springer springer sep 1979 (81 risultati)

Buch. Condizione: Neu. Neuware - 1. 1. The Principle of Universalizability-an informal explication This work is concerned with the so-called Principle of Universalizability. As we shall understand it, this principle represents a claim that moral properties of things (persons, actions, state of affairs, situations) are essentially independent of their purely 'individual' or-as one often says -'numerical' aspects. l Thus, if a thing, x, is better than another thing, y, then this fact is not dependent on x's being x nor on y's being y. If a certain person, a, has a duty to help another person, b, then this duty does not arise as a consequence of their being a and b, respectively. And if in a certain situation, W, it ought to be the case that certain goods are transferred from one person to another, then this moral obligation does not depend on the individual identities of the persons involved. The Universalizability Principle may also be expressed in terms of similarities. Instead of saying that the moral properties of x are essentially independent of the individual aspects of x, we may say that any object which is exactly similar to x, which is precisely like x in all non-individual, 'qualitative' respects, must exhibit exactly similar moral properties. Thus, if two persons are exactly similar to each other, (if they are placed in exactly similar circumstances, have exactly similar information, preferences, character, etc. ), then they will have exactly similar rights and duties.

Buch. Condizione: Neu. Neuware - The VIth World Symposium on Cardiac Pacing in Montreal 1979 opened with a course, meant to be an introduction for newcomers and an updating re fresher and link between the various fields of knowledge needed by experienced persons for cardiac pacing. Invited guest lecturers were selected for their world recognized expertise in the individual subjects. This book is a collection of the various presentations on historical, clinical, electrophysiological and technical aspects of cardiac pacing. Together they cover the fundamentals of cardiac stimulation. We hope that this book may become an introductory guide to the field of cardiac pacing and that it may contribute to a better understanding of the pacemaker system and a better treatment of the pacemaker patient. Claude C. Meere Hilbert J. Th. Thalen ACKNOWLEDGEMENT The editors of 'Fundamentals on Cardiac Pacing' acknowledge the under standing and support of their families, during the long nocturnal hours and weekends during which this book was prepared. A special note of appreciation is extended to our secretaries, especially Mrs. Carolyn Gaarenstroom-Arriens and Miss Katrien Schuurman for their 'emergency typing' and Miss Lynn Bacon and Mr. Boudewijn Commandeur from Martinus Nijhoff Publishers, who succeeded in completing the book in time for the Montreal meeting. Only those involved are able to realize the importance of their contribution. CONTRIBUTORS David L. Bowers, B.S.E.E., Vitarel Inc. San Diego, California, U.S.A. Guy Fontaine, M.D., Groupe Hospitalier, Pitie-Salpetriere, Paris, France.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bordism groups.- Differentiable involutions.- Maps of odd period. 188 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Seminormal operators.- Concrete realizations of seminormal operators.- Two basic results on seminormal operators.- Perturbation determinants and the phase shift.- The principal function. 132 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Preliminaries.- L-projections and M-projections.- M-Ideals.- The centralizer.- Function modules.- M-Structure of some classes of Banach spaces.- Remarks.- The Banach-Stone theorem.- The Banach-Stone property and the strong Banach-Stone property.- Centralizer-norming systems.- M-structure of Co(M,X).- Generalizations of the Banach-Stone theorem.- Remarks. 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With contributions by numerous experts 324 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dedicated to the Memory of Rufus Bowen (1947-1978) 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 732 pp. Englisch, Französisch, Deutsch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The structure of odd L-groups.- The surgery group L 3 h (Z(G)) for G a finite 2-group.- Whitehead torsion for PL fiber homotopy equivalences.- Localization in quadratic L-theory.- K2(Z[Z/5]) is generated by relations among 2¿ matrices.- Surgery spaces: Formulae and structure.- Balanced splitings of semi-free actions on homotopy spheres.- Some examples of finite group actions.- The homotopy structure of finite group actions on spheres.- Addition of equivariant surgery obstructions.- Obstructions to realizing equivariant witt classes.- Stable G-smoothing.- Linear actions on friendly spaces.- The kunneth formula in equivariant K-theory.- Isotopy classes of periodic diffeomorphisms on spheres.- Original brown-peterson spectra.- Bp-operations and mappings of stunted complex projective spaces.- On the stable homotopy of symplectic classifying and thom spaces.- New applications of commutative algebra to brown-peterson homology.- The signature of symplectic and self-conjugate manifolds.- Homology isomorphisms.- An isomorphism between products of abelian groups.- Axiomatic homotopy theory.- Construction of mod p H-spaces II.- The mod 3 cohomology of the exceptional lie group E8.- A counterexample to the transfer conjecture.- Infinite loop space theory revisited.- A J-homomorphism associated with a space of empty varieties (addenda and corrigenda to two papers on the J-homomorphism). 676 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An intuitive derivation of symplectic concepts in mechanics and field theory.- Nonrelativistic particle dynamics.- Field theory.- Examples. 268 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The HIB 79 Congress is the second one organized by the European Federation for l-iedical Informatics (EFMI). The host society is the 'Deutsche Gesellschaft fur l-ledizinische Dokurnentation, Informatik und Statistik (GMDS) who are holding their 24th annual meeting at this time. The program of MIB 79 covers every aspect of the application of information science to medicine and public health, and as such respresents the state of the art. Medical Informatics (M. I. ) is now at a turning pOint. To date, despite the efforts made by specialists in many countries, the balance sheet of M. I. remains rather poor. One of the reasons for this situation is the fact that the computers of yesterday were the prerogative of an elite of users. They were expensive, difficult to use, remot. e from the users, and mainly in the hands of a sacerdotal caste of data processing speciali sts - In the future, data processing facilities will be cheap, easy to handle, and immediately accessible. Data processing will have a chance of becoming truly democratic thanks to two important and complementary trends in computer technology: 1. a network due to computer communication partnership; 2. miniaturization due to the dramatic expansion of micro-processor and computer technology. IV The combination of these two main hardware achievements for which some neologisms have been invented - 'compunication' in the USA and 'telEnnatique' in France - will lead to a completely new way of processing data which may be called 'distributed informatics. 996 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It isn't that they can't see the Approach your problems from the right end and begin with the solution. It is that they can't see answers. Then, one day, perhaps the problem. you will find the final question. 'The Hermit Clad in Crane Feathers' G. K. Chesterton, The scandal of in R. Van Gulik's The Chinese Maze Father Brown 'The point of a Murders. pin' Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the 'tree' of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be com pletely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crys tal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces. 204 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Section A: Molecular Biophysics.- A1 7-cis retinal, an artificial chromophore of bacteriorhodopsin.- A2 On the determination of the absorption spectra of some 11-cis-retinal conformeres by polarisation spectroscopy using extremely thin crystal plates.- A3 Resonance CARS spectroscopy of bacteriorhodopsin.- A4 Kinetic infrared spectroscopy on the photocycle of bacteriorhodopsin.- A5 Kinetic infrared investigation on the photodissociation of sperm whale CO-myoglobin.- A6 Some theoretical and practical aspects of enzyme immobilisation at the example urease / activated aluminiumhydroxide.- A7 Kinetic of urease-catalysed urea hydrolysis in the presence of alkaline earth halides.- A8 Ion atmosphere relaxation of simple electrolytes and polyionic biopolymers in electric fields.- A9 High-resolution temperature-jump measurements in biochemistry.- A10 Demonstration of G¿U wobble base pairs by Raman and IR spectroscopy.- A11 A new model for the activation and inactivation of neocarzinostatin, an antitumor protein.- A12 Generation of pre-neocarzinostatin and its antagonistic effect on neocarzinostatin-induced DNA strand scission.- A13 The production of strand breaks by the interaction of bleomycin with supercoiled col E1 DNA: An unexpected concentration dependence.- A14 Electron spin resonance study of cobalt leghaemoglobin.- A15 Interactions of ATP phosphate groups with amines and divalent metal ions: 31P-NMR studies.- A16 Investigations on the interaction of NADH with Cu(II): ESR and optical absorption spectroscopy.- A17 Experiments on the reaction kinetics between ¿platinum blue¿ compounds and several biomolecules.- A18 Investigations on the molecular interaction of the anti carcinogenic compound cis-dichlorodiammineplatinum (II): The formation of colored platinum complexes.- A19 Modification of the radiation effect on nucleobases and nucleosides by nitroimidazole-derivatives and ascorbic acid.- A20 Radikalerzeugung in Einkristallen decarboxylierter aromatischer Aminos¿en.- Section B: Cell- and Membrane Research.- B1 Polymorphism of pure and mixed phospholipid monolayers.- B2 Spectroscopic investigations of macroscopically ordered lecithin ¿ water ¿ multibilayers.- B3 Neutron small angle scattering on model membranes.- B4 Kinetic investigations of the phase transition of lecithin bilayers.- B5 The interaction between L-ascorbic acid, -tocopherol, and phospholipid model membranes.- B6 The interaction of synthetic phospholipids with melittin as a model to study lipid-protein interactions.- B7 Einflu¿k¿nstlicher Ionophore auf die Struktur von Modellmembranen.- B8 31-P-NMR studies on the lipid containing bacteriophage PM2.- B9 The head group mobility in phosphatidylcholine membranes in the presence of cholesterol as seen by a dielectric investigation.- B10 A time averaged picture of the conformation and segmental. disorder of phosphatidylcholine in bilayers investigated by neutron diffraction.- B11 Determination of lipid order parameters from fluorescence depolarization experiments.- B12 Lipid-protein interactions in bacteriorhodopsin-phosphatidylcholine vesicles.- B13 Aggregated and monomeric bacteriorhodopsin pumps protons.- B14 On the interpretation of lipid membrane cooperativity data.- B15 Statistical description of phospholipid bilayers with application to deuterium NMR.- B16 Structural order of lipids and proteins in membranes. New evaluation of fluorescence anisotropy data.- B17 New measurements of the water-permeability across lipid bilayer vesicles, the effect of cholesterol.- B18 Investigations of lipoid pH indicators as probes for electrostatic potential of micelles and vesicles.- B19 A. Influence of cholesterol on permeability and structural properties of artificial membranes containing enantiomeric phosphatidylcholines and ether analogues.- B20 Surface potential studies of monolayers from different sterols and various phospholipid / sterol mixtures.- B21 Influence of surface potential on ion transport through lipid bilayer membranes.- B22 Influence of local anesthetics on ion transport through lipid bilayer membranes.- B23 Negative hydrophobic ions as carriers for positive hydrophobic ions.- B24 Laser-temperature-jump method for the determination of the rate of desorption of hydrophobic ions in lipid membranes.- B25 Voltage dependent noise current of lipid bilayer membranes generated by hydrophobic ions.- B26 Noise analysis of carrier-mediated ion transport under nonequilibrium conditions.- B27 1 / f noise in track-etched mica membranes.- B28 Current fluctuations in biological transport systems far from equilibrium.- B29 Ion transport through pores: oscillatory phenomena at transient states.- B30 Why single file pores .- B31 Properties of ionic channels made from derivatives of gramicidin A.- B32 State dependent blocking effects on the alamethicin pore by divalent cations.- B33 Structural requirements for membrane modifying activity in alamethicin-type antibiotics.- B34 Investigations on monolayers of alamethicin-type antibiotics at an air / water interphase.- B35 Transport of matter through membranes. The influence of protein on the kinetics of the free dialysis of detergents.- B36 Vesicle spread membranes, a novel way for membrane reconstitution.- B37 Matrix protein / ATPase proteolipid / acetylcholine receptor in vesicle spread membranes.- B38 Formation and characterization of bilayer membranes from vesicle-spread monolayers.- B39 Studies on photocurrent kinetics of purple membrane on black lipid membranes.- B40 Association equilibria between oligomers of band 3-protein from human erythrocyte membranes: Time needed for relaxation towards equilibrium.- B41 Properties of large ion-permeable pores formed by porins from Salmonella typhimurium in lipid bilayer membranes.- B42. Reversible electrical breakdown of lipid bilayer membranes.- B43 Dependence of the electrical breakdown voltage on the charging time in Valonia utr.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Unified description of discrete time controllers.- Unified description of continuous time controllers.- Stability of discrete time controllers.- Stability of continuous time controllers. 168 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Bordism groups.- Differentiable involutions.- Maps of odd period.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 188 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Seminormal operators.- Concrete realizations of seminormal operators.- Two basic results on seminormal operators.- Perturbation determinants and the phase shift.- The principal function.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 132 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Preliminaries.- L-projections and M-projections.- M-Ideals.- The centralizer.- Function modules.- M-Structure of some classes of Banach spaces.- Remarks.- The Banach-Stone theorem.- The Banach-Stone property and the strong Banach-Stone property.- Centralizer-norming systems.- M-structure of Co(M,X).- Generalizations of the Banach-Stone theorem.- Remarks.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -With contributions by numerous expertsSpringer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 324 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Dedicated to the Memory of Rufus Bowen (1947-1978)Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 732 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The structure of odd L-groups.- The surgery group L 3 h (Z(G)) for G a finite 2-group.- Whitehead torsion for PL fiber homotopy equivalences.- Localization in quadratic L-theory.- K2(Z[Z/5]) is generated by relations among 2¿ matrices.- Surgery spaces: Formulae and structure.- Balanced splitings of semi-free actions on homotopy spheres.- Some examples of finite group actions.- The homotopy structure of finite group actions on spheres.- Addition of equivariant surgery obstructions.- Obstructions to realizing equivariant witt classes.- Stable G-smoothing.- Linear actions on friendly spaces.- The kunneth formula in equivariant K-theory.- Isotopy classes of periodic diffeomorphisms on spheres.- Original brown-peterson spectra.- Bp-operations and mappings of stunted complex projective spaces.- On the stable homotopy of symplectic classifying and thom spaces.- New applications of commutative algebra to brown-peterson homology.- The signature of symplectic and self-conjugate manifolds.- Homology isomorphisms.- An isomorphism between products of abelian groups.- Axiomatic homotopy theory.- Construction of mod p H-spaces II.- The mod 3 cohomology of the exceptional lie group E8.- A counterexample to the transfer conjecture.- Infinite loop space theory revisited.- A J-homomorphism associated with a space of empty varieties (addenda and corrigenda to two papers on the J-homomorphism).Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 676 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The HIB 79 Congress is the second one organized by the European Federation for l-iedical Informatics (EFMI). The host society is the 'Deutsche Gesellschaft fur l-ledizinische Dokurnentation, Informatik und Statistik (GMDS) who are holding their 24th annual meeting at this time. The program of MIB 79 covers every aspect of the application of information science to medicine and public health, and as such respresents the state of the art. Medical Informatics (M. I. ) is now at a turning pOint. To date, despite the efforts made by specialists in many countries, the balance sheet of M. I. remains rather poor. One of the reasons for this situation is the fact that the computers of yesterday were the prerogative of an elite of users. They were expensive, difficult to use, remot. e from the users, and mainly in the hands of a sacerdotal caste of data processing speciali sts ¿ In the future, data processing facilities will be cheap, easy to handle, and immediately accessible. Data processing will have a chance of becoming truly democratic thanks to two important and complementary trends in computer technology: 1. a network due to computer communication partnership; 2. miniaturization due to the dramatic expansion of micro-processor and computer technology. IV The combination of these two main hardware achievements for which some neologisms have been invented - 'compunication' in the USA and 'telEnnatique' in France - will lead to a completely new way of processing data which may be called 'distributed informatics.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 996 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It isn't that they can't see the Approach your problems from the right end and begin with the solution. It is that they can't see answers. Then, one day, perhaps the problem. you will find the final question. 'The Hermit Clad in Crane Feathers' G. K. Chesterton, The scandal of in R. Van Gulik's The Chinese Maze Father Brown 'The point of a Murders. pin' Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the 'tree' of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be com pletely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crys tal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 204 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Unified description of discrete time controllers.- Unified description of continuous time controllers.- Stability of discrete time controllers.- Stability of continuous time controllers.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 168 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -An intuitive derivation of symplectic concepts in mechanics and field theory.- Nonrelativistic particle dynamics.- Field theory.- Examples.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 268 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Representations spheriques uniformement bornees des groupes de Lorentz.- Les distributions de type positif relativement a un groupe fini d'isometries.- Les sous-groupes paraboliques de SU(p,q) et Sp(n,R) et applications a l'etude des representations.- S¿es compl¿ntaires associ¿ ¿ertains paraboliques de SU(n,n).- Un theoreme central-limite.- Sur les coefficients des representations unitaires des groupes de Lie simples.- Sur la chomologie continue des representations unitaires irreductibles des groupes de lie semi-simples complexes.- An application of topological paley-wiener theorems to invariant differential equations on symmetric spaces.- La transformation de Fourier et son inverse sur le groupe des ax+b d'un corps local.- Positive definite spherical functions on a non-compact, rank one symmetric space.- Un theoreme de structure pour les sous-groupes fermes, connexes des groupes extensions compactes de groupes nilpotents.- Approximating lie algebras of vector fields by nilpotent lie algebras.- Sur 1a 1-cohomologie des repr¿ntations unitaires de certains groupes de Lie.- Character formulas for the discrete series for semisimple Lie groups.- Compactifications of symmetric spaces and harmonic functions.- Integrales d'entrelacement pour un groupe de Chevalley sur un corps p-adique.- Marches aleatoires sur les espaces homogenes des groupes de Lie nilpotents simplement connexes.- Une serie degeneree de representations de SLn(R).- Travaux de Kostant sur la serie principale.- Quelques resultats sur l'analyse harmonique dans l'espace symetrique non compact de rang I du type exceptionnel.- Espaces homogenes moyennables et representations des produits semi-directs.- L'inegalite de hardy pour l'espace H1(SU(2)).- L'analyse harmonique sur les espaces symetriques de rang 1 une reduction aux espaces hyperboliques reels de dimension impaire. 660 pp. Englisch, Französisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Avec des contributions de nombreux expertes 464 pp. Englisch, Französisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains the results of the 7th International Symposium on Acute Care, held in Rio de Janeiro from 21st to 24th November 1977. I would like to thank all the participants for their wonderful cooperation which made this Symposium a real success. I am especially grateful to the excellent speakers from all special ist fields and from all nations: I assure you, we all learned a great deal! I would also like to thank the members of the organizing and scientific committees whose combined efforts ensured the smooth running of the Symposium, a meeting with a high-level discussion of scientific and philosophic problems as its goal. But first and foremost, we should like to express profound gratitude to the man whose idea it was to hold an annual conference in Rio: Dr. Brenildo Tavares, the Director of the Rio Symposia on Acute Care. He is one of the great pioneers of intensive, critical, acute, and emergency care, not only in.south America, but allover the world. The secret of the success of his symposia lies in his interdisciplinary and international approach. The symposia have brought together a great number of people who have since become close friends and continue to meet throughout the world. We all congratulate and thank him and wish him much success in the future. 368 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. General Aspects.- Prognostic Factors and Nosological Criteria of Breast Cancer from the Pathologist¿s Point of View.- Growth Rate of Tumours and Natural Life Expectancy.- The Reporting of Non-significant Results in Clinical Trials.- Notes on Clinical Trial Methodology.- 2. Design and Performance of Clinical Trials.- The Cardiff Mastectomy Trial.- Experiences from a Multicentric Trial of Adjuvant Chemotherapy.- Thirty Years Experience with Breast Cancer Clinical Trials at the Christie Hospital in Manchester ¿ Clinical Aspects.- Thirty Years Experience of Breast Cancer Trials in Manchester ¿ Statistical Aspects.- The King¿s/Cambridge Trial.- Operable Breast Cancer with Positive Axillary Nodes: The Experience of the Milan Cancer Institute.- 3. Treatment Departures.- Problems in Withdrawal of Patients in a Randomized Study, when Treatment in One of the Groups Cannot be Carried Out.- Treatment Departure and Survival Analysis in a Randomized Trial on the Value of Pre- and Postoperative Radiotherapy in Breast Cancer.- 4. Stochastic Models.- Stochastic Models in Clinical Trials.- 5. Regression Models.- Aspects of the Cox Model in the Analysis of Survival Data.- Time Dependend Covariates.- A Large Sample Study of the Estimate for the Survival Distribution in Cox¿s Regression Model.- 6. Competing Risks.- Comparing Treatments, Adjusting for Competing Risks.- Why the Present Approach to Competing Risks Should be Abandoned.- Competing Risk Models in Early Breast Cancer Trials.- 7. Log Rank Test.- Some Extensions of the Log Rank Test.- Discussion.- Appendix Controlled Illness Processes with Incomplete Information ¿ A Re-examination of the Basic Hypothesis in Constructing Stochastic Models P. Tautu.- List of Participants. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -F. Melchers, M. Potter, NL. Warner HISTORICAL Prior to 1964 many workers had experienced considerable difficulty in establishing continuous lines of murine plasmacytoma in culture. Pettingill and Sorenson in 1966 grew X5563 after a painstaking period of adaptation. During a visit to the Salk Instiute in 1965 Leo Sachs began experiments with K. Horibata,E. S. Lennox and M. Cohn that ulti mateley convinced most workers that murine plasmacytomas could be grown in vitro with ease. They adapted MOPC-21 {called P3 at the Salk Institute) to in vitro culture and showed the cells produced a large amount of the IgG1 myeloma protein. Horibata, Lennox and Sachs did not report the important finding though a manuscript was written and accepted. The reason for the failure to publish the paper was that the original line was not recovered from the freezer and knowing there would be many requests for it the paper was withdrawn. As it later turned out, the failure to recover the line may have been triv ial, for Horibata and Harris (1970) soon re-established a continuous line of P3 now named P3K. This line was distributed to other workers including Cesar Milstein in Cambridge. Soon after the success with P3, Scharff and colleagues at Albert Einstein established MPC-11 in cul ture. Up to now continuous growth of human myeloma cells in vitro has remained a formidable problem. 276 pp. Englisch.