springer us apr 1983 (5 risultati)

Buch. Condizione: Neu. Neuware - In Harch of 1980, we organized the first symposium on how to evaluate new antiarrhythmic agents in which the participants included members of the Cardio-Renal Division of the Food and Drug Administration, academic investigators from the United States and Abroad and directors and imple mentors of pharmacological research representing the pharmaceutical industry. By bringing together all three elements, it was hoped that better communication and under standing would ensue to more rapidly bring new cardiac agents to the American public. This goal was important since a rather limited number of antiarrhythmic agents were and are currently available to treat patients with such disorders in the United States. These agents are needed not only for the treatment of patients with sustained ventricular tachyarrhythmias which produce life-threatening hemodynamic consequences but also and in fact more potentially important as a prophylactic measure in the high risk patient subject to sudden cardiac death. This book represents the proceedings of the third of these Symposiums whose purpose was to evaluate the clinical research methodology and models used in the evaluation of ne' antiarrhythmic agents for not only acute therapeutic inter vention but also for the prophylaxis of sudden cardiac death. In addition, new devices have evolved over the past few years that can detect and treat life-threatening cardiac arrhythmias and the evaluation of efficacy and safety of these devices is detailed.

Buch. Condizione: Neu. Neuware - In addition to performing its prime function as a vehicle for scientific communications of varied colora tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth. One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes. This is a very broad subject that calls for broader coverage than could be included in one book issue. However, I have elected to include only certain contributions that serve as general examples of the principles involved. There are six articles on enzyme regulation in hepatocyte culture. These include arginase and argino-succi nate synthetase, y-glutamyl transferase and plasminogen activitor. Other regulatory enzymes that are discussed are protein kinases, 2,3-bisphosphoglycerate synthetases, carbamoyl phosphate synthetase, heme oxygenase, cytochrome P-450, tyrosine hydroxylase, fatty acid synthetase, acetyl eoA carboxylase, among others. Also included is the regulation of several enzyme messengers RNAs. As in the past, subscribers to the journal will receive this double volume as a continuation of regular issues of the journal Molecular and Cellular Biochemistry. This double volume will also be available separately in the form of a book issue to interested readers through Martinus Nijhoff Publishers. v.A. Najjar Part I Molecular and Cellular Biochemistry 53;54,11-21 (1983). 1983, Martinus 1 ij hoff Publishers. Boston. Printed in The Netherlands.

Buch. Condizione: Neu. Neuware - The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978, the 'International Conference on Physiological and Regulatory Funetions of Adenosine and Adenine Nueleotides,' held in Banff, Canada, served as an effective catalyst in enabling scientists with differ ent points of view to exchange information and ideas on this subject. Since 1978, the amount of research on different as peets of adenosine metabolism, mechanism of action, transport, and function in various tissues (in both nor maI and abnormal states) has increased exponentially, and there was an urgent need for another meeting for updating information on this burgeoning subject. The focus of the meeting was extremely sharp, but the scope of the subject material was very broad. Scientists categorized as chemists, biochemists, physiologists, pharmacologists, and immunologists, working with cells and eelI fragments, with tissues such as heart, brain, musele, fat, kidney, and with human beings having immune deficiency diseases participated in the sym posium. They had an opportunity to air their differences, reinforce their areas of agreement, and, most important, they educated each other with respeet to research on adenosine; it is hoped that they also enriched their own research programs from the information they gained from their fellow participants.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Why another dermatology text In 1973, when Drs. Nasemann and Sauerbrey wrote the introduction to the first edition of Haut krankheiten und venerische Infektionen. they addressed this question. They promised their book would be concise and profusely illustrated to best teach the fundamentals of dermatology. The German text, now in its fourth edition, has been widely successful. In undertaking an American revised translation of their work, it was my hope to meet a need in the English-language literature similar to that met by the German text. I believe that both students and non dermatologic physicians will find this volume a useful introduction to the art and science of treating skin disorders. The practice of dermatology differs from country to country. This text is therefore not simply a translation, but an adaptation that incorporates much new material. In the pages that follow, I have built on the successful framework of the German text, incorporating its excellent photographs and other teaching aids. Discussion of therapy has been extensively revised to reflect current practice in the United States. Original chapters on male infertility and proctology (two dermatologic domains in Germany) are not included in this book. They have been replaced by wholly new chapters on cutaneous surgery and tropical dermatology. We are grateful to Ronald G. Wheeland, M.D., for contributing the surgical chapter.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 396 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -application was given describing the research No fund-raising technique is as effective as a personal presentation, a detailed discussion be techniques, pre-application negotiations with the tween the applicant and the potential funder of granting agency, and the strong features of the the proposed activity held before the written re written application that contributed to its success. quest is submitted. If, during the discussion, the Examples that have appeared and continue to appear in GRANTS MAGAZINE were sug presentation is made effectively, the chance of success is immeasurably greater and the final gested or contributed by many people, among preparation of the application is comparatively them the magazine's editors, editorial board members, and their colleagues, friends, and easier. It is not, unfortunately, always possible to associates many of whom are successful grantees make a personal presentation. In many, actually or administrators of grant programs. It became most, cases the only form of contact the applicant clear from the number of reprint requests for the has with the funding organization is the written Grant Clinic feature that a compendium of some request. And even in those cases where there has examples that had appeared there would make a been extensive discussion, there always comes a time useful reference volume containing exemplary when a request must be presented in writing in some form. applications. 252 pp. Englisch.