springer netherlands mrz 2015 (63 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is an easy to use instructional aide. Explore sustainability issues in contemporary society through a transdisciplinary approach. Chapters include ethics, public resources, public policy, combustion, heat exchangers, nuclear, solar, water, and wind energy. A short summary is presented for each topic, followed by additional topics for research, assignments, and references. The complex assignments require students to grow in their professional judgment. 88 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Late Cenozoic Yushe Basin, Shanxi Province, China embodies the bulk of our knowledge on successions of terrestrial vertebrates in the northern part of East Asia. Everything we know about Asian mammals of the last 6 million years has a historical basis in the documentation of the geology of Yushe. This volume introduces the basin in its geological setting, describes the succession of fossiliferous strata, and shows how it is dated. It develops an unsurpassed level of precision for its age control. Geological maps and stratigraphic sections provide the backbone for individual studies to follow on varied fossil groups. The volume explores the history of exploration of the last century in Yushe Basin and places development of paleontology there into the context of the birth of the modern epoch of science in China. 128 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book makes a case for Margaret Mead's contributions to education discourses, which in retrospect appear visionary and profoundly democratic, non judgemental and transdisciplinary, and for their relevance for education today at primary, secondary and tertiary levels. Mead combined her substantial skills and knowledge as a linguist, anthropologist and psychologist to draw attention to the primary role of culture and society in identity formation, privileging against sterner perspectives, the idea that the conditions that support the emergence of balanced personalities, able to contribute to society and to progress themselves as individuals, starts with observation of self before that of others. This observation of and reflection on self was for her a necessary demonstration of transparency while close observation of others was 'an act of love', much as the artist contemplates his/her subject, that dissolved negative differences of culture, belief and status. 104 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The current volume is comparative and inter-disciplinary, and it provides a reflection on what thinking might become after Heidegger's philosophy. Its aim is to critically expand the current field of research by presenting unfamiliar and unchartered avenues that will guide and carry the Heidegger scholarship into the twenty-first century. By doing so, it addresses fundamental questions in the Heideggerian scholarship, including its problems, restraints, and future direction. It also engages and broadens the increasingly disparate approaches to Heidegger's work, whether those approaches are traditional in their employment of phenomenology and hermeneutics or whether they apply to Heidegger's thinking in new and surprising ways. The first section of the volume emphasizes the importance of methodology for the future of Heidegger studies while the second section examines the historical, ethical and vocal-poetical in Heidegger's thought and draws conclusions relevant to the Heidegger scholar of today. The final section demonstrates Heidegger's appeal to a variety of other discourses besides philosophy and the way his thinking could be creatively approached, utilized and implemented in our century. Contributions come from cutting-edge scholars such as Babette E. Babich, Dermot Moran, François Raffoul and Trish Glazebrook. 212 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book presents some of the findings of research into China's water quality criteria for toxic pollutants, including heavy metals, PAHs and emerging pollutant. Water quality criteria (WQC) are the scientific basis for establishing water quality standards (WQSs). For a long time, the study of WQC in China has been neglected, so that almost all of China's WQSs were developed based on foreign WQC. This book provides valuable information for environmental management and revision of WQSs. It has been written for researchers and graduate students in the field of environmental science and risk assessors for chemical and pollutants etc.Dr. Zhen-guang Yan is an Associate Professor at the Chinese Research Academy of Environmental Sciences.Dr. Zhengtao Liu is a Professor at the Chinese Research Academy of Environmental Sciences. 148 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book offers an original contribution towards a new theory of intersubjectivity which places ethics of breath, hospitality and non-violence in the forefront. Emphasizing Indian philosophy and religion (Vedas and Upanishads) and related cross-cultural interpretations, it provides new intercultural interpretations of key Western concepts which traditionally were developed and followed in the vein of re-conceptualizations or revitalizations of Greek thought, as in Nietzsche and Heidegger, for example. The significance of the book lies in its establishment of a new platform for thinking philosophically about intersubjectivity, so as to nudge contemporary philosophy towards a more sensitive approach, which is needed in our times. Its originality lies in its innovative approach, which searches for the origin of ethical gestures (represented in respecting the breath/breathing) through the newly introduced concept of 'mesocosm' as a space of a ritual, or a new ethical space of intersubjective encounters. The book also introduces the possibility of an original ethics based on breath. Intended for philosophers, feminists and others concerned with intercultural philosophy and comparative religion, the book will appeal to readers interested in contemporary ethical and political theories of peaceful conflict resolution and concepts of hospitality. A Breath of Hospitality will benefit all who seek a more sensitive approach in philosophy, including philosophy of religion, and often-neglected practical and educational layers of our everyday intersubjective relations. 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book introduces a variety of neural network methods for solving differential equations arising in science and engineering. The emphasis is placed on a deep understanding of the neural network techniques, which has been presented in a mostly heuristic and intuitive manner. This approach will enable the reader to understand the working, efficiency and shortcomings of each neural network technique for solving differential equations. The objective of this book is to provide the reader with a sound understanding of the foundations of neural networks and a comprehensive introduction to neural network methods for solving differential equations together with recent developments in the techniques and their applications.The book comprises four major sections. Section I consists of a brief overview of differential equations and the relevant physical problems arising in science and engineering. Section II illustrates the history of neural networks starting from their beginnings in the 1940s through to the renewed interest of the 1980s. A general introduction to neural networks and learning technologies is presented in Section III. This section also includes the description of the multilayer perceptron and its learning methods. In Section IV, the different neural network methods for solving differential equations are introduced, including discussion of the most recent developments in the field.Advanced students and researchers in mathematics, computer science and various disciplines in science and engineering will find this book a valuable reference source. 128 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book offers the reader a practical guide to the control and characterization of laser diode beams. Laser diodes are the most widely used lasers, accounting for 50% of the global laser market. Correct handling of laser diode beams is the key to the successful use of laser diodes, and this requires an in-depth understanding of their unique properties.Following a short introduction to the working principles of laser diodes, the book describes the basics of laser diode beams and beam propagation, including Zemax modeling of a Gaussian beam propagating through a lens. The core of the book is concerned with laser diode beam manipulations: collimating and focusing, circularization and astigmatism correction, coupling into a single mode optical fiber, diffractive optics and beam shaping, and manipulation of multi transverse mode beams. The final chapter of the book covers beam characterization methods, describing the measurement of spatial and spectral properties, including wavelength and linewidth measurement techniques. The book is a significantly revised and expanded version of the title Laser Diode Beam Basics, Manipulations and Characterizations by the same author. New topics introduced in this volume include: laser diode types and working principles, non-paraxial Gaussian beam, Zemax modeling, numerical analysis of a laser diode beam, spectral property characterization methods, and power and energy characterization techniques. The book approaches the subject in a practical way with mathematical content kept to the minimum level required, making the book a convenient reference for laser diode users. 148 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design. 252 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the past years, Saudi Arabia has been affected by particularly severe torrential rains and floods. This book presents an in-depth and all-encompassing study on the floods that occurred in the Jeddah area in 2009 and 2011, including water-flow mechanisms, state-of-the-art techniques for flood assessment, flood control and appropriate management approaches. It highlights a number of methods and concepts that can be applied in similar areas in Saudi Arabia in order to reduce and mitigate the impact of torrential rains and floods. 184 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The main objective of the Water Framework Directive in the European countries is to achieve a 'good status' of all the water bodies, in the integrated management of river basins. In order to assess the impact of improvement measures, water quality models are necessary. During the previous decades the progress in computer technology and computational methods has supported the development of advanced mathematical models for pollutant transport in rivers and streams. This book is intended to provide the fundamental knowledge needed for a deeper understanding of these models and the development of new ones, which will fulfil future quality requirements in water resources management. This book focuses on the fundamentals of computational techniques required in water quality modelling.Advection, dispersion and concentrated sources or sinks of contaminants lead to the formulation of the fundamental differential equation of pollutant transport. Its integration, according to appropriate initial and boundary conditions and with the knowledge of the velocity field, allows for pollutant behaviour to be assessed in the entire water body. An analytical integration is convenient only in one-dimensional approach with considerable simplification. Integration in the numerical field is useful for taking into account particular aspects of water body and pollutants.To ensure their reliability, the models require accurate calibration and validation, based on proper data, taken from direct measurements. In addition, sensitivity and uncertainty analysis are also of utmost importance. All the above items are discussed in detail in the 21 chapters of the book, which is written in a didactic form for professionals and students. 308 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides the first comprehensive international coverage of key issues in mandatory reporting of child abuse and neglect. The book draws on a collection of the foremost scholars in the field, as well as clinicians and practice-based experts, to explore the nature, history, impact and justifiability of mandatory reporting laws, their optimal form, legal and conceptual issues, and practical issues and challenges for reporters, professional educators and governments. Key issues in non-Western nations are also explored briefly to assess the potential of socio-legal responses sex trafficking, forced child labour and child marriage. The book is of particular value to policy makers, educators and opinion leaders in government departments dealing with children, and to professionals and organisations who work with children. It is also intended to be a key authority for researchers and teachers in the fields of medicine, nursing, social work, education, law, psychology, health and allied health fields. 592 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Increasing performance demands in integrated circuits, together with limited energy budgets, force IC designers to find new ways of saving power. One innovative way is the presented adaptive voltage scaling scheme, which tunes the supply voltage according to the present process, voltage and temperature variations as well as aging. The voltage is adapted 'on the fly' by means of in-situ delay monitors to exploit unused timing margin, produced by state-of-the-art worst-case designs. This book discusses the design of the enhanced in-situ delay monitors and the implementation of the complete control-loop comprising the monitors, a control-logic and an on-chip voltage regulator. An analytical Markov-based model of the control-loop is derived to analyze its robustness and stability. Variation-Aware Adaptive Voltage Scaling for Digital CMOS Circuits provides an in-depth assessment of the proposed voltage scaling scheme when applied to an arithmetic and an image processing circuit. This book is written for engineers interested in adaptive techniques for low-power CMOS circuits. 96 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The books provides a timely analysis in support of a paradigm shift in the field of wastewater management, from 'treatment for disposal' to 'treatment for reuse' by offering a variety of value propositions for water, nutrient and energy recovery which can support cost savings, cost recovery, and profits, in a sector that traditionally relies on public funding. The book provides new insights into the economics of wastewater use, applicable to developed and developing countries striving to transform wastewater from an unpleasant liability to a valuable asset and recasting urbanization from a daunting challenge into a resource recovery opportunity.'It requires business thinking to transform septage and sewage into valuable products. A must read for water scholars, policy makers, practitioners, and entrepreneurs'. Guy Hutton, Senior Economist, Water and Sanitation Program, Water Global Practice, World Bank 'This book provides compelling evidence and real solutions for the new 'resource from waste' approach that is transforming sanitation, boosting livelihoods, and strengthening urban resilience'. Christopher Scott, Professor and Distinguished Scholar, University of Arizona 'This book shows how innovative business thinking and partnerships around resource recovery and reuse fit well within an inclusive green economy and climate change adaptation and mitigation strategies'. Akiça Bahri, Coordinator of the African Water Facility, Tunisia, and award-winning researcher 296 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is the first to bring together research material from different communities, Computer Science and especially Artificial Intelligence, and Social Sciences, e.g. Anthropology, Social Psychology, Political Science that present ideas and viewpoints, methods and models on inter-cultural collaboration and negotiation.With increasing globalization of business and science, cultural differences of the parties are an important factor that affects the process and outcomes of collaborative and self-interested interactions. The social science literature on culture as well as human collaboration and negotiation is vast. Most of this literature is devoted to work within the same culture. Artificial intelligence researchers, on the other hand, have developed computational models of cooperation, conflict resolution and negotiation, but paying almost no attention to identifying and modeling cultural factors. In recent years, we have witnessed a great increase in interest in understanding inter-cultural interactions. This has led to increased interest of social scientists and computational scientists in theoretical and experimental analysis of inter-cultural exchanges, modeling and support. Currently, these communities are largely unconnected. There is a great need to bring them together to share research work and experiences, discuss ideas and forge interdisciplinary collaborative relations. This book will be of interest to researchers from AI/computer science and social/behavioral sciences fields, such as psychology, sociology, communications, organizational science. 212 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - We all view the ubiquitous term 'sustainability' as a worthwhile goal. But how can we apply the principles of sustainability in the real world, at the sharp end of communities in developing nations where income insecurity is the troubled norm This volume provides some practical answers, explaining the precepts of the 'sustainable livelihood approach' (SLA) through the case study of a microfinance scheme in Africa. The case study, centered around the work of the Catholic Church's Diocesan Development Services organization, involved an SLA implemented over two years designed in part to help enhance its existing microfinance operation through closer links between local communities and international donors. The book's central conclusion is that we must move beyond the concept of sustainable livelihood itself, with its in-built polarities between developed and developing nations, and embrace a more global notion of 'sustainable lifestyle'; a more nuanced and inclusive approach that encompasses not just how we make a sustainable living, but how we can live sustainable lives. 208 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this new volume in the World Soil series, the various types of Icelandic soils, their different characteristics, their formation, degradation and erosion are reviewed. At the same time, the book also deals with the agriculture and land use in general to give a complete view of Icelandic soils. The first part details the natural parameters such as the climate and the geography of Iceland. It also explains Icelandic geology, which is the major parameter controlling the soil formation in this country. The author describes the formation of Iceland, the main volcanic systems, central volcanoes, tephra production and its influence on the soils. Explanations on rocks, glaciers, rivers and other main geologic features are also given. The book continues with a description of the Icelandic geomorphology, giving insights on the main surface types, frost, cryoturbation and other cryogenic features. Then it details the different types of soils, their formation and main features, comparing the Icelandic soils to other soils elsewhere in the world. Erosion and land degradation are then reviewed, including the exceptionally active wind erosion and dust production. Finally, it gives an insight on land use, agriculture and vegetation types. All this accompanied by the most amazing photos to illustrate the great diversity of Icelandic Soil. 204 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book presents a new focus on the legal philosophical texts of Aristotle, which offers a much richer frame for the understanding of practical thought, legal reasoning and political experience. It allows understanding how human beings interact in a complex world, and how extensive the complexity is which results from humans' own power of self-construction and autonomy. The Aristotelian approach recognizes the limits of rationality and the inevitable and constitutive contingency in Law. All this offers a helpful instrument to understand the changes globalisation imposes to legal experience today.The contributions in this collection do not merely pay attention to private virtues, but focus primarily on public virtues. They deal with the fact that law is dependent on political power and that a person can never be sure about the facts of a case or about the right way to act. They explore the assumption that a detailed knowledge of Aristotle's epistemology is necessary, because of the direct connection between Enlightened reasoning and legal positivism. They pay attention to the concept of proportionality, which can be seen as a precondition to discuss liberalism. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The changes of populations are determined by fertility, mortality and migration. On the national level, international migration is a factor of increasing demographic, economic, social and political importance. This book addresses the debate on the impact of international migration and economic activity on population and labour force resources in future. It presents a study conducted for 27 European countries, looking 50 years ahead (2002-2052). An extended discussion of theories and factors underlying the assumed evolution of the components of change and economic activity is included as well as a detailed analysis of the historical trends. These theoretical and empirical considerations lead to defining scenarios of future mortality, fertility, economic activity and international migration, which have been fed into a projection model, producing various future population dynamics and labour force trajectories. In addition, simulations have been made to estimate the size of replacement migration needed to maintain selected demographic and labour market parameters in the countries of Europe. The results presented in this book allow researchers, governments and policy makers to evaluate to what extent various migration and labour market policies may be instrumental in achieving the desired population and labour size and structures.The secondary purpose of this volume is to reveal the methodology and argumentation lying behind a complex population forecasting and simulation exercise, which is not done frequently, but is critical for the assessment of the forecasts and also valuable from a purely didactic point of view. 364 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book reviews a series of new urban ideas or themes designed to help make cities more liveable, sustainable, safe and inclusive. Featuring examples drawn from cities all over the world, the various chapters provide critical assessments of each of the various approaches and their potential to improve urban life.New Urbanism: creating new areas based on a more humane scale with neighbourhood cohesionJust Cities: creating more fairness in decision-making so all residents can participate and benefit.Green Cities: helping places become greener with environmental rehabilitation and protection Sustainable Cities: avoiding the waste of resources and harmful pollution in settlementsTransition Towns: developing local initiatives for more sustainable actionsWinter Cities: making cities in cold climates more comfortable and enjoyable Resilient Cities: strengthening cities to better enable them to withstand natural hazardsCreative Cities: supporting cultural industries and attracting talented individuals Knowledge Cities: creating, renewing and spreading knowledge and innovation Safe Cities: ensuring that citizens are better protected against criminal actionsHealthy Cities: making improvements in the health of people in citiesFestive Cities: rediscovering the utility of festive events in settlementsSlow Cities: enhancing locally unique activities, such as local cuisines and community interactionsThis volume offers a host of approaches designed to give a new direction and focus to planning policies, helping readers to fully understand the advantages and disadvantages of each potential idea. It seeks to solve the many current problems associated with urban developments, making it a valuable resource for university and college students in urban geography, urban planning, urban sociology and urban studies as well as to planners and the general public. 636 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines the social aspects of healthy ageing for older individuals. It features more than 15 papers that explore the relevance of the social environment for health on the micro, meso, and macro level. Overall, the book applies a comprehensive contextual approach that includes discussion of how family and friends, neighborhoods, nations, and welfare regimes influence health.The book first explores the issue on the individual level. It looks at the importance of social capital for health among older people, examines types of social networks and health among older Americans, as well as discusses dynamic social capital and mental health in late life.Next, the book looks at the issue through a neighborhood and societal context, which takes into account day-to-day interaction in the immediate environment as well as the social, health, and economic policies in place in different regions in the world, including America, Europe, Asia, and Africa.From there, the book goes on to offer implications and recommendations for research and practice, including the management of related concepts of research on well-being and health. It also offers a psychosocial approach to promoting social capital and mental health among older adults.This book provides health professionals as well as researchers and students in gerontology, sociology, social policy, psychology, and social work with vital insights into the social factors that increase healthy life years and promote well-being. 284 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The core aim of this book is to determine how anthropology and demography can be used in conjunction in the field of population and development. The boundaries of demography are not as clearly defined or as stable as one might think, especially in view of the tension between a formal demography centered on the 'core of procedures and references' and a more open form of demography, generally referred to as Population Studies.Many rapprochements, missed opportunities and isolated attempts marked the disciplinary history of anthropology and demography, both disciplines being founded on distinct and highly differentiated traditions and practices. Moreover, the role and the place assigned to epistemology differ significantly in ethnology and demography. Yet, anthropology and demography provide complementary models and research instruments and this book shows that neither discipline can afford to overlook their respective contributions.Based on research conducted in West Africa over more than twenty years, it is a defense of field demography that makes case for a continuum ranging from the initial conception of fieldwork and research to its effective implementation and to data analysis. Changes in behaviors relating to fertility, poverty or migration cannot be interpreted without invoking the cultural factor at some stage. Representations in their collective and individual dimensions also fit into the extended explanatory space of demography. 224 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development.Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future.The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail. 284 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book offers different perspectives on Humanism as developed by Catholic Social Teaching, with a particular focus on its relevance in economics and business. The work is composed of three sections, covering what is meant by Christian Humanism, how it links with economic activity, and its practical relevance in the business world of today. It reviews the historical development of Christian Humanism and discusses the arguments which justify it in the current cultural context and how it contributes to human development. The book argues that the current recognition of human dignity and the existence of innate human rights are both ultimately rooted in Christian Humanism. It sets out the importance of the concept for economic activities, and how Christian Humanism can serve as a metaphysical foundation and ethical basis for a social market economy. Applying Christian Humanism to business leads to the centrality of the person in organizations and to seeing the company as a community of persons working together for the common good. Three thought-provoking case studies illustrate the wide-reaching positive impacts of applying Christian Humanism in the organization. 260 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design. 252 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Berlin Group for scientific philosophy was active between 1928 and 1933 and was closely related to the Vienna Circle. In 1930, the leaders of the two Groups, Hans Reichenbach and Rudolf Carnap, launched the journal Erkenntnis. However, between the Berlin Group and the Vienna Circle, there was not only close relatedness but also significant difference. Above all, while the Berlin Group explored philosophical problems of the actual practice of science, the Vienna Circle, closely following Wittgenstein, was more interested in problems of the language of science. The book includes first discussion ever (in three chapters) on Walter Dubislav's logic and philosophy. Two chapters are devoted to another author scarcely explored in English, Kurt Grelling, and another one to Paul Oppenheim who became an important figure in the philosophy of science in the USA in the 1940s-1960s. Finally, the book discusses the precursor of the Nord-German tradition of scientific philosophy, Jacob Friedrich Fries. 344 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This title reports the state-of-the-art advancements in modeling and characterization of fundamental and the recently designed carbon based nanocomposites (graphenes, fullerenes, polymers, crystals and allotropic forms).Written by leading experts in the field, the book explores the quantification, indexing, and interpretation of physical and chemical exotic properties related with space-time structure-evolution, phase transitions, chemical reactivity, and topology.Exotic Properties of Carbon Nanomatter is aimed at researchers in academia and industry. 408 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Analysis of the orbital motion of the Earth, the Moon and other planets and their satellites led to the discovery that all bodies in the Solar System are moving with the first cosmic velocity of their proto parents. The mean orbital velocity of each planet is equal to the first cosmic velocity of the Protosun, the radius of which is equal to the semi-major axis of the planet's orbit. The same applies for the planets' satellites. All the small planets, comets, other bodies and the Sun itself follow this law, a finding that has also been proven by astronomical observations. The theoretical solutions based on the Jacobi dynamics explain the process of the system creation and decay, as well as the nature of Kepler's laws. 320 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Violence is one of the most important challenges, not only for public health systems, but also for public mental health. Violence can have immediate as well as long-term and even transgenerational effects on the mental health of its victims. This book provides a comprehensive and wide-ranging assessment of the mental health legacy left by violence. It addresses the issues as they affect states, communities and families, in other words at macro-, meso- and microlevels, beginning by describing the impact of violence on neurobiology and mental health, as well as the spectrum of syndromes and disorders associated with different forms of violence.The work moves on to tackle violence at the international-and intranational-level before zeroing in on the nature of violence in communities such as villages or city districts. It also examines the results of violence in the family. Each type of violence has distinct effects on mental health and in each chapter specific groups are explored in depth to demonstrate the heterogeneity of violence as well as the diversity of its outcomes in the realm of public mental health. Finally, the book addresses the notion of 'undoing violence' by detailing case studies of effective interventions and prevention occurring in countries, communities and families. These cases give us pause to reflect on the nature of resilience and dignity in the context of violence and mental health.All the chapters have been written by leading authors in the field and provide a state-of-the-art perspective. The authors, from different fields of expertise, facilitate interdisciplinary and international insights into the impact of violence on mental health. 440 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With so many terms available to define the same thing, it would seem nearly irresponsible to introduce yet another term (complex situation) to describe a phenomenological state of such as a system. However, a complex situation infers both a broader meaning and imposes a different perspective. Complex in this context is dependent on understanding and reality rather than observer and knowledge. Situation imposes a gestalt that cannot be characterized within a singular perspective that relegates paradox to a superior/subordinate hierarchy. This also infers that complex situation has no monotonic definition or each definition is by default incomplete. Therefore the perennial derivations for systems such as complex systems, system of systems, federation of systems is no longer a sufficient descriptor for complex situation. Ergo system and its genealogy lack the constitution to define complex situations. The books' intent is to explore this pathology through a series of papers written by authors that work in complex situations and have dealt with the limitations of the status quo: systems. 276 pp. Englisch.