Springer springer mär 2012 (Oltre 2900 risultati)

Taschenbuch. Condizione: Neu. Neuware -The economics of forestry has always fascinated me as one of the most brain-taxing cases in economics. As an investment forestry is different from many other projects as it has unusually long gestation periods. For example, in the United Kingdom it takes over 40 years to grow coniferous and over 100 years for deciduous timber. These long gestation periods make it very clear how import ant are the magnitude of the discount rate and the method of discounting in the evaluation of investment projects. Any errors in these will misguide investors in forestry one way or the other. In addition, forestry redistributes income between gener ations. Its long gestation periods make it obvious that more than one generation will be involved in any venture. When we plant trees we know that the bulk of the benefits will be captured by future generations. Conversely, when we fell trees we reap the benefit of projects which were established in the past, mostly by generations who are long gone. So far most economists have devoted their time and energy to analysing income distribution in an intragenerational context, and this is a very sensitive and controversial issue. After all, most revolutions have taken place because of the uneven income distribution which was oppressive for the majority. Forestry helps us to study the case from the viewpoint of different generations. Forestry necessitates estimating timber prices a long time ahead.…

Taschenbuch. Condizione: Neu. Neuware -The present work is an attempt to provide a systematic treatment of genetic linkage in diploid heredity. Part A presents a general account of statistical methods which can be brought to bear on the problem. The primary emphasis is on the practical aspects of estimation. A large proportion, if not the majority, of mutant genes fail to match up to 'textbook' genes-with faultless segregation ratios and expression-yet, these are the materials with which the practical researcher has to cope. For this reason, it is important to know how to deal with the assortment of genes which may display significant deviations from expectation. Part B examines the accumulated data on linkage for most of the laboratory mammals and provides a comprehensive and up-to-date survey. The need for a critical review has often been expressed and it is hoped that the present analysis will fill the gap. The volume of material is probably the most important in the animal kingdom other than that for Drosophila species.…

Taschenbuch. Condizione: Neu. Neuware -Presently, and in the past, the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. Recent data from a number of laboratories suggest that arterial mesenchyme is of considerable importance in the pathogenesis and fate of arteriosclerotic lesions. The significance of some of these observations made it clear that there was need for intensified research on the connective tissue components of the arteriosclerotic lesion and that arteriosclerosis research workers could benefit from a more comprehensive view of the subject. Because of their experience in the field of arteriosclerosis and their interest in stimulating new directions for research on the lesion, the Committee on Coronary Artery Lesions and Myocardial Infarctions of the Council on Arteriosclerosis, American Heart Association, planned an International Workshop on Arterial Mesenchyme and Arteriosclerosis. The Workshop brought together scientists expert in connective tissue research and research on arteriosclerosis who presented the current status of knowledge in their areas of expertise. The Workshop was held April 2-3, 1973 at the Royal Orleans Hotel, New Orleans, Louisiana and was attended by more than 170 people. The twenty papers and discussions presented in this volume summarize the proceedings of the Workshop and represent a comprehensive review of the role of arterial mesenchyme in arteriosclerosis.…

Taschenbuch. Condizione: Neu. Neuware -Ten years ago the first International Symposium on Computer and Information Sciences (COINS-63) was held at Northwestern University. Since that time, computer and information sciences have witnessed a great intensification of research and education. The activities in this field have been significantly broadened and enriched. During this ten-year period, we have organized four COINS symposia to provide a forum for promoting com munication among scientists, engineers, and educators in the computer and information science field and to act as a catalyzer for stimulating creative thinking within the community of information processing. The COINS-72 symposium, which took place in Miami Beach on December 14--16,1972, under the cosponsorship of the U.S. Army Research Office, the Atomic Energy Commission, and the University of Florida, is the fourth International Symposium on Computer and Information Sciences. The theme of this COINS symposium is information systems. This theme has been selected for the following reasons: Information systems have offered widespread applications in education, government, industry, and science. The bulk of research in computer and information science is now geared to the development of improved information systems. A major portion of software engineering is concerned with computer software and sophisticated information system design. It seems logical that a symposium on information systems should follow the preceding software engineering conference.…

Taschenbuch. Condizione: Neu. Neuware -The papers contained in this volume were presented at the third meeting of the International Organization for the Study of Human Development, held in Madrid on September 21-24, 1975. The primary objective of the Organization is to bring together persons from a wide range of disciplines concerned with problems of human development. The first meeting typified this interdisciplinary approach by concentrating on problems relating to genetic expression. The second meeting considered milk and lactation from a variety of viewpoints, including those of the molecular biologist and the geographer. The present meeting deals with nutrition as an integral part of human life as well as a fundamental discipline in the area of biology. The editors wish to thank Professors Ettore Rossi and Fabio Sereni and Dr. Frank Falkner for their invaluable assistance in planning this conference, and would particularly like to express their appreciation toward Professor Cipriano Canosa and his staff for their gracious and hospitable assist ance in providing facilities and accommodations for the participants. The editorial assistance of Mary Lynn Hendrix has aided us in our contribution; and the secretarial support of Millie Fazzi and Natalie Stover is gratefully acknowledged.…

Taschenbuch. Condizione: Neu. Neuware -This book contains the Proceedings of the S~cond U. S. -Japan Seminar on Learning Control and Intelligent Control. The seminar, held at Gainesville, Florida, from October 22 to 26, 1973, was sponsored by the U. S. -Japan Cooperative Science Program, jointly supported by the National Science Foundation and the Japan Society for the Promotion of Science. The full texts of the twenty-one presented papers are included. The papers cover a variety of topics related to learning control and intelligent control, ranging from pattern recognition to system identification, from learning control to intelligent robots. During the past decade, there has been a considerable increase of interest in problems of machine learning, systems which exhibit learning behavior. In designing a system, if the a priori infor mation required is unknown or incompletely known, one approach is to design a system which is capable of learning the unknown infor mation during its operation. The learned information will then be used to improve the system's performance. This approach has been used in the design of pattern recognition systems, automatic control systems and system identification algorithms. If we naturally extend our goal to the design of systems which will behave more and more intelligently, learning systems research is only a preliminary step towards a general concept of integrated intelligent systems. One example of this class of systems is the intelligent robot, which integrates pattern recognition. learning and problem-solving into one intelligent system.…

Taschenbuch. Condizione: Neu. Neuware -This book sets out to provide a useful directory to writers, reviewers, and citizens interested in the environmental impact statement (EIS) process in the United States. Although several 'environmental' directories address a narrow portion of EIS subject matter, there is no single directory that covers the wide range of agencies and organizations involved in the EIS process. Therefore, the purpose of this directory is to bring EIS-related agencies and organizations into one comprehensive reference book. EIS writing and reviewing can be improved by providing practioners with a directory that puts them quickly in touch with the national EIS net work. At the present time, practioners must rely on their personal, and sometimes, limited network of agencies and organizations for the exchange of information. The EIS Directory quickly connects EIS-related agencies and organizations throughout the United States at the national, regional, state, and local levels. The EIS Directory is a compilation of directories provided by members of the EIS community. A written survey of over five hundred agencies and or ganizations was made in 1980. The response to the survey provided a wide range of in-house directories. This book contains approximately 4,000 entries developed from over 300 documents. This book was written in the hope that it will help people communicate more easi1y--u1timately improving the quality of EIS decision making. I re alize the limitations of this initial edition and accept the challenge of providing a more effective reference tool in future editions.…

Taschenbuch. Condizione: Neu. Neuware - The European Organization for Research into Cancer Treatment (OERTC), founded in 1962 initially under the name Groupe Europeen de Chimiotherapie Anti cancereuse (GECA), is an extramural European Institute for collecting, co-ordinating and encouraging the work of scientists researching into cancer treatment at 16 European institutes: 3 in W. Germany, 2 in Italy, 2 in Belgium, 3 in the Netherlands, 2 in the United Kingdom, 1 in Switzerland and 3 in France. The first President of OERTC was Professor GEORGES MATHE, now succeeded by Professor SILVIO GARATTINI of Milan. The organization has a Board of 20 Directors, responsible for co-ordinating the entire range of activities and guiding research and experimental studies on animals, also the first human trials of new therapeutic agents which have been fully tested on animals. The Co-operating Groups carry out com plementary testing involving large numbers of patients. Thus, OER TC is not a 'learned society' but an agency for co-ordinating work. OER TC's annual plenary meeting for 1968 was held in Paris on 22nd and 23rd March. It was given over to an intensive study of the scientific basis of chemotherapy in the treatment of cancer in man. These two working sessions brought together members of all groups, both directing and co-operating. The first day was in effect a teaching seminar, open to all practitioners wishing to use chemotherapy in cancer, and explaining the scientific basis of such treatment. This seminar constitutes the present monograph.…

Taschenbuch. Condizione: Neu. Neuware - This book sets out to provide a useful directory to writers, reviewers, and citizens interested in the environmental impact statement (EIS) process in the United States. Although several 'environmental' directories address a narrow portion of EIS subject matter, there is no single directory that covers the wide range of agencies and organizations involved in the EIS process. Therefore, the purpose of this directory is to bring EIS-related agencies and organizations into one comprehensive reference book. EIS writing and reviewing can be improved by providing practioners with a directory that puts them quickly in touch with the national EIS net work. At the present time, practioners must rely on their personal, and sometimes, limited network of agencies and organizations for the exchange of information. The EIS Directory quickly connects EIS-related agencies and organizations throughout the United States at the national, regional, state, and local levels. The EIS Directory is a compilation of directories provided by members of the EIS community. A written survey of over five hundred agencies and or ganizations was made in 1980. The response to the survey provided a wide range of in-house directories. This book contains approximately 4,000 entries developed from over 300 documents. This book was written in the hope that it will help people communicate more easi1y--u1timately improving the quality of EIS decision making. I re alize the limitations of this initial edition and accept the challenge of providing a more effective reference tool in future editions.…

Taschenbuch. Condizione: Neu. Neuware - The economics of forestry has always fascinated me as one of the most brain-taxing cases in economics. As an investment forestry is different from many other projects as it has unusually long gestation periods. For example, in the United Kingdom it takes over 40 years to grow coniferous and over 100 years for deciduous timber. These long gestation periods make it very clear how import ant are the magnitude of the discount rate and the method of discounting in the evaluation of investment projects. Any errors in these will misguide investors in forestry one way or the other. In addition, forestry redistributes income between gener ations. Its long gestation periods make it obvious that more than one generation will be involved in any venture. When we plant trees we know that the bulk of the benefits will be captured by future generations. Conversely, when we fell trees we reap the benefit of projects which were established in the past, mostly by generations who are long gone. So far most economists have devoted their time and energy to analysing income distribution in an intragenerational context, and this is a very sensitive and controversial issue. After all, most revolutions have taken place because of the uneven income distribution which was oppressive for the majority. Forestry helps us to study the case from the viewpoint of different generations. Forestry necessitates estimating timber prices a long time ahead.…

Taschenbuch. Condizione: Neu. Neuware - Spectroscopic Tricks was introduced in 1959 as a special section in the journal Applied Spectroscopy. Its purpose was to provide a means for communicating information on new devices, modifica tions of existing apparatuses, and other items of this nature of interest to the working spectroscopist. That it has proved valuable is indicated by the continuing publication of this section now under the title of Spectroscopic Techniques. However, the use fulness of these contributions, scattered through the many issues of the journal, diminishes as time passes since the reader must consult the annual indices of many volumes of the journal to find the contri bution that may hold the solution to his problem. The collection of the contributions into a single volume for the years 1959 through 1965 made it easier for the reader to make this search. The success of the first volume has prompted the continuation of these collec tions. The contributions in this second volume are selected from the the years 1966 through 1969. They are arranged in the same manner as in the previous volume according to the area of spectroscopy. Those concerned with the same devices are placed together so that the reader can compare them readily. To maintain the advantages inherent in a single collection of articles, the subject index for this volume includes all the entries and page references from the original volume. Both author and journal indices are are also provided, the latter citing the original Applied Spectroscopy edition.…

Taschenbuch. Condizione: Neu. Neuware - Modern technology began in the 1950's and 1960's, with the devel opment of transistor technology. At first it was useful in improving the performance of voice communications. But then it made possible extraordinary computer capability in manageable size-and at man ageable cost. First came large mainframe computers for only the largest companies; and later the microcomputer as we know it today. The increasing use of computers, in the 1960's with their ability to manipulate and store vast quantities of information, stimulated the need for computers to communicate with one another and so tele phone circuits had to be segregated and conditioned specifically for computer traffic, using the modem. Computers ushered in a new era of business communications in which data could be developed, ma nipulated, stored or transmitted with remarkable ease. The recent pace of technological advancement has been breath taking and, today, the distinction between communications and computers is no longer even necessary. Computers, at the very core of communications networks, route and control communications on major common carriers. The decade of the 1980's is bearing the fruits of the marriage of computers and communications. For the first time networks are en abling organizations to utilize the combined processing power of computers and communications equipment.…

Taschenbuch. Condizione: Neu. Neuware - The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having only recently passed through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have so far been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective as well as to develop an invaluable reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere but which also provides a logical progression of developing facts and integrated concepts.…

Taschenbuch. Condizione: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in foodstuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying en thusiasm, sincerity, and efforts shown by all the individuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those thalt persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly developed ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemi cal, food technological, medical, pharmacological, and toxicological disciplines.…

Taschenbuch. Condizione: Neu. Neuware - In a previous volume, Families as Learning Environments for Children, we presented a series of chapters that dealt with research programs on the role of families as learning environments for children. Those studies were based on empirical data and sought answers to basic research questions, with no explicit concern for the application of the results to practical problems. Rather, their purpose was to contribute primarily to conceptualization, research methodology, and psychological theory. Now, in this volume, we turn our attention to intervention-efforts to modify the way a family develops. As in our previous conference, the participants of the working conference on which the present volume is based are research scientists and scholars interested in application. This group is distinct from practitioners, however, whose primary focus is service; participants in this conference have as their primary interest research into the problems of processes of application. Applied professional issues concerning the lives of families come from many varied sources, from some that are distant and impersonal (e. g. , the law) to direct face-to-face efforts (educators, therapists). The variety of sources and types of applications are eloquent testimony to the degree to which families are subject to a host of societal forces whose implicit or explicit aim is to modify family functioning. For example, some educators may wish to alter family child-rearing patterns to enhance child development; the clinician seeks to help families come to terms and to cope with a schizophrenic child. The list can be extended.…

Taschenbuch. Condizione: Neu. Neuware - The goals of the science of photobiology can be divided into four categories: to develop (I) ways to optimize the beneficial effects of light on man and his environment, (2) methods to protect organisms, including man, from the detrimental effects of light, (3) photochemical tools for use in studies of life processes, and (4) photochemical therapies in medicine. To achieve these goals will require the knowledgeable collaboration of biologists, chemists, engineers, mathematicians, physicians, and physicists; because photobiology is a truly multidisciplinary science. While a multi disciplinary science is more intellectually demanding, it also has a greater potential for unexpected breakthroughs that can occur when data from several areas of science are integrated into new concepts for theoretical or practical use. Photochemical and Photobiological Reviews continues to provide in depth coverage of the many specialty areas of photobiology. It is hoped that these reviews will provide an important service to the younger scientists in the field and to senior scientists in related fields, because they provide a ready access to the recent literature in the field, and more importantly, they frequently offer a critical evaluation of the direction that the field is taking, or suggest a redirection when appropriate. Kendric C. Smith Editor vii Contents v Contents of Earlier Volumes . . Preface . . vii Chapter 1. The Activation of Enzymes with Light . . …

Taschenbuch. Condizione: Neu. Neuware - These volumes contain the invited and contributed talks of the first general Conference of the Condensed Matter Division of the European Physical Society, which took place at the campus of the University of Antwerpen.

Taschenbuch. Condizione: Neu. Neuware - Twenty years is a long time in the life of a science. While the historical roots of psychology have not changed since the first edition of this book, some of the offshoots of the various theories and systems discussed have been crit- ically reexamined and have undergone far-reaching modifications. New and bold research has led to a broadening of perspectives, and recent devel- opments in several areas required a considerable amount of rewriting. I have been fortunate in the last fifteen years to have worked with about 2,000 psychologists and other behavioral scientists who contributed to several collected volumes I have edited. As the editor-in-chief of the In- ternational Encyclopedia of Psychiatry, Psychology, Psychoanalysis and Neurol- ogy, I have had the privilege of reading, scrutinizing, and editing the work of 1,500 experts in psychology and related disciplines. In addition, I have written several books and monographs and over one hundred scientific papers. Armed with all that experience, I have carefully examined the pages of the first edition. Chapter 8 required substantial rewriting and several new sections have been added to other chapters: 'Current Soviet Psychol- ogy' (Chapter 2, Section 7); 'New Ideas on Purposivism' (Chapter 5, Sec- tion 4); 'Recent Developments in the Sociological School of Psychoanalysis' (Chapter 9, Section 4); and 'Present Status of Gestalt Psychology' (Chapter 12, Section 4). Chapter 15 was omitted, and two new chapters were added: Chapter 14 ('Humanistic Psychology') and Chapter 16 ('Selected Research Areas').…

Taschenbuch. Condizione: Neu. Neuware - This volume represents the proceedings of a NATO Advanced Study Institute on Amino Acids as Chemical Transmitters, which took ~lace at Spatind Hotel in Norway, August 14-21, 1977. The meeting is related to two previous meetings on metabolic compart mentation in the brain. The first of these meetings took place at Rockefeller Foundation, Bellagio, Italy, July 11-16, 1971 and the proceedings, Metabolic Compartmentation in Brain, were edited by R. Balazs and J. E. Cremer and published by Macmillan in 1973. The second meeting was an Advanced Study Institute on Metabolic Com partmentation and Neurotransmission Relation to Brain Structure and Function, which was held in Oxford, September 1-8, 1974. The proceedings were edited by S. Berl, D. D. Clarke and D. Schneider and published as Volume 6 of the NATO ASI Life Science series by Plenum Press. The object of the present meeting was to review and discuss the present status of amino acids as chemical transmitters. Several issues such as electrophysiological response, localization, synthe sis, release and receptor binding of transmitter candidates were discussed. The possible morphological correlates to these func tions were also reviewed. During the meeting 24 leading papers were given. In addition, several of the participants presented important new findings during the discussion. Some of these have been included as short reports. The main financial support was obtained from NATO, Scientific Affairs Division.…

Taschenbuch. Condizione: Neu. Neuware -This second volume of the Charged Particle Traps deals with the rapidly expanding body of research exploiting the electromagnetic con nement of ions, whose principles and techniques were the subject of volume I. These applications include revolutionary advances in diverse elds, ranging from such practical elds as mass spectrometry, to the establishment of an ult- stable standard of frequency and the emergent eld of quantum computing made possible by the observation of the quantum behavior of laser-cooled con nedions. Bothexperimentalandtheoreticalactivity intheseapplications has proliferated widely, and the number of diverse articles in the literature on its many facets has reached the point where it is useful to distill and organize the published work in a uni ed volume that de nes the current status of the eld. As explained in volume I, the technique of con ning charged particles in suitable electromagnetic elds was initially conceived by W. Paul as a thr- dimensional version of his rf quadrupole mass lter. Its rst application to rf spectroscopy on atomic ions was completed in H. G. Dehmelt¿s laboratory where notable work was later done on the free electron using the Penning trap. The further exploitation of these devices has followed more or less - dependently along the two initial broad areas: mass spectrometry and high resolution spectroscopy. In volume I a detailed account is given of the theory of operation and experimental techniques of the various forms of Paul and Penning ion traps.…

Taschenbuch. Condizione: Neu. Neuware - Existence of huge amounts of data on the Web has developed anundeferring need to locate right information at right time, as well asto integrating information effectively to provide a comprehensivesource of relevant information.There is a need to develop efficient tools for analyzing and managingWeb data, and efficiently managing Web information from the databaseperspective. The book proposes a data model called WHOM (WarehouseObject Model) to represent HTML and XML documents in the warehouse. Itdefines a set of web algebraic operators for building new web tablesby extracting relevant data from the Web, as well as generating newtables from existing ones. These algebraic operators are used forchange detection.…

Taschenbuch. Condizione: Neu. Neuware - This second volume of the Charged Particle Traps deals with the rapidly expanding body of research exploiting the electromagnetic con nement of ions, whose principles and techniques were the subject of volume I. These applications include revolutionary advances in diverse elds, ranging from such practical elds as mass spectrometry, to the establishment of an ult- stable standard of frequency and the emergent eld of quantum computing made possible by the observation of the quantum behavior of laser-cooled con nedions. Bothexperimentalandtheoreticalactivity intheseapplications has proliferated widely, and the number of diverse articles in the literature on its many facets has reached the point where it is useful to distill and organize the published work in a uni ed volume that de nes the current status of the eld. As explained in volume I, the technique of con ning charged particles in suitable electromagnetic elds was initially conceived by W. Paul as a thr- dimensional version of his rf quadrupole mass lter. Its rst application to rf spectroscopy on atomic ions was completed in H. G. Dehmelt's laboratory where notable work was later done on the free electron using the Penning trap. The further exploitation of these devices has followed more or less - dependently along the two initial broad areas: mass spectrometry and high resolution spectroscopy. In volume I a detailed account is given of the theory of operation and experimental techniques of the various forms of Paul and Penning ion traps.…

Taschenbuch. Condizione: Neu. Neuware - Exploratory data analysis, also known as data mining or knowledge discovery from databases, is typically based on the optimisation of a specific function of a dataset. Such optimisation is often performed with gradient descent or variations thereof. In this book, we first lay the groundwork by reviewing some standard clustering algorithms and projection algorithms before presenting various non-standard criteria for clustering. The family of algorithms developed are shown to perform better than the standard clustering algorithms on a variety of datasets.We then consider extensions of the basic mappings which maintain some topology of the original data space. Finally we show how reinforcement learning can be used as a clustering mechanism before turning to projection methods. We show that several varieties of reinforcement learning may also be used to define optimal projections for example for principal component analysis, exploratory projection pursuit and canonical correlation analysis. The new method of cross entropy adaptation is then introduced and used as a means of optimising projections. Finally an artificial immune system is used to create optimal projections and combinations of these three methods are shown to outperform the individual methods of optimisation.…

Taschenbuch. Condizione: Neu. Neuware - The possibility of initiating chemical reactions by high-intensity laser exci tation has captured the imagination of chemists and physicists as well as of industrial scientists and the scientifically informed public in general ever since the laser first became available. Initially, great hopes were held that laser-induced chemistry would revolutionize synthetic chemistry, making possible 'bond-specific' or 'mode-specific' reactions that were impos sible to achieve under thermal equilibrium conditions. Indeed, some of the early work in this area, typically employing high-power continuous-wave sources, was interpreted in just this way. With further investigation, however, a more conservative picture has emerged, with the laser taking its place as one of a number of available methods for initiation of high-energy chemical transformations. Unlike a number of these methods, such as flash photolysis, shock tubes, and electron-beam radiolysis, the laser is capable of a high degree of spatial and molecular localization of deposited energy, which in turn is reflected in such applications as isotope enrichment or localized surface treatments. The use of lasers to initiate chemical processes has led to the discovery of several distinctly new molecular phenomena, foremost among which is that of multiple-photon excitation and dissociation of polyatomic molecules. This research area has received the greatest attention thus far and forms the focus of the present volume.…

Taschenbuch. Condizione: Neu. Neuware - The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter cellular transmitters, the receptors, signal transduction processes and regula tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho lipid components of the membranes is emphasized by recent studies.…

Taschenbuch. Condizione: Neu. Neuware - JOSEPH MEITES The idea that the endocrine system is involved in aging processes is as old as the beginnings of endocrinology. The first endocrine experiment related to aging was reported by Brown-Sequard, who is usually re garded as the 'father of endocrinology. ' In 1889, at the age of 72 years, he reported that he had succeeded in rejuvenating himself by injections of testicular extracts from dogs and guinea pigs. Although the favorable effects observed may have been due mainly to the powers of auto suggestion, his reports created a considerable interest in endocrinology and its relation to aging, and eventually led to the use of estrogens for treating certain pre-and postmenopausal symptoms in women, and an drogens for treating some symptoms in aging men. Up to about the 1960's, the relatively few studies on endocrine-aging relationships dealt mainly with changes in weight and histological appearance of endocrine organs in aging animals and human subjects, and included a limited number of measurements of endocrine function by bioassays and chem ical (for steroids) procedures. Within these limitations, gerontological investigators were unable to establish any definite relationships between endocrine functions and aging processes, with the exception of the con nection between reproductive decline and gonadal and pituitary activity.…

Taschenbuch. Condizione: Neu. Neuware - Volume 3 of the Encyclopedia of the Alkaloids covers the literature to the end of October 1976 and includes a large number of these compounds which have been discovered since the first two volumes were published in 1975. There are some entries where recent work has resulted in new structures being put forward or where additional details regarding compounds have been provided. Additional references to compounds given in the first two volumes are marked with an asterisk. The opportunity has also been taken to provide a formula index covering all three volumes. It is a great pleasure to thank Academician Professor S. Yu. Yunusov of the Institute of Chemistry at the University of Tashkent, Uzbekistan, for pointing out a number of errors in the two previous volumes and for kindly providing me with invaluable detailed information of the alkaloids which have been isolated and studied by Soviet chemists over many years.…

Taschenbuch. Condizione: Neu. Neuware - Volume 4 of the Encyclopedia of the Alkaloids covers the literature to the end of 1981 and includes those compounds which have been discovered since Volume 3 was published in 1977. There is also a small number of entries giving recently determined structure or addi tional information regarding alkaloids given in the preceding three volumes. It is a great pleasure to thank the staff of the John Rylands Science Library of the Univer sity of Manchester for kindly providing me with access to the literature on this subject. Woodhouses, JOHN S. GLASBY Manchester, England May, 1982 Contents A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I N . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 B . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 262 C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 P . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 Q . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 E . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141 R . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 F . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152 S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31O G . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158 T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 U . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 358 I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 192 V . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361 J . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 W . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 367 K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 X . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 368 L . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369 M . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227 Z . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 370 Formula Index. . . . . . . . . . . . . . . . . . . . 371 A ACETYLALLOYOHIMBINE (Alkaloid NRB6) C23H2SN203 M. p. Indefinite I I OAc The root bark of Rauwolfia nitida yields this yohimbine-type alkaloid which has been ob tained as an off-white amorphous powder having no definite melting point. The base is lae 2 vorotatory with a specific rotation of [aJ5 -89° (c 0. 01, CHCI ) and gives an ultraviolet 3 spectrum in MeOH with absorption maxima at 225,284 and 290 nm. The structure has been established from chemical and spectroscopic analysis. M. A. Amer, W. E. Court, Phytochem. , 20,2569 (1981) 14-ACETYLBROWNINE ___ :(OMe M. p.…

Taschenbuch. Condizione: Neu. Neuware - The primary metabolism of protobionts was probably based on the electron transfer reactions regulated by catalysts or photo sensitizing pigments. The action of photoreceptive pigments was inevitable in the case of electron transfer leading to light energy storage in the reaction products. The primitive tetrapyrrolic pig ments formed abiogenically (porphin, chlorin) as well as their more complicated biogenic analogs (chlorophylls) are capable of photo sensitizing electron transfer in systems, having various degrees of molecular complexity. The inorganic photosensitizers (titanium dioxide. zinc oxide. etc.). being excited in the near ultraviolet. are able to perform the same reactions as porphyrins--electron transfer from donor to acceptor molecule (including photoreduction of viologens) or water molecule photooxidation (oxygen liberation). coupled with reduction of ferric compounds and quinones. The in organic photosensitizers are not used in biological evolution; actually the inorganic ions entered into tetrapyrrolic cycle. form ing effective photocatalysts. Inclusion of pigments into primary membranes led to elaborated coupling between pigments and enzymatic systems. The involvement of the excited pigments into the biocata lytic electron transfer chain was prerequisite to effective func tion of photosynthetic organisms. REFERENCES 1. Oparin. A. I., 'Origin of Life on Earth,' Izd. AN SSSR. Moscow. 1957. 2. Gaffron, H., in: 'Horizons in Biochemistry' (Kasha. M and Pullmann, B eds.), p. 59. Academic Press, New York. 1962. 3. Calvin. M 'Chemical Evolution,' C1arendon Press, Oxford. 1969. 4. Pasynsky. A. G . and Pav1ovskaya. T. E . Uspekhii khimii 33, 1198 (1964).…

Taschenbuch. Condizione: Neu. Neuware - R. Y.Calne Surgeons are transplanting kidneys in ever increasing numbers-more than 10000 renal allografts have now been reported to the Transplant Registry. With related donors 75% of grafted kidneys continued to function after 2 years, compared with 50% when the donors were unrelated. The therapeutic value is obvious, but the management is largely empirical and results have improved little in the past 5 years. The basic sciences related to tissue transplantation have advanced rapidly. New serological and tissue culture techniques and chemical analysis of antigens and anti bodies have produced complicated data that is almost incomprehensible to the non specialist. Mathematical treatment of genetic probabilities and of immunological kinetics are similarly difficult to follow for those not especially trained. There has always been a gulf between the practical clinician whose patients do not behave like inbred rodents and the biologist who likes carefully controlled experiments with easily observed results. Both realize, however, that predictable and safe control of rejection must involve close collaboration and co-operation between the laboratory and the clinic. Unfortwlately, the different nature of the work and the workers has widened the gap between them. The clinicians tend to improve their techniques and patient care, whilst the biologists seek clearer and more precisely deflned experi ments which lead them to use increasingly artiflcial experimental models.…