springer us aug 1991 (28 risultati)

Buch. Condizione: Neu. Neuware - This volume contains a selection of papers that focus on the state-of the-art in formal specification and verification of real-time computing systems. Preliminary versions of these papers were presented at a workshop on the foundations of real-time computing sponsored by the Office of Naval Research in October, 1990 in Washington, D. C. A companion volume by the title Foundations of Real-Time Computing: Scheduling and Resource Management complements this hook by addressing many of the recently devised techniques and approaches for scheduling tasks and managing resources in real-time systems. Together, these two texts provide a comprehensive snapshot of current insights into the process of designing and building real time computing systems on a scientific basis. The notion of real-time system has alternative interpretations, not all of which are intended usages in this collection of papers. Different communities of researchers variously use the term real-time to refer to either very fast computing, or immediate on-line data acquisition, or deadline-driven computing. This text is concerned with the formal specification and verification of computer software and systems whose correct performance is dependent on carefully orchestrated interactions with time, e. g. , meeting deadlines and synchronizing with clocks. Such systems have been enabled for a rapidly increasing set of diverse end-uses by the unremitting advances in computing power per constant-dollar cost and per constant-unit-volume of space. End use applications of real-time computers span a spectrum that includes transportation systems, robotics and manufacturing, aerospace and defense, industrial process control, and telecommunications.

Buch. Condizione: Neu. Neuware - Provides a thorough description of all major plastics processing methods, including theory and practice.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text takes the reader step-by-step through the receiving and inspection processes involved in judging the quality of fresh and frozen fish and shellfish as well as live shellfish. It gives receiving procedures and sampling plans, and tells how to conduct simple, fair tests on products. It also tells clearly and in detail what quality points to look for with a wide range of seafood products, from live shellfish to frozen coated portions. Especially useful is the chapter on substitutions that tells how to determine whether other products are being passed off as more expensive items. More than 100 photographs and drawings illustrate critical distinctions and make it easier to conduct accurate assessments. Simple methods are provided for checking and testing for short weight, inferior size and quality, and fraudulent delivery whether deliberate or accidental. This definitive guide will enable the reader to avoid the expense of indifferent or disputed product quality. This book should be of interest to restaurant and seafood buyers; chefs, managers of restaurants; supermarket seafood buyers; seafood wholesalers. 144 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The traditional use of organic colorants is to impart color to a substrate such as textiles, paper, plastics, and leather. However, in the last five years or so organic colorants have become increasingly important in the high technology (hi-tech) industries of electronics and particularly reprographics. In some of these reprographics applications the organic colorant is used in its traditional role of imparting color to a substrate, typically paper or plastic. Examples are dyes for ink-jet printing, thermally transferable dyes for thermal transfer printing, and dyes and pigments for colored toners in photocopiers and laser printers. In other applications it is a special effect of an organic colorant that is utilized, not its color. Examples are electrical effects, such as photoconduction and the electrostatic charging of toners, both of which are essential features for the operation of photocopiers and laser printers, and the selective absorption of infrared radiation, which is utilized in optical data storage. In electronic applications the organic colorant is often employed in a device. Typical examples include liquid crystal dyes, laser dyes, electro chromic dyes, dyes for solar cells, dyes for micro color filters, and dyes for nonlinear optical applications. 312 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This text takes the reader step-by-step through the receiving and inspection processes involved in judging the quality of fresh and frozen fish and shellfish as well as live shellfish. It gives receiving procedures and sampling plans, and tells how to conduct simple, fair tests on products. It also tells clearly and in detail what quality points to look for with a wide range of seafood products, from live shellfish to frozen coated portions. Especially useful is the chapter on substitutions that tells how to determine whether other products are being passed off as more expensive items. More than 100 photographs and drawings illustrate critical distinctions and make it easier to conduct accurate assessments. Simple methods are provided for checking and testing for short weight, inferior size and quality, and fraudulent delivery whether deliberate or accidental. This definitive guide will enable the reader to avoid the expense of indifferent or disputed product quality. This book should be of interest to restaurant and seafood buyers; chefs, managers of restaurants; supermarket seafood buyers; seafood wholesalers.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 144 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Real-time computing systems are vital to a wide range of applications. For example, they are used in the control of nuclear reactors and automated manufacturing facilities, in controlling and tracking air traffic, and in communication systems. In recent years, real-time systems have also grown larger and become more critical. For instance, advanced aircraft such as the space shuttle must depend heavily on computer sys tems [Carlow 84]. The centralized control of manufacturing facilities and assembly plants operated by robots are other examples at the heart of which lie embedded real-time systems. Military defense systems deployed in the air, on the ocean surface, land and underwater, have also been increasingly relying upon real-time systems for monitoring and operational safety purposes, and for retaliatory and containment measures. In telecommunications and in multi-media applications, real time characteristics are essential to maintain the integrity of transmitted data, audio and video signals. Many of these systems control, monitor or perform critical operations, and must respond quickly to emergency events in a wide range of embedded applications. They are therefore required to process tasks with stringent timing requirements and must perform these tasks in a way that these timing requirements are guaranteed to be met. Real-time scheduling al gorithms attempt to ensure that system timing behavior meets its specifications, but typically assume that tasks do not share logical or physical resources. Since resource-sharing cannot be eliminated, synchronization primitives must be used to ensure that resource consis tency constraints are not violated. 200 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Generalized LR parsing algorithm (some call it 'Tomita's algorithm') was originally developed in 1985 as a part of my Ph.D thesis at Carnegie Mellon University. When I was a graduate student at CMU, I tried to build a couple of natural language systems based on existing parsing methods. Their parsing speed, however, always bothered me. I sometimes wondered whether it was ever possible to build a natural language parser that could parse reasonably long sentences in a reasonable time without help from large mainframe machines. At the same time, I was always amazed by the speed of programming language compilers, because they can parse very long sentences (i.e., programs) very quickly even on workstations. There are two reasons. First, programming languages are considerably simpler than natural languages. And secondly, they have very efficient parsing methods, most notably LR. The LR parsing algorithm first precompiles a grammar into an LR parsing table, and at the actual parsing time, it performs shift-reduce parsing guided deterministically by the parsing table. So, the key to the LR efficiency is the grammar precompilation; something that had never been tried for natural languages in 1985. Of course, there was a good reason why LR had never been applied for natural languages; it was simply impossible. If your context-free grammar is sufficiently more complex than programming languages, its LR parsing table will have multiple actions, and deterministic parsing will be no longer possible. 184 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Great Lakes Computer Science Conference is held biannually in Kalamazoo, Michigan. It is a wide-focus conference concerning all areas of Computer Science. Typically, research in data structures, algorithms (both parallel and sequential), database and VLSI design. Artificial intelligence has received the most attention. The 1989 proceedings of the Great Lakes Computer Science Conference consists of 64 papers. Artificial Intelligence, with 11 papers, is the field which was widely attended. 460 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Global Climate Change and Life on Earth focuses on the greenhouse effect and its relation to such crucial issues as deforestation, overpopulation and hunger, pollution, sea level changes, and the loss of biodiversity. These environmental threats now facing us could have so much momentum that unless steps are taken now to reverse them, they may soon overwhelm our ability to respond. 308 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As we move into the 21st century it is becoming increasingly difficult to offer appropriate introductory clinical experiences for medical students. Many schools offer clinical experiences in the first year of medical school, when the learner has little background in the traditions and origins of the doctor-patient interaction. Others begin this process in the second year, after a professional language base has been established, but concise educational materials are scarce that integrate the meaning of the privileged clinical encounter with the process and content of interviewing and examining patients. In the tertiary hospitals, where most medical schools are based, the educators must provide an orienta tion to the clinical encounter, an intensely personal experience, in the midst of glittering technological marvels that easily distract both the novice physician and the wizened teacher. Understanding the context and historical basis for the privilege of interviewing and examining another person about intimate matters relating to health and disease is essential to this process. Considering these factors, this textbook is written to assist medical educators and medical students involved in early clinical training. As the demand for 'high-tech' medicine has accelerated, so has the public concern over the loss of 'high-touch' or compassionate, humane interactions with physicians. Physicians are perceived as more concerned with readouts from machines and fiberoptic views of the patient than with understanding and car ing about the people we have labeled as patients. 452 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The traditional use of organic colorants is to impart color to a substrate such as textiles, paper, plastics, and leather. However, in the last five years or so organic colorants have become increasingly important in the high technology (hi-tech) industries of electronics and particularly reprographics. In some of these reprographics applications the organic colorant is used in its traditional role of imparting color to a substrate, typically paper or plastic. Examples are dyes for ink-jet printing, thermally transferable dyes for thermal transfer printing, and dyes and pigments for colored toners in photocopiers and laser printers. In other applications it is a special effect of an organic colorant that is utilized, not its color. Examples are electrical effects, such as photoconduction and the electrostatic charging of toners, both of which are essential features for the operation of photocopiers and laser printers, and the selective absorption of infrared radiation, which is utilized in optical data storage. In electronic applications the organic colorant is often employed in a device. Typical examples include liquid crystal dyes, laser dyes, electro chromic dyes, dyes for solar cells, dyes for micro color filters, and dyes for nonlinear optical applications. 312 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -As we move into the 21st century it is becoming increasingly difficult to offer appropriate introductory clinical experiences for medical students. Many schools offer clinical experiences in the first year of medical school, when the learner has little background in the traditions and origins of the doctor-patient interaction. Others begin this process in the second year, after a professional language base has been established, but concise educational materials are scarce that integrate the meaning of the privileged clinical encounter with the process and content of interviewing and examining patients. In the tertiary hospitals, where most medical schools are based, the educators must provide an orienta tion to the clinical encounter, an intensely personal experience, in the midst of glittering technological marvels that easily distract both the novice physician and the wizened teacher. Understanding the context and historical basis for the privilege of interviewing and examining another person about intimate matters relating to health and disease is essential to this process. Considering these factors, this textbook is written to assist medical educators and medical students involved in early clinical training. As the demand for 'high-tech' medicine has accelerated, so has the public concern over the loss of 'high-touch' or compassionate, humane interactions with physicians. Physicians are perceived as more concerned with readouts from machines and fiberoptic views of the patient than with understanding and car ing about the people we have labeled as patients.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 452 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Global Climate Change and Life on Earth focuses on the greenhouse effect and its relation to such crucial issues as deforestation, overpopulation and hunger, pollution, sea level changes, and the loss of biodiversity. These environmental threats now facing us could have so much momentum that unless steps are taken now to reverse them, they may soon overwhelm our ability to respond.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In his treatment of activity measurement in the fields of medicine and psychology, Tryon gives us a book that clearly accomplishes the three purposes set out in its preface. The reader is definitely encouraged to wrestle with the concepts ofbehavior and activity in terms of 'dynamic physical quantities.' Moreover, the reader cannot help but become familiarized with the technology available for performing activity measurements. Motivation to use some of this technology is enhanced by the very extensive summary of other people's uses of it provided throughout the book. Readers may find the book provocative on a number of Ievels. It is concep tually provocative to those of us struggling with understanding basic issues in the assessment and measurement of behavior. It is practically provocative to those of us working with various forms of behavioral difference, especially in clinical popula tions. The book provokes because it is essentially an unfinished exploration, open ing us to numerous pathways that, when traveled, reveal still more paths to explore. In this sense the book should be heuristically useful both in the more traditional empirical sense, and in terms of its Stimulation of conceptual discussion.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Vorwort In der Natur entwickelten sich die Echtzeitsysteme seit einigen 100 Mil Honen Jahren. Tierische Nervensysteme haben zur Aufgabe, auf die Nachrichten aus der Umwelt die Steuerungsbefehle an die aktiven Or gane zu geben. Dabei spielen zum Beispiel bedingte Reflexe eine wichtige Rolle. Vielleicht kann man die Entstehung des Menschen etwa zu der Zeit ansetzen, als sein sich allmahlich entwickelndes Gehirn Gedanken entwickelte, deren Bedeutung in vorausplanender Weise iiber die gerade vorliegende Situation hinausging. Das fiihrte schliesslich unter anderem zum heutigen Wissenschaftler, der seine Theorien und Systeme aufgrund langwieriger Uberlegungen aufbaut. Die Entwicklung der Computer ging im wesentlichen den umgekehrten Weg. Zunachst diente sie nur der Durchfiihrung 'starrer' Programme, wie z.B. das erste programmgesteuerte Rechengerat Z3, das der Unterzeichner im Jahre 1941 vorfiihren konnte. Es folgte unter an derem ein Spezialgerat zur Fliigelvermessung, das man als den ersten Prozessrechner bezeichnen kann. Es wurden etwa vierzig als Analog Digital-Wandler arbeitende Messuhren yom Rechnerautomaten abgele sen und im Rahmen eines Programms als Variable verarbeitet. Abel' auch das erfolgte noch in starrer Reihenfolge. Die echte Prozesssteuerung - heute auch Echtzeitsysteme genannt - erfordert aber ein Reagieren auf bestandig wechselnde Situationen. 344 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Monte Carlo simulation is now a well established method for studying semiconductor devices and is particularly well suited to highlighting physical mechanisms and exploring material properties. Not surprisingly, the more completely the material properties are built into the simulation, up to and including the use of a full band structure, the more powerful is the method. Indeed, it is now becoming increasingly clear that phenomena such as reliabil ity related hot-electron effects in MOSFETs cannot be understood satisfac torily without using full band Monte Carlo. The IBM simulator DAMOCLES, therefore, represents a landmark of great significance. DAMOCLES sums up the total of Monte Carlo device modeling experience of the past, and reaches with its capabilities and opportunities into the distant future. This book, therefore, begins with a description of the IBM simulator. The second chapter gives an advanced introduction to the physical basis for Monte Carlo simulations and an outlook on why complex effects such as collisional broadening and intracollisional field effects can be important and how they can be included in the simulations. References to more basic intro the book. The third chapter ductory material can be found throughout describes a typical relationship of Monte Carlo simulations to experimental data and indicates a major difficulty, the vast number of deformation poten tials required to simulate transport throughout the entire Brillouin zone. The fourth chapter addresses possible further extensions of the Monte Carlo approach and subtleties of the electron-electron interaction. 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In his treatment of activity measurement in the fields of medicine and psychology, Tryon gives us a book that clearly accomplishes the three purposes set out in its preface. The reader is definitely encouraged to wrestle with the concepts ofbehavior and activity in terms of 'dynamic physical quantities.' Moreover, the reader cannot help but become familiarized with the technology available for performing activity measurements. Motivation to use some of this technology is enhanced by the very extensive summary of other people's uses of it provided throughout the book. Readers may find the book provocative on a number of Ievels. It is concep tually provocative to those of us struggling with understanding basic issues in the assessment and measurement of behavior. It is practically provocative to those of us working with various forms of behavioral difference, especially in clinical popula tions. The book provokes because it is essentially an unfinished exploration, open ing us to numerous pathways that, when traveled, reveal still more paths to explore. In this sense the book should be heuristically useful both in the more traditional empirical sense, and in terms of its Stimulation of conceptual discussion. 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume records the proceedings of the Workshop on Advanced Meth ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response. 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -If ever a book could be called timely, this is it. Sleep disorders medicine has made rapid advances in recent years. The field has attained growing respectability, with a textbook recently published, a congressionally man dated National Commission on Sleep Disorders Research, and a growing public awareness of the importance of sleep disorders. However, this rapid growth has made the discrepancy among certain components of the field all the more obvious. Thus, we find that patients who complain of insom nia are almost never in the majority of those seen in sleep disorders centers, in spite of the well-known fact that the prevalence of such individ uals in our society is by far the largest. Current articles on insomnia abound, but they tend to be facile recitations of diagnosis and impractical global recommendations for treat ment, without providing the essential details. Indeed, the clinical profes sions really do not know what to do about insomnia. This is reflected in a number of observations I have made in the recent past. For example, the majority of individuals who complain of insomnia take alcohol, aspirin, over-the-counter medications, hot baths, and a host of other nostrums, but rarely seek a physician. In the unlikely event that a physician is consulted, he is likely to prescribe a sleep medication but without any particular consistency, or any clear instructions on its use. 276 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -If ever a book could be called timely, this is it. Sleep disorders medicine has made rapid advances in recent years. The field has attained growing respectability, with a textbook recently published, a congressionally man dated National Commission on Sleep Disorders Research, and a growing public awareness of the importance of sleep disorders. However, this rapid growth has made the discrepancy among certain components of the field all the more obvious. Thus, we find that patients who complain of insom nia are almost never in the majority of those seen in sleep disorders centers, in spite of the well-known fact that the prevalence of such individ uals in our society is by far the largest. Current articles on insomnia abound, but they tend to be facile recitations of diagnosis and impractical global recommendations for treat ment, without providing the essential details. Indeed, the clinical profes sions really do not know what to do about insomnia. This is reflected in a number of observations I have made in the recent past. For example, the majority of individuals who complain of insomnia take alcohol, aspirin, over-the-counter medications, hot baths, and a host of other nostrums, but rarely seek a physician. In the unlikely event that a physician is consulted, he is likely to prescribe a sleep medication but without any particular consistency, or any clear instructions on its use.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well. 428 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We are pleased to present our readers the proceedings of the International symposium on 'New Aspects of Human Polymorpho nuclear Leukocytes' which was held in Freiburg im Breisgau, FRG, from October 26-28th, 1989. The meeting provided an unique framework for close interaction between scientists from various disciplines, including bioche mistry, biology, physiology, pathology, clinical chemistry, hematology, gynecology, surgery, intensive care medicine, nephrology, rheumatology, and infectious diseases. We would like to express our gratitude and appreciation for all those who have stimulated, encouraged, and supported us to hold the symposium in Freiburg. This endeavor could not have been possible without the generous financial support of Asid Bonz (Böblingen), Bayer AG (Leverkusen), Bayropharm GmbH (Köln), Baxter (München), Ciba-Geigy (Wehr/Baden), Cilag GmbH (Sulzbach), Fresenius AG (Oberursel), Gambro (Martinsried), Gry-Pharma GmbH (Kirchzarten), Hoechst AG (Frankfurt), Hospal (Nürnberg), Knoll AG (Ludwigshafen), Lederle-Cyanamid (Wolfratshausen) , E. Merck (Darmstadt), MSD Sharp and Dohme GmbH (München), Pfizer GmbH (Karlsruhe), and Kabi/Pfrimmer (Erlangen). We are indebted to Mrs. I. Szkibik for her invaluable ass i stance both with the organization of the meeting and the pre paration of the manuscripts. 240 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The 1990 Cargese Summer Institute on ZO-Physics was organized by the Univer site Pierre et Marie Curie, Paris (M. Levy and J.-L. Basdevant), CERN (M. Jacob), the Universite Catholique de Louvain (D. Speiser and J. Weyers), and the Katholieke Universiteit te Leuven (R. Gastmans), which, since 1975, have joined their efforts and worked in common. It was the ninth Summer Institute on High Energy Physics orga nized jointly at Cargese by these three universities. Because of the start-up of LEP in the summer of 1989, we broke with our tradition of having our Summer Institutes in the odd years. Indeed, it seemed to us that the many new data from LEP had to be presented in detail as soon as possible in order to prepare the young researchers in particle physics better for the experimental results with which they will be confronted in the coming years. The main theme of the school was therefore ZO-physics, with particular emphasis on the way the experiments at LEP are analyzed. We had one lecturer from each LEP experiment: they agreed among each other to present different topics in e+e- physics. Nevertheless, they made sure that all the major topics were discussed and that the results could be critically compared. 542 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume records the proceedings of the Workshop on Advanced Meth ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Seeing is life. Seeing is transfonning luminous col We wish to extend our academic and theoretical ored stimulations and shapes into amental represen knowledge and also to complete and exchange our tation, structured in space and in time. But seeing is technical and professional experience to prepare also opening onto the world that surrounds us: it is corrective means for the future. thus a means for communicating and learning. Numerous questions have yet to be answered, Jean-Jacques Rousseau, a philosopher worth such as: quoting during the bicentennial of the French Revo lution of which he was an instigator, stated, 'of all ¿ Will it one day be possible to defer or stop the the senses, vision is that wh ich can be the least aging of the accommodative apparatus readily separated from judgments of the mind. ' ¿ Is further improvement of the current corrective Sight is increasingly called on in our modern means possible, whether spectacles or contact world. Maturity is affected at about 40-45 years by lenses the on set of presbyopia. Atthat age, which demands ¿ How are behavioral and psychological presbyope all our intellectual and physical means, our sight typologies to be integrated in the course of exam should be irreproachable. Our efficiency must not be ination, prescription, and fitting with corrective diminished. 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The 1990 Cargese Summer Institute on ZO-Physics was organized by the Univer site Pierre et Marie Curie, Paris (M. Levy and J.-L. Basdevant), CERN (M. Jacob), the Universite Catholique de Louvain (D. Speiser and J. Weyers), and the Katholieke Universiteit te Leuven (R. Gastmans), which, since 1975, have joined their efforts and worked in common. It was the ninth Summer Institute on High Energy Physics orga nized jointly at Cargese by these three universities. Because of the start-up of LEP in the summer of 1989, we broke with our tradition of having our Summer Institutes in the odd years. Indeed, it seemed to us that the many new data from LEP had to be presented in detail as soon as possible in order to prepare the young researchers in particle physics better for the experimental results with which they will be confronted in the coming years. The main theme of the school was therefore ZO-physics, with particular emphasis on the way the experiments at LEP are analyzed. We had one lecturer from each LEP experiment: they agreed among each other to present different topics in e+e- physics. Nevertheless, they made sure that all the major topics were discussed and that the results could be critically compared.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 542 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -We are pleased to present our readers the proceedings of the International symposium on 'New Aspects of Human Polymorpho nuclear Leukocytes' which was held in Freiburg im Breisgau, FRG, from October 26-28th, 1989. The meeting provided an unique framework for close interaction between scientists from various disciplines, including bioche mistry, biology, physiology, pathology, clinical chemistry, hematology, gynecology, surgery, intensive care medicine, nephrology, rheumatology, and infectious diseases. We would like to express our gratitude and appreciation for all those who have stimulated, encouraged, and supported us to hold the symposium in Freiburg. This endeavor could not have been possible without the generous financial support of Asid Bonz (Böblingen), Bayer AG (Leverkusen), Bayropharm GmbH (Köln), Baxter (München), Ciba-Geigy (Wehr/Baden), Cilag GmbH (Sulzbach), Fresenius AG (Oberursel), Gambro (Martinsried), Gry-Pharma GmbH (Kirchzarten), Hoechst AG (Frankfurt), Hospal (Nürnberg), Knoll AG (Ludwigshafen), Lederle-Cyanamid (Wolfratshausen) , E. Merck (Darmstadt), MSD Sharp and Dohme GmbH (München), Pfizer GmbH (Karlsruhe), and Kabi/Pfrimmer (Erlangen). We are indebted to Mrs. I. Szkibik for her invaluable ass i stance both with the organization of the meeting and the pre paration of the manuscripts.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the previous two volumes of this series, we presented classic problems in internal medicine as illustrated by actual cases cared for in our institution. It has been gratifying for us to see the interest that these volumes have generated with students and trainees. We remain committed to the case method of instruction, and believe that there is no better method to learn medicine than to have an individual patient problem as the basis for study of pathophysiology, natural history, diagnosis and management. We hope that our readers find this third volume as enjoyable and instructive as the editors found it. Juan M. Bowen, MD Ernest L. Mazzaferri, MD, FACP xiii Acknowledgement The editors are grateful to Jeff Smith and Jenny Riegler for their unflagging professionalism and patience. xiv Contents Case 1 Mitral Regurgitation - Chronic Versus Acute: Implications for Timing of Surgery - . - - - . . - . . . . . - . . . . . . . . . . . 1 Harisios Boudoulas, MD Charles F. Wooley, MD Advances and diagnostic imaging in a surgical technique have changed the approach to mitral valve regurgitation. This chapter provides an expert's perspective. Case 2 Cystic Fibrosis in Adults . - ------------ 36 Andrew Libertin, MD John S. Heintz, MD As children with cystic fibrosis grow into adulthood, the internist assumes a greater role in their care. Case 3 Thrombotic Thrombocytopenic Purpura . . . . . . . . . . 51 . . . Donald E. Thornton, MD Earl N. Metz, MD, FACP Patients with ITP continue to present difficulties in diagnosis and management. Two experts discuss the current approach to ITP. 308 pp. Englisch.