springer netherlands apr 2017 (66 risultati)

Taschenbuch. Condizione: Neu. Neuware -Machine learning is concerned with the analysis of large data and multiple variables. It is also often more sensitive than traditional statistical methods to analyze small data. The first and second volumes reviewed subjects like optimal scaling, neural networks, factor analysis, partial least squares, discriminant analysis, canonical analysis, fuzzy modeling, various clustering models, support vector machines, Bayesian networks, discrete wavelet analysis, association rule learning, anomaly detection, and correspondence analysis. This third volume addresses more advanced methods and includes subjects like evolutionary programming, stochastic methods, complex sampling, optional binning, Newton's methods, decision trees, and other subjects. Both the theoretical bases and the step by step analyses are described for the benefit of non-mathematical readers. Each chapter can be studied without the need to consult other chapters. Traditional statistical tests are, sometimes, priors to machine learning methods, and they are also, sometimes, used as contrast tests. To those wishing to obtain more knowledge of them, we recommend to additionally study (1) Statistics Applied to Clinical Studies 5th Edition 2012, (2) SPSS for Starters Part One and Two 2012, and (3) Statistical Analysis of Clinical Data on a Pocket Calculator Part One and Two 2012, written by the same authors, and edited by Springer, New York.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book describes a pathway for sustainable phosphorus management via the Global Transdisciplinary Processes for Sustainable Phosphorus Management project (Global TraPs). Global TraPs is a multi-stakeholder forum in which scientists from a variety of disciplines join with key actors in practice to jointly identify critical questions and to articulate what new knowledge, technologies and policy processes are needed to ensure that future phosphorus use is sustainable, improves food security and environmental quality and provides benefits for the poor. The book offers insight into economic scarcity and identifies options to improve efficiency and reduce environmental impacts of anthropogenic phosphorus flows at all stages of the supply and use chain.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 328 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Mineral resource estimation has changed considerably in the past 25 years: geostatistical techniques have become commonplace and continue to evolve; computational horsepower has revolutionized all facets of numerical modeling; mining and processing operations are often larger; and uncertainty quantification is becoming standard practice. Recent books focus on historical methods or details of geostatistical theory. So there is a growing need to collect and synthesize the practice of modern mineral resource estimation into a book for undergraduate students, beginning graduate students, and young geologists and engineers. It is especiallyfruitful that this book iswritten by authors with years of relevant experience performing mineral resource estimation and with years of relevant teaching experience. This comprehensivetextbook and reference fills this need.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 348 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 192 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Coastal habitats provide the link between the land and the sea. They are dynamic, combine to form ecosystems of great complexity and provide significant areas for wildlife. Their landscapes are treasured by visitors, painters and musicians. They also provide locations for significant economic activity and are intimately bound up with fisheries, providing food and shelter for some species of commercially exploited fish stocks. The habitats themselves provide a buffer to tides and wave action, which may be particularly important in areas where relative sea level is rising and during storm periods. Managing these assets in the face of continuing pressure from human populations on a sustainable basis is a major task.

Taschenbuch. Condizione: Neu. Neuware -In the present age of migration, the influx of immigrants from distant lands leads inevitably to the spatial and social restructuring of cities and regions. It is often accompanied by fears of and hostility towards the newcomers. Nevertheless, in Europe, North America and Japan this influx of immigrants is essential to economic growth. How can immigrants become accepted members of the society of their adopted country How can strangers become neighbours What alchemies of political and social imagination are required to achieve peaceful coexistence in the mongrel cities of the 21st century What philosophies and policies have made integration successful in Canada and how can it be translated into European context The book tackles an important contemporary issue ¿ the social integration of immigrants in a large metropolis ¿ by way of the detailed case study of one Canadian city. The book provides a large political and legal context which makes this case study comprehensible and inspiring to readers outside Canada.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book provides a solid overview of mobile phone programming for readers in both academia and industry. Coverage includes all commercial realizations of the Symbian, Windows Mobile and Linux platforms. The text introduces each programming language (JAVA, Python, C/C++) and offers a set of development environments 'step by step,' to help familiarize developers with limitations, pitfalls, and challenges.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 500 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Ad-hoc Networks, Fundamental Properties and Network Topologiesprovides an original graph theoretical approach to the fundamental properties of wireless mobile ad-hoc networks. This approach is combined with a realistic radio model for physical links between nodes to produce new insights into network characteristics like connectivity, degree distribution, hopcount, interference and capacity.This book clearly demonstrates how the Medium Access Control protocols impose a limit on the level of interference in ad-hoc networks. It hasbeen shown that interference is upper bounded, and a new accurate method for the estimation of interference power statistics in ad-hoc and sensor networks is introduced here. Furthermore, this volume shows how multi-hop traffic affects the capacity of the network. In multi-hop and ad-hoc networks there is a trade-off between the network size and the maximum input bit rate possible per node. Large ad-hoc or sensor networks, consisting of thousands of nodes, can only support low bit-rate applications.This work provides valuable directives for designing ad-hoc networks and sensor networks. It will not only be of interest to the academic community, but also to the engineers who roll out ad-hoc and sensor networks in practice.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This volume provides preliminary recommendations on ways to educate and develop experience-based expertise among disaster response, security and other professionals from diverse backgrounds, whose current and future interests relate to crisis management.The book takes a multidisciplinary approach to improving regional security cooperation and to addressing the complex issues of climate change and disasters on military activities.The main aims of this proceedings volume are: -to provide an Education and Individual Training Activity Common Core Curriculum, whose main purpose is to support increased awareness of the implications of Climate Change;to identify broad issues on climate change and disasters, particularly those with the highest importance and relevance to regional security.The Crisis Management and Disaster Response Centre of Excellence (CMDR COE) conducted an Advanced Research Workshop ¿Climate Change Implications on Military Activities in the Balkans Region¿ between 05-07 July, 2016. The event was supported by the NATO Science for Peace (SPS) Program and gathered distinguished experts from various international organizations and civil-military agencies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume provides preliminary recommendations on ways to educate and develop experience-based expertise among disaster response, security and other professionals from diverse backgrounds, whose current and future interests relate to crisis management.The book takes a multidisciplinary approach to improving regional security cooperation and to addressing the complex issues of climate change and disasters on military activities.The main aims of this proceedings volume are: -to provide an Education and Individual Training Activity Common Core Curriculum, whose main purpose is to support increased awareness of the implications of Climate Change;to identify broad issues on climate change and disasters, particularly those with the highest importance and relevance to regional security.The Crisis Management and Disaster Response Centre of Excellence (CMDR COE) conducted an Advanced Research Workshop ¿Climate Change Implications on Military Activities in the Balkans Region¿ between 05-07 July, 2016. The event was supported by the NATO Science for Peace (SPS) Program and gathered distinguished experts from various international organizations and civil-military agencies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.

Buch. Condizione: Neu. Neuware -This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide.This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Heme and chlorophyll (Chl) are porphyrins. Porphyrins (also referred to as tetrapyrroles) are essential for life in the biosphere. Chlorophyll catalyzes the conversion of solar energy to chemical energy via the process of photosynthesis. Organic life in the biosphere is made possible by consumption of the chemical energy generated by photosynthesis.Hemes are the prosthetic groups of cytochromes which are involved in electron transport during oxidative phosphorylation and photosynthetic phosphorylation which generate ATP and NADPH. The latter are essential for many cellular functions.Chlorophyll on the other hands catalyzes the process of photosynthesis. Indeed, life in the biosphere depends on the process of photosynthesis which converts light energy, carbon dioxide and water into the chemical energy, required for the formation of food and fiber. Photosynthetic efficiency is controlled by extrinsic factors such as the availability of water, CO2, inorganic nutrients, ambient temperature and the metabolic and developmental state of the plant, as well as by intrinsic factors (Lien and San Pietro, 1975). The most important intrinsic factor is the efficiency of the photosynthetic electron transport system (PETS).Conventional agriculture is one of the few human activities that have not undergone a revolution to join other activities such as overcoming gravity by flying, and landing on the moon, crossing underwater the polar cap, and communicating wirelessly over long distances via electromagnetic waves. We now feel that enough biochemical and molecular biological knowledge has accumulated to render this dream amenable to experimentation. We believe that the time has come to bioengineer chloroplasts capable of synthesizing a short chain carbohydrate such as glycerol at rates that approach the upper theoretical limits of photosynthesis [Rebeiz, C. A. (2010) Investigations of possible relationships between the chlorophyll biosynthetic pathway and the assembly of chlorophyll-protein complexes and photosynthetic efficiency. In: Rebeiz, C. A. Benning, C., Bohnert, H.J., Daniell, H., Hoober J. K., Lichtenthaler, H. K., Portis , A. R., and Tripathy, B. C. eds. The chloroplast: Basics and Applications. Springer. The Netherlands, p 1-24]. In order to achieve this goal a thorough knowledge of the Chl biosynthetic pathway is needed along with knowledge in other domains (Rebeiz 2010). In this context, this monograph is devoted to an in depth discussion of our present knowledge of the Chl biosynthetic pathway. The complexity and biochemical heterogeneity of the Chl biosynthetic pathway and the relationship of this complexity to the structural and biosynthetic complexity of photosynthetic membranes will be emphasized. We will also emphasize in historical perspective, key stages in our understanding of the Chl biosynthetic heterogeneity. The reader should keep in mind that a complex biosynthetic process is only fully understood when it becomes possible to reconstitute in vitro every step of the process. We are not yet at this stage of understanding of thylakoid membrane biogenesis. Considerable progress has been achieved however, in the understanding of numerous facets of the Chl biosynthetic pathway, namely (a) detection and identification of various major and minor metabolic intermediates (b) precursor-product relationships between various intermediates, (c) structure and regulation of many enzymes of the pathway, and (d) the relationship of the Chl biosynthetic heterogeneity to the structural and functional heterogeneity of thylakoid membranes.In addition topics related to the development of Analytical techniques, Cell-free systems, Herbicides, Insecticides, and Cancericides are also discussed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book is a reprint of the topical issue ¿UV Astronomy 2011¿ published by the journal Astrophysics and Space Science. Papers included in that topical issue cover four main topics of UV astronomy: stellar physics and evolution, planets, Milky Way and other galaxies and finally, UV instrumentation with an update on the current status of the main missions and technologies. This builds on the remarkable progress made in the field since the earlier topical issue: ¿Space Astronomy: the UV window to the Universe¿ which appeared in 2008.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance.The volume will cover the latest innovative researches in prostate cancer, with particular emphasis to the state-of-the-art analysis technologies that are essential for the accurate identification of molecular targets for disease diagnosis, molecular mechanisms of tumorigenesis, markers for susceptibility, molecular-based prognostic prevision, characterization of biomarkers of drug efficacy and drug resistance, validation of new therapeutics and diagnostics. Current advancements on the intersecting data concerning transcriptomes, proteomes, the molecular techniques referred as 'omes', will be reported and discussed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This volume contains the collection of papers from the second workshop on Experimental Acoustic Inversion Techniques for Exploration of the Shallow Water Environment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 348 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This volume is a continuation of Volume 1 following the previously published Editorial. More emphasis is given to novel nanocarrier designs, their characterization and function, and applications for drug discovery and treatment. A number of chapters will deal with nanofibers as a new major application within the biomedical field with a very high success rate particularly in wound healing and diabetic foot and spine injuries. A major new subdivision will deal with mathematical methods for the assembly of nanocarriers both for simulation and function.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 500 pp. Englisch.

Buch. Condizione: Neu. Neuware -This is the first comprehensive science-based textbook on the biology and ecology of the Baltic Sea, one of the world¿s largest brackish water bodies. The aim of this book is to provide students and other readers with knowledge about the conditions for life in brackish water, the functioning of the Baltic Sea ecosystem and its environmental problems and management. It highlights biological variation along the unique environmental gradients of the brackish Baltic Sea Area (the Baltic Sea, Belt Sea and Kattegat), especially those in salinity and climate.pt;font-family:'Arial','sans-serif'; color:#262626'>The first part of the book presents the challenges for life processes and ecosystem dynamics that result from the Baltic Seäs highly variable recent geological history and geographical isolation. The second part explains interactions between organisms and their environment, including biogeochemical cycles, patterns of biodiversity, genetic diversity and evolution, biological invasions and physiological adaptations. In the third part, the subsystems of the Baltic Sea ecosystem ¿ the pelagic zone, the sea ice, the deep soft sea beds, the phytobenthic zone, the sandy coasts, and estuaries and coastal lagoons ¿ are treated in detail with respect to the structure and function of communities and habitats and consequences of natural and anthropogenic constraints, such as climate change, discharges of nutrients and hazardous substances. Finally, the fourth part of the book discusses monitoring and ecosystem-based management to deal with contemporary and emerging threats to the ecosystem¿s health.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 716 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This volume documents the contributions presented at the Seventh Scientific Meeting of the Spanish Astronomical Society (Sociedad Española de Astronomía, SEA). The event bought together 301 participants who presented 161 contributed talks and 120 posters, the greatest number of contributions in the history of the meeting. The fact that most exciting items of the current astronomical research were addressed in the meeting is proof of the good health of the SEA, a consolidated organization founded fifteen years ago in Barcelona.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -ICEM13 focused on all aspects of experimental mechanics of solids with emphasis on mechanical characterization and testing at the micro and nano scale levels. The technical program of ICEM13 was the product of hard work and devotion of more than 100 world leading experts.This volume contains two-page abstracts of the 482 papers presented at ICEM13. The accompanying CD contains the full length papers. The abstracts of the fifteen plenary lectures are included in the beginning of the book. The remaining 467 abstracts are arranged in 23 tracks and 28 special symposia/sessions with 225 and 242 abstracts, respectively. The papers of the tracks have been contributed from open call, while the papers of the symposia/sessions have been solicited by the respective organizers.The volume contains the latest research work of renowned experts in experimental analysis of engineering materials and structures and is useful for students, engineers and researchers who want to get an integrated picture of the recent developments in the area of experimental mechanics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 1024 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The writing of this book is based on: 1. earlier experience writing textbooks for biology students with a university-level background in biology and biochemistry with many (>200) gures in these books (in Hungarian), 2. and on the necessity to present university lectures as power point presentations to catch the interest of s- dents. The author realizes that young readers who were grown up in an information society are relactant to read too much unless they have to take exams. Even then they prefer books which contain illustrations for a better understanding. In collaboration with colleagues, referees and members of the publishing staff an extensive set of photographs and illustrations were collected to provide a graphic follow-up to the text. Further aids for the student, instructor and the curious reader are provided by summaries, extensive sets of readings and references for each chapter, a glossary of the terms, list of abbreviations and a DVD with a red-blue eyeglass to visualize three dimensional chromatin structures. The reader could ask: Why another book on apoptosis The answer to the question is related to the de nition of the process. The term apoptosis has been introduced to describe typical morphological changes leading to controlled se- destruction of cells. The rst demonstrated biochemical feature of this type of cell death was internucleosomal fragmentation, which was occasionally preceded by the generation of large DNA fragments.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -III European Conference on Computational Mechanics: Solids, Structures and Coupled Problem in EngineeringComputational Mechanics in Solid, Structures and Coupled Problems in Engineering is today a mature science with applications to major industrial projects. This book contains the edited version of the Abstracts of Plenary and Keynote Lectures and Papers, and a companion CD-ROM with the full-length papers, presented at the III European Conference on Computational Mechanics: Solids, Structures and Coupled Problems in Engineering (ECCM-2006), held in the National Laboratory of Civil Engineering, Lisbon, Portugal 5th - 8th June 2006. The book reflects the state-of-art of Computation Mechanics in Solids, Structures and Coupled Problems in Engineering and it includes contributions by the world most active researchers in this field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 864 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -There are many books on the use of numerical methods for solving engineering problems and for modeling of engineering artifacts. In addition there are many styles of such presentations ranging from books with a major emphasis on theory to books with an emphasis on applications. The purpose of this book is hopefully to present a somewhat different approach to the use of numerical methods for - gineering applications. Engineering models are in general nonlinear models where the response of some appropriate engineering variable depends in a nonlinear manner on the - plication of some independent parameter. It is certainly true that for many types of engineering models it is sufficient to approximate the real physical world by some linear model. However, when engineering environments are pushed to - treme conditions, nonlinear effects are always encountered. It is also such - treme conditions that are of major importance in determining the reliability or failure limits of engineering systems. Hence it is essential than engineers have a toolbox of modeling techniques that can be used to model nonlinear engineering systems. Such a set of basic numerical methods is the topic of this book. For each subject area treated, nonlinear models are incorporated into the discussion from the very beginning and linear models are simply treated as special cases of more general nonlinear models. This is a basic and fundamental difference in this book from most books on numerical methods.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 1028 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Arabian Deserts provides a comprehensive coverage of all the deserts of Arabia largely based on the author¿s experience in Arabia over the last fifty years. It deals with every type of desert found there, including those formed by great sand seas, dunefields, evaporites, clay pans, stony plains, volcanic flows, desert plateaux and mountains, deltas, and desert islands. Distinctive landforms of Arabia deserts are described, together with their geological setting and the influence of climates both past and present. The six great sand seas of Arabia are emphasized since Ar Rub¿ al Khali Desert forms the world¿s largest continuous sand desert. Sources, sedimentology, and the mechanisms of formation of these great sand deserts are examined. Distinctive sand dunes and interdunes types found in Arabia are described, classified and explained. Fluvial processes are discussed, as well as the many oases, and lake deposits formed in milder, more humid intervals. Extensive areas of black, basaltic, volcanic desert are described covering three times the area of Belgium. Ecology of Arabia and human influence on desertification are outlined. Climatic changes in the evolution of Arabian deserts during the Quaternary and their causes are explained and a chronology of climatic events during their formation is established.AudienceThis book will be of interest to geoscientists, especially Quaternary geologists, geomorphologists, geographers, sedimentologists interested in aeolian and fluvial processes,climatologists, coastal studies groups, desertification interest groups, and ecologists with interest in arid lands.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 664 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume contains a section on the wider evolutionary context of venom in animals, the molecular evolutionary processes involved in generating diversity, and the concept of venom evolution as being driven by an arms race that also involves evolution of resistance to toxins by prey. It also studies the relationship between the evolution of toxins and the evolution of the animals that they evolved within. The last section discusses the evolution of venom delivery systems. The definition of a venomous animal, as opposed to a poisonous one, encompasses the evolution not just of toxins but also a specialized mechanism for administering them by injection.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 468 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume deals mainly with the specialized aspect of toxins and drug discovery. Man has been using natural resources especially plants to treat diseases from very early times in history of mankind. Although many drugs derived from plants and microbes have been discovered and being used in clinical practice, not many drugs have been developed from venoms and toxins although many laboratories worldwide are actively working on it. This volume describe some of the recent developments in this research area, such as snake venoms, conotoxins , bioinformatics in drug discovery from peptide toxins.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 484 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.