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    • Lingua: Inglese

      Editore: Springer New York Nov 2013, 2013

      1461493714 / 9781461493716

      Serie: Libro 108 di 322 - SpringerBriefs in Computer Science

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condizione: Neu. Neuware -This brief provides methods for harnessing Twitter data to discover solutions to complex inquiries. The brief introduces the process of collecting data through Twitter's APIs and offers strategies for curating large datasets. The text gives examples of Twitter data with real-world examples, the present challenges and complexities of building visual analytic tools, and the best strategies to address these issues. Examples demonstrate how powerful measures can be computed using various Twitter data sources. Due to its openness in sharing data, Twitter is a prime example of social media in which researchers can verify their hypotheses, and practitioners can mine interesting patterns and build their own applications. This brief is designed to provide researchers, practitioners, project managers, as well as graduate students with an entry point to jump start their Twitter endeavors. It also serves as a convenient reference for readers seasoned in Twitter data analysis. 88 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer London Nov 2013, 2013

      1447129474 / 9781447129479

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condizione: Neu. Neuware -Preimplantation genetic diagnosis (PGD) is a rapidly advancing field of reproductive genetics. With the significant improvements achieved over the last few years in the understanding of many genetic diseases and in the techniques of molecular genetic testing, new genetic diseases are being added to the list of conditions amenable to PGD almost on a weekly basis. Therefore, the subject of PGD is becoming relevant to a much wider variety of medical disciplines and an increasing number of patients who may wish to know more about this treatment option. This unique book offers a comprehensive yet practical 'user-friendly' guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD. Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics. 248 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer, Springer Nov 2013, 2013

      9401052999 / 9789401052993

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      Da: Wegmann1855, Zwiesel, GermaniaWegmann1855

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      Taschenbuch. Condizione: Neu. Neuware -The idea for the present volume stems from the In many cases we had to decide ourselves what long time friendship between the series editor and changes had to be made in the manuscript. This the volume editor. The field work was carried out was done, however, with the prior consent of during several years of the last two decades by Professor Pandeya. We hope that we did not Professor Pandeya and his team of workers: overlook any items which should have been S. C. Sharma, H. K. Jain, K. C. Paliwal, V. M. changed - if we did, it is our responsibility. In Bhanot, S. J. Pathak, R. Sharma, S. C. Bhatt, P. K. order to demonstrate our responsibility I have Mathur, Y. N. Rao and G. V. Saratbabu. The wide signed as co-editor of this volume. scope of the undertaking required expeditions and The series editor accepted this unusual task individual field studies for which reports were because the topic is of great significance for dry available. subtropical regions of the world. It was the task of Professor Pandey a to sift all The Cenchrus grasslands are of great importance this information and put it together in a form in the dry areas of South East Asia. The value of understandable for an international audience. the ecological grassland study for range manage The manuscript was delivered to the series edi ment is therefore obvious.

    • Lingua: Inglese

      Editore: Springer Nov 2013, 2013

      9401052999 / 9789401052993

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      EUR 78,76

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      Taschenbuch. Condizione: Neu. Neuware - The idea for the present volume stems from the In many cases we had to decide ourselves what long time friendship between the series editor and changes had to be made in the manuscript. This the volume editor. The field work was carried out was done, however, with the prior consent of during several years of the last two decades by Professor Pandeya. We hope that we did not Professor Pandeya and his team of workers: overlook any items which should have been S. C. Sharma, H. K. Jain, K. C. Paliwal, V. M. changed - if we did, it is our responsibility. In Bhanot, S. J. Pathak, R. Sharma, S. C. Bhatt, P. K. order to demonstrate our responsibility I have Mathur, Y. N. Rao and G. V. Saratbabu. The wide signed as co-editor of this volume. scope of the undertaking required expeditions and The series editor accepted this unusual task individual field studies for which reports were because the topic is of great significance for dry available. subtropical regions of the world. It was the task of Professor Pandey a to sift all The Cenchrus grasslands are of great importance this information and put it together in a form in the dry areas of South East Asia. The value of understandable for an international audience. the ecological grassland study for range manage The manuscript was delivered to the series edi ment is therefore obvious.

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      EUR 86,37

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      Taschenbuch. Condizione: Neu. Neuware - Volume 7 of Developments in Applied Spectroscopy is a collection of forty-two papers selected from those that were presented at the 7th National Meeting of the Society of Applied Spectroscopy, held (in place of the 19th Mid-America Symposium on Spectroscopy) in Chicago, May 13-17, 1968. These papers, selected by the editors and reviewed by persons knowledgeable in the field, are those of the symposium type and not those pertaining to specific research topics that one would expect to be submitted to a journal. It is the opinion of the committee that this type of publication has an important place in the literature. The relatively large number of papers would result in quite a sizable volume if bound in one set of covers. For this reason, and to present the material in areas of more specific iilterest, Volume 7 was divided into two parts, Part A, Physical-Inorganic, and Part B, Physical-Organic Developments. The 7th National Meeting was sponsored by the Chicago Section as host in cooperation with the St. Louis, New England, Penn York, Niagara-Frontier, Cincinnati, Ohio Valley, New York, Baltimore-Washington, North Texas, Rocky Mountain, and Southeastern Sections of the Society for Applied Spectroscopy and the Chicago Gas Chromatography Group. The editors wish to express their appreciation to the authors and to those who helped with the reviewing. The latter include Dr. Elma Lanterman, Mr. John E. Forrette, Dr. Carl Moore, Dr. B. Jaselskis, Mr. H. G. Zelinski, Mr.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1461582369 / 9781461582366

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      Taschenbuch. Condizione: Neu. Neuware - The three articles of the present volume clearly exhibit a wide scope of articles, which is the aim of this series. The article by Kahana and Baltz lies in the main flow of the large stream of work currently in progress with heavy-ion accelerators. A related article by Terry Fortune on 'Multinuclear Transfer Reactions with Heavy Ions' is scheduled to appear in the next volume. The article by Whitehead, Watt, Cole, and Morrison pertains to the nuclear-shell model for which a number of articles have appeared in our series. Our very first volume had an article on how SU(3) techniques can, with great elegance, enable one to cope with the sizable number of states within a configuration. But the actual nuclear force is not exactly that yielded by the elegant techniques, and so interest continued in dealing with the large number of states by brute force. Then the Glasgow school of Whitehead et al. discovered that mathematical techniques existed for coping more simply with the lowest eigenvalues of large matrices. The present ar ticle aims generally to make accessible to nuclear physicists the methods developed at Glasgow. The final article by Baer, Crowe, and Truol on radiative pion capture describes a new field of importance because of the advent of the meson factories. More and more pions and muons will become standard tools in nuclear physics.

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      EUR 88,00

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      Taschenbuch. Condizione: Neu. Neuware - Volume 7 of Developments in Applied Spectroscopy is a collection of forty-two papers selected from those that were presented at the 7th National Meeting of the Society of Applied Spectroscopy, held (in place of the 19th Mid-America Symposium on Spectroscopy) in Chicago, May 13-17, 1968. These papers, selected by the editors and reviewed by persons knowledgeable in the field, are those of the symposium type and not those pertaining to specific research topics that one would expect to be submitted to a journal. It is the opinion of the committee that this type of publication has an important place in the literature. The relatively large number of papers would result in quite a sizable volume if bound in one set of covers. For this reason, and to present the material in areas of more specific mterest, Volume 7 was divided into two parts, Part A, Physical-Inorganic, and Part B, Physical-Organic Developments. The 7th National Meeting was sponsored by the Chicago Section as host in cooperation with the St. Louis, New England, Penn York, Niagara-Frontier, Cincinnati, Ohio Valley, New York, Baltimore-Washington, North Texas, Rocky Mountain, and Southeastern Sections of the Society for Applied Spectroscopy and the Chicago Gas Chromatography Group. The editors wish to express their appreciation to the authors and to those who helped with the reviewing. The latter include Dr. Elma Lanterman, Mr. John E. Forrette, Dr. Carl Moore, Dr. B. Jaselskis, Mr. H. G. Zelinski, Mr.

    • Lingua: Inglese

      Editore: Springer Berlin Heidelberg Nov 2013, 2013

      3642270190 / 9783642270192

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condizione: Neu. Neuware -This book constitutes the refereed post-proceedings of the Third IFIP WG 9.7 Conference on the History of Nordic Computing, HiNC3, held in Stockholm, Sweden, in October 2010. The 50 revised full papers presented together with a keynote address and a panel discussion were carefully reviewed and selected from numerous submissions. The papers focus on the application and use of ICT and ways in which technical progress affected the conditions of the development and use of ICT systems in the Nordic countries covering a period from around 1970 until the beginning of the 1990s. They are organized in the following topical sections: computerizing public sector industries; computerizing management and financial industries; computerizing art, media, and schools; users and systems development; the making of a Nordic computing industry; Nordic networking; Nordic software development; Nordic research in software and systems development; teaching at Nordic universities; and new historiographical approaches and methodological reflections. 484 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer Berlin Heidelberg, Springer Nov 2013, 2013

      3642269575 / 9783642269578

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      Da: Wegmann1855, Zwiesel, GermaniaWegmann1855

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      EUR 106,99

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      Taschenbuch. Condizione: Neu. Neuware -This book presents models and algorithms forcomplex scheduling problems. Besides resource-constrained project scheduling problems with applications also job-shop problems with flexible machines, transportation or limited buffers are discussed. Discrete optimization methods like linear and integer programming, constraint propagation techniques, shortest path and network flow algorithms, branch-and-bound methods, local search and genetic algorithms, and dynamic programming are presented. They are used in exact or heuristic procedures to solve the introduced complex scheduling problems. Furthermore, methods for calculating lower bounds are described. Most algorithms are formulated in detail and illustrated with examples.In this second edition some errors were corrected, some parts were explained in more detail, and new material has been added. In particular, further generalizations of the RCPSP, additional practical applications and some more algorithms were integrated.

    • Lingua: Tedesco

      Editore: Springer, Berlin, Springer Nov 2013, 2013

      364236943X / 9783642369438

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      EUR 32,99

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      Buch. Condizione: Neu. Neuware -Der medizinisch-technische Fortschritt führt verbunden mit der demographischen Entwicklung dazu, dass immer mehr, und v.a. ältere und vorerkrankte Menschen intensivmedizinisch behandelt werden. Die Vorhersage des Behandlungsergebnisses bleibt dabei häufig schwierig. Im Verlauf einer intensivmedizinischen Behandlung geraten Ärzte und Pflegekräfte oft in ein Spannungsfeld zwischen dem, was technisch möglich ist, und dem, was dem Patientenwillen entspricht. Immer wieder wird man deshalb bei Intensivpatienten mit sehr ernster Prognose entscheiden müssen, den Therapieumfang zu begrenzen oder das Therapieziel vom kurativen Ansatz zur Symptomkontrolle und Begleitung zu verändern. Hier sind für das therapeutische Team Entscheidungshilfen und konkrete Handlungsanleitungen, basierend auf ethischen Überlegungen, dem Willen des Patienten und juristischen Regularien, hilfreich. Das vorliegende Werk beschäftigt sich u.a. mit folgenden Themen: ethische Prinzipien, juristische Grundlagen, Patientenautonomie, Entscheidungsfindung und operative Umsetzung bei Therapiebegrenzung und Therapiezieländerung, Einheit von Patient und Familie, kulturelle und religiöse Einflüsse sowie Konflikte und Burnout im Behandlungsteam. Für alle auf Intensivstationen tätigen Ärzte und Pflegekräfte, die sich mit schwierigen Entscheidungen auseinandersetzen. 171 pp. Deutsch.

    • Lingua: Tedesco

      Editore: Springer, Berlin, Springer Nov 2013, 2013

      364236943X / 9783642369438

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      Da: Rheinberg-Buch Andreas Meier eK, Bergisch Gladbach, GermaniaRheinberg-Buch Andreas Meier eK

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      Buch. Condizione: Neu. Neuware -Der medizinisch-technische Fortschritt führt verbunden mit der demographischen Entwicklung dazu, dass immer mehr, und v.a. ältere und vorerkrankte Menschen intensivmedizinisch behandelt werden. Die Vorhersage des Behandlungsergebnisses bleibt dabei häufig schwierig. Im Verlauf einer intensivmedizinischen Behandlung geraten Ärzte und Pflegekräfte oft in ein Spannungsfeld zwischen dem, was technisch möglich ist, und dem, was dem Patientenwillen entspricht. Immer wieder wird man deshalb bei Intensivpatienten mit sehr ernster Prognose entscheiden müssen, den Therapieumfang zu begrenzen oder das Therapieziel vom kurativen Ansatz zur Symptomkontrolle und Begleitung zu verändern. Hier sind für das therapeutische Team Entscheidungshilfen und konkrete Handlungsanleitungen, basierend auf ethischen Überlegungen, dem Willen des Patienten und juristischen Regularien, hilfreich. Das vorliegende Werk beschäftigt sich u.a. mit folgenden Themen: ethische Prinzipien, juristische Grundlagen, Patientenautonomie, Entscheidungsfindung und operative Umsetzung bei Therapiebegrenzung und Therapiezieländerung, Einheit von Patient und Familie, kulturelle und religiöse Einflüsse sowie Konflikte und Burnout im Behandlungsteam. Für alle auf Intensivstationen tätigen Ärzte und Pflegekräfte, die sich mit schwierigen Entscheidungen auseinandersetzen. 171 pp. Deutsch.

    • Lingua: Inglese

      Editore: Springer Nov 2013, 2013

      9401088284 / 9789401088282

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      EUR 123,72

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      Taschenbuch. Condizione: Neu. Neuware - In recent years, there has been an increased interest in the use of polarization effects for radar and electromagnetic imaging problems (References 1, 2, and 3). The problem of electro magnetic imaging can be divided into the following areas: (1) Propagation of the Stokes' vector from the transmitter to the target region through various atmospheric conditions (rain, dust, fog, clouds, turbulence, etc.). (2) Scattering of the Stokes' vector from the object. (3) Scattering of the Stokes' vector from the rough surface, terrain, and the volume scattering. (4) Propagation of the Stokes' vector from the target region to the receiver. (5) The characteristics of the receiver relating the Stokes' vector to the output. The propagation characteristics of the Stokes' vector through various media can be described by the equation of transfer. Even though the scalar equation of transfer has been studied extensively in the past, the vector equation of transfer has not received as much attention. In recent years, however, a need for further study of the vector radiative transfer theory has become increasingly evident and several important studies have been reported. This paper presents a general formulation of the vector theory of radiative transfer under general anisotropic scattering conditions. Some useful solutions are also presented 4 8 for several practical situations. - 2. GENERAL FORMULATION OF VECTOR RADIATIVE TRANSFER THEORY Let us consider the plane-parallel problem Shovlll in Figure 1.

    • Lingua: Inglese

      Editore: Springer Nov 2013, 2013

      3642269575 / 9783642269578

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      EUR 151,73

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      Taschenbuch. Condizione: Neu. Neuware - This book presents models and algorithms for complex scheduling problems. Besides resource-constrained project scheduling problems with applications also job-shop problems with flexible machines, transportation or limited buffers are discussed. Discrete optimization methods like linear and integer programming, constraint propagation techniques, shortest path and network flow algorithms, branch-and-bound methods, local search and genetic algorithms, and dynamic programming are presented. They are used in exact or heuristic procedures to solve the introduced complex scheduling problems. Furthermore, methods for calculating lower bounds are described. Most algorithms are formulated in detail and illustrated with examples. In this second edition some errors were corrected, some parts were explained in more detail, and new material has been added. In particular, further generalizations of the RCPSP, additional practical applications and some more algorithms were integrated.

    • Lingua: Inglese

      Editore: Springer International Publishing Nov 2013, 2013

      3319010735 / 9783319010731

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      EUR 160,49

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      Buch. Condizione: Neu. Neuware -This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common 'cardiovascular events' to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention. 204 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer International Publishing Nov 2013, 2013

      3319010735 / 9783319010731

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      Da: Rheinberg-Buch Andreas Meier eK, Bergisch Gladbach, GermaniaRheinberg-Buch Andreas Meier eK

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      Buch. Condizione: Neu. Neuware -This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common 'cardiovascular events' to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention. 204 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer International Publishing, Springer International Publishing Nov 2013, 2013

      3319010735 / 9783319010731

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      Da: Wegmann1855, Zwiesel, GermaniaWegmann1855

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      Buch. Condizione: Neu. Neuware -This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common ¿cardiovascular events¿ to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1489920242 / 9781489920249

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      EUR 161,93

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      Taschenbuch. Condizione: Neu. Neuware - Neuropsychology has become an increasingly active participant in forensie issues over the past decade. This has been the result of increased recognition by psychologists of the potential role they can play in evaluating patients involved in lawsuits and the increasing sophistication of lawyers who have recognized that damages can go beyond claims of physical and motoric impairment. However, this increase in involvement has not always been matched by a more sophisticated recognition of how the client (whether plaintiff or defendant) can best be served by the neuropsychologist. I have personally seen or reviewed many cases in which the psychologists involved did not effectively present their case. This partially occurred because they failed to recognize the difference in presentations aimed at clinical audiences and those aimed at a legal proceeding. It also occurred because they failed to recognize that the standard of proof necessary is very different in a hospital and in a courtroom. Finally, it occurred because they rarely recognized what the unique role of the psychologist can be in either countering or supporting the testimony of medical specialists. The purpose of this volume is to bring some light on these questions. The presentations here are write-ups of the work presented at the Third Annual Conference on the Luria-Nebraska Neuropsychological Battery held in Omaha during May, 1985. All of the papers emphasize the role of the Luria-Nebraska but the ideas can be used with almost any test.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1475796781 / 9781475796780

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      Taschenbuch. Condizione: Neu. Neuware - This volume is intended to address contemporary aspects of child rearing in the home and the school, as well as major dimensions of inter face between the home and the school. The authors of these chapters have used varying styles and approaches, and the range of perspectives is very broad and inclusive. An essential notion integrating all chapters is that child rearing is a human ecological concern of dominant importance for the home, the school, and the community during the 1980's and that this will continue to be true in the future. This volume is intended to be useful as a reference book, as a text, for researchers and for policy-makers. It is hoped that the volume also will be of use to parents, teachers, school administrators, child-care workers and others who are interested in child nurturance. The editors wish to extend appreciation to many individuals who made this effort possible. Our colleagues, Hiram Fitzgerald and Marjorie Kostelnik, have been most helpful and encouraging. We thank them for their patience, support, and invaluable editorial assistance during the production of the camera-ready copy of the volume. We also thank Barbara Taylor for her assistance in typing the chapters, and Carrie DeMyers for typing the camera-ready copy. Carrie's good-nature and posi tive outlook helped to smooth over the many frustrations inherent in the assembly and production of anthologies such as this one.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1489905561 / 9781489905567

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      Taschenbuch. Condizione: Neu. Neuware - There is a considerable amount of interest within pediatrics and pri mary health care that is currently being directed toward the behavioral and emotional problems of childhood. Traditionally, these areas have been emphasized by child psychiatrists, child psychologists, and psy chiatric social workers. Now, however, the detection and, in some cases, the assessment and treatment of children with these types of disturb ances fall within the province of primary child health care profession als. Even when the child psychiatrist or child psychologist provides the primary mental health treatment for the child, specialists such as pediatricians, family physicians, pediatric nurses, pediatric nurse prac titioners, and speech therapists remain instrumental in support of the ongoing psychotherapeutic process as providers of some other aspect of total health care to the child and family. For these pediatricians, family physicians, and other nonpsychol ogist primary health care providers, it is essential to acquire an under standing and effective working knowledge of important psychological information and concepts to utilize within their own framework and professional responsibilities. In order that this may be accomplished, these professionals with limited backgrounds in psychology must better understand how psychologists themselves assess children and how they derive the conclusions reflected in the statements and reports that are shared with members of their own and other disciplines. In short, nonpsychologists must become substantially more familiar with psy chological assessment, particularly with psychological testing and the subsequent reporting of results.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1468485644 / 9781468485646

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      Taschenbuch. Condizione: Neu. Neuware - There is little prospect of an immediate cure for cancer. The seeds of destruction seem to be sown within all of us, and there is no consensus about how these seeds develop into tumors or about what can be done to halt that development. Indeed, it is often difficult to find a consensus about any aspect of cancer research. The sharply conflicting views of investigators in different subdisciplines has been most aptly summarized by Charles Heidelberger of the McArdle Laboratory for Cancer Research, who argues that 'the mechanism of cancer is a mirror into which each man looks and sees himself. ' This is true despite the fact that large infusions of money and manpower now come to the aid of cancer research. In late 1974, Betty Ford and Margaretta (Happy) Rockefeller underwent surgery for breast cancer. The extensive publicity surrounding these mastectomies provoked a great deal of interest in the subject of cancer, particularly breast cancer. Newspaper and television stories associated with the operations gave their audiences some insight into the nature of cancer and cancer research, but they provided only a glimpse of the sweeping changes that the directions of cancer research have under gone in the last few years. In large part, these changes simply reflect the natural progression of research, but there is little question that that progression was sharply accelerated by the National Cancer Act of 1971, which initiated what politicians then termed a 'crusade against cancer.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1489941320 / 9781489941329

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      Taschenbuch. Condizione: Neu. Neuware - Milestones in the techniques and methodology of polypeptide structure determination include the determination of the sequence of insulin by Sanger in 1951 (I) and the introduction of the repeti tive degradation of proteins with phenylisothiocyanate by Edman in 1959 (2). The automation of Edman chemistry (3) played a major role in the determination of polypeptide structures. Important modifications of Edman chemistry include the solid-phase approach by Laursen in 1971 (4) and the use of modified Edman reagents such as 4-N,N-dimethylaminoazobenzene-4'-isothiocy- ate (DABITC) for manual sequencing by Chang et al. (5) in 1976. A second major breakthrough in the analysis of polypeptides was automated amino acid analysis described by Spackman et al. in 1958 (6). However, during the period from 1975 to 1980, it became increasingly clear that the amount of material required for struc tural analysis was more than could be easily isolated for the vast majority of proteins. The field was criticized for its lack of sensitive techniques for the analysis of growth factors, immune modulators, membrane receptors, and peptide hormones. In addition, very little had been done to modernize and improve the original instruments introduced in the mid-1960s. The first indications of improved instrumentation for Edman chemistry came from Wittmann-Liebold's laboratory (7), followed by the introduction of a 'micro' sequencer by Hunkapiller and Hood in 1978 (8). The movement toward improved instrumentation culminated in the 'gas'-phase sequencer of Hewick et al. (9) in 1981.

    • Lingua: Inglese

      Editore: Springer Nature B.V. Nov 2013, 2013

      1475752431 / 9781475752434

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      Taschenbuch. Condizione: Neu. Neuware - The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target enzyme, but have quite different cellular pharmacokinetics than the parent monoglutamate. Hence, nearly three and a half decades after 4-aminoantifolates were first applied clinically in the treatment of human neoplasms, we have begun to appreciate a new dimension in antifolate pharmaco logy which may have profound implications for our understanding of the mechanism of the cytotoxicity and selectivity of this class of agents. With the development of highly sensitive methodology for the rapid detection of folyl and antifolyl polyglutamates, it is now possible to define in depth the intracellular transformation of these agents and their role in determining antifolate action against normal and malignant cells. This information will very likely influence how regimens with methotrexate and related antifolates will be further developed and employed clinically.

    • Lingua: Tedesco

      Editore: Springer, Berlin, Springer Vieweg Nov 2013, 2013

      3658010010 / 9783658010010

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      Da: Rheinberg-Buch Andreas Meier eK, Bergisch Gladbach, GermaniaRheinberg-Buch Andreas Meier eK

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      Taschenbuch. Condizione: Neu. Neuware -Nach dem Konzept der bewährten Physik-Aufgabensammlung begleitet dieses Übungsbuch durch ein breites Spektrum von Fragestellungen aus allen Teilgebieten der Chemie, bis hin zu Anwendungen in der physikalischen Chemie, Elektrochemie, Werkstoff-, Energie- und Verfahrenstechnik. Neben unkomplizierten Aufgaben für Studienanfänger zur Wiederholung der Schulchemie finden sich auch umfangreichere und komplexere Aufgaben für Fortgeschrittene in Bachelor- und Masterstudiengängen. Das detaillierte Stichwortverzeichnis und der übersichtliche Formelsatz führen zielsicher zu Lösungswegen bei der Prüfungsvorbereitung und in der beruflichen Praxis. Querverweise in die Physik-Formelsammlung und das Chemie-Buch stellen einen hilfreichen Bezug der Werke untereinander her. 221 pp. Deutsch.

    • Lingua: Tedesco

      Editore: Springer, Berlin, Springer Vieweg Nov 2013, 2013

      3658010010 / 9783658010010

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condizione: Neu. Neuware -Nach dem Konzept der bewährten Physik-Aufgabensammlung begleitet dieses Übungsbuch durch ein breites Spektrum von Fragestellungen aus allen Teilgebieten der Chemie, bis hin zu Anwendungen in der physikalischen Chemie, Elektrochemie, Werkstoff-, Energie- und Verfahrenstechnik. Neben unkomplizierten Aufgaben für Studienanfänger zur Wiederholung der Schulchemie finden sich auch umfangreichere und komplexere Aufgaben für Fortgeschrittene in Bachelor- und Masterstudiengängen. Das detaillierte Stichwortverzeichnis und der übersichtliche Formelsatz führen zielsicher zu Lösungswegen bei der Prüfungsvorbereitung und in der beruflichen Praxis. Querverweise in die Physik-Formelsammlung und das Chemie-Buch stellen einen hilfreichen Bezug der Werke untereinander her. 221 pp. Deutsch.

    • Lingua: Inglese

      Editore: Springer New York Nov 2013, 2013

      1461482461 / 9781461482468

      Serie: Libro 8 di 38 - AAPS Advances in the Pharmaceutical Sciences

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      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Buch. Condizione: Neu. Neuware -The volume aim to be a comprehensive overview of the drug and biologic development process that is often called 'the valley of death' (pre-IND through approval) where high costs of studies and high rates of product failure are part of the drug development landscape. Imaging tools can serve in this period by adding high value data, the images and the kinetic information they can provide, and cost-effective development alternative tools which potentially improve pivotal study designs. Imaging may identify safety issues early such as unwanted organ or tissue distributions, and then can serve advanced development with added certainty of a drug or biologic's success to senior corporate management and investors. There are numerous textbooks, reference texts and treatises on medical imaging technologies, teaching tools on medical cases and physics books on the science of detector and computer interface systems. Rarely, in each of these are examples of medical imaging protocols and animal models of disease i.e. a text on methodology in drug development is currently unavailable. 420 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer International Publishing, Springer International Publishing Nov 2013, 2013

      3319010735 / 9783319010731

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      Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000

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      EUR 160,49

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      Buch. Condizione: Neu. Neuware -This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common ¿cardiovascular events¿ to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

    • Lingua: Inglese

      Editore: Springer Vienna, Springer Vienna Nov 2013, 2013

      3709140366 / 9783709140369

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      Taschenbuch. Condizione: Neu. Neuware - The observation of the scaling properties of the structure functions w and vw of deep inelastic electron 1 2 nucleon scattering [1]+ has been taken by many people as an indication for an approximate scale invariance of the world. It was pointed out by Wilson [2], that in many field theories it is possible to assign a dimension d to every fundamental field, which proves to be a conserved quantum number as far as the most singular term of an operator product expansion at small distances ((x-y) +a) is con- JJ cerned++. Later it was shown, at the canonical level, that in many field theories the dimension of a field seems to be a c:pod quantum number even in the terms less singular at small (x-y) , as long as they all belong to the strongest l light cone singularity (i. e. (x-y)2+a) [3]. The assumption that this type of scale invariance on the light cone be present in the operator product ex pansion of two electromagnetic currents has provided us with a rather natural explanation of the observed scaling phenomena. We should like to mention, however, that this ex planation cannot account for the precocity with which scaling is being observed experimentally in energy regions, in which resonances still provide prominent contributions to the final states [4].

    • Lingua: Inglese

      Editore: Springer Nov 2013, 2013

      9400999658 / 9789400999657

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      Taschenbuch. Condizione: Neu. Neuware - Die vorliegende Arbeit stiitzt sich irn wesentlichen auf Feldarbeiten, die wah rend der Jahre 1970-1975 in Indonesien und Malaysia durchgefiihrt wurden_ Es ist hier nicht moglich, auch nur annahernd die Namen derjenigen aufzufiih ren, die mir wahrend dieser Zeit bei den ausgedehnten Reisen behilflich waren und auch die Erreichung normalerweise nur schwer zugiinglicher Gebiete ermoglichten. Der Vice-Chancellor der University of Science of Malaysia in Penang, Yang Berbahagia Tan Sri Professor Hamzah Sendut, erwies mit grofl,ziigiger Urlaubsrege lung und finanzieller Unterstiitzung seitens der Universitiit grofl,es Verstiindnis fiir die Durchfiihrung der F eldarbeiten. Prof. Dr. C.G.G.J. van Steenis, emeritierter Direktor des Rijksherbariums in Leiden, gab zahlreiche briefliche Hinweise und nach meiner Riickkehr nach Euro pa auch miindlich weitere Anregungen. Unter seiner Leitung wurde auch ein Teil der umfangreichen Herbarsammlung, die wahrend der Feldarbeiten in SE-Asien angelegt wurde, bestirnmt. Dr. P. Bass vom Holzanatomischen Institut des Rijks herbariums in Leiden iibernahm die Bestirnmung von fossilen Holzproben. Prof. Dr. J. Schmithiisen gab wertvolle sachliche und methodische Anregungen zu Be ginn und wahrend der Niederschrift. Prof. Dr. H. Sleumer, Rijksherbarium in Lei den, Hefl, mich in zuvorkommender Weise an seiner reichen Erfahrung iiber Erica ceen und deren Verbreitung irn malayischen Archipel teilnehmen. Den Herausgebern der Reihe Biogeographica danke ich fiir die Aufnahme der Arbeit in diese Reihe.

    • Lingua: Inglese

      Editore: Springer Us Nov 2013, 2013

      1468486969 / 9781468486964

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      Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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      Taschenbuch. Condizione: Neu. Neuware - This volume presents a collection of papers given at the 16th Mid -America Symposium on Spectroscopy held in Chicago, June 14-17, 1965. The Mid-America Symposium is sponsored annually by the Chicago Section of the Society for Applied Spectroscopy in cooperation with the St. Louis, Niagara Frontier, Cleveland, Detroit, lndianapolis, and Milwaukee Sections of the Society and the Chicago Gas Chromatography Discussion Group. Although we refer to this meeting as the Mid-America Symposium, it continues to attract attendance, interest, and inquiry from many parts of the world. Sessions on lnfrared, Raman, Ultraviolet, Visible, Emis sion, Flame, Atomic Absorption, Nuclear Particle, Gamma Ray, Nuclear Magnetic Resonance, X-Ray Spectroscopy, Spec troscopy, Spectrophosphorimetry, and Gas Chromatography provided interesting papers involving both applied and theo retical principles. This volume continues a series of the Proceedings initiated in 1961 and is composed of a collection of 37 papers presented at this meeting. It is the opinion of the Symposium Committee that although not a complete account of the proceedings, publication of this collection as a reference is warranted. As editors of this volume, we wish to express our gratitude to the authors who gave their time and effort in submitting their manuscripts so that this volume could be published. The Symposium Committee, L. S. Gray, W. Baer, Vivian Biske, W. Los eki , M. S. Wang, F. Leahy, J. L. Ogilvie, B. D.

    • Lingua: Inglese

      Editore: Springer New York Nov 2013, 2013

      1461487714 / 9781461487715

      • Rilegato

      Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

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      Buch. Condizione: Neu. Neuware -Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude. Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases. Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients. High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases. 508 pp. Englisch.