Springer springer us okt 2011 (801 risultati)

Taschenbuch. Condizione: Neu. Neuware - In 1937 there appeared a paper that was to have a profound influence on the progress of combinatorial enumeration, both in its theoretical and applied aspects. Entitled Kombinatorische Anzahlbest immungen jUr Gruppen, Graphen und chemische Verbindungen, it was published in Acta Mathematica, Vol. 68, pp. 145 to 254. Its author, George Polya, was already a mathematician of considerable stature, well-known for outstanding work in many branches of mathematics, particularly analysis. The paper in Question was unusual in that it depended almost entirely on a single theorem -- the 'Hauptsatz' of Section 4 -- a theorem which gave a method for solving a general type of enumera tion problem. On the face of it, this is not something that one would expect to run to over 100 pages. Yet the range of the applica tions of the theorem and of its ramifications was enormous, as Polya clearly showed. In the various sections of his paper he explored many applications to the enumeration of graphs, principally trees, and of chemical isomers, using his theorem to present a comprehen sive and unified treatment of problems which had previously been solved, if at all, only by ad hoc methods. In the final section he investigated the asymptotic properties of these enumerational results, bringing to bear his formidable insight as an analyst.…

Taschenbuch. Condizione: Neu. Neuware - Evolutionary Biology, of which this is the twenty-second volume, continues to offer its readers a wide range of original articles, reviews, and commentaries on evolution, in the broadest sense of that term. The topics of the reviews range from anthropology, molecular evolution, and paleobiology to principles of systematics. In recent volumes, a broad spectrum of articles have appeared on such subjects as asymmetric sexual isolation, biochemical systematics in plants, species selection, DNA hybridization and phylogenetics, modes of evolution in Pleistocene rodents, and development and evolution of the vertebrate limb. We have also attempted to provide a forum for con flicting ideas. Articles such as these, often too long for standard journals, are the material for Evolutionary Biology. The editors continue to solicit manuscripts on an international scale in an effort to see that everyone ofthe many facets of biological evolution is covered. Manuscripts should be sent to anyone of the following: Max K. Hecht, Department of Biology, Queens College of the City University of New York, Flushing, New York 11367; Bruce Wallace, Department of Biology, Virginia Polytechnic Institute and State University, Blacks burg, Virginia 24061; GhilleanT. Prance, New York Botanical Garden, Bronx, New York 10458. The Editors vii Contents 1. Phylogeny of Early Vertebrate Skeletal Induction and Ossification Patterns . 1 John G. Maisey Introduction: The Fossil Record. . . . . . . . . . . . . . . . 1 . …

Taschenbuch. Condizione: Neu. Neuware - The relationship of theoretical and applied linguistics has lately prompted numer ous debates. This volume originated at one of them. The essence of most of the chapters, of all of them except Fraser's and Davies's, was actually presented at the Round Table on 'The Relationships of Theoretical and Applied Linguistics,' organized during the 7th World Congress of Applied Linguistics, held in Brus sels, in August 1984. Individually and collectively the chapters assembled here offer support to the idea that applied linguistics should not be juxtaposed to theoretical linguistics; it is a field of research with theoretical as well as applied aspects. Written by different authors from a wide variety of different countries, the chapters may at times express views that are not totally consistent. Nevertheless, we believe that the variability of viewpoints counts among the merits (rather than the defaults) of this internationally written and edited volume. It is our hope that it will prove stimulating to linguists and practitioners in related fields and instructive to students. We wish to express our thanks to Albert Valdman for the interest he has shown in the volume and to record our appreciation to our editors, in particular Eliot Werner and Declan Scully, for their tolerance and patience.…

Taschenbuch. Condizione: Neu. Neuware - The organization of data is clearly of great importance in the design of high performance algorithms and architectures. Although there are several landmark papers on this subject, no comprehensive treatment has appeared. This monograph is intended to fill that gap. We introduce a model of computation for parallel computer architec tures, by which we are able to express the intrinsic complexity of data or ganization for specific architectures. We apply this model of computation to several existing parallel computer architectures, e.g., the CDC 205 and CRAY vector-computers, and the MPP binary array processor. The study of data organization in parallel computations was introduced as early as 1970. During the development of the ILLIAC IV system there was a need for a theory of possible data arrangements in interleaved mem ory systems. The resulting theory dealt primarily with storage schemes also called skewing schemes for 2-dimensional matrices, i.e., mappings from a- dimensional array to a number of memory banks. By means of the model of computation we are able to apply the theory of skewing schemes to var ious kinds of parallel computer architectures. This results in a number of consequences for both the design of parallel computer architectures and for applications of parallel processing.…

Taschenbuch. Condizione: Neu. Neuware - Plasma cell dyscrasias are common causes of peripheral neuropathy. Peri pheral neuropathy may be the first manifestation of multiple myeloma, amyloidosis, or monoclonal gammopathy of undetermined significance (MGUS). Peripheral neuropathy occurs in more than one-half of patients with osteosclerotic myeloma. The hematologic disorders are such an important association with peripheral polyneuropathy that, for the last decade, we have obtained a metastatic bone survey and immunoelectrophoresis of serum and a 24-hour urine specimen on all patients older than 40 years with undiagnosed peripheral neuropathy. This textbook on polyneuropathies and plasma cell dyscrasia is welcome, because the subject is of considerable medical importance and because the authors are expert in these disorders. Kelly's studies have shown that a systematic search for monoclonal proteins in plasma and urine among patients with neuropathy of unknown cause increases diagnostic yield. Latov's studies have focused on the role of myelin associated glycoproteins (MAG) in the induction of neuropathy. Kyle, director of the Special Protein Laboratory at Mayo Clinic, brings a broad clinical and laboratory perspective and experi ence. The timing of the textbook is just right, because there is much new information which needs to be summarized.…

Taschenbuch. Condizione: Neu. Neuware - Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.…

Taschenbuch. Condizione: Neu. Neuware - The present volume of essays on industrial organization, which are based on conferences held at Nijenrode and Brussels, differs considerably from its predecessor. Even more than in the first volume the essays demonstrate the broad scope of industrial organization analysis. Besides the traditional topics such as economies of scale, monopoly and competition policy, there are essays on methodology, on stagflation, and on the relationship between industrial struc ture and international trade and trade policies. The latter topics are of growing importance. The issue of restructuring industries and the question of whether free trade or some measure of protection is more appropriate are topics of increasing relevance today (and will no doubt continue to be in future years as well). The problem of persistent inflation which other essays address is also of major concern. Apart from being broad in scope and venturing into new fields, this volume is also controversial. Its central feature is a debate about welfare aspects. Here, more than in pure analysis, economists tend to entertain different points of view. One of the participants in the Nijenrode conference, Professor John Blair, who died in December 1976 and whom we honour as having been an active promoter of this kind of meeting, wrote to the editors shortly before his death to say that the first volume had succeeded very well in acquainting the reader with the results of empirical investigations, notably on trends and levels of concentration.…

Taschenbuch. Condizione: Neu. Neuware - A symposium seems an appropriate vehicle to review recent, as well as new, data on important topics. It is therefore our goal to present a symposium on selected topics of importance every three years. Some topics will be updated and new topics will be presented. A vast amount of information has been accumulated over the past ten years on the significance of anaerobic bacteria in infectious diseases. This symposium was organized to discuss laboratory aspects, normal flora, pathogenicity, serology, and the patients' immune re sponse to anaerobic infection. Important imformation on the patients' immune response and serology of anaerobes which has accumulated over the last few years made these topics an important part of the sympo sium. Development of serological diagnostic tests undoubtedly will provide quicker and less expensive identification of certain anaerobic species in the future. Utilization of the patients' immune response to anaerobic septicemia has the potential of providing a diagnosis of the causative agent within 24 hours after onset of symptoms. The development of such diagnostic methods and the use of these methods in the clinical laboratory in the future would provide rapid diag nostic information to the clinician on these life-threatening infec tions. Campylobacter was included in the symposium to emphasize the important role of this organism in human acute gastroenteritis. The pathogenesis of Campylobacter in gastroenteritis has been recognized in certain European countries since 1972, although we have recognized the importance of Campylobacter gastroenteritis in the United States only within the past two years.…

Taschenbuch. Condizione: Neu. Neuware - To understand what we know and be aware of what is to be known is a necessary approach to treating CAD/CAM issues. The challenge for all of us interested in CAD/CAM and engineering data handling is to under stand what we know and what we need to know about today's and tomorrow's technology, to track the explosive development of our field and its broadening range of applications, to sort through the details which compete for our attention, and to perceive underlying trends. A key development in the past year was the rapid and widespread acceptance by all user segments of personal computer-based CAD/CAM workstations, coupled with widespread use of software packages, both those developed for PC-based workstations and others converted from main frame and mini systems for use on PC-based or 32-bit workstations. If this trend continues for a few more years, as much as 900/0 of all design work may be accomplished on advanced versions of PC-based workstations. Many software systems vendors unknown until recently to the PC-based CAD/CAM community have now come to dominate the market-companies such as Autodesk, Chessell-Robocom, Future Net, T&W Systems, P-CAD, Cascade, 4-D Graphics, CADAM, Wang & Hornbuckle, and more than 20 other companies who sell PC-based CAD/CAM software.…

Taschenbuch. Condizione: Neu. Neuware - This volume has been composed to commemorate the day, 25 years ago, that Dr. P. J. Verdoorn delivered his inaugural lecture after his appointment as professor of economics at the Netherlands School of Economics at Rotterdam. The prompt and enthusiastic reactions by several members of the profession on our request for a contribution illustrates the fact that Verdoorn is held in high esteem by those who worked with him and those who are acquainted with his work. We thank all the contributors for having helped us to realize our plan to honour Verdoorn with the publication of this 'liber amicorum'. Verdoorn was appointed part time professor of business statistics, market research and marketing in 1952. He held this post until 1969. In that year he started lectures closer related to his work as deputy director of the Central Planning Bureau: general economic research. He became full professor of macro-economic policy in 1975. Verdoorn showed a great versatility in all the fields on which he worked. Without exaggeration he may be characterised as one of the most many-sided economists in the Nether lands. However much the subjects he studied may have varied, the methods he applied show persistent characteristics: theories are formulated to yield testable hypotheses which, when they can be maintained, are made operatio nal for policy purposes. In all these phases of a research program Verdoorn showed a high level of inventivity. A combination of rigour and imagination enabled him to maintain a constant stream of high-quality publications.…

Taschenbuch. Condizione: Neu. Neuware - In cats anesthetized lightly with pentobarbital or alpha-chloralose, electrical stimulation of the paramedian lobule of cerebellum resulted in a change of EEG pattern. Prior to stimulation the pattern consisted of h igh-ampl itude slow waves with superimposed low-ampl itude fast activity. In addition, the EEGs of animals anesthetized with chloralose showed 'chloralose spikes'. Immediately following brief cerebellar stimulation the slow wave activity and spikes disappeared, leaving only low-voltage fast activity. The effect was most pronounced in the contralateral leads from the rostral portions of the cerebrum. Study of the parameters most effective in evoking this effect revealed that stimulation frequency, train duration, and probably pulse duration affected the duration of suppression in a sigmoid fashion, with inflection points at approximately 90 Hz, 2.5 sec, and 1 msec, respectively. Above threshold values, stimulation cur rent showed an approximately linear relationship to duration of EEG sup pression. The after-discharge resulting from focal electrical stimulation of the cerebral cortex could be shortened by electrical stimulation of the para median lobule. The effect was essentially the same when cerebellar stim ulation preceded, occurred during, or followed the cerebral cortical stim ulation. The great variability of the after-discharge resulting from cerebral cortical stimulation as well as the variability of the effects of cerebellar stimulation made it impractical to study systematically the parameters op timal for shorten ing after-discharge. Such a study wi II require use of an awake, preferably partially restrained animal with electrodes chronically implanted.…

Taschenbuch. Condizione: Neu. Neuware - The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.…

Taschenbuch. Condizione: Neu. Neuware - The papers in this volume were presented as part of the University of Kansas Department of Anthropology Distinguished Lecture Program on Anthro pological Genetics. Consecutively, each contributor spent approximately a week on the campus at Lawrence participating in a seminar. The contributors to this volume were not on campus at one time, but visited us on alternating weeks; hence, a symposium-type interchange was not possible between all participants. However, the students and faculty of Kansas University acted as a sounding board. This volume can be considered a companion and continuation of Methods and Theories of Anthropological Genetics, which was based upon a symposium on the state of the art in 1971. This present volume reflects what we consider to be some of the advances and current developments in anthropological genetics since 1973. Emphasis has shifted, to some degree, away from population struc ture analysis (as depicted in Crawford and Workman) to genetic epidemiology. However, population structure still remains a fertile and ongoing area of research with many theoretical questions still remaining unanswered.…

Taschenbuch. Condizione: Neu. Neuware - This book is an edited selection of the papers presented at the International Workshop on VLSI for Artiflcial Intelligence which was held at the University of Oxford in July 1988. Our thanks go to all the contributors and especially to the programme committee for all their hard work. Thanks are also due to the ACM-SIGARCH, the Alvey Directorate, the lEE and the IEEE Computer Society for publicising the event and to Oxford University for their active support. We are particularly grateful to David Cawley and Paula Appleby for coping with the administrative problems. Jose Delgado-Frias Will Moore October 1988 Programme Committee Igor Aleksander, Imperial College (UK) Yves Bekkers, IRISA/INRIA (France) Michael Brady, University of Oxford (UK) Jose Delgado-Frias, University of Oxford (UK) Steven Krueger, Texas Instruments Inc. (USA) Simon Lavington, University of Essex (UK) Will Moore, University of Oxford (UK) Philip Treleaven, University College London (UK) Benjamin Wah, University of Illinois (USA) Prologue Research on architectures dedicated to artificial intelligence (AI) processing has been increasing in recent years, since conventional data- or numerically-oriented architec tures are not able to provide the computational power and/or functionality required. For the time being these architectures have to be implemented in VLSI technology with its inherent constraints on speed, connectivity, fabrication yield and power. This in turn impacts on the effectiveness of the computer architecture.…

Taschenbuch. Condizione: Neu. Neuware - This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.…

Taschenbuch. Condizione: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitour inary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…

Taschenbuch. Condizione: Neu. Neuware - During the past three decades, the sugar moiety of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and to participate in a variety of cellular functions. The long polysaccharide side chains of the lipopolysaccharides on the outer membrane of Gram negative organisms provide surface antigens for differential serodiagnosis. Bacterial surface lectins are important in mediating the attachment of bacteria to host cells in the of infectious diseases. The carbohydrate pathogenesis moieties of cell surface glycoconjugates (glycoproteins and glycolipids) of mammals are the sites for intercellular recognition and for the regulatory molecular interactions such as interaction of complex carbohydrate with hormones or hepatic lectins. The carbohydrate side chains of many complex carbohydrates play essential roles as antigenic determinants b of human blood group ABH, Lea, Le , I, and i activities, as the Forssman specific determinant, and as tumor associated antigenic determinants. Prompted by these and other advances in the field, a Symposium on Molecular Immunology of Complex Carbohydrates was organized as a satellite meeting of the 8th International Glycoconjugate Conference held on September 8- 13, 1985, in Houston, Texas, U. S . A. Many eminent scientists contributed their knowledge at this meeting. The lecture and poster materials of the symposium are contained in this proceeding book, which is divided into four Sections and one Appendix. Section I is entitled Antibody Specificity, Epitope, and Lectinology. Dr. Elvin A.…

Taschenbuch. Condizione: Neu. Neuware - Developments in the field of instrumentation of innovative instrumentation. Although laser applications have permeated nearly every aspect are among the major contributions to human advancement. The history of surgery has seen of surgical therapy, the expectations have fre many revolutionary developments cause quantum quently been unrealistic and the evaluation of leaps in progress. Electrocautery, the anesthesia technological development has always been machine, computed axial tomography, and the painfully slow. The properties of vaporization, surgical microscope are all revolutionary in coagulation, and cutting unified in an invisible struments that have irrevocably changed the shaft of light have enabled the neurosurgeon to direction of neurological surgery. vaporize inaccessible tumors of brain and spinal In the early stages of application, there are cord, harness recalcitrant bleeding sites, and cut always detractors and valid controversy concern through the most formidable calcified tumors. ing the value of a new instrument. Some will The application of this new energy form in remember those who argued that the magnifica tandem with the surgical microscope has, in my tion and illumination provided by the micro opinion, extended the scope of all aspects of scope were not valuable to the skilled surgeon neurosurgery. We have much more work to do. and would prolong the operative time and in lt is necessary to document improved results and crease infection rates. Others may recall that demand technological advances and safe inno Cushing was told to abandon the blood pressure vations.…

Taschenbuch. Condizione: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung can cer, genitourinary cancer, pediatric oncology, etc.; second, by asking emi nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…

Taschenbuch. Condizione: Neu. Neuware - This book is the compilation of papers presented at the International Symposium on in vivo Body Composition Studies, held at the University of Toronto, Ontario, Canada, June 20 - 23, 1989. The purpose of this conference was to report on advances in techniques for the in vivo measurement of body composition and to present recent data on normal body composition and changes during disease. This conference was the most recent of several meetings on body composition studies, and follows two successful such meetings, one at Brookhaven National Laboratory in 1986, and at Edinburgh in 1988. The large number of excellent research papers and posters presented at these conferences demonstrates the rapid growth of the field and the broad interest in the subject of in vivo body composition studies. The proceedings of the Brookhaven meeting 'In Vivo Body Composition Studies', is published by The Institute of Physical Sciences in Medicine, London. Both the Brookhaven and the current Toronto meeting emphasized the clinical applications, together with the techniques employed. The Edinburgh meeting placed more emphasis on the methodological problems and design of instrumentation. Because of the number of papers presented at the meeting it was necessary to ask the authors from the same institution to combine their presentations into a single paper where appropriate. The editors wish to thank the authors for their cooperation and for graciously accepting the minor revisions made to each manuscript.…

Taschenbuch. Condizione: Neu. Neuware - Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long term survivors from disseminated disease, these are only a small proportion of the total. Breast cancer, although 'sensitive' to a multitude of drugs appears to have yielded neither survival benefit, nor cure to the efforts of therapists, while tumours such as those of the colon remain stubbornly unresponsive. Against this backcloth it is apparent that additional more selective treatments are needed if further impact is to be made on the problem of cancer. The development of such agents requires the integration of a multidisciplinary effort encompassing the fields of chemistry, biology and medicine. This symposium provided a forum for clinical and preclinical sCientists, where current aspects of cancer treatment were reviewed and approaches to the development of a new generation of more selective anticancer drugs discussed.…

Taschenbuch. Condizione: Neu. Neuware - This book originated at a meeting of American and European specialists in in dustrial organization, at the Instituut voor Bedrijfskunde, Nijenrode (The Netherlands) in August, 1974. The conference endeavored to bring together re searchers in a field where, paradoxically, the underlying phenomena studied are increasingly coordinated and internationalized, yet the observers remain pre dominantly isolated. Only rarely do they resort to comparisons between coun tries, and still less frequently to an analysis from a transnational outlook. As the contributions to this collection demonstrate, it has become clearer and clearer that -whether or not as a result of a random process, or of technological conditions, or of deliberate enterprise strategy - the determinants of market structures and their changes as time passes, have created fundamentally similar effects in different countries, resulting in industrial structures of the same kind. Thus, the largest firms and plants are found in the same sectors, and the most concentrated industries are more or less the same from one country to the other. The studies of Prais, Reid, Jacquemin & Phlips and Linda likewise show that a broad trend toward concentration has been manifest. …

Taschenbuch. Condizione: Neu. Neuware - Neoplastic disease confined to the liver is an important worldwide problem. In the industrialized nations, metastatic disease of the most common cancers involves the liver in upwards of 50% of cases. Primary hepatic tumors are virtually epidemic in most third world countries and certainly constitute one of the ten most common causes of cancer deaths on a worldwide scale. Amazingly, little specific attention has been devoted to therapeutic approaches of liver and biliary tumors until recently. We attribute this apparent lack of interest to the uniformly poor progno sis of patients so afflicted, and attribute the renewed interest to the exciting new developments in diagnostic and therapeutic technology as well as in tumor biology. The purpose of this book is to collect in one volume an integrated selection of articles that would provide the therapist with a comprehensive, yet practical, overview of liver cancer. We believe the contributors to the book are superbly qualified experts on the various subjects and provide in-depth information on respective fields. The edit ing process for us was not only educational but thrilling as the high quality and complementary nature of the chapters became evident as we received them. Be cause many areas in the field of liver cancer are controversial, the reader will notice that contradictory opinions are presented by some of the authors.…

Taschenbuch. Condizione: Neu. Neuware - From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983.

Taschenbuch. Condizione: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear spo radically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourina ry cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…

Taschenbuch. Condizione: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis of management of a particular malignancy The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single per sonal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an an nual or biannual basis. Each topic and tumor type is covered in a volume appear ing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…

Taschenbuch. Condizione: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis or management ofa particular malignancy The few general onco logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimi nary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can nev er be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by div iding the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…

Taschenbuch. Condizione: Neu. Neuware - Lung cancer remains an extremely difficult neoplasm to treat effectively. A large part of our lack of success in dealing with these patients is related to our empiric therapeutic attempts. Slowly our basic understanding of the lung cancers is improving and techniques are becoming available to allow us to better understand the biology of these neoplasms. This volume reviews several areas of interest in regard to the biologic behavior and characteris of lung cancer. tics Chapters deal with the in vitro growth of small cell lung cancer, the inves tigation of growth factors in human lung cancer, the production of mono clonal antibodies against lung cancer and the application and potential use fulness of the human tumor cloning assay in lung cancer management. These avenues of investigation are likely to establish a more scientific basis on which more rational therapy can be designed. Carney and associates have established several continuous small cell lung cancer cell lines in their laboratory. The amine precursor uptake and decar boxylation (APUD) properties of this neoplasm have been confirmed by demonstrating the presence of neurosecretory granules and high levels of the APUD enzyme L-dopa decarboxylase. In addition, several new markers have been documented including bombesin, creatine-kinase BB and neuron specific enolase. These tumor products along with others may be useful serum markers in patients with small cell lung cancer.…

Taschenbuch. Condizione: Neu. Neuware - The importance of protecting the environment against pollution is an objective which gained international acceptance in the recent years. According to the first principle of the Declaration of the United Nations Conference on the Human Environment which took place in Stockholm in 1972, 'man . bears a solemn responsibility to protect and improve the environment for present and future genera tions'. The United Nations again in their desire to improve the sanitation conditions allover the world decided to proclaim the period between 1981-1990 as the 'International Drinking Water Supply and Sanitation Decade.' Although attempts have been made by inter national organizations to prevent pollution, it is difficult to say that these attempts gave satisfactory results in developing countries. The most common reasons of failure are: a) To find solutions to their environmental problems, develop ing countries usually seek the assistance of engineers and scientists from developed countries. Many times, how ever, either out of ignorance of the local condition or due to financial motivations, these experts come out with solutions which are far from being considered as the 'most appropriate.' As a result, the basic objective of protecting the environment is not achieved. b) Attempts made by developed countries to 'export' their wastes - especially the hazardous ones - to the developing world, is another danger - and sometimes reason of failure encountered in the field of Environmental Management.…

Taschenbuch. Condizione: Neu. Neuware - This volume contains the papers presented at the Fifth International Workshop on Database Machines. The papers cover a wide spectrum of topics on Database Machines and Knowledge Base Machines. Reports of major projects, ECRC, MCC, and ICOT are included. Topics on DBM cover new database machine architectures based on vector processing and hypercube parallel processing, VLSI oriented architecture, filter processor, sorting machine, concurrency control mechanism for DBM, main memory database, interconnection network for DBM, and performance evaluation. In this workshop much more attention was given to knowledge base management as compared to the previous four workshops. Many papers discuss deductive database processing. Architectures for semantic network, prolog, and production system were also proposed. We would like to express our deep thanks to all those who contributed to the success of the workshop. We would also like to express our apprecia tion for the valuable suggestions given to us by Prof. D. K. Hsiao, Prof. D.…