferreira. 5. Brain COX-2 in Experimental Models of Epilepsy and Stroke: Signalling Pathways Leading to Enhanced Expression; N.G. Bazan, et al. 6. New Highly Selective Cyclooxygenase-2 Inhibitors; A.W. Ford-Hutchinson. 7. Characteristics of Cyclooxygenase-1 and Cyclooxygenase-2-Deficient Mice; S.G. Morham, R. Langenbach. 8. X-Ray Crystal Structure of Human Cyclooxygenase-2; M. Browner. 9. Risk of Gastrointestinal Side Effects Caused by Non-Steroid Anti-Inflammatory Drugs (NSAIDs); H. Jick. 10. Expression and Regulation of Cyclooxygenase-2 in Synovial Tissues of Arthritic Patients; L.J. Crofford. 11. Differential Target Tissue Presentation and COX-1/COX-2 Inhibition by Non-Steroid Anti-Inflammatory Drugs: A Rationale for a New Classification; H. Fenner. 12. Clinical Experience with Meloxicam, a Selective COX-2 Inhibitor; W. Bolten. 13. Enzymatic Regulation of the Prostaglandin Response in a Human Model of Inflammation; B.F. Adam, G.A. Fitzgerald. 14. Cyclooxygenase-2 and Intestinal Cancer; R.N. DuBois, et al. 15. Cytokines and Adhesion Molecules in the Lung Inflammatory Response; P.A. Ward. 16. Adhesion Molecules as Targets for Therapy in Rheumatoid Arthritis; P.E. Lipsky, et al. Index. …

Buch. Condizione: Neu. Neuware - It is beyond any doubt that East-Central European countries such as Czech Republic, Hungary, Poland and Slovakia has dramatically changed its shape through its radical transition from centrally planned to the market economies in last 7 years. Many economists divide the process of economic transformation into areas of Stabilization, Liberalization, and Privatization/Restructuring. The traditional view is that stabilization and liberalization can be achieved rather quickly-by balancing budgets, balance of payments, tightening money supply, freeing prices and liberalizing trade-but that the area of privatization is one that could be moved to the future and will require much more time. Until 1991, none of the post-communist nations except former East Germany (which had a large decree of support from West Germany) had succeeded in privatizing large numbers of enterprises, even though more than two years had passed since the changes in government in these nations. The privatization has been, however, seen as an extremely important part of reform package together with stabilization and liberalization especially in the Czech Republic from the very beginning. The Czechs originally as a part of the Czechoslovak Federal Republic embarked on an unprecedented path that should have lead not only to stabilization and liberalization, but also to very rapid, mass privatization of its sector of large enterprises that have dominated its economy to an extreme extent.…

Buch. Condizione: Neu. Neuware - Since the beginning of agricultural production, there has been a continuous effort to grow more and better quality food to feed ever increasing popula tions. Both improved cultural practices and improved crop plants have allowed us to divert more human resources to non-agricultural activities while still increasing agricultural production. Malthusian population predictions continue to alarm agricultural researchers, especially plant breeders, to seek new technologies that will continue to allow us to produce more and better food by fewer people on less land. Both improvement of existing cultivars and development of new high-yielding cultivars are common goals for breeders of all crops. In vitro haploid production is among the new technologies that show great promise toward the goal of increasing crop yields by making similar germplasm available for many crops that was used to implement one of the greatest plant breeding success stories of this century, i. e. , the development of hybrid maize by crosses of inbred lines. One of the main applications of anther culture has been to produce diploid homozygous pure lines in a single generation, thus saving many generations of backcrossing to reach homozygosity by traditional means or in crops where self-pollination is not possible. Because doubled haploids are equivalent to inbred lines, their value has been appreciated by plant breeders for decades. The search for natural haploids and methods to induce them has been ongoing since the beginning of the 20th century.…

Buch. Condizione: Neu. Neuware - Over the last decade, high performance Capillary electrophoresis (HPCE) has emerged as a powerful and versatile separation technique that promises to rival high performance liquid chromatography when applied to the separation of both charged and neutral species. The high speed and high separation efficiency which can be attained using any of the various modes of HPCE has resulted in the increased use of the technique in a range of analytical environments. The procedures are, however, still in the early stages of development and several barriers remain to their adoption as the technique of choice for a range of analytical problems. One such barrier is the selection and optimization of the conditions required to achieve reproducible separations of analytes and it is in this area that this new book seeks to give assistance. The book is written by an international team of authors, drawn from both academic and industrial users, and the manufacturers of instruments. At its heart are a number of tables, divided into specific application areas. These give details of published separations of a wide range of archetypal analytes, the successful separation conditions and the matrix in which they were presented. These tables are based on separations reported since 1992 and are fully referenced to the original literature. The tables are supported by discussions of the problems that a particular area presents and the strategies and solutions adopted to overcome them. The general areas covered are biochemistry, pharmaceutical science, bioscience, ion analysis, food analysis and environmental science.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is a comprehensive account of trends in Russian public opinion over the period 1988-94. Analysing data from Russian polling organizations, it covers the development of a professional polling industry and looks at changing popular moods; the depth of democratic values; attitudes towards political institutions; the attempt to introduce a free market economy and views about the loss of empire. Concluding sections consider attitudinal differences between social groups, and the impact of public opinion on postcommunist politics. 269 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Software Engineering and Environment examines the various aspects of software development, describing a number of software life cycle models. Twelve in-depth chapters discuss the different phases of a software life cycle, with an emphasis on the object-oriented paradigm. In addition to technical models, algorithms, and programming styles, the author also covers several managerial issues key to software project management. Featuring an abundance of helpful illustrations, this cogent work is an excellent resource for project managers, programmers, and other computer scientists involved in software production. 340 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recent studies on diverse aspects of the biology of clitellate works (oligochaetes and leeches) are found in the Proceedings of the most recent International Symposium on Aquatic Oligochaete Biology - from development to population dynamics and from ultrastructure to evolution. The majority of the contributions, which have a very broad geographic scope, are investigations of the biology and ecology of oligochaete works in natural and polluted waters. 312 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Section A: Methods of Autoantibody Detection This Section provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. Section B: Autoantigens This Section contains the first compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is greatly enhanced by many beautiful schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields. This Manual is an ideal text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders. 576 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Non-governmental organizations (NGOs) are increasingly recognised as playing a significant role in the health sector in developing countries. This book examines the background to the growth both in the sector and interest in it, the strengths and weaknesses of NGOs and the arguments for and against their use for different aspects of the health sector. It focuses particularly on the relationship between the State and non-governmental organizations and the issues critical to the development of policies towards the sector. 229 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last twenty years more and more historians of the eighteenth and early nineteenth centuries have turned their eyes away from the records of central administration, towards local archives, and the lives of the poor. What they have found is a wealth of sources some of which chronicle the lives, and many of which record the words, of working people. This book will bring together some of the best work based on these sources. 248 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Violence is a more and more ubiquitous phenomenon. While a great deal of attention has been paid to certain aspects, terrorism for example, it has not been studied as a political phenomenon in and of itself. In The Legitimization of Violence eight well-known specialists explore various types of violence, from ideological to fundamentalist movements, within a framework of comparative theory. 413 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines how China's decentralization process has affected and will affect the country's macroeconomic performance and the functioning of the market. With an innovative application of game theory, the author develops an analytical framework that can explain the behaviour of the central and local governments under alternative institutional environments. The study also suggests how to establish desirable rules of games in China's political and economic institutions through appropriate reforms. 188 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book investigates different notions of communitarianism and citizenship, and their application within a number of fields, in particular education, politics and social welfare. Whilst there can be no doubt that most observers regard the responsible conduct of citizens as a goal worth pursuing, difficult problems lie with questions of how, and indeed whether, responsible citizenship can be achieved. This book looks beyond communitarian ideology to investigate more detailed discussion of citizenship in contemporary society. 226 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The provision of legal technical assistance has in recent years become a major concern for international financial institutions, such as the World Bank, and for Western-based bilateral donor agencies. This book offers critical perspectives for the evaluation of legal technical assistance projects and contains proposals for action and research. Five chapters offer general perspectives on law, state and civil society and the remaining six case studies on themes such as economic regulation, agrarian reform, representation of women and access to justice. 286 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Imaginative literature, argues Michael Dash, does not merely reflect, but actively influences historical events. He demonstrates this by a close examination of the relations between Haiti and the United States through the imaginative literature of both countries. The West's mythification of Haiti is a strategy used to justify either ostracism or domination, a process traced here from the nineteenth-century until it emerges with a voyeuristic fierceness in the 1960s. In an effort to resist these stereotypes, Haitian literature becomes a subversive manoeuvre permitting Haitians to 'rewrite' themselves. The Unites States 'invented' Haiti as a land of savagery and mystery, a source of evil and shame. Weaving together text and historical context, Dash discusses the durability of these images, which continue to shape official policy and popular attitudes today. 182 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The provision of legal technical assistance has in recent years become a major concern for international financial institutions, such as the World Bank, and for Western-based bilateral donor agencies. This book offers critical perspectives for the evaluation of legal technical assistance projects and contains proposals for action and research. Five chapters offer general perspectives on law, state and civil society and the remaining six case studies on themes such as economic regulation, agrarian reform, representation of women and access to justice. 286 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book analyses the Europeanization of the Portuguese political system in the context of globalization and the so-called Third Wave of Democratization. It pursues the thesis that democratization and Europeanization are two intertwined processes in the case of Portugal. Integration into the European Union has changed considerably the rationalities within the political structures of the Portuguese political system. Furthermore, the author stresses the necessity to encourage greater political participation of the population and to evolve towards a project of sustainable democracy. 217 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is the second collection of the series of lectures, held annually at City University, London, in honour of Henry Thornton, the renowned 19th Century monetary economist. As with Monetary Economics in the 1980s (0-333-46220-3), the essays by extremely eminent contributors are wide-ranging in both subject and approach but all develop topics considered by Henry Thornton over a century ago and link historical perspectives to contemporary debates about financial institutions and monetary economics. 204 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 331 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interaction of antigen-antibody complexes with cells via specific immunoglobulin Fc receptors (FcR) triggers major immunological reactions such as efficient uptake of antigen, phagocytosis of microorganisms, cytotoxicity towards tumor or virus infected cells, mast cell degranulation and inflammation, etc. This book reviews the FcR for the different immunoglobulin isotypes, focusing on the structural bases of their biological functions, and on the regulation of their expression in physiology and pathology. 201 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 30 of this authoritative series provides detailed information about current advances in both fundamental and applied electrochemical research. 542 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interstellar carbon monoxide (CO) was first detected in 1970 by R.W. Wilson, K.B. Jefferts, and A.A. Penzias through observations of its lowest rotational transition at 2.6 mm wavelength. This discovery opened the door to a profound new understanding of several diverse yet related fields, including the phases of the interstellar medium, the initial and final phases of stellar evolution, the chemistry of dense and diffuse interstellar matter and of the solar system, the structure of the Milky Way galaxy, and the content and structure of other galaxies. These are among the most fundamental research areas in astrophysics, and spectroscopic information about CO and other molecules serves as a primary tool of investigation. Continuing developments in instrumentation will further increase the power and utility of millimeter and submillimeter-wavelength molecular line spectroscopy. The twenty-fifth anniversary of the detection of CO was an opportunity for researchers from all branches of millimeter-wave astronomy to gather and review progress and future directions. These Proceedings discuss the state of the field and consider important unanswered questions. 532 pp. Englisch.…