Springer nature mai 2013 (144 risultati)

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware.

Taschenbuch. Condizione: Neu. Neuware - Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on 'Vascular Endothelium: Receptors and Transduction Mechanisms' held in Porto Carras, Greece from June 18-29, 1988.…

Taschenbuch. Condizione: Neu. Neuware - - National Institute of Child Health and Development.- Evolutionary Insights from Reptilian Sexual Differentiation.- Sexual Differentiation in Marsupials.- Antiquity of the Genetic Mechanism of Sex Determination and the Immortality of the Primary Sex Determining Gene.- Searches for Human H-Y by Conventional Means, and How it all Began.- Serological Analysis of H-Y Antigen.- Immunogenetic Analysis of the H-Y Antigen.- Sex Determination and H-Y Antigen in Mice.- Genes on the Human Y Chromosome.- The Detection of Y DNA in Intersex Subjects with Mosaicism for a Y Cell Line.- Evidence that the X-Y Pairing/Recombination Region May be Involved in tda-1 Inherited Sex Reversal.- Centromeric Alphoid DNA on the Y Chromosome.- Do BKM Sequences Play a Role in Human Sex Determination .- Localization of a Gene for the Male Enhanced Antigen on Human and Mouse Chromosomes.- Abbreviations.- Contributors.…

Taschenbuch. Condizione: Neu. Neuware - Volume 1 of Theory and Research in Belwvioral Pediatrics drew attention to issues related to the assessment of the preterm infant, to organizational processes in infant development, and to the systemic nature of caregiver-infant relationships. Vol ume 2 continued the theme of systemic organization while ex amining various contextual and ecological factors that affect development during infancy and childhood. Volume 3 con tinues these themes. Interdisciplinary and cross-disciplinary studies, cross-cul tural comparisons, prospective longitudinal designs, and so phisticated multivariate correlational models have encouraged developmentalists to formulate new conceptualizations of the dynamic relationships among those organismic, transactional, and ecological variables that regulate organizational processes. As a result, many traditional models of development have been discarded or, at minimum, have been markedly transformed. Similarly, many time-honored 'facts' of development have been seriously challenged both theoretically and empirically. In Chapter 1, Philip R. Zelazo challenges traditional ap proaches to infant developmental assessment. Zelazo goes a step beyond noting the poor predictive validity of infant devel opmental examinations, by arguing that such examinations bias the evaluation of infants with handicapping conditions. The emphasis in standard developmental examinations on motor performance, receptive language, and behavioral compliance Vll Vlll PREFACE works against infants whose handicapping conditions involve neuromotor, attentional, or auditory dysfunctions. Zelazo's pro posed alternative is to directly assess mental activity using cog nitive-behavioral measures of mental competence derived from central processing models of schema formation.…

Taschenbuch. Condizione: Neu. Neuware - The chapters of this volume were originally presented at a symposium on 'Depression in Schizophrenics' held at the University of Calgary, Health Sciences Centre on July 06 and 07, 1988. It was the intent of the organizers to draw together leading international researchers to address, in a comprehensive fashion, the persisting problem of depression in schizophrenic individuals. As many of the authors point out, depression was clearly identified as a central problem in schizophrenia by the pioneers of psychiatry. Their wisdom and clinical acumen was lost for a time to be only recently re discovered. Their insights must now be integrated with modern taxonomic systems, evolving etiological models and methods of assessment. With increased recognition of the problem of depression in this population we must also examine appropriate methods of ameliorating the suffering of those afflicted. The conference was divided into sections (theoretical aspects, phenomenology, suicide and treatment) and the chairmen of these sections have given brief introductions. Necessary overlap of topics and methods provided a convergent and validating examination of empirical results which may serve to direct continuing studies. As well we hope that thoughtful review may directly influence clinical practice and thereby improve the quality of life for schizophrenic patients.…

Taschenbuch. Condizione: Neu. Neuware - Families are undergoing dramatic changes in our society. Our tradi tional views are being challenged by new family arrangements. These new family arrangements are forcing redefinitions of what consti tutes a family and raising significant issues regarding the potential developmental consequences for children in these families, if such exist. Moreover, the ramifications of redefined families and their bear ing on children's development extend into the legal, political, and societal arenas. This book focuses on the relationships between di verse family arrangements and children's development, as well as on legal and social implications. Our interest in this area emanates from our experience in directing the Fullerton Longitudinal Study. In the course of this investigation, we observed families undergoing transformation, most commonly in maternal employment and marital status. Our initial research on the role of maternal employment in children's development provided the scientific foundation for our interest. Just as we feel that maternal employment and dual-earner families should be comprehensively re searched regarding their relationships to children's development, we also believe that other contemporary family arrangements should receive extensive attention in the developmental literature. Hence, the idea for this book emerged.…

Taschenbuch. Condizione: Neu. Neuware - Just over 20 years ago the publication of two books indicated the reemergence of Darwinian ideas on the public stage. E. O. Wilson's Sociobiology: The New Synthesis and Richard Dawkins' The Selfish Gene, spelt out and developed the implications of ideas that had been quietly revolutionizing biology for some time. Most controversial of all, needless to say, was the suggestion that such ideas had implications for human behavior in general and social behavior in particular. Nowhere was the outcry greater than in the field of anthropology, for anthropologists saw themselves as the witnesses and defenders of human di versity and plasticity in the face of what they regarded as a biological determin ism supporting a right-wing racist and sexist political agenda. Indeed, how could a discipline inheriting the social and cultural determinisms of Boas, Whorf, and Durkheim do anything else Life for those who ventured to chal lenge this orthodoxy was not always easy. In the mid-l990s such views are still widely held and these two strands of anthropology have tended to go their own way, happily not talking to one another. Nevertheless, in the intervening years Darwinian ideas have gradually begun to encroach on the cultural landscape in variety of ways, and topics that had not been linked together since the mid-19th century have once again come to be seen as connected. Modern genetics turns out to be of great sig nificance in understanding the history of humanity.…

Taschenbuch. Condizione: Neu. Neuware - In the myth of Daphne and Apollo, Cupid fired two arrows: one causing flight from love, the other passionate attraction. Cupid aimed his first arrow at Daphne, a beautiful nymph who loved her freedom; the next struck Apollo, who lusted after Daphne. Daphne, frightened and intent upon virginity, fled Apollo but was unable to run fast enough. When her strength was almost gone, she sought protection in the familiar waters of her father's river. He answered her prayers: Her hair became leaves, and her feet, roots growing into the ground; she was transformed into a laurel tree. Apollo, kissing the sprouting bark, pledged to honor Daphne by placing a laurel wreath on the head of every hero who won a victory. Unable to evade the consequences of the arrow that wounded her, Daphne called upon the river, the creative power of both nature and time-a symbol of fertility, but also of oblivion-to help her survive when her strength was gone. Daphne's inner triumph in the face of injury is an appropriate sym bol for the types of transformation witnessed by psychologists. In his book on symbols, Circlot (1962, p. 173) writes that the crowning of the poet, artist, or conqueror with laurel leaves 'presupposes a series of inner victories over the negative and dissipative influence of the basest forces. ' Further, the tree 'denotes the life of the cosmos: its consistence, growth, proliferation, generative, and regenerative processes' (Circlot, 1962, p. 328). …

Taschenbuch. Condizione: Neu. Neuware - The bright side of the 1980s, or the 'Hispanic decade,' as it was dubbed early on, may ironically turn out to be the detail and sophistication with which the economic and social reversals affecting most Latinos in this period have been tracked, with a fresh cohort of Latino scholars playing an increasingly prominent role in this endeavor. As this volume conveys, these analyses are steadily probing more deeply into the fine grain of the processes bearing on the social conditions of U. S. Latinos and particularly into the diversity of the experiences of the several Latino-origin nationalities until recently generally treated in the aggre gate as 'Hispanics. ' Though still fragmented and tentative in perspective, as are the disciplines on which they draw and the research apparatus on which they rest, the quest among these new voices for a unifying perspective also comes across in this collection of essays. There is manifestly more under way here than a simple demand for inclusion of neglected instances on the margin of supposedly well understood larger or 'mainstream' dynamics. The 1990s open with a more confident assertion of the centrality of the Latino presence and Latino actors in the overarching transformations reshaping U. S. society, and especially in the playing out of these restructurings in the regions and cities of Latino concentra tion.…

Taschenbuch. Condizione: Neu. Neuware - How are we to understand the complex forces that shape human behav ior A variety of diverse perspectives, drawing on studies of human behavioral ontogeny, as well as humanity's evolutionary heritage, seem to provide the best likelihood of success. It is in an attempt to synthesize such potentially disparate approaches to human development into an integrated whole that we undertake this series on the genesis of beh- ior. In many respects, the incredible burgeoning of research in child development over the last two decades or so seems like a thousand lines of inquiry spreading outward in an incoherent starburst of effort. The need exists to provide, on an ongoing basis, an arena of discourse within which the threads of continuity among those diverse lines of research on human development can be woven into a fabric of meaning and under standing. Scientists, scholars, and those who attempt to translate their efforts into the practical realities of the care and guidance of infants and children are the audience that we seek to reach. Each requires the oppor tunity to see-to the degree that our knowledge in given areas per mits-various aspects of development in a coherent, integrated fashion. It is hoped that this series-which brings together research on infant biology, developing infant capacities, animal models, and impact of so cial, cultural, and familial forces on development, and the distorted products of such forces under certain circumstances-serves these important social and scientific needs.…

Taschenbuch. Condizione: Neu. Neuware - During the past decade the theoretical physics community has learned how to evaluate accurately polarizabilities and susceptibilities for many-electron systems such as atoms, solids, and liquids. The most accurate numerical technique employs a method often called the Time-Dependent Local Density Approximation, which is abbreviated TDLDA. The present volume is a review of recent research on the theory of po larizabilities and susceptibilities. Both authors have been doing these cal culations. However, this review surveys the entire field, summarizing the research of many contributors. The application of an external field, either ac or de, will induce a dipole moment which can be calculated and compared with experiment. For mod erately strong fields, both linear and nonlinear processes contribute to the moment. We cover topics such as polarizability, hyperpolarizability, pho toionization, phonons, and piezoelectricity. Density functional theory in the Local Density Approximation (LDA) has been shown to be a very accurate method for calculating ground state prop erties of electronic system. For static external fields, the induced moments are properties of the ground state. Then the calculation of the polarizability is very accurate. For ac fields, the moment is not part of the ground state. However, the TDLDA methods are still very accurate.…

Taschenbuch. Condizione: Neu. Neuware - Although there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries. This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.…

Taschenbuch. Condizione: Neu. Neuware - This book originated in the Proceedings of the Second Symposium on Polymeric Liquid Crystals held by the Division of Polymer Chemistry in the framework of the 1983 Fall Meeting of the American Chemical Society. At the First Symposium in 1977, the literature in this field could be encompassed in a single volume. To day, that is no longer possible. The field of Polymeric Liquid Crystals grew, and continues to grow, at a very rapid pace. At present, we know of every major mesophase in its polymeric form and of polymeric glasses, elastomers and fluids in their liquid crystalline form. Every year, new polymeric mesophases are being discovered. The aim of this book is to go beyond a compilation of papers presented at the 1983 ACS Fall Meeting. It is conceived as a learning tool for the benefit of the sci entist interested in Polymeric Liquid Crystals. The book is divided into three sections. The first section contains articles discussing synthetic, physico chemical, structural and rheological aspects of Polymeric Liquid Crystals in their generality. A chapter on methods currently used in this field is also included. There are also chapters on theoretical and classification aspects of PLCs. These self-contained tutorial chapters provide an introduction to this field as well as to the specific papers given in the book. They provide an exhaustive cover age of literature on the subject from its inception to the present.…

Taschenbuch. Condizione: Neu. Neuware - The NATO-Advanced Research Workshop 'Esterases, Lipases and Phospholipases: From Structure to Clinical Significance' was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The purpose of this NATO-ARW was to bring together experts (both clinical and scientific) in all three interrelated fields to review the current basic and clinical position and discuss future developments particularly with respect to future research aimed at determining the basic biochemical lesion involving hydrolytic enzymes involved in human disease and the use of these enzymes in diagnosis. As well as formal lectures from established researchers, the meeting also involved a number of lively round-table discussions on future developments and presentations from younger research workers, all of which are recorded in this Proceedings and which contribute to the success of the meeting.…

Taschenbuch. Condizione: Neu. Neuware - Biomedical scientists widely acknowledge that individuals' immune respon siveness is important in resistance to infections by microorganisms, including fungi. Because of the devastating acquired immunodeficiency syndrome (AIDS) epidemic, caused by the human immunodeficiency retrovirus, it is now accepted that suppressed immune responses, especially cellular immu nity, are important contributors to increased individual susceptibility to opportunistic infections-including infections caused by fungi which were at one time thought to be very lowly or nonpathogenic. Within the last few years, there has been an almost explosive increase in interest and studies concerning the nature and mechanisms of the immune response to fungal infections. Many immunologists who are not well versed in mycology have begun to study the nature and mechanisms of antifungal immunity using a wide variety of newer as well as more conventional immunologic technologies, both in vivo and in vitro. Up to the 1980s, however, there was little interest among basic immunologists concerning fungal immunity. This situation has changed dramatically in the past half decade, mainly because of AIDS.…

Taschenbuch. Condizione: Neu. Neuware - It is a source of great satisfaction to us that a Second Edition of this treatise should be called for, especially because it has given us the opportunity to produce, we believe, a better book. Eighteen chapters, amounting to one-third of the whole, are new, and of these, 13 deal with subjects not covered at all in the First Edition. We have paid more attention to embryonic and fetal growth, with chapters on cell differentiation (Lehtonen and Saxen), embryonic growth (O'Rahilly and Muller), control of fetal size (Snow), regulation of fetal growth (D'Ercole and Underwood), and ultrasonic studies offetal growth (Meire). At last the data are available for a chapter on the evolution of the human growth curve, by Eliz abeth Watts. Large parts of the endocrine section have been rewritten (by Michael Preece, and by William Crowley and Margaret Wierman), and the genetics section has been largely recast, with new contributions by William Mueller and Ronald Wilson. Reynaldo Marto rell has contributed a new chapter on growth in developing countries, and Tanner discusses growth surveys and standards as well as catch-up growth. Finally, there are two new chap ters dealing with growth as a monitor of the health of populations-one by Tadeusz Bie licki, considering the contemporary scene, and the other by Robert Fogel, on the contri bution that such studies are making to the economic history of the eighteenth and nineteenth centuries. …

Taschenbuch. Condizione: Neu. Neuware - The last two decades have seen unprecedented increases in health care costs and, at the same time, encouraging progress in psychotherapy research. On the one hand, accountability, cost-effectiveness, and efficiency have now become commonplace terms for providers of mental health services whereas, on the other hand, an increasingly voluminous literature has emerged supporting the effectiveness of a number of types of psychotherapies. There now exists the possibility for the design and delivery of mental health services that-drawing upon this literature-more closely approximate empirically established data concerning the appropriateness and effectiveness of psychotherapy. The Handbook of the Brief Psychotherapies is intended to capture one major thrust of this movement: the development of a group of empirically grounded, time-limited therapies all sharing a common interest in the clinical utilization of a structured focus and an emphasis on time and action. For many years, professional self-interest, competing theoretical para digms, and the vagaries of practice, wisdom, and clinical myth have influenced the practice of psychotherapy. A critical questioning of the resulting, predomi nantly nondirective, open-ended, and global therapies has led to a growing emphasis on action-oriented, problem-focused, time-limited therapies. Yet, ironically, this interest in the brief psychotherapies has not so much involved a radical departure from traditional therapeutic modalities as it has emphasized a new pragmatism about how time, action, and structure operate in life as well as in therapy.…

Taschenbuch. Condizione: Neu. Neuware - In 1969 the North Atlantic Treaty Organization (NATO) established the Committee on Challenges of Modern Society (CCMS). The subject of air pollution was from the start one of the priority problems under study within the framework of various pilot studies undertaken by this Committee. The organization of a yearly conference dealing with air pollution modeling and its application has become one of the main activities within the pilot study relating to air pollution. The international conference was organized for the first five years by the United States and for the second five years by the Federal Republic of Germany. Belgium, represented by the Prime Minister's Office for Science policy, became responsible in 1980 for organizing the third five years of the annual conference. This volume contains the papers presented at the 15th NATO/CCMS International Technical Meeting (ITM) on Air Pollution Modeling and Its Application, held in St. Louis, Missouri, from the 15th to 19th April 1985. This ITM was jointly organized by the Prime Minister's Office for Science Policy, Belgium (Pilot Country); by the Environmental Protection Agency, Atmospheric Sciences Research Laboratory, United States (Host Country); and by Washington University, Mechanical Engineering Department (Host Organization).…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using Martin Esslin's 'invention' - the Theatre of the Absurd - to examine Pinter's works, Wong brings the complexities and intricacies of the plays to the forefront, provoking readers and audiences to reconsider and problematize more conventional studies of his plays. 103 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In a turbulent global economy, the popular idea of declining farms and factories is largely unfounded. UN and World Bank data show growing output everywhere, but it remains hidden by the faster-growing service sector. Engineers, programmers, surgeons, and pilots make up an increasing share of what is actually the service sector, showing that this sector is not in decline. There is no doubt that industries are shifting, but how does it all add up Quantifying these technology-driven shifts is fundamental, yet such publication has lagged for years, with stale ideas about what makes a healthy economy persisting since the 1940s. In this new work, Atikian gives us a freshly updated overview countering our tired assumptions about off-shoring, low wages, and industrial decline and providing us with.some fact based confidence in the economy. 136 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This annotated edition of the unpublished letters that Iris Murdoch wrote to Jeffrey Meyers includes her discussion of writers from Conrad to Updike; her quarrel with Rebecca West; and her difficulty with Alzheimer's. With both scholarly insight and personal reflection, this volume will deepen our understanding of Murdoch's complex life and work. 124 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Investigates how and to what extent the self-employed and micro-enterprise workers can be represented in the social arena. A cross-sector approach to responsibility for government as well as private businesses. 197 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drawing from recent research that seeks to expand our understanding of modernism, this volume offers practical pedagogical approaches for teaching modernist literature and culture in the twenty-first century classroom. 203 pp. Englisch.…