Springer new york aug 2010 (30 risultati)

Taschenbuch. Condizione: Neu. Neuware - Geriatric anesthesia is a rapidly growing and evolving field. The last few years have seen significant advancements in and important new modalities for addressing the needs of an aging population. The editors of Geriatric Anesthesiology's second edition are uniquely situated to put together a text highlighting both essential knowledge and recent breakthroughs of importance to any who work with the elderly. For the second edition, the editors have introduced a streamlined chapter format and have assembled a selection of chapters intended to deepen the understanding of anesthesic management of the geriatric patient.…

Buch. Condizione: Neu. Neuware - From the reviews:'The first volume is devoted to ergodic theory and dynamical systems. It contains 19 papers divided into four groups . . The reader will find a wealth of information and ideas that can still ignite inspiration and motivate students as well as senior researchers. The reader will also have a touch of Sinai's personality, his taste, enthusiasm, and optimism, which are just as invaluable as his mathematical results.' (Nikolai Chernov, Mathematical Reviews, Issue 2012 e).…

Buch. Condizione: Neu. Neuware - The20 papers contained in this volume span the areas of mathematical physics, dynamical systems, and probability. Yakov Sinai is one of the most important and influential mathematicians of our time, having won the Boltzmann Medal (1986), the Dirac Medal (1992), Dannie Heinemann Prize for Mathematical Physics (1989), Nemmers Prize (2002), and the Wolf Prize in Mathematics (1997). He is well-known as both a mathematician and a physicist, with numerous theorems and proofs bearing his name in both fields, and this book should be of interest to researchers from all fields of the physical sciences.This volume follows Volume I.From the reviews:'The second volume covers statistical mechanics and related topics. It contains 22 papers divided into four groups: Part I: Probability Theory; Part II: Statistical Mechanics; Part III: Mathematical Physics; Part IV: Mathematical Fluid Dynamics. The volume represents Sinai's work on the above topics spanning almost 40 years:the earliest paper is dated 1972, and the latest 2008. The choice of papers was made by Sinai himself, and he provides commentary for each one. The reader will find a wealth of information and ideas that can still ignite inspiration and motivate students as well as senior researchers. The reader will also have a touch of Sinai's personality, his taste, enthusiasm, and optimism, which are just as invaluable as his mathematical results.' (Nikolai Chernov, Mathematical Reviews 2012e). …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It may at first seem that the world of subatomic physics is far removed from our every day lives. Isn't it all just a waste of time and taxpayers' money Hopefully, all who read this book will come to a different conclusion. Collider physics is all about our origins, and this aspect alone makes it worthy of our very best attention. The experiments conducted within the vast collider chambers are at the forefront of humanity's quest to unweave the great tapestry that is the universe. Everything is connected. Within the macrocosm is the microcosm. By knowing how matter is structured, how atoms and elementary particles interact, and what forces control the interactions between the particles, we discover further clues as to why the universe is the way it is, and we uncover glimpses of how everything came into being. The Large Hadron Collider (LHC), in the process of coming online at CERN, is the world's largest and most complex machine. It represents the pinnacle of human ingenuity, and its physical characteristics, costs, and workings astound us at every turn.We are literally humbled by the machine that has been produced through a grand international collaboration of scientists. This book is about what those scientists hope to discover with the LHC, for hopes do run high, and there is much at stake. Careers, reputations and prestigious science prizes will be realized, and possibly lost, in the wake of the results that the LHC will produce. And there are risks, real and imagined. The LHC will probe the very fabric of matter and it will help us understand the very weft and the weave of the universe. 252 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For a long time I have been giving scientific lectures in different countries and on diverse topics, generally related to astronomy and to my work at the Arecibo Observatory. No matter which parti- lar topic I am talking about, the same question always comes up: Have we had any contact at Arecibo with 'them' My negative answer does not satisfy anyone. In fact, the answer either confirms their suspicions that there is a conspiracy afoot by higher autho- ties not to release information or their intentions to deceive the general public. The reasons for the deception have to do with the idea that, as in the movie Contact, the received messages contain important and useful information that will bring great advantage to whoever gets it. Many of us want to believe that extraterrestrial creatures can talk to us, that perhaps they are even living among us, as UFO fans believe. It would be fascinating if it were true, a more than extra- dinary discovery, the answer to an eternal question. There is p- sibly a deep psychological motive in this desire to know if we are alone in this huge universe, and the need to believe in something beyond our limited world, in space and time. There is no doubt, then, that this topic brings with it many scientific and philosophical discussions, as well as speculations that, on many occasions, fall into pure pseudoscience because of the lack of a reference framework. 232 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Art of Proof is designed for a one-semester or two-quarter course. A typical student will have studied calculus (perhaps also linear algebra) with reasonable success. With an artful mixture of chatty style and interesting examples, the student's previous intuitive knowledge is placed on solid intellectual ground. The topics covered include: integers, induction, algorithms, real numbers, rational numbers, modular arithmetic, limits, and uncountable sets. Methods, such as axiom, theorem and proof, are taught while discussing the mathematics rather than in abstract isolation. Some of the proofs are presented in detail, while others (some with hints) may be assigned to the student or presented by the instructor. The authors recommend that the two parts of the book -- Discrete and Continuous -- be given equal attention.The book ends with short essays on further topics suitable for seminar-style presentation by small teams of students, either in class or in a mathematics club setting. These include: continuity, cryptography, groups, complex numbers, ordinal number, and generating functions. 182 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Second Order Differential Equations presents a classical piece of theory concerning hypergeometric special functions as solutions of second-order linear differential equations. The theory is presented in an entirely self-contained way, starting with an introduction of the solution of the second-order differential equations and then focusingon the systematic treatment and classification of these solutions.Each chapter contains a set of problems which help reinforce the theory. Some of the preliminaries are covered in appendices at the end of the book, one of which provides an introduction to Poincaré-Perron theory, and the appendix also contains a new way of analyzing the asymptomatic behavior of solutions of differential equations.This textbook is appropriate for advanced undergraduate and graduate students in Mathematics, Physics, and Engineering interested in Ordinary and Partial Differntial Equations. A solutions manual is available online. 232 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This unusually lively textbook on complex variables introduces the theory of analytic functions, explores its diverse applications and shows the reader how to harness its powerful techniques. 'Complex Analysis' offers new and interesting motivations for classical results and introduces related topics that do not appear in this form in other texts. Stressing motivation and technique, and containing a large number of problems and their solutions, this volume may be used as a text both in classrooms and for self-study. Topics covered include: The complex numbers; functions of a complex variable; analytic functions; line integrals and entire functions; properties of entire functions and of analytic functions; simply connected domains; isolated singularities; the residue theorem and applications; contour integral techniques; conformal mapping and the riemann mapping theorem; maximum-modulus theorems for unbounded domains; harmonic functions; forms of analytic functions; analytic continuation; the gamma and zeta functions; application to other areas of mathematics. For this second edition, the authors have revised some of the existing material and have provided new exercises and solutions. 340 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Topics in Hyperplane Arrangements, Polytopes and Box-Splines brings together many areas of research that focus on methods to compute the number of integral points in suitable families or variable polytopes. The topics introduced expand upon differential and difference equations, approximation theory, cohomology, and module theory.This book, written by two distinguished authors, engages a broad audience by proving thea strong foudation.This book may be used in the classroom setting as well as a reference for researchers. 404 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including an introduction to ultrasound physics and principles, while individual chapters provide concise 'how-to' text supplemented with numerous full-color figures and tables that summarize key content. Residents, fellows, and trainees in critical care will benefit from the detailing of indications and contraindications for performing core procedures, while more experienced intensivists will find the book a reliable source of review material. Key procedures described include:-Ultrasound-guided vascular access-Ultrasound-guided drainage-Focused echocardiography-Airway management-Dialysis and apheresis-Pericardiocentesis-Insertion of vena cava filters-Percutaneous dilational tracheostomy-Open tracheostomy-Transbronchial biopsy-Percutaneous endoscopic gastrostomy-Intracranial monitoring 356 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A long long time ago, echoing philosophical and aesthetic principles that existed since antiquity, William of Ockham enounced the principle of parsimony, better known today as Ockham's razor: 'Entities should not be multiplied without neces sity. ' This principle enabled scientists to select the 'best' physical laws and theories to explain the workings of the Universe and continued to guide scienti c research, leadingtobeautifulresultsliketheminimaldescriptionlength approachtostatistical inference and the related Kolmogorov complexity approach to pattern recognition. However, notions of complexity and description length are subjective concepts anddependonthelanguage'spoken'whenpresentingideasandresults. The eldof sparse representations, that recently underwent a Big Bang like expansion, explic itly deals with the Yin Yang interplay between the parsimony of descriptions and the 'language' or 'dictionary' used in them, and it became an extremely exciting area of investigation. It already yielded a rich crop of mathematically pleasing, deep and beautiful results that quickly translated into a wealth of practical engineering applications. You are holding in your hands the rst guide book to Sparseland, and I am sure you'll nd in it both familiar and new landscapes to see and admire, as well as ex cellent pointers that will help you nd further valuable treasures. Enjoy the journey to Sparseland! Haifa, Israel, December 2009 Alfred M. Bruckstein vii Preface This book was originally written to serve as the material for an advanced one semester (fourteen 2 hour lectures) graduate course for engineering students at the Technion, Israel. 396 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite the accelerating pace of globalization, it is impossible to ignore the marginalization of the developing world, as billions of people continue to slip deeper into poverty. While many theories, policies, and practices have been proposed to help redress the disparities between the 'haves' and the 'have-nots,' only recently have proponents of sustainable economic development and entrepreneurship discovered each other. In this provocative and timely book, A. Coskun Samli fills the gap by making the connections explicit and arguing that entrepreneurship may be the only hope for countries that have fallen into the trap of relying on foreign aid and bowing to the pressures of multinational conglomerates driven by short-term profit-maximizing goals. Samli builds the case that some cultures are more entrepreneurial than others, and demonstrates the importance of creating the right conditions, infrastructure, policies, and educational systems that inspire and support new business creation. 164 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years biocompatible polymers for injuries and wounds have seen advances and innovations that have outpaced the growing field's literature. In this book Dr. Jan W. Gooch, a National Research Council Research Associateship Award recipient, reveals how innovative polymer technology can be applied to the common combat and trauma wounds associated with damaged soft tissue and bleeding. The scope of his investigation spans four distinct devices for wounds, liquid and particulate barrier dressings for soft tissue wounds, sutureless tissue adhesives, antibacterial nanoemulsions, one-hand operated and automatic tourniquets for the battlefield. 200 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. 276 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Combat Radiology provides unique insights into a military radiologist's role in the modern battlefield environment. Drawing on his recent experiences in Iraq, Col. Les Folio, a retired air force radiologist and flight surgeon with over twenty years of service, presents a comprehensive introduction to diagnostic imaging technology for the deployed military physician. Topics in the book include descriptions of imaging capabilities of hospitals in deployed military bases in combat zones; practical imaging techniques and terminology associated with penetrating/perforating blast and ballistic injuries; recent medical advances on the battlefield; and the changing role of imaging modalities in combat situations. Additionally, specific anatomic and pathologic imaging cases from combat situations are presented, including traumatic brain injury, chest, abdomen/pelvis, and skeletal trauma. Combat Radiology will appeal not only to military radiologists and surgeons, but also to civilian emergency radiologists and trauma physicians who encounter patients with ballistic and blast injuries resulting from armed conflict, terrorism, and disaster situations. 240 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In recent years biocompatible polymers for injuries and wounds have seen advances and innovations that have outpaced the growing field's literature. In this book Dr. Jan W. Gooch, a National Research Council Research Associateship Award recipient, reveals how innovative polymer technology can be applied to the common combat and trauma wounds associated with damaged soft tissue and bleeding. The scope of his investigation spans four distinct devices for wounds, liquid and particulate barrier dressings for soft tissue wounds, sutureless tissue adhesives, antibacterial nanoemulsions, one-hand operated and automatic tourniquets for the battlefield.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 200 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Complex physiopathological relationships have been proven to exist between two of the body's most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and the basic-helix-loop-helix transcription factors in neural differentiation. Ground-breaking and authoritative, Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems is a must have for all researchers in cardiovascular medicine and neuroscience and will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light. 268 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Topics in Number 49 include:- In-depth review of the durability issues in PEFCs - Understanding and mitigation of degradation in the polymer membrane and electrocatalyst - Summary of experimental diagnostics and modeling studies of cold start- Methods for distributed diagnostics of species, temperature and current in PEFCs- The operational principles of neutron radiography for in-situ visualization of liquid water distribution- Magnetic resonance imaging (MRI) technique for visualization of water in PEFCs and tunable diode laser absorption spectroscopy (TDLAS) for measurement of water vapor concentration- Liquid water transport in porous DM due to capillarity- Meso-scale modeling of two-phase transport- The atomistic simulations of electrochemical reactions on ectrocatalysts and the transport of protons through the polymer electrolyteFrom reviews of previous volumes:'This long-standing series continues its tradition of offering high quality reviews of established and emerging subject areas, together with the less common aspects of electrochemical science. [and]. deserves a place in electrochemistry libraries and should prove useful to electrochemists and related workers.'-Chemistry and Industry'Continues the valuable service that has been rendered by the Modern Aspects series.'-Journal of Electroanalytical Chemistry'Will definitely be of much use to researchers in the field of electrochemistry. . . . The editors of this well-produced volume deserve all appreciation for maintaining the excellent standard of the series.'-Bulletin of Electrochemistry'Extremely well-referenced and very readable. Maintains the overall high standards of the series.'-Journal of the American Chemical Society 420 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this book, we synthesize a rich and vast literature on econometric challenges associated with accounting choices and their causal effects. Identi cation and es- mation of endogenous causal effects is particularly challenging as observable data are rarely directly linked to the causal effect of interest. A common strategy is to employ logically consistent probability assessment via Bayes' theorem to connect observable data to the causal effect of interest. For example, the implications of earnings management as equilibrium reporting behavior is a centerpiece of our explorations. Rather than offering recipes or algorithms, the book surveys our - periences with accounting and econometrics. That is, we focus on why rather than how. The book can be utilized in a variety of venues. On the surface it is geared - ward graduate studies and surely this is where its roots lie. If we're serious about our studies, that is, if we tackle interesting and challenging problems, then there is a natural progression. Our research addresses problems that are not well - derstood then incorporates them throughout our curricula as our understanding improves and to improve our understanding (in other words, learning and c- riculum development are endogenous). For accounting to be a vibrant academic discipline, we believe it is essential these issues be confronted in the undergr- uate classroom as well as graduate studies. We hope we've made some progress with examples which will encourage these developments. 488 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area. 292 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this book, we synthesize a rich and vast literature on econometric challenges associated with accounting choices and their causal effects. Identi cation and es- mation of endogenous causal effects is particularly challenging as observable data are rarely directly linked to the causal effect of interest. A common strategy is to employ logically consistent probability assessment via Bayes¿ theorem to connect observable data to the causal effect of interest. For example, the implications of earnings management as equilibrium reporting behavior is a centerpiece of our explorations. Rather than offering recipes or algorithms, the book surveys our - periences with accounting and econometrics. That is, we focus on why rather than how. The book can be utilized in a variety of venues. On the surface it is geared - ward graduate studies and surely this is where its roots lie. If we¿re serious about our studies, that is, if we tackle interesting and challenging problems, then there is a natural progression. Our research addresses problems that are not well - derstood then incorporates them throughout our curricula as our understanding improves and to improve our understanding (in other words, learning and c- riculum development are endogenous). For accounting to be a vibrant academic discipline, we believe it is essential these issues be confronted in the undergr- uate classroom as well as graduate studies. We hope we¿ve made some progress with examples which will encourage these developments.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 488 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The articles in this volume cover, for the first time, all aspects of planetary magnetism, from the observations made by space missions to their interpretation in terms of the properties of all the planets in the solar system. Studies of dynamo-generated magnetic fields in Mercury, the Earth, the giant planets, as well as in Ganymede, one of Jupiter's moons, are presented. Crustal magnetic field in Mars, the Mon and the Earth are described as well as magnetic fields induced in the solar system bodies. There are several articles dealing with dynamo theory and modelling and applications to the different planets. 672 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Axons are neuronal output elements and are responsible for the transfer and processing of signals from one neuron to another, even over very large distances. For a given neuronal cell type, axons are unique and display very heterogeneous patterns with respect to shape, length and target structure. Axons are the usually long process of a nerve fiber that generally conducts impulses away from the body of the nerve cell. This book is intended to summarize recent findings covering morphological, physiological, developmental, computational and pathophysiological aspects of axons. It attempts to cover new findings concerning axonal structure and functions together with their implications for signal transduction, processes implicated in the formation of axonal arbors and the transport of subcellular elements to their targets, and finally how a dysfunction in one or several of these steps could lead to axonal degeneration and ultimately to neurodegenerative diseases. 256 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P. 184 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It is a privilege to introduce the reader to this book, as I believe that it will make a signi cant contribution to, given the dif culties in the knowledge of the Indian Ocean, developing cooperation in the Indian Ocean region. There have been numerous failed efforts at regional cooperation in different fora in the Indian Ocean. As a result of the land-based orientation of the people in the region, the importance for countries to develop the power to govern the sea has largely been ignored. The maritime approach taken by Manoj Gupta to the Indian Ocean as a region in international relations offers a timely and critical assessment of the potential for regional cooperation and ocean governance. The political leadership in the region can no longer ignore the need for coop- ation in maritime affairs in the Indian Ocean. This book enriches the literature on Indian Ocean issues as it argues convincingly that the security of nations, economic well-being of the people and health of the Indian Ocean cannot be divested from one another. All are fundamentally dependant on the ability of the countries in the region to individually and collectively exert the power to govern the sea. 400 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The articles in this volume cover, for the first time, all aspects of planetary magnetism, from the observations made by space missions to their interpretation in terms of the properties of all the planets in the solar system. Studies of dynamo-generated magnetic fields in Mercury, the Earth, the giant planets, as well as in Ganymede, one of Jupiter¿s moons, are presented. Crustal magnetic field in Mars, the Mon and the Earth are described as well as magnetic fields induced in the solar system bodies. There are several articles dealing with dynamo theory and modelling and applications to the different planets.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 672 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems.Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway.This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: 1) Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), 2) Serve as a platform to highlight the key findings in this highly volatile and evolving field, and 3) Provide answers to various techniques both related to microarray and cell signaling to the readers. 928 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -New Drug Development: Second Edition provides an overview of the design concepts and statistical practices involved in therapeutic drug development. This wide spectrum of activities begins with identifying a potentially useful drug candidate that can perhaps be used in the treatment or prevention of a condition of clinical concern, and ends with marketing approval being granted by one or more regulatory agencies. In between, it includes drug molecule optimization, nonclinical and clinical evaluations of the drug's safety and efficacy profiles, and manufacturing considerations. The more inclusive term lifecycle drug development can be used to encompass the postmarketing surveillance that is conducted all the time that a drug is on the market and being prescribed to patients with the relevant clinical condition. Information gathered during this time can be used to modify the drug (for example, dose prescribed, formulation, and mode of administration) in terms of its safety and its effectiveness. The central focus of the first edition of this book is captured by its subtitle, 'Design, Methodology, and Analysis'. Optimum quality study design and experimental research methodology must be employed if the data collected-numerical representations of biological information-are to be of optimum quality. Optimum quality data facilitate optimum quality statistical analysis and interpretation of the results obtained, which in turn permit optimum quality decisions to be made: Rational decision making is predicated on appropriate research questions and optimum quality numerical information. The book took a non-computational approach to statistics, presenting instead a conceptual framework and providing readers with a sound working knowledge of the importance of design, methodology, and analysis. Not everyone needs to be an expert in statistical analysis, but it is very helpful for work (or aspire to work) in the pharmaceutical and biologics industries to be aware of the fundamental importance of a sound scientific and clinical approach to the planning, conduct, and analysis of clinical trials. 256 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 928 pp. Englisch.…