Springer nature mai 1999 (29 risultati)

Buch. Condizione: Neu. Neuware - This book covers significant discoveries in the rapidly advancing field of metals and genetics. The aim of this volume is to bring together investigators from diverse fields of clinical medicine, genetics, biochemistry, and chemistry to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume is divided into five sections. The first discusses genetic response to environmental exposure to metals. The section on metal carcinogenesis and metal caused DNA damage presents the latest advances in our knowledge of the molecular mechanisms of metal-induced mutagenis and carcinogenesis. A section is devoted to metals and neurodegenerative diseases. The identification of several disease genes related to metals is a major breakthrough in recent years. The section on genetics and biochemistry of metal-related diseases presents authoritative accounts of current information on both inherited and acquired metal-related diseases. They have discussed the genetics and pathophysiology of these diseases and reported the cloning, expression, purification, and characterization of gene products. Exciting results have been reported recently describing regulation of gene expression by metals. Chapters in this section on metals and gene regulation report recent advances dealing with the mechanism of metal-mediated regulation and control of gene expression.…

Buch. Condizione: Neu. Neuware - In the following essays discussing clinical ethics consultation, three sorts of reflective writing are presented. The first is a description of a clinical ethics consultation, more generously detailed than most that have been published, yet obviously limited as a documentation of the experiences at its source. It is followed by three examples of a second kind in the probing commentaries by highly regarded figures in biomedical and clinical ethics - François Baylis, Tom Tomlinson, and Barry Hoffmaster. Finally, these are followed by a third variety of reflection in the form of responses to those three commentaries, by Bilton and Stuart G. Finder, and my Afterword - a further reflection on some of the issues and questions intrinsic to clinical ethics consultation and to these various essays. The consultation itself was conducted by Bliton; but Finder not only assisted at one point (he is the `colleague' mentioned in Bliton's manuscript) but frequently participated in the discussions that are invariably part of our clinical ethics consultative practice in our Center for Clinical and Research Ethics at Vanderbilt University Medical Center. It was thus natural for Finder to participate in the response. Each of these essays is fascinating and important on its own; together, however, they constitute a truly unusual and, we believe, very significant contribution that will hopefully figure prominently in subsequent discussions, and in shaping and deepening an endeavor - clinical ethics - still in much-needed search of its own discipline, method rationale and place in the domain of clinical practice more generally. This group of essays is also quite unique, addressing as it does the coherence of a form of practice - and, it must be emphasized, several forms of writing about as well as theoretical proposals for understanding that practice - whose current and future character remains very much in contention. That a situationsuch as the one discussed here often provokes strong and passionate responses will be no surprise &endash; whether because of its relative novelty, its risky nature, the high stakes involved, or something else. It is in any event a striking feature of ethics consultations that the people directly or even indirectly involved tend at times to feel rather passionately about what is said (and not said), what is done (and not done), and what is then reported (or, it may be, left out). Even so, such energetic feelings, much less the candor of my colleague's response to such passion, are rarely if ever apparent from published reports. For this reason alone, a considerable debt of gratitude is surely owed to our commentators &endash; reflective and deliberative, yet passionate and forceful as each of them are.…

Buch. Condizione: Neu. Neuware - This study describes the diverse experiences and political opinions of the colonial Anglican clergy during the American Revolution. As an intercolonial study, it depicts regional variations, but also the full range of ministerial responses including loyalism, neutrality, and patriotism. Rhoden explores the extraordinary dilemmas which tested these members of the King's church, from the 1760s controversy over a proposed episcopate to the 1780s formation of the Episcopal Church, and thoroughly demonstrates the impact of the Revolution on their lives and their church. …

Buch. Condizione: Neu. Neuware - This volume contains up-to-date information on aldehyde dehydrogenase, alcohol dehydrogenase, short- and medium-chain dehydrogenase, and reductases. Sixty-nine contributions provide a wide variety of information on enzymology, molecular biology, and metabolic aspects of these carbonyl metabolizing oxido-reductases. Much new information is provided, including previously unreported three-dimensional structures of enzymes and new aspects of gene regulation, along with sequence alignments, metabolism and enzyme mechanisms.…

Buch. Condizione: Neu. Neuware - In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Intended to teach readers Java and object orientation, as well as presenting object oriented design and analysis, Java for Practitioners is written such that it is possible to dip into chapters as required. It introduces concepts by getting the reader to follow exercises, rather than by extensive discussion, and includes the new release 1.2 of Java. Practicals are included at the of each chapter, as well as the Java Self-Tester, designed to allow readers to determine whether they are ready to take the Sun Java Certification exam, and follows a similar format and style to the actual Online Certification Examination. In short, a thoroughly comprehensive guide. 670 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 267 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An excellent book addressing the dilemmas in the new policy agendas for women and government. Gender relations are being transformed and a new gender settlement is being created. The challenge to ensure the social inclusion of women within this new settlement is complicated by the diversity in women's lives, in particular between those who are qualified and able to engage in employment and those who are not. This wide-ranging book is written by leading academics who have advised key members of the Labour Party. 219 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Remembering the past in the Middle Ages is a subject that is usually perceived as a study of chronicles and annals written by monks in monasteries. Following in the footsteps of early Christian historians such as Eusebius and St Augustine, the medieval chroniclers are thought of as men isolated in their monastic institutions, writing about the world around them. As the sole members of their society versed in literacy, they had a monopoly on the knowledge of the past as preserved in learned histories, which they themselves updated and continued. A self-perpetuating cycle of monks writing chronicles, which were read, updated and continued by the next generation, so the argument goes, remained the vehicle for a narrative tradition of historical writing for the rest of the Middle Ages. Elisabeth van Houts forcefully challenges this view and emphasises the collaboration between men and women in the memorial tradition of the Middle Ages through both narrative sources (chronicles, saints' lives and miracles) and material culture (objects such as jewellery, memorial stones and sacred vessels). Men may have dominated the pages of literature from the period, but they would not have had half the stories to write about if women had not told them: thus the remembrance of the past was a human experience shared equally between men and women. 196 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Macedonian question has been at the heart of the Balkan crisis for most of the twentieth century. This important book is the first to bring together international experts to analyse the recent history of Macedonia since the break-up of Yugoslavia, and includes seminal analyses of key issues in ethnic relations, politics, and recent history. It is edited by James Pettifer, a British authority on the southern Balkans, and is likely to prove a landmark in its field. 311 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies. 192 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is divided into three sections: synaptic transmission, synaptic modulation, and synaptic plasticity. Some of the topics covered include: molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysial nerve terminals; alcohol and general anesthetic modulation of GABA A and neuronal nicotinic acetylcholine receptors; alcohol and the 5-HT 3 receptor, adenosine and ethanol; metabotropic hypothesis for ethanol sensitivity of GABAergic and glutamatergic central synapses; alcohol, memory, and molecules; novel forms and analyses of ethanol effects on synaptic plasticity; and ethanol suppression of hippocampal plasticity. 232 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The question of ethics has dominated recent developments within the humanities. This volume brings together the most recent theories of ethics and reading and applies them to a wide variety of literary texts. Ethical and literary issues explored by the contributors include biography, sensibility, national identity, feminism, postcolonialism, religion, subjectivity and stylistics. Literary authors and philosophers/theorists discussed range from Shakespeare and Mary Shelley to Michele Roberts and Salman Rushdie, and from Kant and Coleridge to Derrida and Levinas. 281 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Many of the world's leading authorities in history, sociology, political science and psychology shed new light on the major genocides of the twentieth century. Featured authors include Irving Louis Horowitz, Helen Fein, Vahakn Dadrian, Roger W. Smith, Henry Huttenbach, Ervin Staub, and Turkish historian Taner Ak . The volume covers the genocides of the Armenians, Ukrainians, Jews, Gypsies, Rwandans and Bosnians, and also topics of genocide denial and prevention. 270 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Jane Austen is a formative influence on how we think about 'England' and 'Englishness', about class, ideology and gender issues. But the critical convoy for 'Jane', as she is patronizingly styled, aligns her with conservative views which her texts entertain - but don't finally sign up for. In fact, as Edward Neill points out in this devastating new study, it is possible to show that 'Tory Jane' is largely illusion, and that much traditional critical effort has been fundamentally misdirected. This exhilarating book seeks to 'liberate' the reading of Jane Austen by offering a very different critical inflection from those of traditional critical appropriations. 175 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The term 'structural adjustment' has been associated with rioting as angry and hungry masses protest food price increases due to subsidy cuts or due to other structural adjustment conditions prescribed by the IMF and the World Bank. Structural adjustment, and the neo-liberal paradigm that underlies it, is now the dominant economics paradigm practised by developing countries. The main purpose of the book is to rely on evidence and to go beyond rhetoric, ideology and anecdotes in assessing structural adjustment in Pakistan and the developing world more generally to examine how reform can be combined with pragmatism and social justice. 197 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is an authoritative and comprehensive guide to the essential relationship between markets and morals. Smith, Burke and Marx, Durkheim, Polyani and Hayek - all sought to situate market exchange and property-based acquisitiveness in the broader context of human interaction and social values. This framework of interdependence and ethics embeds the capitalist market economy in an ongoing whole of which the calculative present-day is but a part. The book argues that the stability of conservatism anchors the dynamism of entrepreneurship in a matrix of patterns and habits without which orderly free enterprise would be at risk of degenerating into the Hobbesian war of each against all. 277 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines the ways in which EU policies towards developing countries are changing in response to the new challenges of globalization and the end of the Cold War. It analyses the patchwork of relationships between the fifteen Member States and more than 140 countries throughout Africa, Asia, Latin America and the Mediterranean. 365 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -America's current transformation from an industrial to a new information-based culture presents new challenges as well as new perspectives on old debates. This book offers a comprehensive survey of America's changing values. It examines notions of American exceptionalism and how the 'melting pot' is coping with race relations and changing demographics; it assesses the agenda of government, the domestic and global constraints, and how social exclusion can be tackled. Current changes in the US are likely to be a harbinger for other societies, and the authors examine new models of civic society, of learning and of reconfiguring social values for a fast-changing world. 229 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The management of cultural diversity is a major challenge in many states. This book follows up the theoretical analysis of Ethnic Diversity and Public Policy with detailed case studies from leading international experts on Malaysia, Tanzania, Mauritius, Trinidad and Tobago, Northern Ireland, Spain and the United States of America to discover what lessons can be learnt for policy-makers in other divided societies. 222 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book explores through theory and in-depth textual criticism how novelists from formerly colonised societies have exploited indigenous codes and conventions of aesthetic representation to transform the novel into an effective medium for cultural and political resistance to (neo)colonialism. Concentrating on novels written between the late 1940s and early 1990s in Africa, Polynesia, and the West Indies, it offers a fresh mode of postcolonial critique which takes account of the ideological impulses behind the novelists' interpretation of the colonial experience. 236 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Jefferson and the Iconography of Romanticism is the first full-length study to examine how Jefferson, in the process of inventing the USA as the first new nation of the Romantic era, sought to find an appropriate imagery to represent the people, their homeland and the cultural ideal to which they should aspire. It examines in detail the role of his villa at Monticello in embodying the national ideal, shows how those ideals emerged and how they were subsequently challenged by the reinterpretation of Jefferson's iconography. 207 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Wei-Bin Zhang offers an authoritative guide to the philosophy of Confucianism and its impact in the Confucian regions, covering mainland China, Taiwan, Hong Kong, Macao, Japan, South Korea, North Korea, Vietnam and Singapore. All, except Singapore, employed Confucianism as the state ideology before the West came to East Asia. The differences and similarities between the variety of Confucian schools are examined. The author concludes that the philosophical and ethical principles of Confucianism will assist in the industrialization and democratization of the region. 229 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book tells the story of the women's suffrage movement in Britain beginning with John Stuart Mill's proposal of a women's suffrage amendment to a reform bill. It ends with the victory of 1928, concluding more than 50 years of repeated defeats, anti-suffragism, militancy, imprisonment, hunger strikes and forcible feeding, and multiple internal splits and their only partial victory of 1918. It is not intended to break new ground in academia, but to provide an introduction to the general reader that covers the entire relevant time period and introduces major themes and issues. 227 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a compelling analysis of the conditions in which women are sustained within prostitution in Britain at the end of the millennium. Based on a major empirical study, it is a unique glimpse into how some women, who live lives completely torn apart by poverty, violence and criminalization, are able to understand their lives in prostitution and make sense of the choices they make in their struggle to survive. 200 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -What have we learned from the first experiments performed at the reconstructed Globe on Bankside What light have recent productions shed on the way Shakespeare intended his plays to be seen Written by the Leverhulme Fellow appointed to study and record actor use of this new-old playhouse, here is the first analytical account of the discoveries that have been made in its important first years, in workshops, rehearsals and performances. It shows how actors, directors and playgoers have responded to the demands of 'historical' constraints (and unexpected freedoms) to provide valuable new insights into the dynamics of Elizabethan theatre. 175 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The mechanism of information transfer between cells is the subject of Introduction to Signal Transduction. Until recently various aspects of signaling by hormones were studied (and taught) under the subject of endocrinology, and signaling by neurotransmitters was the subject of neurochemistry. With growing awareness of the many similarities between hormonal and neurotransmitter signalling, recent years have witnessed the emergence of Signal Transduction as an independent discipline covering all aspects of information transfer between cells irrespective of the nature and source of the signals.This book is designed for senior undergraduate/graduate-level students interested in a basic understanding of the major participants in the cellular Signal Transduction pathways. The book covers the major topics in Signal Transduction: receptors, which recognize the signals at the cell surface; G-proteins, which transduce the signals; and adenylate cyclases, guanlate cyclases, and phospholipases, which generate second messengers. Chapters also focus on ion channels, phosphodiesterases, protein kinases, phosphoprotein phosphatases and nitric oxide, which participate in the cellular response to signals; the health consequences of defects in Signal Transduction proteins; and the central role Signal Transduction plays in drug abuse.The book is suitable for an introductory course in Signal Transduction as well as for self-study and review. It is recommended for biology and medical students, as well as for interdisciplinary science majors and pharmaceutical researchers. 328 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An authoritative assessment of the reform efforts in African economies during the 1980s and early 1990s, with the focus on economic liberalization in those socialist countries which began from a position of pervasive state intervention. A companion theoretical volume (0-333-66545-7) examines the changing role of the state during the period of transition. This volume examines the important debate on agricultural reforms in the period, and provides in-depth country studies of the transition economies, covering Congo, Madagascar, Tanzania and the impact of war on transition in Angola and Mozambique. These books are the first in an important new series in association with the Centre for the Study of African Economies, University of Oxford. 370 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An authoritative assessment of the reform efforts in African economies during the 1980s and early 1990s. The focus is on the reform process in the socialist countries which began from a position of pervasive state intervention. The impact of the subsequent economic liberalization and the changing role of the state during the period of transition is the focus of this theoretical overview, with particular coverage of macroeconomic management and the privatization of state enterprises. A companion volume (0-333-71237-4) contains in-depth country studies. These books are the first in an important new series in association with the Centre for the Study of African Economies, University of Oxford. 342 pp. Englisch.…