Springer netherlands feb 2015 (49 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Machine learning is a novel discipline concerned with the analysis of large and multiple variables data. It involves computationally intensive methods, like factor analysis, cluster analysis, and discriminant analysis. It is currently mainly the domain of computer scientists, and is already commonly used in social sciences, marketing research, operational research and applied sciences. It is virtually unused in clinical research. This is probably due to the traditional belief of clinicians in clinical trials where multiple variables are equally balanced by the randomization process and are not further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods. 284 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book, written by one of the leaders in the field of the neurosciences, will give an explanation of the symptoms and eventual untimely suicide of one of literatures greatest authors; Virginia Woolf. The sources used are letters and statements from Woolf herself, the literature she wrote and comments, letters and any other documentation that referred to her mental state and her medical status. The author will use current insight into depression, the mental consequences of child abuse and drug interactions/effects to illustrate this case study. The book should appeal to researchers in the neurosciences, psychology and psychiatry as well as to a broader audience, mainly individuals who are interested in the (external and internal) forces that drove Woolf to write her material. 232 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work presents one of the original and fundamental experiments of Didactique, a research program whose underlying tenet is that Mathematics Education research should be solidly based on scientific observation. Here the observations are of a series of adventures that were astonishing for both the students and the teachers: the reinvention of fractions and of decimal numbers in a sequence of lessons and situations that permitted the students to construct the concepts for themselves. The book leads the reader through the highlights of the sequence's structure and some of the reasoning behind the lesson choices. It then presents explanations of some of the principal concepts of the Theory of Situations. In the process, it offers the reader the opportunity to join a lively set of fifth graders as they experience a particularly attractive set of lessons and master a topic that baffles many of their contemporaries. 232 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This root-and-branch re-evaluation of Darwin's concept of sexual selection tackles the subject from historical, epistemological and theoretical perspectives. Contributions from a wealth of disciplines have been marshaled for this volume, with key figures in behavioural ecology, philosophy, and the history of science adding to its wide-ranging relevance. Updating the reader on the debate currently live in behavioural ecology itself on the centrality of sexual selection, and with coverage of developments in the field of animal aesthetics, the book details the current state of play, while other chapters trace the history of sexual selection from Darwin to today and inquire into the neurobiological bases for partner choices and the comparisons between the hedonic brain in human and non-human animals.Welcome space is given to the social aspects of sexual selection, particularly where Darwin drew distinctions between eager males and coy females and rationalized this as evolutionary strategy. Also explored are the current definition of sexual selection (as opposed to natural selection) and its importance in today's biological research, and the impending critique of the theory from the nascent field of animal aesthetics. As a comprehensive assessment of the current health, or otherwise, of Darwin's theory, 140 years after the publication of his Descent of Man, the book offers a uniquely rounded view that asks whether 'sexual selection' is in itself a progressive or reactionary notion, even as it explores its theoretical relevance in the technical biological study of the twenty-first century. 332 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This work presents one of the original and fundamental experiments of Didactique, a research program whose underlying tenet is that Mathematics Education research should be solidly based on scientific observation. Here the observations are of a series of adventures that were astonishing for both the students and the teachers: the reinvention of fractions and of decimal numbers in a sequence of lessons and situations that permitted the students to construct the concepts for themselves. The book leads the reader through the highlights of the sequence's structure and some of the reasoning behind the lesson choices. It then presents explanations of some of the principal concepts of the Theory of Situations. In the process, it offers the reader the opportunity to join a lively set of fifth graders as they experience a particularly attractive set of lessons and master a topic that baffles many of their contemporaries.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 232 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Factor X: Re-source-Designing the Recycling Society explores the role of recycling in efforts to achieve the sustainable world envisioned in the Federal Environment Ministry's Resource Efficiency Programme, known as ProgRess. The chapters build a roadmap to a Recycling Society in which the decoupling of resource consumption and economic growth is accomplished. 300 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book explores how the design, construction, and use of robotics technology may affect today's legal systems and, more particularly, matters of responsibility and agency in criminal law, contractual obligations, and torts. By distinguishing between the behaviour of robots as tools of human interaction, and robots as proper agents in the legal arena, jurists will have to address a new generation of 'hard cases.' General disagreement may concern immunity in criminal law ( e.g. , the employment of robot soldiers in battle), personal accountability for certain robots in contracts ( e.g. , robo-traders), much as clauses of strict liability and negligence-based responsibility in extra-contractual obligations ( e.g. , service robots in tort law). Since robots are here to stay, the aim of the law should be to wisely govern our mutual relationships. 228 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book addresses environmental and climate change induced migration from the vantage point of migration studies, offering a broad spectrum of approaches for considering the environment/climate/migration nexus. Research on the subject is still frequently narrowed down to climate change vulnerability and the environmental push factor. The book establishes the interconnections between societal and environmental vulnerability, and migration and capability, allowing appreciation of migration in the frame of climate as a case of spatial and social mobility, that is, as a strategy of persons and groups to deal with a grossly unequal distribution of life chances across the world. In their introduction, the editors fan out the current debate and state the need to transcend predominantly policy-oriented approaches to migration. The first section of the volume focuses on 'Methodologies and Methods' and presents very distinct approaches to think climate induced migration. Subsequent chapters explore the sensitivity of existing migration flows to climate change in Ghana and Bangladesh, the complex relationship between migration, demographic change and coping capacities in Canada, methodological challenges of a household survey on the significance of migration and remittances for adaptation in the Hindu Kush region and an econometric study of the aftermath of the 1998 floods in Bangladesh. The second part, 'Areas of Concern: Politics and Human Rights', deepens the analysis of discourses as well as of the implications of proposed and implemented policies. Contributors discuss such topics as environmental migration as a multi-causal problem, climate migration as a consequence in an alarmist discourse and climate migration as a solution. A study of an integrated relocation program in Papua New Guinea is followed by chapters on the promise and the flaws of planned relocation policy, global policy on protection of environmental migrants including both internally displaced peoples and those who cross international borders. A concluding chapter places human agency at centre stage and explores the interplay between human rights, capability and migration. 280 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Synthesizing decades of work, but up-to-date, this book focuses on organism-level responses to pollutants by marine animals, mainly crustaceans, molluscs, and fishes. Emphasizing effects on physiological processes (feeding/digestion, respiration, osmoregulation), life-cycle (reproduction [including endocrine disruption], embryo development, larval development, developmental processes later in life (growth, regeneration, molting, calcification, cancer), and behaviour, the book also covers bioaccumulation and detoxification of contaminants, and the development of tolerance. The major pollutants covered are metals, organic compounds (oil, pesticides, industrial chemicals), nutrients and hypoxia, contaminants of emerging concern, and ocean acidification. Some attention is also devoted to marine debris and noise pollution. 472 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Flooding is one of the most devastating natural hazards in the world. Available records suggest that both flood frequency and severity are on the rise and this is likely to worsen in the context of climate change. As population, infrastructure and poverty grow rapidly in developing countries, particularly in urban agglomerations of 10 million people or more, floods could cause widespread devastation, economic damage and loss of life. Assessment of vulnerability and risk from naturally occurring phenomena is therefore imperative in order to achieve urban sustainability. This book uses geospatial techniques to evaluate hazards, risk and vulnerability at a metropolitan scale in a data-scarce country. An empirical study was performed using remote sensing, GIS and census data. This research offers a new approach to mapping population, infrastructures and communities at risk which can greatly contribute to the deeper understanding of flood disasters in a rapidly expanding megacity. Examples shown in this book are from Dhaka Megacity, however, the techniques and methods can easily be implemented in medium to large cities of similar characteristics. The book is essential reading for hazard researchers, geospatial scientists, disaster management professionals, geographers, urban planners, and social scientists. Ashraf M. Dewan is currently a Lecturer in the Department of Spatial Sciences at Curtin University, Western Australia (on leave from his substantive position as Associate Professor in the Geography & Environment Department at the University of Dhaka, Bangladesh). 228 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biobank research and genomic information are changing the way we look at health and medicine. Genomics challenges our values and has always been controversial and difficult to regulate. In the future lies the promise of tailored medical treatments and pharmacogenomics but the borders between medical research and clinical practice are becoming blurred. We see sequencing platforms for research that can have diagnostic value for patients. Clinical applications and research have been kept separate, but the blurring lines challenges existing regulations and ethical frameworks. Then how do we regulate it This book contains an overview of the existing regulatory landscape for biobank research in the Western world and some critical chapters to show how regulations and ethical frameworks are developed and work. How should international sharing work How design an ethical informed consent An underlying critique: the regulatory systems are becoming increasingly complex and opaque. The international community is building systems that should respond to that. According to the authors in fact, it is time to turn the ship around. Biobank researchers have a moral responsibility to look at and assess their work in relation to the bigger picture: the shared norms and values of current society. Research ethics shouldn't only be a matter of bioethicists writing guidelines that professionals have to follow. Ethics should be practiced through discourse and regulatory frameworks need to be part of that public discourse. Ethics review should be then not merely application of bureaucracy and a burden for researchers but an arena where researchers discuss their projects, receive advice and practice their ethics skills. 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Science teacher educators prepare and provide professional development for teachers at all grade levels. They seek to improve conditions in classroom teaching and learning, professional development, and teacher recruitment and retention.Science Teacher Educators as K-12 Teachers: Practicing What We Teach tells the story of sixteen teacher educators who stepped away from their traditional role and entered the classroom to teach children and adolescents in public schools and informal settings. It details the practical and theoretical insights that these members of the Association of Science Teacher Educators (ASTE) earned from experiences ranging from periodic guest teaching to full-time engagement in the teaching role.Science Teacher Educators as K-12 Teachers shows science teacher educators as professionals engaged in reflective analysis of their beliefs about and experiences with teaching children or adolescents science. With their ideas about instruction and learning challenged, these educators became more aware of the circumstances today's teachers face. Their honest accounts reveal that through teaching children and adolescents, teacher educators can also renew themselves and expand their identities as well as their understanding of themselves in the profession and in relation to others.Science Teacher Educators as K-12 Teachers will appeal to all those with an interest in science education, from teacher educators to science teachers, as well as teacher educators in other disciplines. Its narratives and insights may even inspire more teacher educators to envision new opportunities to serve teachers, K-12 learners and the local community through a variety of teaching arrangements in public schools and informal education settings. 336 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book addresses the question of what it means to be moral and which capacities one needs to be moral.It questions whether empathy is a cognitive or an affective capacity, or perhaps both. As most moral beings behave immorally from time to time, the authors ask which factors cause or motivate people to translate their moral beliefs into action Specially addressed is the question of what is the role of internal factors such as willpower, commitment, character, and what is the role of external, situational and structural factors The questions are considered from various (disciplinary) perspectives. 360 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed, perceptive addition to the linguistics literature analyzes the semantic components of event predicates, exploring their fine-grained elements as well as their agency in linguistic processing. The papers go beyond pure semantics to consider their varying influences of event predicates on argument structure, aspect, scalarity, and event structure.The volume shows how advances in the linguistic theory of event predicates, which have spawned Davidsonian and neo-Davidsonian notions of event arguments, in addition to 'event structure' frameworks and mereological models for the eventuality domain, have sidelined research on specific sets of entailments that support a typology of event predicates. Addressing this imbalance in the literature, the work also presents evidence indicating a more complex role for scalar structures than currently assumed. It will enrich the work of semanticists, psycholinguists, and syntacticians with a decompositional approach to verb phrase structure. 260 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book brings together state-of-the-art research on successful aging in Asian populations and highlights how the factors that contribute to successful aging differ from those in the West. It examines the differences between the Asian and Western contexts in which the aging process unfolds, including cultural values, lifestyles, physical environments and family structures. In addition, it examines the question of how to add quality to longer years of life. Specifically, it looks at ways to promote health, preserve cognition, maximize functioning with social support and maintain emotional well-being despite inevitable declines and losses. Compared to other parts of the world, Asia will age more quickly as a result of the rapid socioeconomic developments leading to rising longevity and historically low fertility rates in some countries. These demographic forces in vast populations such as China are expected to make Asia the main driver of global aging in the coming decades. As a result, researchers, professionals, policymakers, as well as the commercial sector, in both East and West, are increasingly interested in gaining a deeper understanding of aging in Asia. 356 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book represents an interdisciplinary approach to the relevant aspects of agricultural production related to the interactions between natural processes, human activities and the environment. It provides condensed and comprehensive knowledge on the functions of various agroecosystems at the field, landscape and global scale. Understanding and integrating complex ecological processes into field production, land management and food systems is essential in order to deal with the challenges of modern crop and livestock production: the need for food security for the growing human population, and the necessity to combat the detrimental effects of food production on the environment. The book provides the scientific basis required by students and scientists involved in the development of sustainable agroecosystems and contributes to a range of disciplines including Agriculture, Biology, Geography, Landscape Ecology, Organic Farming, Biological Control, and Global Change Ecology. 340 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The concept of 'Place' has become prominent in natural resource management, as professionals increasingly recognize the importance of scale, place-specific meanings, local knowledge, and social-ecological dynamics. Place-Based Conservation: Perspectives from the Social Sciences offers a thorough examination of the topic, dividing its exploration into four broad areas. Place-Based Conservation provides a comprehensive resource for researchers and practitioners to help build the conceptual grounding necessary to understand and to effectively practice place-based conservation. 276 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Indigenous Education is a compilation of conceptual chapters and national case studies that includes empirical research based on a series of data collection methods. The book provides up-to-date scholarly research on global trends on three issues of paramount importance with indigenous education-language, culture, and identity. It also offers a strategic comparative and international education policy statement on recent shifts in indigenous education, and new approaches to explore, develop, and improve comparative education and policy research globally. Contributing authors examine several social justice issues related to indigenous education. In addition to case perspectives from 12 countries and global regions, the volume includes five conceptual chapters on topics that influence indigenous education, including policy debates, the media, the united nations, formal and informal education systems, and higher education. 496 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Australopithecusspecies have been the topic of much debate in palaeoanthropology since Raymond Dart described the first species,Australopithecus africanus, in 1925. This volume synthesizes the geological and paleontological context of the species in East and South Africa;covers individual sites, such as Dikika, Hadar, Sterkfontein, and Malapa;debates the alpha taxonomy of some of the species;and addresses questionsregardingthe movements of the species across the continent.Additional chapters discuss the genus in terms of sexual dimorphism, diet reconstruction using microwear and isotopic methodologies, postural and locomotor behavior, and ontogeny.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 296 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book brings together state-of-the-art research on successful aging in Asian populations and highlights how the factors that contribute to successful aging differ from those in the West. It examines the differences between the Asian and Western contexts in which the aging process unfolds, including cultural values, lifestyles, physical environments and family structures. In addition, it examines the question of how to add quality to longer years of life. Specifically, it looks at ways to promote health, preserve cognition, maximize functioning with social support and maintain emotional well-being despite inevitable declines and losses. Compared to other parts of the world, Asia will age more quickly as a result of the rapid socioeconomic developments leading to rising longevity and historically low fertility rates in some countries. These demographic forces in vast populations such as China are expected to make Asia the main driver of global aging in the coming decades. As a result, researchers, professionals, policymakers, as well as the commercial sector, in both East and West, are increasingly interested in gaining a deeper understanding of aging in Asia.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 356 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This detailed, perceptive addition to the linguistics literature analyzes the semantic components of event predicates, exploring their fine-grained elements as well as their agency in linguistic processing. The papers go beyond pure semantics to consider their varying influences of event predicates on argument structure, aspect, scalarity, and event structure.The volume shows how advances in the linguistic theory of event predicates, which have spawned Davidsonian and neo-Davidsonian notions of event arguments, in addition to ¿event structure¿ frameworks and mereological models for the eventuality domain, have sidelined research on specific sets of entailments that support a typology of event predicates. Addressing this imbalance in the literature, the work also presents evidence indicating a more complex role for scalar structures than currently assumed. It will enrich the work of semanticists, psycholinguists, and syntacticians with a decompositional approach to verb phrasestructure.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 260 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Most interesting and difficult problems in equilibrium statistical mechanics concern models which exhibit phase transitions. For graduate students and more experienced researchers this book provides an invaluable reference source of approximate and exact solutions for a comprehensive range of such models.Part I contains background material on classical thermodynamics and statistical mechanics, together with a classification and survey of lattice models. The geometry of phase transitions is described and scaling theory is used to introduce critical exponents and scaling laws. An introduction is given to finite-size scaling, conformal invariance and Schramm-Loewner evolution.Part II contains accounts of classical mean-field methods. The parallels between Landau expansions and catastrophe theory are discussed and Ginzburg--Landau theory is introduced. The extension of mean-field theory to higher-orders is explored using the Kikuchi--Hijmans--De Boer hierarchy of approximations. In Part III the use of algebraic, transformation and decoration methods to obtain exact system information is considered. This is followed by an account of the use of transfer matrices for the location of incipient phase transitions in one-dimensionally infinite models and for exact solutions for two-dimensionally infinite systems. The latter is applied to a general analysis of eight-vertex models yielding as special cases the two-dimensional Ising model and the six-vertex model. The treatment of exact results ends with a discussion of dimer models. In Part IV series methods and real-space renormalization group transformations are discussed. The use of the De Neef-Enting finite-lattice method is described in detail and applied to the derivation of series for a number of model systems, in particular for the Potts model. The use of Pad'e, differential and algebraic approximants to locate and analyze second- and first-order transitions is described. The realization of the ideas of scaling theory by the renormalization group is presented together with treatments of various approximation schemes including phenomenological renormalization. Part V of the book contains a collection of mathematical appendices intended to minimise the need to refer to other mathematical sources. 812 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Provides a comprehensive approach to the legal challenges of robotics technologyPresents case studies illustrating the current discussion on the agency of autonomous and 'intelligent' machinesContains a special chapter on new forms of accountability for future useSpringer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 228 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease. 496 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This publication characterizes the environmental burden of disease in the United Arab Emirates (UAE), measured by the excess number of deaths and illnesses in the population due to exposure to environmental hazards. The robust methods used in this risk analysis can be applied to any country or region. This publication documents the systematic, multi-step process used to identify environmental priorities and the detailed methods used to quantify the disease burden attributable to each risk. Based on the results of the burden of disease assessment, the publication summarizes the subsequent steps that are recommended to further reduce the burden of disease resulting from various environmental risk factors. Authors and ContributorsThis book represents the synthesis of research carried out by a large, interdisciplinary team from several institutions and multiple nations between June 2008 and June 2011.The lead authors are responsible for weaving together the pieces prepared by the team.Nonetheless, this book would not have been possible without major contributions from each team member.The list below shows contributors to each chapter.Following this list are biographies of all of the authors and contributors. Lead Authors Jacqueline MacDonald Gibson, Frederic J. P. Launay, Jens T. W. Thomsen, Angela Brammer, Christopher DavidsonAdditional Contributors (by Chapter)Chapter 2: Prioritizing Environmental Risks to HealthHenry H. Willis, Aimee Curtright, Gary Cecchine, Zeinab S. Farah,Sandra A. Geschwind, Jianhui Hu, Ying Li, Melinda Moore, Sarah Olmstead, Hanine Salem, Regina A. Shih, J. Jason WestChapter 3: Assessing the Environmental Burden of Disease:Method OverviewTiina Folley, Elizabeth S. Harder, Mejs HasanChapter 4: Burden of Disease from Outdoor Air PollutionYing Li, Gavino Puggioni, Prahlad Jat, Mejs Hasan, Marc Serre, Kenneth G. Sexton, J. Jason West, Saravanan Arunachalam, Uma Shankar, William Vizuete, Mohammed Zuber FarooquiChapter 5: Burden of Disease from Indoor Air PollutionChris B. TrentChapter 6: Burden of Disease from Occupational ExposuresTiina Folley, Leena A. Nylander-French Chapter 7: Burden of Disease from Climate ChangeRichard N. L. Andrews, Leslie Chinery, Elizabeth S. Harder, J. Jason West Chapter 8: Burden of Disease from Drinking Water ContaminationGregory W. Characklis, Joseph N. LoBuglio Chapter 9: Burden of Disease from Coastal Water PollutionGregory W. Characklis, Leigh-Anne H. Krometis, Joseph N. LoBuglioChapter 10: Burden of Disease from Soil and Groundwater ContaminationChidsanuphong Chart-asa, Stephanie Soucheray-GrellChapter 11: Burden of Disease from Produce and Seafood ContaminationLeigh-Anne H. Krometis, Leslie Chinery 524 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as 'antennae' for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function. 292 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although monotherapy is generally recommended as the treatment of choice, treatment resistance of patients with psychosis, cognitive, mood and anxiety disorders represents a significant clinical problem. In this context, augmentation and combination strategies are commonly employed to address this problem. Although multiple medication use common in psychiatric practice, reasons, efficacy and safety for polypharmacy, and augmentative strategies have remained unclear. It remains unclear if there is an evidence base to support polypharmacy. Furthermore, excessive and inappropriate use of psychotropic medications has been recognized as a public health problem. This volume is the first comprehensive, clinically oriented, reference on the multiple medication use to treat psychotic, cognitive, mood and anxiety disorders. 340 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are:Recent advances in ALS researchNews about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspectsPredictive, Preventive and Personalised Medicine in aging macular degenerationAdvances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen SelectionMultiple sclerosis related biomarkers: perspectives for clinical applicationPreventive clinical trials in brain aging: new trends & the need of guidelinesMCI_ clinical guidelines in early diagnosis of dementiaAlzheimer's disease: diagnostics, prognostics and the road to preventionBiomarkers for early diagnosis of Parkinson's and Alzheimer's diseasesSynucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms 416 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains. 428 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book attempts to provide insights into the achievement of a sustainable urban form, through spatial planning and implementation; here, we focus on planning experiences at the levels of local cities and some metropolitan areas in Asian countries. This book investigates the impact of planning policy on spatial planning implementation, from multidisciplinary viewpoints encompassing land-use patterns, housing development, transportation, green design, and agricultural and ecological systems in the urbanization process. We seek to learn from researchers in an integrated multidisciplinary platform that reflects a variety of perspectives, such as economic development, social equality, and ecological protection, with a view to achieving a sustainable urban form. 484 pp. Englisch.…