springer us apr 2012 (361 risultati)

Taschenbuch. Condizione: Neu. Neuware -Statistics is of ever-increasing importance in Science and Technology and this book presents the essentials of the subject in a form suitable either as the basis of a course of lectures or to be read and/or used on its own. It assumes very little in the way of mathematical knowledge-just the ability to substitute numerically in a few simple formulae. However, some mathematical proofs are outlined or given in full to illustrate the derivation of the subject; these can be omitted without loss of understanding. The book does aim at making clear the scope and nature of those essential tests and methods that a scientist or technologist is likely to need; to this end each chapter has been divided into sections with their own subheadings and some effort has been made to make the text unambiguous (if any reader finds a misleading point anywhere I hope he will write to me about it). Also with this aim in view, the equality of probability to proportion of population is stated early, then the normal distribution and the taking of samples is discussed. This occupies the first five chapters. With the principles of these chapters understood, the student can immediately learn the significance tests of Chapter 6 and, if he needs it, the analysis of variance of Chapter 7. For some scientists this will be most of what they need. Howcver, they will be in a position to read and/or use the remaining chapters without undue difficulty.

Taschenbuch. Condizione: Neu. Neuware - The first ACS Adhesion Symposium was held in Washington, D.C., September 1971. During the four years since that meeting, much interest in adhesion has been generated among six divisions of the American Chemical Society. Then, in 1974, the Macromolecular Secretariat appointed me to work closely with the six Session chairmen in organizing this Symposium on Science and Technology of Adhesion. Needless to say, the success of the Symposium which took place between April 7 and 10, 1975 in Philadelphia, Pa., is due to their excellent cooperation and the enthusiastic response of con tributors. As originally planned, each division was responsible for one session, and most of the papers, including several late con tributions, are published in these two volumes of proceedings. During the Symposium, we held a banquet in honor of Professor Herman Mark in celebration of his eightieth birthday. His Plenary Lecture and the Symposium Address by Professor Murray Goodman are published in full at the beginning of the first volume. I thank Professors Mark and Goodman for their excellent presentations on this memorable occasion.

Taschenbuch. Condizione: Neu. Neuware - Examination of the tables of contents of journals - biochemical, molecular biological, ultrastructural, and physiological-provides convincing evidence that membrane biology will be in the 1970s what biochemical genetics was in the 1960s. And for good reason. If genetics is the mechanism for main taining and transmitting the essentials of life, membranes are in many ways the essence of life. The minimal requirement for independent existence is the individualism provided by the separation of 'life' from the environment. The cell exists by virtue of its surface membran~. One might define the first living organism as that stage of evolution where macromolecular catalysts or self-reproducing polymers were first segregated from the surrounding milieu by a membrane. Whether that early membrane resembled present cell membranes is irrelevant. What matters is that a membrane would have provided a mechanism for maintaining a local concentration of molecules, facilitating chemical evolution and allowing it to evolve into biochemical evolution. That or yet more primitive membranes, such as a hydrocarbon monolayer at an air-water interface, could also have provided a surface that would facilitate the aggregation and specific orientation of molecules and catalyze their interactions. If primitive membranes were much more than mere passive barriers to free diffusion, how much more is this true of the membranes of contemporary forms of life. A major revolution in biological thought has been the recogni tion that the cell, and especially the eukaryotic cell, is a bewildering maze of membranes and membranous organelles.

Taschenbuch. Condizione: Neu. Neuware - This volume is the third in the Contemporary Geriatric Medicine series. As in previous volumes, information is presented in the form of easy-to read essays to bring the reader up to date on state-of-the-art develop ments in the area of geriatric medicine. Once again, a system approach is utilized. In addition, several new topics-including alcoholism, throm boembolic disease, and decubitus ulcer management-have been intro duced to enhance this volume's usefulness to the busy clinician and student. Each chapter is not meant to be an exhaustive review of all topics in the field, but rather to focus on issues currently receiving a great deal of attention. Our goal continues to be to create an exciting approach to contemporary issues in geriatric medicine. The editors are once again appreciative for having been given the opportunity to develop this series. Appreciation is also expressed to our professional colleagues, families, and administrative assistants, who have enabled this volume to reach fruition. As in the past, we thank, most of all, our elderly patients for providing the inspiration and impetus to improve our knowledge and understanding of the health care needs of the elderly. Steven R. Gambert, M.D. V alhalla, New York ix Contents Chapter 1 Geriatric Cardiology and Blood Pressure 1 Edmund H. Duthie, Jr., and Michael H. Keelan, Jr.

Taschenbuch. Condizione: Neu. Neuware - The Conference on Emerging Priorities in Ceramic Engineer ing and Science, held at Alfred University, November 4-6, 1974, was arranged to provide a basis for reassessment of professional goals, procedures and outlook. American priorities among comfort, safety, national prestige, security, convenience and environmental quality are significantly different from those of a dozen years ago. Economic factors have shifted, as exempli fied by scarcities in energy, mate rials and world food supplies. At the same time, demands for safer products, healthier work ing conditions and fairer rules of behavior are making them selves felt. Governmental, corporate and consumer interests are all involved and they are intricately inte rrelated. Higher education, for its part, must not only respond wisely to changing student attitude, itself a part of the national scene, but must gain perspective toward the present and toward changes of yet unknown nature which can be expected in the future. Persistent and pointed questions from engineers, managers, and students were an indication to us of wide-spread concern to understand the new pattern of priorities that is presently emerging. In response to this need, Conference papers were invited from distinguished engineers, scientists, and other specialists; their willingness to contribute from their expertise and their thinking is very much appreciated by the editors. The first four chapters of the volume deal with the larger scene and with the viewpoints of those concerned with it in behalf of government, corporations and the professions.

Taschenbuch. Condizione: Neu. Neuware - When Dr. Katherine Tansley's 'Vision in Vertebrates' appeared in 1965, it filled a real void that had hitherto existed. It did so by serving at once as a text-book: for an undergraduate course, a general introduction to the subject for post-graduate students embarking on research on some aspect of vision, and the interested non-specialists. Gordon Walls' 'The Vertebrate Eye and It. s Adaptive Radiation' and A. Rochon-Duvigneaud's 'Les Yeux et la Vision des Vertebres' have served as important sources of information on the subject and continue to do so even though it is 40 years since they appeared. However, they are essentially specialised reference works and are not easily accessible to boot. The genius of Katherine Tansley was to present in a succinct (132 pages) and lucid way a clear and an interesting survey of the matter. Everyone liked it, particularly the students because one could read it quickly and understand it. Thus, when it seemed that a new edition was desirable, especially in view of the enormous strides made and the vast literature that had accumulated in the past 20 years, one of us (MAA) asked Dr. Tansley if she would undertake the task. Since she is in retirement and her health not in a very satisfactory state both she and her son, John Lythgoe (himself a specialist of vision), asked us to take over the task.

Taschenbuch. Condizione: Neu. Neuware - The goals of the science of photobiology can be divided into four categories: to develop (I) ways to optimize the beneficial effects of light on man and his environment, (2) methods to protect organisms, including man, from the detrimental effects of light, (3) photochemical tools for use in studies of life processes, and (4) photochemical therapies in medicine. To achieve these goals will require the knowledgeable collaboration of biologists, chemists, engineers, mathematicians, physicians, and physicists; because photobiology is a truly multidisciplinary science. While a multidis ciplinary science is more intellectually demanding, it also has a greater potential for unexpected breakthroughs that can occur when data from several areas of science are integrated into new concepts for theoretical or practical use. Photochemical and Photobiological Reviews continues to provide in depth coverage of the many specialty areas of photobiology. It is hoped that these reviews will provide an important service to the younger scientists in the field and to senior scientists in related fields, because they provide a ready access to the recent literature in the field, and more importantly, they frequently offer a critical evaluation of the direction that the field is taking, or suggest a redirection when appropriate. Since it is important that this review series remain responsive to the needs of photochemists and photobiologists, the Editor would value com ments and suggestions from its readers.

Taschenbuch. Condizione: Neu. Neuware - Epithelial cells are present in many different tissues in the body, and possess a diverse number of functional properties. However, all epithelial cells share some common characteristics. The cells possess a morphological polarity (an-apical and basolateral surface), and are interconnected by tight junctions. The epithelial cells also possess the capacity to transport select solutes across the monolayer. Transport systems localized on either the apical or basolateral surface are respon sible for this vectorial transport. Such characteristics of epithelial cells can be examined in the tissue culture situation. This volume discusses the use of cell culture techniques to study these fundamental properties of epithelial cells. Ma jor questions concerning epithelia which may be examined in culture are ad dressed. The approaches which are taken to answer these questions are described in detail with regards to kidney cell cultures. Similar investigations may be done with epithelial cell cultures derived from other tissues, following the kidney cell culture paradigm.

Taschenbuch. Condizione: Neu. Neuware - The aim of the editors of this volume is to use basic and ap plied studies in the field of mutagenesis to approach a problem of especial concern. The problem is that of the usage of toxic chemi cals, particularly agricultural chemicals, in ever-increasing quan tities in those parts of the world that feed the most people. Agri cultural chemicals that are in use in Pakistan are emphasized here. These are the same chemicals that are in use throughout the develop ing world, although the quantities of the different types that are used may vary from country to country, and from region to region within countries. A number of these chemicals can no longer be sold in Europe or in the United States, and it is often difficult to iden tify a scientific reason as to why they are sold at all. It is ironic that toxic chemicals are used as a humanitarian device to rid the world of Pestilence and Famine -- two of the Horsemen of the Apocalypse. If we do not wish poisonous chemicals to become the fifth Horseman of the Apocalypse, then we must begin now to identify and regulate the large-scale usage of toxic sub stances everywhere.

Taschenbuch. Condizione: Neu. Neuware - Anyone who has any contact with mental patients, old or young, or their families, or just visits a mental hospital or school for the retarded, is aware of the tremendous suffering caused by malfunctioning of the brain. The func tion of no other organ is so crucial for our everyday life, our proper func tioning, indeed our happiness, and no other illness causes as much anguish to patients or their families as mental illness. It is surprising and sad, therefore, how little effort has been devoted to research in this area; more so because such research is the only hope to ameliorate this suffering, or, to speak in the language of politics or economics, to decrease the enormous sums that we spend on trying to help our patients, with what is must generally be agreed are the most primitive and inadequate methods of treatment. Clearly, since functions of the brain are vital not only in illness, but in health, pathology is not the only area of concern to neurochemists, but it is an area that urgently needs neurochemical contributions. Progress in this field has been slower than in other areas of neurochemistry, and it seems that solutions in this field are very elusive. The reason for this is that the experimental approach is especially difficult in conditions specific for humans, or specific for complex behavior.

Taschenbuch. Condizione: Neu. Neuware - Allen I. Laskin Biosciences Research Exxon Research and Engineering Company Linden, New Jersey I was contacted in the Fall of 1981 by Professors Martin Dworkin and Palmer Rogers, of the University of Minnesota and asked to participate in the orgnization of the 1983 conference in the series, 'Interface Between Biology and Medicine'. They and the other members of the advisory committee had the vision to realize that this was a time to depart somewhat from the traditional theme, since one of the major areas of interest in the biological and related sciences these days is that of biotechnology in a broader sense than its impact on medicine alone. In designing the format of the Conference, we considered another factor. There has been a plethora of conferences, symposia, and meetings on biotechnology over the past few years, and the faces and topics have become rather familiar. There has been a strong emphasis on the development of the technology and the 'biotechnology industry'; less attention has been paid to the science behind it. One might get the impression from some of these meetings and from the popular press that biotechnology has just recently sprung up, apparently full blown; the very fundamental scientific discoveries and the great body of 1 ALLEN I. LASKIN 2 continuing research that forms that basis for the technology is often obscured.

Taschenbuch. Condizione: Neu. Neuware - Volume 6 of Cerebral Cortex is in some respects a continuation of Volume 2, which dealt with the functional aspects of cortical neurons from the physiological and pharmacological points of view. In the current volume, chapters are devoted to the catecholamines, which for a number of reasons were not represented in the earlier volume, and to acetylcholine and the neuropeptides, about which much new information has recently appeared. Volume 6 deals in part with the structure and function of cholinergic and catecholaminergic neuronal systems in the cerebral cortex and with new aspects of the cortical peptidergic neurons, notably the almost universal propensity of the known cortical peptides for being colocalized with classical transmitters and with one another. It thus completes our coverage of the major cortical neuro transmitter and neuromodulatory systems. Other chapters in this volume deal with data pertaining to the proportions of different types of cells and synapses in the neocortex and the physiology of the cortical neuroglial cells. These latter are topics that rarely receive separate treatment and the current chapters serve again to continue discussions of subjects that were introduced in Volume 2. The previous volumes have all been devoted to the neocortex but the present one introduces the subject of the archicortex. To this end, separate chapters are devoted to the physiology and anatomy of the hippocampal formation.

Taschenbuch. Condizione: Neu. Neuware - There is no need in the 1970s to explain the writing of a book on 'Environmen tal Chemistry. ' The despoliation of the environment by man's activities has long been clear to chemists. However, it has been the subject of public debate for a short time-since the late 1960s. Curiously, there has been little reaction in the textbook literature to reflect this concern. Apart from some brief and sketchy paperbacks for schools, there has not yet been published a substantial review of environmental chemistry. One reason for this is the breadth of the chemistry involved: it could scarcely be covered by one or two authors, for it is as wide as chemistry itself. The ideal way to write such a book would be to gather a couple of dozen authors in one place and keep them together for 6 months of discussions and writing. This not being very practical, it was decided to do the next best thing and to attempt to network a number of men together in mutual correspondence and interaction, which would lead to a book that had the advantages of the expertise of a large number of persons, and lacked many of the usual disadvan tages of the multi author book. Thus, synopses of the various articles were sent to each author, and they were encouraged to interact with each other in attempting to avoid repetition and in keeping their symbols uniform and their presentation style coordinated.

Taschenbuch. Condizione: Neu. Neuware - The International Thermal Conductivity Conference was started in 1961 with the initiative of Mr. C. F. Lucks and grew out of the needs of researchers in the field. From 1961 to 1973 the Confer ences were held annually, and have been held biennially since 1975 when our Center for Information and Numerical Data Analysis and Synthesis (CINDAS) of Purdue University became the permanent Spon sor of the Conferences. These Conferences provide a broadly based forum for researchers actively working on the thermal conductivity and closely related properties to convene on a regular basis to ex change their ideas and experiences and report their findings and results. The Conferences have been self-perpetuating and are an example of how a technical community with a common purpose can transcend the invisible, artificial barriers between disciplines and gather togeth er in increasing numbers without the need of national publicity and continuing funding support, when they see something worthwi1e going on. It is believed that this series of Conferences not only will grow stronger, but will set an example for researchers in other fields on how to jointly attack their own problem areas.

Taschenbuch. Condizione: Neu. Neuware - Metal ions and proteins are ubiquitous. Therefore, not surprisingly, new protein-metal interactions continue to be dis covered, and their importance is increasingly recognized in both physical and life sciences. Because the subject matter is so broad and affects so many disciplines, in organizing this Symposium, I sought participation of speakers with the broadest possible range of interests. Twenty-two accepted my invitation. To supplement the verbal presentations, the Proceedings include five closely re lated invited contributions. The ideas expressed are those of the various authors and are not necessarily approved or rejected by any agency of the United States Government. No official recommendation concerning the sub ject matter or products discussed is implied in this book. This book encompasses many aspects of this multifaceted field. Topics covered represent biochemical, immunochemical, bioorganic, biophysical, metabolic, nutritional, medical, physiological, toxi cological, environmental, textile, and analytical interests. The discoveries and developments in any of these areas inevitably illumine others. I feel that a main objective of this Symposium, bringing together scientists with widely varied experiences yet with common interests in protein-metal interactions, so that new understanding and new ideas would result has been realized. I hope that the reader enjoys and benefits from reading about the fascinat ing interactions of metal ions and proteins as much as I did.

Taschenbuch. Condizione: Neu. Neuware - Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Becoming a Food Scientist is designed as a reservoir of ideas for those beginning a graduate education in food science or beginning a professional career in the field. Although at times it may read as a how-to manual for success in graduate school, it is meant to encourage each reader to study the research process, to challenge conventional wisdom, and to develop a career path that maximizes the probability of success both in school and beyond. The author has viewed food science graduate programs through the lenses of programs at four universities and service in numerous activities with the Institute of Food Technologists. This book is thus focused on the field of food science, but it may have relevance to other scientific disciplines. The book introduces the concept of research as process in the first chapter. Subsequent chapters focus on individual unit operations of research: idea generation, problem definition, critical evaluation of the literature, method selection, experimental design, data collection, processing and analysis, and knowledge dissemination. Successful graduate students in food science must master each of these operations. The final section of the book pushes the reader beyond graduate school into its practice in the real world. Topics covered in the maturation of a food scientist include the scientific meeting, critical thinking, science and philosophy, ethics, finding and managing the literature, planning, grantsmanship, laboratory setup and management, and career development. This book should be a meaningful companion for any graduate student in the field and those transitioning from graduate school to the food science profession. 180 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last 50 years there have been an increasing number of applications of algebraic tools to solve problems in communications, in particular in the fields of error-control codes and cryptography. More recently, broader applications have emerged, requiring quite sophisticated algebra - for example, the Alamouti scheme in MIMO communications is just Hamilton's quaternions in disguise and has spawned the use of PhD-level algebra to produce generalizations. Likewise, in the absence of credible alternatives, the industry has in many cases been forced to adopt elliptic curve cryptography. In addition, algebra has been successfully applied to problems in signal processing such as face recognition, biometrics, control design, and signal design for radar. This book introduces the reader to the algebra they need to appreciate these developments and to various problems solved by these techniques. 60 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The major reason forpresentingabiblio ultraviolet light, or which make only a casual graphy on fluorescence and phosphorescence reference to the fluorescence technique were can be summed up in one statement: A recent usually rejected. However, occasionally survey showed that twenty-two percent of all papers of this nature were included because chemical and clinical research was uninten fluorescence methods seem to have unusual tionally duplicated. A comprehensive source potential for the problems discussed. Again, if pertinent papers were missed the authors book of fluorescence and phosphorescence would be grateful to have these omissions techniques is therefore needed not only to suggest ideas for future research, but to help called to their attention. The abbreviations of journal names em decrease needless duplication and expense, ployed in this Guide are those used by and thus to promote the development of both disciplines. Chemical Abstracts. Each paper has been The authors hope that researchers new given an alpha-numericalidentification. Sec to fluorescence techniques will appreciate tion A contains papers published in theyears the convenience of this Guide for obtaining 1950-1953, section B the years 1954-1956, data which otherwise could be found only by section C the years 1957-1959, and section reviewing dozens of papers, many difficult to D the years 1960-1964. Section E contains find, and that old hands will find ita valuable papers missed in the original compilation. 376 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Low dimensionality is a multifarious concept which applies to very diversified materials. Thus, examples of low-dimensional systems are structures with one or several layers, single lines or patterns of lines, and small clusters isolated or dispersed in solid systems. Such low dimensional features can be produced in a wide variety of materials systems with a broad spectrum of scientific and practical interests. These features, in turn, induce specific properties and, particularly, specific transport properties. In the case of zeolites, low dimensionality appears in the network of small-diameter pores of molecular size, extending in one, two or three di mensions, that these solids exhibit as a characteristic feature and which explains the term of 'molecular sieves' currently used to name these ma terials. Indeed, a large number of industrial processes for separation of gases and liquids, and for catalysis are based upon the use of this low dimensional feature in zeolites. For instance, zeolites constitute the first class of catalysts employed allover the world. Because of the peculiarity and flexibility of their structure (and composition), zeolites can be adapted to suit many specific and diversified applications. For this reason, zeolites are presently the object of a large and fast-growing interest among chemists and chemical engineers. 440 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -One of the ways in which the cerebral organization of sensory sys tems in general, and the auditory system in particular, can be in vestigated is by studying defects of the perception and discrimina tion of acoustic stimuli resulting from destruction of different parts of the auditory system by a pathological focus in them or by their surgical removal. The disturbances accompanying lesions of the peripheral part of the auditory system (disturbances of sound conduction, dis turbances arising in the ha ir cells of the cochlea) are weIl known. It is much more difficult to determine the character of disturb ances specific for lesions of the central parts of the auditory sys tem and, in particular, of the auditory cortex. Types of visual disturbances in man associated with lesions of the visual cortex - homonymous hemianopia with preservation of central vision in unilateral lesions and cortical blindness in bilateral lesions - are described in the neurological literature (Brower, 1936). The visual agnosias found in lesions of the secondary visual areas and inferior temporal zones of the human and animal cortex are also weIl known. Analogous facts showing that destruction of the parietal cor tex disturbs complex (epicritic) forms of sensation but leaves more elementary sensation (protopathic) intact are described by Head. 132 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Can the art of predictive medicine anticipate the development of diabetes And if so, what can be done about it How early is early enough to intervene effectively With what therapeutic modality Why Big babies are not an infrequent occurrence in mothers with normal carbohydrate metabolism for another 10, 20, or even 30 years. The abnor mality present during pregnancy is now accepted as what is inherited with the diabetic predisposition, or what can be recognized as the diabetic susceptibility. It occurs before hyperglycemia, during the phase of dy namic resistance to diabetes, during the prediabetic period. Prediabetes means before diabetes, and was applied for the first time by Mara~on in Spain, to signify the stage before hyperglycemia. Foglia in Argentina used the term in 1944 for his pancreatectomized rats. We pub lished the first paper on humans in 1951 (Camerini-Davalos, R.A., Landabure, P., and Serantes, N., Rev Med Cordoba 39: 187). 436 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalu able reference and sourcebook for researchers and students at all levels. This series i~ designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts. 364 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Data analysis is important from two points of view: first, it enables a large mass of information to be reduced to a reasonable compass, and second, it assists in the interpretation of experimental results against some framework of theory. The purpose of this text is to provide a practical introduction to numerical methods of data analysis which have applica tion in the field of experimental chemical kinetics. Recognizing that kinetic data have many features in common with data derived from other sources, I have considered it appropriate to discuss a selection of general methods of data analysis in the early chapters of the text. It is the author's experience that an outline of these methods is not always easy to locate in summary form, and that their usefulness is often not sufficiently appreciated. Inclusion of these methods in the early chapters has been aimed at simplifying discussion in the later chapters which are more particularly concerned with kinetic systems. By the provision of a number of worked examples and problems, it is hoped that the reader will develop a feeling for the range of methods available and for their relative merits. Throughout the text, the mathematical treatment has been kept relatively simple, lengthy proofs being avoided. I have preferred to indicate the 'sense' and usefulness of the various methods rather than to justify them on strict mathematical grounds. 140 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains the edited transcript of the Second Topical Colloquium based on leads developed at the original conference on the artery and the process of arteriosclerosis (the Lindau Conference of 1970). The first follow-up colloquium on 'The Smooth Muscle of the Artery' was held in Heidelberg in 1973. Planning for the present one was undertaken by the editors with Dr. C. Forbes Dewey, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. The meeting itself was held June, 1976 at the Delaware Water Gap, Pennsy1vani~, under the joint sponsorship of Totts Gap Institute and the Massachusetts Institute of Technology with financial support from the American Heart Association, the Office of Naval Research, and the Smith, Kline and French Company. The objective of the series of meetings, beginning at Lindau has been to examine from an interdisciplinary and international point of view the fundamental physiologic and pathophysiologic processes pertinent to the development of arteriosclerosis. This colloquium sought to examine critically the evidence relating hemodynamic forces to atherogenesis, to reconcile disparate findings and interpretations in so far as possible; and to make a synthesis of the present state of knowledge of the dynamics of arterial flow. Grateful acknowledgement is made for the valuable assistance of Joan Martin and Helen Goodell in the entire editorial process. The editors acknowledge with thanks the secretarial assistance of Moira Martin, Colleen Nagle, Cindy Carter and Pat Ide. Special thanks are due Joy Lowe who executed the entire final manuscript. 484 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A number of excellent symposia, reviews and monographs on the biology of ethanol have been published during the last decade. Al though it may appear that another such publication may be superflu ous, the subject of alcohol abuse is still open for further explora tion and the field of the biochemical pharmacology of ethanol is in its infancy. This is evidenced, for example, by the unavailability of any drugs that are designed specifically for the treatment of alcohol intoxication or alcohol addiction. The impetus for this publication was generated by a spontane ous enthusiasm following the symposium on BiochemicaZ Ph~acoZogy of EthanoZ that was organized at the annual meeting of the American Chemical Society, Division of Biological Chemistry in August 1973 in Chicago. It was the first symposium on such a topic ever in cluded in the program of that large society of American chemists. The original aim of the symposium was to acquaint the members of the society with some basic facts about the biological chemistry of ethanol. The symposium included seven papers and covered a rela tively narrow range of ethanol biochemistry. In view of the enthu siasm shown at the Chemical Society meeting, the panelists decided to publish the program and to amplify it by inclusion of additional topics which have remained relatively unexplored in earlier publica tions. In addition, reviews have been included which discuss old topics from a new perspective. 388 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The remarkable symposium arranged by Bruce L. Welch and Annemarie S. Welch for the meeting of the American Association for the Advancement of Science in Boston, Massachusetts at the end of the year 1969 was devoted to the physiological effects of audible sound. Dr. Welch and his wife were able to bring together a distinguished group of scientists from all parts of the world. It was very remarkable to be able to discuss the physiological aspects of noise with representative scientists from Israel, France, Germany, Hungary, Russia, Australia, Canada and Argentina. Dr. and Mrs. Welch ran the meeting in a delightful manner and continued to maintain interest and enthusiasm. Now the results of the conference are available. It is to be hoped that this volume will find wide interest and attention. We must differentiate noise from sound. Noise is unpleasant, unwanted or intolerable sound. On the other hand, even ordinary sound may at times be unpleasant, simply because we are not con ditioned to it. The general impression that one gets from reading the various reports on the physiological effects of noise is bad. It's a pollutant that we can each individually reduce, and maybe we can have a great enough effect socially so that we can significantly lower the noise levels which may result in considerable harm to us. It is interesting that noise as a pollutant has only recently attracted attention. 384 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Research on the chemical senses has been growing at a remarkable rate over the last decade. This growth has greatly expanded our understanding of the electrical properties and ultrastructure of chemosensory organs, of the role of chemoreception in the control of behavior, of the organization of higher centers in the chemosensory pathways, and of the chemical constituents of mixtures of biologic significance. But one area where advances have been especially impressive is concerned with the properties of pheromones and substances with similar biologic effects. Pheromones are compounds, produced by certain animals, which have the effect of inducing one or more specific responses within members of the same or closely related species. Some of these substances-the 'primer' pheromones-act on the endocrine system, probably through the central nervous system. The pregnancy block induced in mice by the odor of strange males is a striking example. Others, such as 'signalling' or 'releaser' pheromones, elicit an immediate behavioral response. Sex attractants are prominent examples of this group. While the chemical identity of these compounds is known, in a relatively few cases (and these, mainly in insects) we now have extensive information about their impact on the receiving organism at the receptor, physiologic and behavioral levels. 428 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The old-fashioned doctor, whose departure from the modern medical scene is so greatly lamented, was amply aware of each patient's per sonality, family, work, and way of life. Today, we often blame a doctor's absence of that awareness on moral or ethical deficiency either in medical education or in the character of people who become physicians. An alternative explanation, however, is that doctors are just as moral, ethical, and concerned as ever before, but that a vast amount of additional new information has won the competition for attention. The data available to the old-fashioned doctor were a patient's history, phys ical examination, and 'personal profile,' together with a limited number of generally ineffectual therapeutic agents. A doctor today deals with an enormous array of additional new information, which comes from X-rays, biopsies, cytology, electrographic tracings, and the phantas magoria of contemporary laboratory tests, and the doctor must also be aware of a list of therapeutic possibilities that are both far more effective and far more extensive than ever before. 488 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the publication of the previous volumes many new aspects of the physical and life sciences have been developed in which the properties of water play a dominant role. Although, according to its preface, Volume 5 was to be the last one of the treatise, these recent developments have led to a revision of that statement. The present volume and its companion, still in preparation, deal with topics that were already mentioned in the preface to Volume 5 as gaining in importance. The recent development of X-ray and, more particularly, neutron scattering techniques have led to studies of 'structure' in aqueous solutions of electrolytes on the one hand, and to the role of water in protein structure and function on the other. Both these topics have reached a stage where reviews of the present state of knowledge are useful. The application of ab initio methods to calculations of hydration and conformation of small molecules has a longer history, but here again a critical summary is timely. The role of solvent effects in reaction kinetics and mechanisms should have had a place in Volume 2 of this treatise, but, as sometimes happens, the author who had taken on this task failed tQ live up to his promise. However, since 1972 the physical chemistry of mixed aqueous solvents has made considerable strides, so that the belated discussion of this topic (by a new author) is built on evidence that was not available at the time of publication of Volume 2. 472 pp. Englisch.