Springer new york sep 2016 (346 risultati)

Taschenbuch. Condizione: Neu. Neuware -Protein Design: Method and Applications, Second Editionexpands upon the previous edition with current, detailed ideas on how to approach a potential protein design project. With new chapters onmetals as structure-forming elements and functional sites, the design and characterization of fluorinated proteins, top-down symmetric deconstruction and the design of protein libraries and novel or repurposed enzymes.Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and intuitive,Protein Design: Method and Applications, Second Editionprovides a number of practical protocols and instructive reviews to aid in the creation of new experiments.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 292 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Pell and Pell-Lucas numbers, like the well-known Fibonacci and Catalan numbers, continue to intrigue the mathematical world with their beauty and applicability. They offeropportunities for experimentation, exploration, conjecture, and problem-solving techniques, connecting the fields of analysis, geometry, trigonometry, andvarious areas of discrete mathematics,number theory, graph theory, linear algebra, and combinatorics. Pell and Pell-Lucas numbers belong to an extended Fibonacci family as a powerful tool for extracting numerous interesting properties of a vast array of number sequences.Akey feature of this work is the historical flavor that is interwoven into the extensive and in-depth coverage of the subject.An interesting array of applications to combinatorics, graph theory, geometry, and intriguing mathematical puzzles is another highlight engaging the reader. The exposition is user-friendly, yet rigorous, so that a broad audience consisting of students, math teachers and instructors, computer scientists and other professionals, along with the mathematically curious will all benefit from this book.Finally, Pell and Pell-Lucas Numbers provides enjoyment and excitement while sharpening the reader's mathematical skills involving pattern recognition, proof-and-problem-solving techniques. 456 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -While this book contains numerous facts and empirical findings and touches on policy issues, its main contribution to the existing literature lies in the theoretical perspective it offers. The core of this book is a general equilibrium theory of labor and marriage presented in Chapter 2, which provides the conceptual framework for the rest of the chapters. Two major implications of the theory are sex ratio effects and compensating differentials in marriage. The book demonstrates how a few core concepts, linked via economic analysis, help explain a multitude of findings based on statistical analyses of data from a wide variety of cultures. It is hoped that readers of this book will improve their understanding of how marriage works to help us design better economic and social policies as well as help people live better and happier lives, making the book of interest to not only economists but sociologists and anthropologists as well. 220 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Distributions in the Physical and Engineering Sciences is a comprehensive exposition on analytic methods for solving science and engineering problems. It is written from the unifying viewpoint of distribution theory and enriched with many modern topics which are important for practitioners and researchers. The goal of the books is to give the reader, specialist and non-specialist, useable and modern mathematical tools in their research and analysis. Volume 2: Linear and Nonlinear Dynamics of Continuous Media continues the multivolume project which endeavors to show how the theory of distributions, also called the theory of generalized functions, can be used by graduate students and researchers in applied mathematics, physical sciences, and engineering. It contains an analysis of the three basic types of linear partial differential equations--elliptic, parabolic, and hyperbolic--as well as chapters on first-order nonlinear partial differential equations and conservation laws, and generalized solutions of first-order nonlinear PDEs. Nonlinear wave, growing interface, and Burger's equations, KdV equations, and the equations of gas dynamics and porous media are also covered. The careful explanations, accessible writing style, many illustrations/examples and solutions also make it suitable for use as a self-study reference by anyone seeking greater understanding and proficiency in the problem solving methods presented. The book is ideal for a general scientific and engineering audience, yet it is mathematically precise. Features Application oriented exposition of distributional (Dirac delta) methods in the theory of partial differential equations. Abstract formalism is keep to a minimum. Careful and rich selection of examples and problems arising in real-life situations. Complete solutions to all exercises appear at the end of the book. Clear explanations, motivations, and illustration of all necessary mathematical concepts. 436 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this volume expert researchers detail in silico methods widely used to study peptides. These include methods and techniques covering the database, molecular docking, dynamics simulation, data mining, de novo design and structure modeling of peptides and protein fragments. Chapters focus on integration and application of technologies to analyze, model, identify, predict, and design a wide variety of bioactive peptides, peptide analogues and peptide drugs, as well as peptide-based biomaterials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Computational Peptidology seeks to aid scientists in the further study into this newly rising subfield. 352 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The second edition of Solar System Astrophysics: Background Science and the Inner Solar System provides new insights into the burgeoning field of planetary astronomy. As in the first edition, this volume begins with a rigorous treatment of coordinate frames, basic positional astronomy, and the celestial mechanics of two and restricted three body system problems. Perturbations are treated in the same way, with clear step-by-step derivations. Then the Earth's gravitational potential field and the Earth-Moon system are discussed, and the exposition turns to radiation properties with a chapter on the Sun. The exposition of the physical properties of the Moon and the terrestrial planets are greatly expanded, with much new information highlighted on the Moon, Mercury, Venus, and Mars.All of the material is presented within a framework of historical importance. This book and its sister volume, Solar System Astrophysics: Background Science and the Inner Solar system, are pedagogically well written, providing clearly illustrated explanations, for example, of such topics as the numerical integration of the Adams-Williamson equation, the equations of state in planetary interiors and atmospheres, Maxwell's equations as applied to planetary ionospheres and magnetospheres, and the physics and chemistry of the Habitable Zone in planetary systems.Together, the volumes form a comprehensive text for any university course that aims to deal with all aspects of solar and extra-solar planetary systems. They will appeal separately to the intellectually curious who would like to know how just how far our knowledge of the solar system has progressed in recent years. 356 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Contingency tables arise in diverse fields, including life sciences, education, social and political sciences, notably market research and opinion surveys. Their analysis plays an essential role in gaining insight into structures of the quantities under consideration and in supporting decision making. Combining both theory and applications, this book presents models and methods for the analysis of two- and multidimensional-contingency tables.An excellent reference for advanced undergraduates, graduate students, and practitioners in statistics as well as biosciences, social sciences, education, and economics, the work may also be used as a textbook for a course on categorical data analysis. Prerequisites include basic background on statistical inference and knowledge of statistical software packages. 324 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides the reader with essential tools needed to analyze complex societal issues and demonstrates the transition from physics to modern-day laws and treaties. This second edition features new equation-oriented material and extensive data sets drawing upon current information from experts in their fields. Problems to challenge the reader and extend discussion are presented on three timely issues: - National Security: Weapons, Offense, Defense, Verification, Nuclear Proliferation, Terrorism- Environment: Air/Water, Nuclear, Climate Change, EM Fields/Epidemiology- Energy: Current Energy Situation, Buildings, Solar Buildings, Renewable Energy, Enhanced End-Use Efficiency, Transportation, Economics Praise for the first edition:'This insight is needed in Congress and the Executive Branch. Hafemeister, a former Congressional fellow with wide Washington experience, has written a book for physicists, chemists and engineers who want to learn science and policy on weapons, energy, and the environment. Scientists who want to make a difference will want this book.'Richard Scribner, first Director, Congressional Science andEngineering Fellow Program, AAAS 'Hafemeister shows how much one can understand about nuclear weapons and missile issues through simple back-of-the-envelope calculations. He also provides compact explanations of the partially successful attempts that have been made over the past 60 years to control these weapons of mass destruction. Hopefully, Physics of Societal Issues will help interest a new generation of physicists in continuing this work.'Frank von Hippel, Professor, Princeton, former Assistant Director,National Security, White House, OSTP 'Energy policy must be quantitative. People who don't calculate economic tradeoffs often champion simplistic hardware.'The solution is more. nuclear power, or electric cars, or photovoltaics, etc.' Some simple physics will show that the true solution matches supply and demand as an 'integrated resource plan.' Physics of Societal Issues is a good place to begin this journey.'Arthur Rosenfeld, former California Energy Commissioner,Professor-emeritus, U. of California-Berkeley 688 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Science is art,' said Regina Dugan, senior executive at Google and former director of DARPA. 'It is the process of creating something that never exists before. . It makes us ask new questions about ourselves, others; about ethics, the future.' This second volume of the Digital Da Vinci book series leads the discussions on the world's first computer art in the 1950s and the actualization of Star Trek's holodeck in the future with the help of artificial intelligence and cyborgs. In this book, Gavin Sade describes experimental creative practices that bring together arts, science and technology in imaginative ways; Mine Özkar expounds visual computation for good designs based on repetition and variation; Raffaella Folgieri, Claudio Lucchiari, Marco Granato and Daniele Grechi introduce BrainArt, a brain-computer interface that allows users to create drawings using their own cerebral rhythms; Nathan Cohen explores artificially created spaces that enhance spatial awareness and challenge our perception of what we encounter; Keith Armstrong discusses embodied experiences that affect the mind and body of participating audiences; Diomidis Spinellis uses Etoys and Squeak in a scientific experiment to teach the concept of physical computing; Benjamin Cowley explains the massively multiplayer online game 'Green My Place' aimed at achieving behavior transformation in energy awareness; Robert Niewiadomski and Dennis Anderson portray 3-D manufacturing as the beginning of common creativity revolution; Stephen Barrass takes 3-D printing to another dimension by fabricating an object from a sound recording; Mari Velonaki examines the element of surprise and touch sensing in human-robot interaction; and Roman Danylak surveys the media machines in light of Marshall McLuhan's dictum 'the medium is the message.' Digital Da Vinci: Computers in the Arts and Sciences is dedicated to polymathic education and interdisciplinary studies in the digital age empowered by computer science. Educators and researchers ought to encourage the new generation of scholars to become as well rounded as a Renaissance man or woman. 312 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across multiple cancers and specific characteristics of individual cancer types. The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources. Cancer Bioinformatics is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine. 396 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents a new approach to the analysis of networks, which emphasizes how one can compress a network while preserving all information relative to the network's spectrum. Besides these compression techniques, the authors introduce a number of other isospectral transformations and demonstrate how, together, these methods can be applied to gain new results in a number of areas. This includes the stability of time-delayed and non time-delayed dynamical networks, eigenvalue estimation, pseudospectra analysis and the estimation of survival probabilities in open dynamical systems. The theory of isospectral transformations, developed in this text, can be readily applied in any area that involves the analysis of multidimensional systems and is especially applicable to the analysis of network dynamics. This book will be of interest to Mathematicians, Physicists, Biologists, Engineers and to anyone who has an interest in the dynamics of networks. 192 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This handbook consists of seventeen chapters written by eminent scientists from the international mathematical community, who present important research works in the field of mathematical analysis and related subjects, particularly in the Ulam stability theory of functional equations. The book provides an insight into a large domain of research with emphasis to the discussion of several theories, methods and problems in approximation theory, analytic inequalities, functional analysis, computational algebra and applications.The notion of stability of functional equations has its origins with S. M. Ulam, who posed the fundamental problem for approximate homomorphisms in 1940 and with D. H. Hyers, Th. M. Rassias, who provided the first significant solutions for additive and linear mappings in 1941 and 1978, respectively. During the last decade the notion of stability of functional equations has evolved into a very active domain of mathematical research with several applications of interdisciplinary nature.The chapters of this handbook focus mainly on both old and recent developments on the equation of homomorphism for square symmetric groupoids, the linear and polynomial functional equations in a single variable, the Drygas functional equation on amenable semigroups, monomial functional equation, the Cauchy-Jensen type mappings, differential equations and differential operators, operational equations and inclusions, generalized module left higher derivations, selections of set-valued mappings, D'Alembert's functional equation, characterizations of information measures, functional equations in restricted domains, as well as generalized functional stability and fixed point theory. 408 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question.This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies. 164 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Automatic detection and segmentation of anatomical structures in medical images are prerequisites to subsequent image measurements and disease quantification, and therefore have multiple clinical applications. This book presents an efficient object detection and segmentation framework, called Marginal Space Learning, which runs at a sub-second speed on a current desktop computer, faster than the state-of-the-art. Trained with a sufficient number of data sets, Marginal Space Learning is also robust under imaging artifacts, noise and anatomical variations. The book showcases 35 clinical applications of Marginal Space Learning and its extensions to detecting and segmenting various anatomical structures, such as the heart, liver, lymph nodes and prostate in major medical imaging modalities (CT, MRI, X-Ray and Ultrasound), demonstrating its efficiency and robustness. 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on 'Engineering Concepts' reviews the relevant fundamental principles that guide rational design. The following section on 'Materials Design' discusses how the design process applies engineering concepts for use in physiological systems. A third section on 'Implementation' discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on 'Clinical Applications' which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. Provides a comprehensive description of drug delivery systems from a materials perspective Includes a wide-ranging discussion of clinical applications of drug delivery systems Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type 376 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book describes recent innovations in 3D media and technologies, with coverage of 3D media capturing, processing, encoding, and adaptation, networking aspects for 3D Media, and quality of user experience (QoE). The contributions are based on the results of the FP7 European Project ROMEO, which focuses on new methods for the compression and delivery of 3D multi-view video and spatial audio, as well as the optimization of networking and compression jointly across the future Internet. The delivery of 3D media to individual users remains a highly challenging problem due to the large amount of data involved, diverse network characteristics and user terminal requirements, as well as the user's context such as their preferences and location. As the number of visual views increases, current systems will struggle to meet the demanding requirements in terms of delivery of consistent video quality to fixed and mobile users. ROMEO will present hybrid networking solutions that combine the DVB-T2 and DVB-NGH broadcast access network technologies together with a QoE aware Peer-to-Peer (P2P) distribution system that operates over wired and wireless links. Live streaming 3D media needs to be received by collaborating users at the same time or with imperceptible delay to enable them to watch together while exchanging comments as if they were all in the same location.This book is the second of a series of three annual volumes devoted to the latest results of the FP7 European Project ROMEO. The present volume provides state-of-the-art information on immersive media, 3D multi-view video, spatial audio, cloud-based media, networking protocols for 3D media, P2P 3D media streaming, and 3D Media delivery across heterogeneous wireless networks among other topics. Graduate students and professionals in electrical engineering and computer science with an interest in 3D Future Internet Media will find this volume to be essential reading.Describes the latest innovations in 3D technologies and Future Internet MediaFocuses on research to facilitate application scenarios such as social TV and high-quality, real-time collaborationDiscusses QoE for 3DRepresents the last of a series of three volumes devoted to contributions from FP7 projects in the area of 3D and networked media 260 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents a unique approach not found in any other text for those looking to improve the clinical results of refractive surgery by gaining a better understanding of corneal biomechanics and the instrumentation related to it. Written by leading experts in the field, this book provides authoritative coverage of the interactions of the cornea and the bioinstrumentation, such as corneal topography, pachymetry, aberrometers, tonometry and optical coherence tomography.Organized in an easy-to-read manner, Corneal Biomechanics and Refractive Surgery is designed for refractive surgeons and general ophthalmologists alike and describes the biomechanical role of the corneal tissue and how each part is affected in refractive surgery. Additionally, showing what the bioinstrumentation can measure, how models can improve understanding of the interaction between biomechanics, bioinstrumentation, and refractive surgery, and how these models and bioinstrumentation together can improve the refractive results, are also discussed. 156 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents new developments in the field of mass spectrometry imaging, covering imaging, software, data analysis, new instrumentations, and new methodological approaches.Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge,Mass Spectrometry Imaging of Small Molecules aims toto bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research. 228 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book covers the issues of monitoring, failure localization, and restoration in the Internet optical backbone, and focuses on the progress of state-of-the-art in both industry standard and academic research. The authors summarize, categorize, and analyze the developed technology in the context of Internet fault management and failure recovery under the Generalized Multi-Protocol Label Switching (GMPLS), via both aspects of network operations and theories. 220 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases. 168 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Receptor Tyrosine Kinases: Methods and Protocols explores on the most widely studied of the protein classes, known for their central role in several cellular functions and in a variety of human pathologies. Beginning with a section on activation and signaling of Receptor Tyrosine Kinases (RTKs), the book continues with chapters on aberrant expression of RTKs, trafficking and negative regulation, as well as RTKs as pharmacological targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Receptor Tyrosine Kinases: Methods and Protocols contains an up-to-date overview of the most relevant and widely used methods employed in this field, providing detailed protocols that molecular and cellular biologists could easily adopt in their research programs on RTKs. 196 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents fundamental concepts and seminal results to the study of vortex filaments in equilibrium. It also presents new discoveries in quasi-2D vortex structures with applications to geophysical fluid dynamics and magnetohydrodynamics in plasmas. It fills a gap in the vortex statistics literature by simplifying the mathematical introduction to this complex topic, covering numerical methods, and exploring a wide range of applications with numerous examples. The authors have produced an introduction that is clear and easy to read, leading the reader step-by-step into this topical area. Alongside the theoretical concepts and mathematical formulations, interesting applications are discussed. This combination makes the text useful for students and researchers in mathematics and physics. 152 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides complete coverage of the computational approaches currently used in Synthetic Biology. Chapters focus on computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and practical, Computational Methods in Synthetic Biology serves as a guide to plan in silico the in vivo or in vitro construction of a variety of synthetic bio-circuits. 372 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This unique book focuses on the non-myeloma plasma cell dyscrasias. A key resource for this group of diseases, the book features the latest in emerging knowledge and therapeutic developments, including novel therapies. Each disease-specific chapter discusses biology, disease course, and appropriate therapeutic interventions, covering plasma cell leukemia, plasmacytoma, POEMS Syndrome and Castleman's Disease, Waldenström macroglobulinemia, immunoglobin deposition disease, and cryoglobulinemic syndromes, among others. The only book dedicated to this intriguing family of diseases,Biology and Management of Unusual Plasma Cell Dyscrasiaswill be a long-lasting reference for clinicians and scientists alike. 216 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents relevantbackground information to understanding the molecular basis governingunconventional protein secretion (UPS), and in particular explores the latesttechniques and protocols that have been successfully applied for the study ofthis topic. Detailed chapters include an overview of conventional andunconventional secretory pathways along with multidisciplinary approaches andmethods used for UPS analysis in different organisms. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Authoritative and cutting-edge, UnconventionalProtein Secretion: Methods and Protocols will be usefulfor all interested in the secretory pathway field as well as applications incell biology, cell development, biomedical research, and healthcare. 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This unique title is designed to illustrate and foster how a closer working relationship between pediatricians and subspecialists can make childhood medicine work more seamlessly. Despite the common lack of training for pediatricians in pediatric neurosurgery, they are challenged almost daily with caring for children with neurologic conditions. Common Neurological Conditions in the Pediatric Practice is replete with a wide range of instructional case vignettes and is organized into sections that loosely approximate the neurologic development of a child and address issues that are commonly encountered. The first section reviews neurologic development and birth related trauma commonly seen in the neonatal intensive care unit. The second part addresses findings commonly encountered by a pediatrician in a child's first month of life. The third section is a comprehensive review of hydrocephalus. Part four describes state of the art imaging techniques for the central nervous system in children, from pre-natal ultrasound through MRI and CT; and the fifth part consists of individual explorations of common neurosurgical conditions that many pediatricians are uncomfortable managing, including brain tumors, spasticity, and vascular lesions to use as a reference tool when caring for a complex neurosurgical patient. Finally a series of chapters related to head trauma, including sections on non-accidental trauma and concussion management, completes the text. 460 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text integrates different mobility data handling processes, from database management to multi-dimensional analysis and mining, into a unified presentation driven by the spectrum of requirements raised by real-world applications. It presents a step-by-step methodology to understand and exploit mobility data: collecting and cleansing data, storage in Moving Object Database (MOD) engines, indexing, processing, analyzing and mining mobility data. Emerging issues, such as semantic and privacy-aware querying and mining as well as distributed data processing, are also covered. Theoretical presentation is smoothly interchanged with hands-on exercises and case studies involving an actual MOD engine. The authors are established experts who address both theoretical and practical dimensions of the field but also present valuable prototype software. The background context, clear explanations and sample exercises make this an ideal textbook for graduate students studying database management, data mining and geographic information systems. 316 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Digital Da Vinci book series opens with the interviews of music mogul Quincy Jones, MP3 inventor Karlheinz Brandenburg, Tommy Boy founder Tom Silverman and entertainment attorney Jay L. Cooper. A strong supporter of science, technology, engineering and mathematics programs in schools, The Black Eyed Peas founding member will.i.am announced in July 2013 his plan to study computer science. Leonardo da Vinci, the epitome of a Renaissance man, was an Italian polymath at the turn of the 16th century. Since the Industrial Revolution in the 18th century, the division of labor has brought forth specialization in the workforce and university curriculums. The endangered species of polymaths is facing extinction. Computer science has come to the rescue by enabling practitioners to accomplish more than ever in the field of music. In this book, Newton Lee recounts his journey in executive producing a Billboard-charting song like managing agile software development; M. Nyssim Lefford expounds producing and its effect on vocal recordings; Dennis Reidsma, Mustafa Radha and Anton Nijholt survey the field of mediated musical interaction and musical expression; Isaac Schankler, Elaine Chew and Alexandre François describe improvising with digital auto-scaffolding; Shlomo Dubnov and Greg Surges explain the use of musical algorithms in machine listening and composition; Juan Pablo Bello discusses machine listening of music; Stephen and Tim Barrass make smart things growl, purr and sing; Raffaella Folgieri, Mattia Bergomi and Simone Castellani examine EEG-based brain-computer interface for emotional involvement in games through music and last but not least, Kai Ton Chau concludes the book with computer and music pedagogy. Digital Da Vinci: Computers in Music is dedicated to polymathic education and interdisciplinary studies in the digital age empowered by computer science. Educators and researchers ought to encourage the new generation of scholars to become as well rounded as a Renaissance man or woman. 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - The educators are dedicated and concerned. The curriculum is successful. Yet some students aren't reading at grade level, and meetings air problems without making progress. Many students continue to flounder, leading to more meetings with the same lack of meaningful results. The Practitioner's Guide to Curriculum-Based Evaluation in Reading gives researchers and professionals the means to break this frustrating cycle, crafted by authors who have not only been there and done that, but can explain in depth how to replicate the method. Focusing on reading but applicable across subject areas, this highly accessible guide defines curriculum-based evaluation (CBE), provides conceptual background, and analyzes its component steps. Assessment and intervention are given equal attention within a problem-solving model featuring tools for skill assessment, progress monitoring, goal setting, and other bedrock tasks. Chapters build to lead readers beyond classroom strategies to guidelines for problem solving and decision making to effectively address individual student needs. Included in the coverage: The curriculum-based evaluation process.Relating CBE to the Multi-Tier System of Support model.Using CBE in daily practice, both in classwork and schoolwide.Decoding, early literacy, and reading comprehension.Progress monitoring and decision making.Plus FAQs, handouts, and other supplemental materials. This level of educational insight and pedagogical detail make the Practitioner's Guide to Curriculum-Based Evaluation in Reading a clarion call for researchers, graduate students, and professionals in school and clinical child psychology; assessment, testing, and evaluation; applied linguistics; language education; special education and allied education; educational psychology; and social work. 324 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Evidence pertaining to continual violence throughout the life cycle coupled with the experience of growing old in a life permeated by intimate violence is scarce. And the focus is usually on the victims usually, the older, battered women and seldom on their aging partners or adult children who were part and parcel of the violent dynamics in the family system. With the increase in longevity and the older population's subsequent growth in size, the number of elderly couples living and aging in long-lasting conflictive relationships is on the rise.The relatively intense preoccupation with elder abuse in the gerontological literature in recent years has not specifically addressed long-term intimate violence among the old adults and its lasting consequences. Similarly, the literature on intimate intergenerational relationships in old age has usually focused on normative exchanges between partners and their extended family, including their adult children. Therefore, conflictive relationships, and particularly violent ones, have also fallen outside the scope of this body of research. This volume describes and analyzes the various perspectives of family members concerning life, and particularly old age, in the shadow of long-term intimate violence. It explores how people make sense out of living and aging in violence, how interpersonal, familial and cross-generational relationships are perceived and reconstructed and how 'we-ness' is achieved, if at all, in such families. 152 pp. Englisch.…