Springer nature jan 2013 (123 risultati)

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.…

Taschenbuch. Condizione: Neu. Neuware - Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electrophysiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.…

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine. Another thirty years were to pass before the possible physiological role of adenosine in coronary vasodilation was studied by Berne and others. Since then, there has been a tremendous increase in research into the actions of adenosine. Workers from many disciplines have employed a wide variety of techniques, since adenosine is a product of and a substrate for a number of metabolic pathways, is transported into cells, and acts at discrete receptor sites to modulate the activity of adenylate cyclase and to produce important actions on many cells and tissues including platelets, adipo cytes, heart, blood vessels, and other smooth muscles. International symposia on the actions of adenosine were held in 1978, 1981, and 1982, and the proceedings of these symposia have been published (Baer and Drummond, 1979; Daly et at., 1983; Berne et at., 1983). Since it is not the primary purpose of the present volume to review our current understanding of the nu merous actions of adenosine, these volumes should be consulted for such details. Rather, the present volume has been planned to provide both graduate students and investigators in pharmacology and related disciplines with a summary of some of the methods now available for the study of the actions of adenosine and, in particular, to highlight their possible uses and limitations.…

Taschenbuch. Condizione: Neu. Neuware - More than for any other volume of the Handbook of Neurochemistry, the chap ters in this volume on Pathological Neurochemistry deal with the interface of the laboratory bench with the patient's bedside. Most of the chapters reflect the confluence of basic scientists, clinical investigators, and physicians. Con sidered here are many of the more important disorders that afflict the nerves, muscles, spinal cord, and/or brain of mankind throughout the world. There are well over 500 such disorders. And our understanding of their nature and of measures for effective prevention or treatment depends significantly on appli cation of the biochemical disciplines that characterize neurochemistry. Before World War II, any attempt to compile a volume on pathological neurochemistry would have been largely descriptive and very rudimentary, as such 'handbooks' by Hans Winterstein (1929), Irvine Page (1937), and others demonstrate. But thanks to the many major advances in research and tech nology in the postwar decades, we now stand at the threshold of understanding how to manage many of the major neurological disorders, and we may expect more such delineations in the immediate decades ahead. Neurochemistry, de fined broadly, has played a central role in this extraordinary turn of events, progressing from what J. L. W, Thudichum in 1884 called objects of anxious empiricism to his anticipation of the proud exercise of chemical precision.…

Taschenbuch. Condizione: Neu. Neuware - G. M. Bernstein, M. L. Fischer, and P. L. Richards Department of Physics, University of California Berkeley, California 94720, U. S. A. J. B. Peterson Department of Physics, Princeton University Princeton, New Jersey 08540, U. S. A. T. Timusk Department of Physics, McMaster University Hamilton, Ontario L8S 4M1 , Canada ABSTRACT. Recent measurements of the diffuse background at millimeter wavelengths indicate no departure from a Planck spectrum near the peak of the blackbody curve. Anisotropy measurements indicate no structure, at the 2% level, in the recently detected submillimeter excess. We report here the results of an April 1987 balloon flight of an instrument designed to measure the spectrum of the cosmic background radiation from 1 mm to 3 mm. A description of the instrument can be found in Peterson, Richards, and Timusk (1985). Modifications were made to the apparatus and experimental procedure in order to identify and reduce systematic errors. Results from the latest flight indicate that two effects hamper the interpretation of the data. These systematic effects will be described in detail in a forthcoming publications; they are probably responsible for the non-Planckian spectrum measured by Woody and Richards (1981). Attempts to remove the systematic effects from our data yield the upper limits to the CBR brightness temperature in 4 bands from 1 mm to 3 mm. There is no evidence for an excess of radiation near the 2. 8 K blackbody peak.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Combining advocacy and memoir with social and cultural history, this book offers a comparative, cross-cultural survey of the whole history of adoption that is grounded in the author's personal experience. 161 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In most organizations, errors - although common and unavoidable - are rarely mentioned bottom-up. Using this example of the high risk aviation industry this book assess how active error management can work and lead to success. Using academic research and 10 actual aviation accidents cases, this book will provide compelling and informative reading. 191 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ralf Emmers assesses whether the joint exploration and development of resources can act as a means to reduce tensions in contested territories. 96 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -What is mathematics about And how can we have access to the reality it is supposed to describe The book tells the story of this problem, first raised by Plato, through the views of Aristotle, Proclus, Kant, Frege, Gödel, Benacerraf, up to the most recent debate on mathematical platonism. 306 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This collection, now in paperback, explores how universities are coping with the range of reforms and changes taking place across higher education today. Analyzing areas such as leadership, quality management, strategic thinking, collegiality and academic work, and from the perspective of different agents within higher education including students, academics and management, this book examines the various differences between reform attempts and the actual changes happening in universities. 248 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The figure of the stranger is in serious need of revision, as is our understanding of the society against which the stranger is projected. Under conditions of globalization, inside/outside markers have been eroded and conventional indicators of 'we-ness' are no longer reliable. We now live in a generalized state of strangeness, one consequence of globalization: we no longer know where our community ends and another one begins. In such circumstances it is often the case that neighbours are the nearest strangers. Strangeness occurs when global consciousness outstrips global connectivity and this means that we need to rethink some core elements of globalization theory.Under conditions of strangeness the stranger is a 'here today, gone tomorrow' figure. This book identifies the cosmopolitan stranger as the most significant contemporary figure of the stranger, one adept at negotiating the 'confined spaces' of globalization in order to promote new forms of social solidarity and connect with distant others. 195 pp. Englisch.…