Springer nature nov 2013 (273 risultati)

Taschenbuch. Condizione: Neu. Neuware - Volume 7 of Developments in Applied Spectroscopy is a collection of forty-two papers selected from those that were presented at the 7th National Meeting of the Society of Applied Spectroscopy, held (in place of the 19th Mid-America Symposium on Spectroscopy) in Chicago, May 13-17, 1968. These papers, selected by the editors and reviewed by persons knowledgeable in the field, are those of the symposium type and not those pertaining to specific research topics that one would expect to be submitted to a journal. It is the opinion of the committee that this type of publication has an important place in the literature. The relatively large number of papers would result in quite a sizable volume if bound in one set of covers. For this reason, and to present the material in areas of more specific mterest, Volume 7 was divided into two parts, Part A, Physical-Inorganic, and Part B, Physical-Organic Developments. The 7th National Meeting was sponsored by the Chicago Section as host in cooperation with the St. Louis, New England, Penn York, Niagara-Frontier, Cincinnati, Ohio Valley, New York, Baltimore-Washington, North Texas, Rocky Mountain, and Southeastern Sections of the Society for Applied Spectroscopy and the Chicago Gas Chromatography Group. The editors wish to express their appreciation to the authors and to those who helped with the reviewing. The latter include Dr. Elma Lanterman, Mr. John E. Forrette, Dr. Carl Moore, Dr. B. Jaselskis, Mr. H. G. Zelinski, Mr. …

Taschenbuch. Condizione: Neu. Neuware - Milestones in the techniques and methodology of polypeptide structure determination include the determination of the sequence of insulin by Sanger in 1951 (I) and the introduction of the repeti tive degradation of proteins with phenylisothiocyanate by Edman in 1959 (2). The automation of Edman chemistry (3) played a major role in the determination of polypeptide structures. Important modifications of Edman chemistry include the solid-phase approach by Laursen in 1971 (4) and the use of modified Edman reagents such as 4-N,N-dimethylaminoazobenzene-4'-isothiocy- ate (DABITC) for manual sequencing by Chang et al. (5) in 1976. A second major breakthrough in the analysis of polypeptides was automated amino acid analysis described by Spackman et al. in 1958 (6). However, during the period from 1975 to 1980, it became increasingly clear that the amount of material required for struc tural analysis was more than could be easily isolated for the vast majority of proteins. The field was criticized for its lack of sensitive techniques for the analysis of growth factors, immune modulators, membrane receptors, and peptide hormones. In addition, very little had been done to modernize and improve the original instruments introduced in the mid-1960s. The first indications of improved instrumentation for Edman chemistry came from Wittmann-Liebold's laboratory (7), followed by the introduction of a 'micro' sequencer by Hunkapiller and Hood in 1978 (8). The movement toward improved instrumentation culminated in the 'gas'-phase sequencer of Hewick et al. (9) in 1981.…

Taschenbuch. Condizione: Neu. Neuware - The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target enzyme, but have quite different cellular pharmacokinetics than the parent monoglutamate. Hence, nearly three and a half decades after 4-aminoantifolates were first applied clinically in the treatment of human neoplasms, we have begun to appreciate a new dimension in antifolate pharmaco logy which may have profound implications for our understanding of the mechanism of the cytotoxicity and selectivity of this class of agents. With the development of highly sensitive methodology for the rapid detection of folyl and antifolyl polyglutamates, it is now possible to define in depth the intracellular transformation of these agents and their role in determining antifolate action against normal and malignant cells. This information will very likely influence how regimens with methotrexate and related antifolates will be further developed and employed clinically.…

Taschenbuch. Condizione: Neu. Neuware - Substance misuse and abuse exist in almost every human society. In our western civilization, the bulk of attention has focused on those indi viduals who specifically seek treatment or those who have become so disabled by these problems that they require treatment. These indi viduals usually qualify for a psychiatric diagnosis of alcohol or other substance abuse. However, just as it has been recognized that primary substance abuse is frequently associated with other diagnosable psychi atric disorders, such as sociopathy or attention deficit disorder (residual type) and that the origins of substance abuse are multivariate, we have also begun to become aware that many other individuals in our society with psychiatric or other problems also suffer, to varying degrees, from substance abuse. These problems may be considered secondary by vari ous specialists or treatment personnel; but nevertheless, they are prob lems, and what disorder is primary or secondary in a given individual may often be very difficult to determine in a meaningful fashion. Thus, within the past decade, research studies have reported significant inci dences of substance abuse/or misuse in high school and college-aged populations, in medical populations, and in individuals with other psy chiatric disorders such as schizophrenia, depression, and the anxiety and personality disorders. Yet to date little has been done to bring together and systematize this widely scattered data that describes the presence of substance abuse problems in various populations.…

Taschenbuch. Condizione: Neu. Neuware - To Liquid Chromatography.- Principles of Liquid Chromatography.- Instrumentation for Liquid Chromatography.- Liquid Chromatography Column Technology.- Therapeutic Drug Monitoring and Toxicology.- Why Measure Drug Levels .- Anticonvulsants.- Theophylline and Antiarrhythmics.- Antibiotics.- Tricyclic Antidepressants.- Antineoplastic Drugs.- Hypnotics and Sedatives.- Toxicology Screening.- Clinical Analysis of Endogenous Human Biochemicals.- Determination of Tyrosine and Tryptophan Metabolites in Body Ruids Using Electrochemical Detection.- Steroids.- Proteins.- Bilirubin and Its Carbohydrate Conjugates.- Porphyrins.- Organic Acids by Ion Chromatography.- Major and Modified Nucleosides, RNA, and DNA.- Polyamines.…

Taschenbuch. Condizione: Neu. Neuware - Phenomenology as practised by Adolf Reinach ( 1883-191 7) in his all too brief philosophical career exemplifies all the virtues of Husserl's Logical Investigations. It is sober, concerned to be clear and deals with specific problems. It is therefore understandable that, in a philosophical climate in which Husserl's masterpiece has come to be regarded as a mere stepping stone on the way to his later Phenomeno logy, or even to the writings of a Heidegger, Reinach's contributions to exact philo sophy have been all but totally forgotten. The topics on which Reinach wrote most illuminatingly, speech acts (which he called 'social acts') and states of affairs (Sachverhalte ), as well as his realism about the external world, have come to be regarded as the preserve of other traditions of exact philosophy. Like my fellow contributors, I hope that the present volume will go some way towards correcting this unfortunate historical accident. Reinach's account of judgements and states of affairs, an account that precedes those of Russell and Wittgenstein, his 1913 treatment of speech acts, his reinter pretation of Hume and aspects of his legal philosophy are the main philosophical topics dealt with in what follows. But his analysis of deliberation as well as his work on movement and Zeno's paradoxes get only a passing mention.…

Taschenbuch. Condizione: Neu. Neuware - This volume contains the contributions from the speakers at the NATO Advanced Research Workshop on 'Structure of the Photosynthetic Bacterial Reaction Center X-ray Crystallography and Optical Spectroscopy with Polarized Light' which was held at the 'Maison d'Hotes' of the Centre d'Etudes Nucleaires de Cadarache in the South of France, 20-25 September, 1987. This meeting continued in the spirit of a previous workshop which took place in Feldafing (FRG), March 1985. Photosynthetic reaction centers are intrinsic membrane proteins which, by performing a photoinduced transmembrane charge separation, are responsible for the conversion and storage of solar energy. Since the pioneering work of Reed and Clayton (1968) on the isolation of the reaction center from photosynthetic bacteria, optical spectroscopy with polarized light has been one of the main tools used to investigate the geometrical arrangement of the various chromophores in these systems. The recent elucidation by X-ray crystallography of the structure of several bacterial reaction centers, a breakthrough initiated by Michel and Deisenhofer, has provided us with the atomic coordinates of the pigments and some details about their interactions with neighboring aminoacid residues. This essential step has given a large impetus both to experimentalists and to theoreticians who are now attempting to relate the X-ray structural model to the optical properties of the reaction center and ultimately to its primary biological function.…

Taschenbuch. Condizione: Neu. Neuware - Science is not a mere collection of facts. It is the correlation of facts, the interpretative synthesis of the available knowledge and its application that excite the imagination of a scientist. Even in these days of modern technology, the need for quick and accurate dissemination of new information and current concepts still exists. Conferences and Symposia offer one direct method of communication. The Summer Schools are another approach. The success of a Summer School is mainly due to that human factor and under standing that goes with it and allows for extensive and often time-unrestricted discussions. During the course of the past 20 years, one of the most in tensively studied groups of elements in the Periodic Table is the Lanthanides. In this period, we have increased our knowledge on these once exotic elements, which were once considered to be a part of a lean and hungry industry, many-fold due to the involve ment of scientists from various disciplines. The purpose of our Summer School was to bring a group of ex perts and participants together for the exchange of ideas and in formation in an informal setting and to promote interdisciplinary interactions. Out of many conceivable topics, we selected the following five as the main basis to broaden our knowledge and understanding I) Systematics 2) Structure 3) Electronic and Magnetic Proper ties 4) Spectroscopic Properties and 5) Lanthanide Geochemistry.…

Taschenbuch. Condizione: Neu. Neuware - Photonic band gap crystals offer unique ways to tailor light and the propagation of electromagnetic waves. In analogy to electrons in a crystal, EM waves propagating in a structure with a periodically-modulated dielectric constant are organized into photonic bands separated by gaps in which propagating states are forbidden. Proposed applications of such photonic band gap crystals, operating at frequencies from microwave to optical, include zero- threshold lasers, low-loss resonators and cavities, and efficient microwave antennas. Spontaneous emission is suppressed for photons in the photonic band gap, offering novel approaches to manipulating the EM field and creating high-efficiency light-emitting structures. Photonic Band Gap Materials identifies three most promising areas of research. The first is materials fabrication, involving the creation of high quality, low loss, periodic dielectric structures. The smallest photonic crystals yet fabricated have been made by machining Si wafers along (110), and some have lattice constants as small as 500 microns. The second area is in applications. Possible applications presented are microwave mirrors, directional antennas, resonators (especially in the 2 GHz region), filters, waveguides, Y splitters, and resonant microcavities. The third area covers fundamentally new physical phenomena in condensed matter physics and quantum optics. An excellent review of recent development, covering theoretical, experimental and applied aspects. Interesting and stimulating reading for active researchers, as well as a useful reference for non-specialists.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Affordable Care Act debate was one of the most important and most public examinations of the Constitution in our history. At the forefront of that debate were the bloggers of the Volokh Conspiracy who, from before the law was even passed, engaged in a spirited, erudite, and accessible discussion of the legal issues involved in the case. 294 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -iOS 7 Development Recipes: A Problem-Solution Approach is your code reference and guide to developing solutions on the iPad, iPhone, and other iOS 7 SDK devices and platforms. This book provides in-depth code samples and discussions for scenarios that developers face every day. You'll find numerous examples of real-world cases that will enable you to build fully functional applications quickly and efficiently. The recipes included in this book are wide in scope and have been geared toward the professional developer. You'll find clear and concise code samples accompanying each recipe, and you will be presented with cutting-edge solutions that bring forth the best that the iOS 7 SDK has to offer. The recipes include:Working with Auto Layout to build flexible user interfaces that adapt to different screen sizes Building applications that incorporate multimedia Building location-aware apps Understanding best practices for application design and development You'll find this book to be an indispensable reference for all your iOS development. 816 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is open access under a CC BY license. The narrative of 20th-century medicine is the conquering of acute infectious diseases and the rise in chronic, degenerative diseases. The history of fungal infections does not fit this picture. This book charts the path of fungal infections from the mid 19th century to the dawn of the 21st century. 225 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Riddles are threaded through The Hobbit , and are key to Tolkien's creative imagination. The Riddles of The Hobbit situates this novel and the rest of Tolkien's writing in the context of Old English riddling culture, and more modern day examples; it sets out to solve the many riddles of the novel in original and often surprising ways. 186 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Hiplife in Ghana explores one international site - Ghana, West Africa - where hip-hop music and culture have morphed over two decades into the hiplife genre of world music. It investigates hiplife music not merely as an imitation and adaptation of hip-hop, but as a reinvention of Ghana's century-old highlife popular music tradition. Author Halifu Osumare traces the process by which local hiplife artists have evolved a five-phased indigenization process that has facilitated a youth-driven transformation of Ghanaian society. She also reveals how Ghana's social shifts, facilitated by hiplife, have occurred within the country's 'corporate recolonization,' serving as another example of the neoliberal free market agenda as a new form of colonialism. Hiplife artists, we discover, are complicit with these global socio-economic forces even as they create counter-narratives that push aesthetic limits and challenge the neoliberal order. 219 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hailed as early Christian texts as important as the Dead Sea Scrolls, yet condemned by the Vatican as Islamic heresies, the Lead books of Granada, written on discs of lead and unearthed on a Granadan hillside, weave a mysterious tale of duplicity and daring set in the religious crucible of sixteenth-century Spain. This book evaluates the cultural status and importance of these polyvalent, ambiguous artefacts which embody many of the dualities and paradoxes inherent in the racial and religious dilemmas of Early Modern Spain. Using the words of key individuals, and set against the background of conflict between Spanish Christians and Moriscos in the late fifteen-hundreds, The Lead Books of Granada tells a story of resilient resistance and creative ingenuity in the face of impossibly powerful negative forces, a resistance embodied by a small group of courageous, idealistic men who lived a double life in Granada just before the expulsion of the Moriscos. 289 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Betrayed takes a new approach to the subject of global poverty, one that doesn't blame the West but also doesn't rely on the West for solutions. Betrayed puts the poor themselves at center stage, and shows how their entrepreneurial energies are shackled by political and social discrimination. When these shackles are removed, as is happening in places such as China and Vietnam, the poor are able to seize opportunities and drive wealth creation. Combining the latest research into poverty and state building with the author's personal observations drawn from years running businesses in the developing world, Betrayed explains how leaders in the developing world can build more inclusive societies and more equitable governments, thereby creating dynamic national economies and giving the poor the opportunity to accumulate the means and skills to control their own destinies. This refreshing new approach will appeal to business people who are fed up with reading critiques of global poverty that see capitalism as the problem, not the solution; people in both the global North and South who want to see attention focused not on Western aid but on what developing countries and their citizens can do to help themselves; scholars and practitioners in the development field who are looking for new, practicable ideas; and general readers who want accessible and engaging accounts of ordinary people struggling to overcome poverty. 294 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This highly practical book explains how executive teams in global companies can work together to successfully drive change, enable fast growth or restructure the business. It demonstrates a clear correlation between team development and business results and even deals with special issues for teams in the not-for-profit sector and emerging markets. 203 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Big Data in History introduces the project to create a world-historical archive, tracing the last four centuries of historical dynamics and change. Chapters address the archive's overall plan, how to interpret the past through a global archive, the missions of gathering records, linking local data into global patterns, and exploring the results. 119 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisinvestigation of Kierkegaard as a political thinker with regard to the Danish context, and to his place in the history of political thought,deals with the more direct discussion of politics in Kierkegaard, and the ways in which political ideas are embedded in his literary, aesthetic, ethical, philosophical ,and religious thought. 147 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite the apparent ubiquity of light literature, and despite the greater cultural prestige it has been afforded in recent decades, very little has been written on the adjective that actually defines this category. What, precisely, does it signify, and what are some of the key strategies by which the effect of lightness is achieved within literary discourse In this original and engaging study, Bede Scott explores the aesthetic quality of lightness as demonstrated by a diverse range of narratives - spanning four different centuries and five different countries. In each case, he focuses on a specific 'type' of lightness, whether it be the refined triviality of Sei Shonagon's Pillow Book , the ludic tendencies of Joaquim Maria Machado de Assis' Posthumous Memoirs of Brás Cubas , or the 'exhilarating and primitive vitality' of Voltaire's Candide . By bringing together such disparate sources, Scott makes a strong case for the universality of this particular aesthetic value, while also subjecting its underlying structural features to close critical scrutiny. 174 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Can a bold investment in education turn around the economy of an entire city Gene I. Maeroff, former national education correspondent for the New York Times , explores how the nonprofit group Say Yes to Education has instituted a network of reforms in Syracuse, New York, that aim to expand the city's the middle class by supporting its children. 227 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Offender supervision in Europe has developed rapidly in scale, distribution and intensity in recent years. However, the emergence of mass supervision in the community has largely escaped the attention of legal scholars and social scientists more concerned with the mass incarceration reflected in prison growth. As well as representing an important analytical lacuna for penology in general and comparative criminal justice in particular, the neglect of supervision means that research has not delivered the knowledge that is urgently required to engage with political, policy and practice communities grappling with delivering justice efficiently and effectively in fiscally straitened times, and with the challenges of communicating the meaning, legitimacy and utility of supervision to an insecure public.This book reports the findings from a survey of European research on this topic, undertaken during the first year of a European research network that spans twenty countries. As such, it provides the first comprehensive review of research on offender supervision in Europe, opening up an important new field of enquiry for comparative social science, and offering the prospects of better informed democratic deliberation about key challenges facing contemporary justice systems, policymakers and practitioners, and the societies they seek to serve. 176 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The political economy landscape has shifted as multinational corporations increase their investment efforts, changing the geographies of extraction. The contributors make the argument for the need of new theoretical perspectives anchored in critical political economy to address structural dynamics in the global industry. 251 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drawing on insights from psychology, sociology, anthropology, religion, history, and literature, this book examines early and contemporary writings of male authors from across the Arab world to explore the traditional and evolving nature of father-son relationships in Arab families. 234 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Assesses to what extent increased international cooperation could help selected financial centres in Europe respond to the future risks and opportunities facing them. The book identifies challenges that the jurisdictions face in coming years by means of representative samples and systematic comparisons of financial centres. 185 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This important collection of essays addresses the question of why scholars can no longer do without class in religious studies and theology, and what we can learn from a renewed engagement with the topic. This volume discusses what new discourses regarding notions of gender, ethnicity, and race might add to developments on notions of class. 224 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using first-hand interview data, Yang Jiang reveals the key trends of China's trade and financial politics after its WTO accession. In particular, she highlights the influence of competing domestic interests, government agencies and different ideas on China's foreign economic policy. 237 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Examining the interplay between geopolitics, the strategic priorities of Europe's most powerful nations, Britain, Germany and France, and the evolution of NATO and CSDP, this book unveils the mechanics of the tension between conflict and cooperation that lies at the heart of European security politics. 286 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -New Formalist Criticism defines and theorizes a mode of formalist criticism that is theoretically compatible with current thinking about literature and theory. New formalism anticipates a move in literary studies back towards the text and, in so doing, establishes itself as one of the most exciting areas of contemporary critical theory. 238 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Medieval Invasions in Modern Irish Literature offers the first book-length treatment of the literary return to and reinterpretation of Giraldus Cambrensis's twelfth century The History of the Conquest of Ireland. Writers studied include W.B. Yeats, Lady Gregory, James Joyce, Sean O'Faoláin, Micheál Mac Liammóir, Brendan Behan and Jamie O'Neill. 198 pp. Englisch.…