springer us nov 1996 (82 risultati)

Buch. Condizione: Neu. Neuware - TheNATO AdvancedStudiesInstituteseries'TargetingofDrugs'wasoriginatedin 1981. It is nowamajorinternationalforum,heldeverytwo yearsin CapeSounion,Greece,in whichthepresentandthefutureofthisimportantareaofresearch in drugdeliveryisdiscussed in greatdepth. PreviousASIsoftheseriesdealtwith drugcarriersofnaturalandsynthetic origin,theirinteractionswith thebiologicalmilieu, waysby whichthefunctionofdrugcarriers iscircumvented and,morerecently,with avarietyofapproaches to carrierdesignor modificationthatcontributeto optimalcarrierfunction. Thepresentbookcontainsthe proceedings ofthe8thNATO ASI, 'TargetingofDrugs:Strategies for Oligonucleotideand GeneDelivery in Therapy', held in CapeSounionduring24June-5 July 1995. Asthetitle implies,thebookdealswith avarietyofsystemsin termsoftheirability to transportnucleic acidsto targetareasin vitro andin vivo in waysthateffectivelymodify,supplement, correct, orcurtailthefunctionofgenesin therapy. Weexpressourappreciation to Mrs. ConchaPerringfor herassistance with the organizationoftheASI. TheASI washeldunderthesponsorship ofNATO ScientificAffairs Division andco-sponsored andgenerouslyfinancedby SmithKlineBeechamPharmaceuticals (KingofPrussia). Financialassistance wasalsoprovidedby SandozPharma(Baseland Athens),GeneMedicine (Houston,USA), ChironCorporation(Emeryville,USA), BYK GuldenLombergChemische (Konstanz,Gernlany),HelpSA(Athens,Greece),Avanti Polar Lipids Inc (Birmingham,USA), OxfordMolecular(Oxford,UK), Pfizer(Kent,UK), andAlza Corporation(PaloAlto, USA). GregoryGregoriadis BrendaMcCormack v CONTENTS Gene Therapy for Inherited Genetic Disease: Possibilities and Problems c. Coutelle Gene Delivery and Therapy: The Case for Cystic Fibrosis 15 E. W. F. W. Alton Immune Responses with Direct Gene Transfer: DNA Vaccines and 21 Implications for Gene Therapy H. L. Davis Oligonucleotides: Molecular Versions for Optimal Use in Vivo 31 E. Saison-Behmoaras, A. Van Aerschot, I. Duroux, C. Hendrix, C. Helene, and P. Herdewijn Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells 45 AJ. Kingsman, Y. Bae, J. c. Griffiths, N. Kim, E. E. Ramsdale, G. Romano, Y. Soneoka, P. M. Cannon, and S. M. Kingsman Adenovirus as Vectors for Gene Therapy 53 M. G. Lee Receptor-Mediated Gene Delivery with Synthetic Virus-like Particles 67 E. Wagner, M. Cotten, and K. Zatloukal Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery 79 A.

Buch. Condizione: Neu. Neuware - Interleaving Planning and Execution for Autonomous Robots develops a formal representation for interleaving planning and execution in the context of incomplete information. This work bridges the gap between theory and practice in robotics by presenting control architectures that are provably sound, complete and optimal, and then describing real-world implementations of these robot architectures. Dervish, winner of the 1994 AAAI National Robot Contest, is one of the robots featured. Interleaving Planning and Execution for Autonomous Robots is based on the author's PhD research, covering the same material taught in CS 224, the very popular Introduction to Robot Programming Laboratory taught at Stanford for four years by Professor Michael Genesereth and the author.

Buch. Condizione: Neu. Neuware - Climate and Environmental Database Systems contains the papers presented at the Second International Workshop on Climate and Environmental Database Systems, held November 21-23, 1995, in Hamburg, Germany. Climate and environmental data may be separated into two classes, large amounts of well structured data and smaller amounts of less structured data. The large amounts are produced by numerical climate models and by satellites, handling data in the order of magnitude of 100 Tbytes for the climate modelling sites and 1000 Tbytes for the recording and processing of satellite data. Smaller amounts of poorly structured data are the environmental data, which come mainly from observations and measurements. Present-day problems in data management are connected with a variety of data types. Climate and Environmental Database Systems addresses the state of the art, practical experience, and future perspectives for climate and environmental database systems, and may be used as a text for a graduate level course on the subject or as a reference for researchers or practitioners in industry.

Buch. Condizione: Neu. Neuware - Physics-Based Deformable Models presents a systematic physics-based framework for modeling rigid, articulated, and deformable objects, their interactions with the physical world, and the estimate of their shape and motion from visual data. This book presents a large variety of methods and associated experiments in computer vision, graphics and medical imaging that help the reader better to understand the presented material. In addition, special emphasis has been given to the development of techniques with interactive or close to real-time performance. Physics-Based Deformable Models is suitable as a secondary text for graduate level courses in Computer Graphics, Computational Physics, Computer Vision, Medical Imaging, and Biomedical Engineering. In addition, this book is appropriate as a reference for researchers and practitioners in the above-mentioned fields.

Buch. Condizione: Neu. Neuware - Recent advances in our understanding of the fundamental role of bioactive lipids in normal and abnormal physiology was the theme of the XVlth International Spring Sympo 6-9, 1996 at the George Washington University School sium on Health Sciences held on May of Medicine in Washington, D.C. Over 250 participants shared their latest findings on fundamental mechanisms in lipid metabolism, transport, and signal transduction. Most of the papers presented at the plenary sessions have been collected in this volume, which is divided into seven parts. The focus of Part I is on the new roles that fatty acids and esters play in cellular function. These activities include regulation of gene expression, control of eicosanoid-me diated responses, and intracellular calcium sequestration. Most biological effects of fatty acids, esters, and phospholipids are transmitted via the interaction of these lipid molecules with specific lipid binding proteins. The chapters in Part II detail the involvement of these in the transport of fatty acids, fatty acyl CoA esters, and phospholipids, and in the proteins modulation of the fatty acid-induced activation of the peroxisome proliferator-activated receptors. The study of arachidonic acid metabolism continues to be the subject of intense interest and research. A number of studies in Part III deal with the substantial differences between the constitutive prostaglandin H synthase isozyme (PGHS-l or COX-I) and the inducible form PGHS-2 (COX-2) regarding compartmentation, control, and expression.

Buch. Condizione: Neu. Neuware - Since the first edition of this book was published in 1987, there have been several important changes in the state of numerical field computation, as discussed in the Introduction. These changes have motivated the publication of this second edition. As with the first edition, the objective of this second edition is to give the newcomer to field computation the information needed to perform practical field computations. Again, clarity of presentation is given greater emphasis than a high degree of sophistication or the state of the art. And again, the basic concepts of field computation are presented as well as the commonly used algorithms. Several persons have provided much valuable information for this second edition. I wish to thank Professor Giorgio Molinari of the University of Genoa, Italy for advice regarding adaptive mesh generation; Dr. C. R. E. Emson of Vector Fields, Ltd., England and Dr. John Brauer of McNeal-Schwendler Corp. for their advice on transient eddy current computation; and Dr. Zoltan Cendes of Ansoft Corp. for information about their adaptive mesh generator. Again, I would like to acknowledge the support for this second edition by my wife, Candace. Again, I could not have written this book without her support.

Buch. Condizione: Neu. Neuware - Object-based Distributed Computing is being established as the most pertinent basis for the support of large, heterogeneous computing and telecommunications systems. The advent of Open Object-based Distributed Systems (OODS) brings new challenges and opportunities for the use and development of formal methods. Formal Methods for Open Object-based Distributed Systems presents the latest research in several related fields, and the exchange of ideas and experiences in a number of topics including: formal models for object-based distributed computing; semantics of object-based distributed systems and programming languages; formal techniques in object-based and object oriented specification, analysis and design; refinement and transformation of specifications; multiple viewpoint modeling and consistency between different models; formal techniques in distributed systems verification and testing; types, service types and subtyping; specification, verification and testing of quality of service constraints and formal methods and the object life cycle. It contains the selected proceedings of the International Workshop on Formal Methods for Open Object-based Distributed Systems, sponsored by the International Federation for Information Processing, and based in Paris, France, in March 1996.

Buch. Condizione: Neu. Neuware - This book addresses the behavior of inorganic material in combustion systems. The past decade has seen unprecedented improvements in understanding the rates and mecha nisms of inorganic transformations and in developing analytical tools to predict them. These tools range from improved fuel analysis procedures to predictive computer codes. While this progress has been met with great enthusiasm within the research community, the practices of the industrial community remain largely unchanged. The papers in this book were selected from those presented at an Engineering Foundation Conference of the same title. All have been peer reviewed. The intent of the conference was to illustrate the application of advanced technology to ash-related problems in boilers and, by so doing, engage the research and industrial communities in more productive dialog. Those attending the conference generally felt that we were successful on these counts. We also engaged the industrial community to a greater extent than ever before in the conference discussion and presentation. We hope these proceedings will facilitate a continued and improved interaction between industrial and research communities. Behavior of inorganic material has long been recognized as one of the major considerations affecting the design and operation of boilers that burn ash-producing fuels. The practical problems associated with the behavior are sometimes catastrophic and spec tacular, ranging from major slag falls that damage the bottom of furnaces to complete plugging of convection passes.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -HTML, or hypertext mark-up language, is the standard for all world wide web pages throughout the world. With HTML 3.0 new features have been added and in addition VRML, the virtual reality mark-up language, is also attracting attention to enable browsers to move through 'virtual reality' web sites. This book provides a reference guide to both HTML and VRML modelled on the author's previous successful reference guides to AutoCad. Each HTML and VRMl command is given a description, its syntax, and examples of its use. - Visual snapshots of each markup in use.- Each HTML tag is marked with its version number to highlight the new 3.0 features.- Covers all the known VRML tags for 2.0.- Examples cover related and optional attributes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this text, Shigeji Fujita and Salvador Godoy guide first and second-year graduate students through the essential aspects of superconductivity. The authors open with five preparatory chapters thoroughly reviewing a number of advanced physical concepts-such as free-electron model of a metal, theory of lattice vibrations, and Bloch electrons. The remaining chapters deal with the theory of superconductivity-describing the basic properties of type I, type II compound, and high-Tc superconductors as well as treating quasi-particles using Heisenberg's equation of motion. The book includes step-by-step derivations of mathematical formulas, sample problems, and illustrations. 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Neural Networks and Fuzzy Systems: Theory and Applications discusses theories that have proven useful in applying neural networks and fuzzy systems to real world problems. The book includes performance comparison of neural networks and fuzzy systems using data gathered from real systems. Topics covered include the Hopfield network for combinatorial optimization problems, multilayered neural networks for pattern classification and function approximation, fuzzy systems that have the same functions as multilayered networks, and composite systems that have been successfully applied to real world problems. The author also includes representative neural network models such as the Kohonen network and radial basis function network. New fuzzy systems with learning capabilities are also covered. The advantages and disadvantages of neural networks and fuzzy systems are examined. The performance of these two systems in license plate recognition, a water purification plant, blood cell classification, and other real world problems is compared. 284 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -. a useful resource for anybody engaged in the manufacture and development of flatbread.'-Food Technology. This comprehensive reference provides a complete overview of flat bread, the most widely consumed bread type in the world. It brings together in-depth knowledge of the technology of flat bread production covering a wide range of topics, from the historic background of wheat, corn, rye, rice, barley, sorghum and millet cultivation to advanced research findings on flat bread technology. The author, a leading expert in the field, introduces a wealth of detailed information on flat bread technology, including: specific ingredients, formulations, production techniques, equipment requirements, quality assessment and shelf life of the final product . Both single and double layered products are explored providing developers with a thorough understanding of flat bread products from around the world and the opportunity to expand existing product lines. Special features of the text include: processing methods of over 45 types of flat breads, including pizza, pita, corn and wheat flour tortillas, foccacia, matzo, rye breads' dosai and injera; theory and practice of sourdough production; technology of synthetic and naturally occurring emulsifiers, and their applications in food and flat bread industries; and a multitude of illustrations of breads and processing steps, names and addresses of over 90 suppliers of ingredients and machinery used in the production of flat breads in United States and Canada. Flat Bread Technology is a welcome and invaluable resource to all those interested in the technical, scientific and historical background of flat breads; from the breeders of wheat and other cereal grains to technical personnel and suppliers of ingredients to milling and baking companies. It will also serve as an excellent guide to students attending baking schools and cereal and food institutions. 228 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Error coding is a fascinating subject as much, if not more so, as it is an indispensable part of modem engineering systems. Unfortunately, in a bid to remain general and to create a solid foundation upon which to build, many books on this subject are out of the reach of those with more engineering-based, or non-mathematical backgrounds. This is a pity because in many cases the maths is tractable with few and simple rules. If we are content to believe that it works, and let others worry about the deeper mysteries of how or why, then with a little practice the design and implementation of practical error coding systems becomes straightforward. In this text I have attempted to reveal the useful kernel of the subject, removing the shell of terms and proofs that usually surrounds it. Being somewhat empirical in nature ( an empiricist), and occasionally heard to quote the adage, 'if it works twice it's a law', my explanations take this form. For many, including myself, abstract ideas are often better grasped by practical illustration than from yards of theory. 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -CyberLaw provides a comprehensive guide to legal issues which have arisen as a result of the growth of the Internet and World Wide Web. As well as discussing each topic in detail, the book includes extensive coverage of the relevant cases and their implications for the future. The book covers a wide range of legal issues, including copyright and trademark issues, defamation, privacy, liability, electronic contracts, taxes, and ethics. A comprehensive history of the significant legal events is also included.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 380 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Practice of Forensic Neuropsychology focuses the awareness of neuropsychologists on the critical areas of forensic practice that should be considered during each phase of a scientific neuropsychological examination/investigation. Written by three eminent neuropsychologists and a seasoned attorney, this important book contains practical information and guidelines for conducting valid and reliable forensic neuropsychological examinations that aid the 'trier-of-fact' in both civil and criminal settings. The authors also include vital information to help attorneys evaluate neuropsychological claims put forth by their own or opposing experts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Embedded computer systems use both off-the-shelf microprocessors and application-specific integrated circuits (ASICs) to implement specialized system functions. Examples include the electronic systems inside laser printers, cellular phones, microwave ovens, and an automobile anti-lock brake controller. Embedded computing is unique because it is a co-design problem - the hardware engine and application software architecture must be designed simultaneously. Hardware-Software Co-Synthesis of Distributed Embedded Systems proposes new techniques such as fixed-point iterations, phase adjustment, and separation analysis to efficiently estimate tight bounds on the delay required for a set of multi-rate processes preemptively scheduled on a real-time reactive distributed system. Based on the delay bounds, a gradient-search co-synthesis algorithm with new techniques such as sensitivity analysis, priority prediction, and idle- processing elements elimination are developed to select the number and types of processing elements in a distributed engine, and determine the allocation and scheduling of processes to processing elements. New communication modeling is also presented to analyze communication delay under interaction of computation and communication, allocate interprocessor communication links, and schedule communication.Hardware-Software Co-Synthesis of Distributed Embedded Systems is the first book to describe techniques for the design of distributed embedded systems, which have arbitrary hardware and software topologies. The book will be of interest to: academic researchers for personal libraries and advanced-topics courses in co-design as well as industrial designers who are building high-performance, real-time embedded systems with multiple processors.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Phantom pain is an intriguing mystery that has captured the imagination of health care providers and the public alike. How is it possible to feel pain in a limb or some other body part that has been surgically removed Phantom pain develops among people who have lost a limb or a breast or have had internal organs removed. It also occurs in people with totally transected spinal cords. Unfortunately, phantom pain is a medical night mare. Many of the people reporting phantom pain make dispropor tionately heavy use of the medical system because their severe pains are usually not treated successfully. The effect on quality of life can be devas tating. Phantom pain has been reported at least since 1545 (Weir Mitchell as related by Nathanson, 1988) and/ or experienced by such diverse people as Admiral Lord Nelson and Ambroise Pare (Melzack & Wall, 1982; Davis, 1993). The folklore surrounding phantom pain is fascinating and mirrors the concepts about how our bodies work that are in vogue at any particu lar time. Most of the stories relate to phantom limbs and date from the mid-1800s. The typical story goes like this: A man who had his leg ampu tated complained about terrible crawling, twitching feelings in his leg. His friends found out where the leg was buried, dug it up, and found maggots eating it. They burned it, and the pain stopped. Another man complained of a swollen feeling with frequent stinging or biting pains.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -. a useful resource for anybody engaged in the manufacture and development of flatbread.'-Food Technology. This comprehensive reference provides a complete overview of flat bread, the most widely consumed bread type in the world. It brings together in-depth knowledge of the technology of flat bread production covering a wide range of topics, from the historic background of wheat, corn, rye, rice, barley, sorghum and millet cultivation to advanced research findings on flat bread technology. The author, a leading expert in the field, introduces a wealth of detailed information on flat bread technology, including: specific ingredients, formulations, production techniques, equipment requirements, quality assessment and shelf life of the final product . Both single and double layered products are explored providing developers with a thorough understanding of flat bread products from around the world and the opportunity to expand existing product lines. Special features of the text include: processing methods of over 45 types of flat breads, including pizza, pita, corn and wheat flour tortillas, foccacia, matzo, rye breads' dosai and injera; theory and practice of sourdough production; technology of synthetic and naturally occurring emulsifiers, and their applications in food and flat bread industries; and a multitude of illustrations of breads and processing steps, names and addresses of over 90 suppliers of ingredients and machinery used in the production of flat breads in United States and Canada. Flat Bread Technology is a welcome and invaluable resource to all those interested in the technical, scientific and historical background of flat breads; from the breeders of wheat and other cereal grains to technical personnel and suppliers of ingredients to milling and baking companies. It will also serve as an excellent guide to students attending baking schools and cereal and food institutions.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Research over the last decade has brought about the development of high-performance systems such as powerful workstations, sophisticated computer graphics, and multimedia systems such as real-time video and speech recognition. A significant change in the attitude of users is the desire to have access to this computation at any location without the need to be connected to the wired power source. This has resulted in the explosive growth of research and development in the area of wireless computing over the last five years.Technologies for Wireless Computing deals with several key technologies required for wireless computing. The topics covered include reliable wireless protocols, portable terminal design considerations, video coding, RF circuit design issues and tools, display technology, energy-efficient applications, specific and programmable design techniques, energy efficiency metrics, low-voltage process technology and circuit design considerations, and CAD tools for low-power design at the behavior, logic and physical design level.Technologies for Wireless Computing is an edited volume of original research comprising invited contributions by leading researchers. This research work has also been published as a special issue of the Journal of VLSI Signal Processing Systems (Volume 13, Numbers 2 & 3).Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 200 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Error coding is a fascinating subject as much, if not more so, as it is an indispensable part of modem engineering systems. Unfortunately, in a bid to remain general and to create a solid foundation upon which to build, many books on this subject are out of the reach of those with more engineering-based, or non-mathematical backgrounds. This is a pity because in many cases the maths is tractable with few and simple rules. If we are content to believe that it works, and let others worry about the deeper mysteries of how or why, then with a little practice the design and implementation of practical error coding systems becomes straightforward. In this text I have attempted to reveal the useful kernel of the subject, removing the shell of terms and proofs that usually surrounds it. Being somewhat empirical in nature ( an empiricist), and occasionally heard to quote the adage, 'if it works twice it's a law', my explanations take this form. For many, including myself, abstract ideas are often better grasped by practical illustration than from yards of theory.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Embedded computer systems use both off-the-shelf microprocessors and application-specific integrated circuits (ASICs) to implement specialized system functions. Examples include the electronic systems inside laser printers, cellular phones, microwave ovens, and an automobile anti-lock brake controller. Embedded computing is unique because it is a co-design problem - the hardware engine and application software architecture must be designed simultaneously. Hardware-Software Co-Synthesis of Distributed Embedded Systems proposes new techniques such as fixed-point iterations, phase adjustment, and separation analysis to efficiently estimate tight bounds on the delay required for a set of multi-rate processes preemptively scheduled on a real-time reactive distributed system. Based on the delay bounds, a gradient-search co-synthesis algorithm with new techniques such as sensitivity analysis, priority prediction, and idle- processing elements elimination are developed to select the number and types of processing elements in a distributed engine, and determine the allocation and scheduling of processes to processing elements. New communication modeling is also presented to analyze communication delay under interaction of computation and communication, allocate interprocessor communication links, and schedule communication. Hardware-Software Co-Synthesis of Distributed Embedded Systems is the first book to describe techniques for the design of distributed embedded systems, which have arbitrary hardware and software topologies. The book will be of interest to: academic researchers for personal libraries and advanced-topics courses in co-design as well as industrial designers who are building high-performance, real-time embedded systems with multiple processors. 168 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Research over the last decade has brought about the development of high-performance systems such as powerful workstations, sophisticated computer graphics, and multimedia systems such as real-time video and speech recognition. A significant change in the attitude of users is the desire to have access to this computation at any location without the need to be connected to the wired power source. This has resulted in the explosive growth of research and development in the area of wireless computing over the last five years. Technologies for Wireless Computing deals with several key technologies required for wireless computing. The topics covered include reliable wireless protocols, portable terminal design considerations, video coding, RF circuit design issues and tools, display technology, energy-efficient applications, specific and programmable design techniques, energy efficiency metrics, low-voltage process technology and circuit design considerations, and CAD tools for low-power design at the behavior, logic and physical design level. Technologies for Wireless Computing is an edited volume of original research comprising invited contributions by leading researchers. This research work has also been published as a special issue of the Journal of VLSI Signal Processing Systems (Volume 13, Numbers 2 & 3). 200 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The analysis and design of engineering and industrial systems has come to rely heavily on the use of optimization techniques. The theory developed over the last 40 years, coupled with an increasing number of powerful computational procedures, has made it possible to routinely solve problems arising in such diverse fields as aircraft design, material flow, curve fitting, capital expansion, and oil refining just to name a few. Mathematical programming plays a central role in each of these areas and can be considered the primary tool for systems optimization. Limits have been placed on the types of problems that can be solved, though, by the difficulty of handling functions that are not everywhere differentiable. To deal with real applications, it is often necessary to be able to optimize functions that while continuous are not differentiable in the classical sense. As the title of the book indicates, our chief concern is with (i) nondifferentiable mathematical programs, and (ii) two-level optimization problems. In the first half of the book, we study basic theory for general smooth and nonsmooth functions of many variables. After providing some background, we extend traditional (differentiable) nonlinear programming to the nondifferentiable case. The term used for the resultant problem is nondifferentiable mathematical programming. The major focus is on the derivation of optimality conditions for general nondifferentiable nonlinear programs. We introduce the concept of the generalized gradient and derive Kuhn-Tucker-type optimality conditions for the corresponding formulations. 492 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rapid increases in chip complexity, increasingly faster clocks, and the proliferation of portable devices have combined to make power dissipation an important design parameter. The power consumption of a digital system determines its heat dissipation as well as battery life. For some systems, power has become the most critical design constraint. Computer-Aided Design Techniques for Low Power Sequential Logic Circuits presents a methodology for low power design. The authors first present a survey of techniques for estimating the average power dissipation of a logic circuit. At the logic level, power dissipation is directly related to average switching activity. A symbolic simulation method that accurately computes the average switching activity in logic circuits is then described. This method is extended to handle sequential logic circuits by modeling correlation in time and by calculating the probabilities of present state lines. Computer-Aided Design Techniques for Low Power Sequential Logic Circuits then presents a survey of methods to optimize logic circuits for low power dissipation which target reduced switching activity. A method to retime a sequential logic circuit where registers are repositioned such that the overall glitching in the circuit is minimized is also described. The authors then detail a powerful optimization method that is based on selectively precomputing the output logic values of a circuit one clock cycle before they are required, and using the precomputed value to reduce internal switching activity in the succeeding clock cycle. Presented next is a survey of methods that reduce switching activity in circuits described at the register-transfer and behavioral levels. Also described is a scheduling algorithm that reduces power dissipation by maximising the inactivity period of the modules in a given circuit. Computer-Aided Design Techniques for Low Power Sequential Logic Circuits concludes with a summary and directions for future research. 204 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hadamard Matrix Analysis and Synthesis: With Applications to Communications and Signal/Image Processing presents the basic concepts of Sylvester's construction of Hadamard matrices, the eigenvalue-eigenvector decompositions, along with its relationship to Fourier transforms. Relevant computational structures are included for those interested in implementing the Hadamard transform. The 2-dimensional Hadamard transform is discussed in terms of a 1- dimensional transform. The applications presented touch on statistics, error correction coding theory, communications signaling, Boolean function analysis and synthesis, image processing, sequence theory (maximal length binary sequences, composite sequences, and Thue-Morse sequences) and signal representation. An interesting application of the Hadamard transform to images is the Naturalness Preserving Transform (NPT), which is presented. The NPT provides a way to encode an image that can be reconstructed when it is transmitted through a noisy or an unfriendly channel. The potential applications of the Hadamard transform are wide and the book samples many of the important concepts among a vast field of applications of the transform. Hadamard Matrix Analysis and Synthesis: With Applications to Communications and Signal/Image Processing serves as an excellent reference source and may be used as a text for advanced courses on the topic. 140 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Plant-Microbe Interactions, Volume 2 Volume 1 of this series has made its appearance and dealt forcefully with impor tant current topics in the field of plant-microbe interactions. We believe that the quality of those chapters was high and should serve as a focal point for the state of the art as well as an enduring reference. Volume 2 builds upon these accom plishments. Chapter 1 discusses the fascinating lipo-chitin signal molecules from Rhizo bium, aspects regarding their biosynthesis, and the basis for host specificity. These molecules are a cardinal example of how microorganisms influence plant development and stimulate speculation that they have identified a previously un known aspect of plant hormone activity. Chapter 2 continues the discussion of Rhizobium by considering the trafficking of carbon and nitrogen in nodules. Al though the ostensible advantage of nodules to plants is the fixation of atmos pheric nitrogen, the actual process involved in supplying reduced nitrogen to the plant host is complex. 244 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recently, there has been interest by regulators, the public and the manufacturers of wireless devices in the issues relating to the safety of radio frequency (RF) energy. These issues require an understanding of the scientific underpinnings of both physics of RF energy and cellular biology. This book is designed to provide precisely such cross-functional expertise. The editors of this book intend to provide a reliable source for a sound scientific understanding of the issues and to stimulate future scientific advances in this area. Therefore, the audience for this book includes such diverse groups as scientists, governmental policy-makers and regulatory bodies, representatives of industry and the public at large. 298 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rough Sets and Data Mining: Analysis of Imprecise Data is an edited collection of research chapters on the most recent developments in rough set theory and data mining. The chapters in this work cover a range of topics that focus on discovering dependencies among data, and reasoning about vague, uncertain and imprecise information. The authors of these chapters have been careful to include fundamental research with explanations as well as coverage of rough set tools that can be used for mining data bases. The contributing authors consist of some of the leading scholars in the fields of rough sets, data mining, machine learning and other areas of artificial intelligence. Among the list of contributors are Z. Pawlak, J Grzymala-Busse, K. Slowinski, and others. Rough Sets and Data Mining: Analysis of Imprecise Data will be a useful reference work for rough set researchers, data base designers and developers, and for researchers new to the areas of data mining and rough sets. 452 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Analog circuit design is often the bottleneck when designing mixed analog-digital systems. A Top-Down, Constraint-Driven Design Methodology for Analog Integrated Circuits presents a new methodology based on a top-down, constraint-driven design paradigm that provides a solution to this problem. This methodology has two principal advantages: (1) it provides a high probability for the first silicon which meets all specifications, and (2) it shortens the design cycle. A Top-Down, Constraint-Driven Design Methodology for Analog Integrated Circuits is part of an ongoing research effort at the University of California at Berkeley in the Electrical Engineering and Computer Sciences Department. Many faculty and students, past and present, are working on this design methodology and its supporting tools. The principal goals are: (1) developing the design methodology, (2) developing and applying new tools, and (3) `proving' the methodology by undertaking `industrial strength' design examples. The work presented here is neither a beginning nor an end in the development of a complete top-down, constraint-driven design methodology, but rather a step in its development. This work is divided into three parts. Chapter 2 presents the design methodology along with foundation material. Chapters 3-8 describe supporting concepts for the methodology, from behavioral simulation and modeling to circuit module generators. Finally, Chapters 9-11 illustrate the methodology in detail by presenting the entire design cycle through three large-scale examples. These include the design of a current source D/A converter, a Sigma-Delta A/D converter, and a video driver system. Chapter 12 presents conclusions and current research topics. A Top-Down, Constraint-Driven Design Methodology for Analog Integrated Circuits will be of interest to analog and mixed-signal designers as well as CAD tool developers. 382 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Improvement in the quality of integrated circuit designs and a designer's productivity can be achieved by a combination of two factors: Using more structured design methodologies for extensive reuse of existing components and subsystems. It seems that 70% of new designs correspond to existing components that cannot be reused because of a lack of methodologies and tools. Providing higher level design tools allowing to start from a higher level of abstraction. After the success and the widespread acceptance of logic and RTL synthesis, the next step is behavioral synthesis, commonly called architectural or high-level synthesis. Behavioral Synthesis and Component Reuse with VHDL provides methods and techniques for VHDL based behavioral synthesis and component reuse. The goal is to develop VHDL modeling strategies for emerging behavioral synthesis tools. Special attention is given to structured and modular design methods allowing hierarchical behavioral specification and design reuse. The goal of this book is not to discuss behavioral synthesis in general or to discuss a specific tool but to describe the specific issues related to behavioral synthesis of VHDL description. This book targets designers who have to use behavioral synthesis tools or who wish to discover the real possibilities of this emerging technology. The book will also be of interest to teachers and students interested to learn or to teach VHDL based behavioral synthesis. 292 pp. Englisch.