springer us okt 1986 (17 risultati)

Buch. Condizione: Neu. Neuware - Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox icity against normal cells. The major focus of modulation has been the agents 5-fluorouracil (FUra), arabinofuranosylcytosine (ara-C), methotrexate (MTX) and a few alkylating agents. The major thrust of the studies has been to increase the flow of the anticancer agent along the pathway responsible for the formation of the cytotoxic species: for example, FUra to FUTP or ara-C to ara-CTP. While in most cases the application of research re sults to clinical trials does not require the subsequent exper tise of the laboratory researchers, application of biochemical modulatory schemes to clinical protocols necessitate a dramatic break with the past procedures. As shown in the laboratory clinical loop below, close collaboration between the laboratory and clinical investigator is essential. While the laboratory REDEFINE TECHNOLOGY, TESTS OR QUESTIONS FOR FURTHER THERAPEUTIC ADVANCE CLINICAL EXPERIMENTAL PROTOCOL (LABORATORY) RESEARCH STUDIES DEFINE AND TEST APPROPRIATE SCIENTIFIC PARAMETERS results define rationally-based regimens, it is essential that the clinical protocols contain the requirement that clinical material (either tumor or normal tissues) be sampled to deter mine whether the biochemical modulation being proposed is in fact beinq accomplished.

Buch. Condizione: Neu. Neuware - The subject of modelling and application of stochastic processes is too vast to be exhausted in a single volume. In this book, attention is focused on a small subset of this vast subject. The primary emphasis is on realization and approximation of stochastic systems. Recently there has been considerable interest in the stochastic realization problem, and hence, an attempt has been made here to collect in one place some of the more recent approaches and algorithms for solving the stochastic realiza tion problem. Various different approaches for realizing linear minimum-phase systems, linear nonminimum-phase systems, and bilinear systems are presented. These approaches range from time-domain methods to spectral-domain methods. An overview of the chapter contents briefly describes these approaches. Also, in most of these chapters special attention is given to the problem of developing numerically ef ficient algorithms for obtaining reduced-order (approximate) stochastic realizations. On the application side, chapters on use of Markov random fields for modelling and analyzing image signals, use of complementary models for the smoothing problem with missing data, and nonlinear estimation are included. Chapter 1 by Klein and Dickinson develops the nested orthogonal state space realization for ARMA processes. As suggested by the name, nested orthogonal realizations possess two key properties; (i) the state variables are orthogonal, and (ii) the system matrices for the (n + l)st order realization contain as their 'upper' n-th order blocks the system matrices from the n-th order realization (nesting property).

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The key contribution of the approach to x-ray mammographic image analysis developed in this monograph is a representation of the non-fatty compressed breast tissue that we show can be derived from a single mammogram. The importance of the representation, called hint, is that it removes all those changes in the image that are due only to the particular imaging conditions (for example, the film speed or exposure time), leaving just the non-fatty 'interesting' tissue. Normalising images in this way enables them to be enhanced and matched, and regions in them to be classified more reliably, because unnecessary, distracting variations have been eliminated. Part I of the monograph develops a model-based approach to x-ray mammography, Part II shows how it can be put to work successfully on a range of clinically-important tasks, while Part III develops a model and exploits it for contrast-enhanced MRI mammography. The final chapter points the way forward in a number of promising areas of research. Audience: This book has been written for a wide readership, including medical image analysts, medical physicists, radiologists, breast surgeons, and research students. The mathematics and algorithms have been relegated to boxes so that the book can be read and understood even if the mathematical detail is skipped. Large parts of the monograph will be of interest to clinicians generally and to patients. 236 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ronald L. Cohen Justice is a central moral standard in social life. It is invoked in judging individual persons and in judging the basic structure of societies. It has been described as akin to a 'human hunger or thirst' (Pascal, Pensees, cited in Hirschman, 1982, p. 91), 'more powerful than any physical hunger, and endlessly resilient' (Pitkin, 1981, p. 349). The most prominent contemporary theory of justice proceeds from the claim that justice is 'the first virtue of social institutions, as truth is systems of thought' (Rawls, 1971, p. 3). However, as the following chapters demonstrate, justice has a complex and controversial history. If, as has been claimed, justice is a central category of human thought and a central aspect of human motivation, can it also be the case that to invoke justice is no more than 'banging on the table: an emotional expression which turns one's demand into an absolute postulate' (Ross, 1959, p. 274) If justice is the first virtue of social institutions, can the concept of social or economic justice at the same time be 'entirely empty and meaningless' so that any attempt to employ it is 'either thoughtless or fraudulent' (Hayek, 1976, pp. xi-xii) In a formal sense, justice concerns ensuring that each person receives what she or he is due. 300 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -AND BACKGROUND 1. 1 CAD, Specification and Simulation Computer Aided Design (CAD) is today a widely used expression referring to the study of ways in which computers can be used to expedite the design process. This can include the design of physical systems, architectural environments, manufacturing processes, and many other areas. This book concentrates on one area of CAD: the design of computer systems. Within this area, it focusses on just two aspects of computer design, the specification and the simulation of digital systems. VLSI design requires support in many other CAD areas, induding automatic layout. IC fabrication analysis, test generation, and others. The problem of specification is unique, however, in that it i! often the first one encountered in large chip designs, and one that is unlikely ever to be completely automated. This is true because until a design's objectives are specified in a machine-readable form, there is no way for other CAD tools to verify that the target system meets them. And unless the specifications can be simulated, it is unlikely that designers will have confidence in them, since specifications are potentially erroneous themselves. (In this context the term target system refers to the hardware and/or software that will ultimately be fabricated. ) On the other hand, since the functionality of a VLSI chip is ultimately determined by its layout geometry, one might question the need for CAD tools that work with areas other than layout. 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Ronald L. Cohen Justice is a central moral standard in social life. It is invoked in judging individual persons and in judging the basic structure of societies. It has been described as akin to a 'human hunger or thirst' (Pascal, Pensees, cited in Hirschman, 1982, p. 91), 'more powerful than any physical hunger, and endlessly resilient' (Pitkin, 1981, p. 349). The most prominent contemporary theory of justice proceeds from the claim that justice is 'the first virtue of social institutions, as truth is systems of thought' (Rawls, 1971, p. 3). However, as the following chapters demonstrate, justice has a complex and controversial history. If, as has been claimed, justice is a central category of human thought and a central aspect of human motivation, can it also be the case that to invoke justice is no more than 'banging on the table: an emotional expression which turns one's demand into an absolute postulate' (Ross, 1959, p. 274) If justice is the first virtue of social institutions, can the concept of social or economic justice at the same time be 'entirely empty and meaningless' so that any attempt to employ it is 'either thoughtless or fraudulent' (Hayek, 1976, pp. xi-xii) In a formal sense, justice concerns ensuring that each person receives what she or he is due.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 300 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The key contribution of the approach to x-ray mammographic image analysis developed in this monograph is a representation of the non-fatty compressed breast tissue that we show can be derived from a single mammogram. The importance of the representation, called hint, is that it removes all those changes in the image that are due only to the particular imaging conditions (for example, the film speed or exposure time), leaving just the non-fatty 'interesting' tissue. Normalising images in this way enables them to be enhanced and matched, and regions in them to be classified more reliably, because unnecessary, distracting variations have been eliminated. Part I of the monograph develops a model-based approach to x-ray mammography, Part II shows how it can be put to work successfully on a range of clinically-important tasks, while Part III develops a model and exploits it for contrast-enhanced MRI mammography. The final chapter points the way forward in a number of promising areas of research. Audience: This book has been written for a wide readership, including medical image analysts, medical physicists, radiologists, breast surgeons, and research students. The mathematics and algorithms have been relegated to boxes so that the book can be read and understood even if the mathematical detail is skipped. Large parts of the monograph will be of interest to clinicians generally and to patients.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -InhaltsangabeIntroduction: Where is the Individual Subject in Scientific Psychology .- Introduction: Where is the Individual Subject in Scientific Psychology .- Individual-Based Inference Methodology: Past, Present, and the Future.- Psychology as a Science.- From Idiographic Approaches to Nomothetic Hypotheses.- The Production, Detection, and Explanation of Behavioral Patterns.- Group versus Individual-Based Inference in Psychology: Logic and Practice.- Phenomena Lost.- Between Groups and Individuals.- The Individual Subject in Behavior Analysis Research.- The Time Domain in Individual Subject Research.- Ordinal Pattern Analysis.- Toward the Study of Individual Subjects: Contributions from Different Fields in Psychology.- Academic Diagnosis.- A Method for the Analysis of Patterns, Illustrated with Data on Mother-Child Instructional Interaction.- The Role of the Case Study in Neuropsychological Research.- Psychophysiological Activation Research.- Sequence-Structure Analysis.- Epilogue: Different Perspectives on Individual-Based Generalizations in Psychology.- Epilogue: Different Perspectives on Individual-Based Generalizations in Psychology. 422 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -InhaltsangabeIntroduction: Where is the Individual Subject in Scientific Psychology .- Introduction: Where is the Individual Subject in Scientific Psychology .- Individual-Based Inference Methodology: Past, Present, and the Future.- Psychology as a Science.- From Idiographic Approaches to Nomothetic Hypotheses.- The Production, Detection, and Explanation of Behavioral Patterns.- Group versus Individual-Based Inference in Psychology: Logic and Practice.- Phenomena Lost.- Between Groups and Individuals.- The Individual Subject in Behavior Analysis Research.- The Time Domain in Individual Subject Research.- Ordinal Pattern Analysis.- Toward the Study of Individual Subjects: Contributions from Different Fields in Psychology.- Academic Diagnosis.- A Method for the Analysis of Patterns, Illustrated with Data on Mother-Child Instructional Interaction.- The Role of the Case Study in Neuropsychological Research.- Psychophysiological Activation Research.- Sequence-Structure Analysis.- Epilogue: Different Perspectives on Individual-Based Generalizations in Psychology.- Epilogue: Different Perspectives on Individual-Based Generalizations in Psychology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 422 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 5 of Cerebral Cortex completes the sequence of three volumes on the individual functional areas of the cerebral cortex by covering the somatosensory and motor areas. However, the chapters on these areas lead naturally to a series of others on patterns of connectivity in the cortex, intracortical and subcortical, so that the volume as a whole achieves a much broader viewpoint. The individual chapters on the sensory-motor areas reflect the considerable diversity of interest within the field, for each of the authors has given his or her chapter a different emphasis, reflecting in part topical interest and in part the body of data resulting from work in a particular species. In considering the functional organization of the somatosensory cortex, Robert Dykes and Andre Ruest have chosen to concentrate on the nature of the mapping process and its significance. Harold Burton, in his chapter on the somatosensory fields buried in the sylvian fissure, shows how critical is an understanding of this mapping process in the functional subdivision of the cortex. A frequently overlooked subdivision of the cortex, the vestibular region, is given the emphasis it deserves in a chapter by John Fredrickson and Allan Rubin. The further functional subdivisions that occur within the first somatosensory area are given an anatom ical basis in the review by Edward Jones of connectivity in the primate sensory motor cortex. 532 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book helps the reader gain more accurate results with contour mapping software and offers generic methods suitable for most commercial mapping and interactive or batch submitted jobs. 334 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Volume 5 of Cerebral Cortex completes the sequence of three volumes on the individual functional areas of the cerebral cortex by covering the somatosensory and motor areas. However, the chapters on these areas lead naturally to a series of others on patterns of connectivity in the cortex, intracortical and subcortical, so that the volume as a whole achieves a much broader viewpoint. The individual chapters on the sensory-motor areas reflect the considerable diversity of interest within the field, for each of the authors has given his or her chapter a different emphasis, reflecting in part topical interest and in part the body of data resulting from work in a particular species. In considering the functional organization of the somatosensory cortex, Robert Dykes and Andre Ruest have chosen to concentrate on the nature of the mapping process and its significance. Harold Burton, in his chapter on the somatosensory fields buried in the sylvian fissure, shows how critical is an understanding of this mapping process in the functional subdivision of the cortex. A frequently overlooked subdivision of the cortex, the vestibular region, is given the emphasis it deserves in a chapter by John Fredrickson and Allan Rubin. The further functional subdivisions that occur within the first somatosensory area are given an anatom ical basis in the review by Edward Jones of connectivity in the primate sensory motor cortex.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 532 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Over the past 25 years, the growing impor cardiovascular. We hope that by having this tance of genetic factors in the basic understand compilation of cardiovascular diseases in one ing of human cardiovascular disease has become source, it will be of value to all who are involved apparent. Prior to this time, there was an era in the care of patients with cardiovascular dis when cardiovascular disease was first viewed at ease or their families. the diagnostic level followed by an era when The first six chapters of this book delineate cardiovascular disease was viewed at a treatment conditions related to congenital cardiac mal level. The first era occurred at the turn of the formations. Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. The development of formations. The first chapter provides discus diagnostic methodology, such as radiographic sion of mechanisms of maldevelopment of the studies and electrocardiography, led to marked heart. We believe that these mechanisms pro changes in our understanding of cardiovascular vide a basis for understanding the genetic and disease. This era was followed by improved environmental factors which operate to produce methods of medical treatment, introduction congenital cardiac malformations. Chapter 2 describes the occurrence of con of medication such as antibiotics, and more genital cardiac malformations in families and sophisticated surgical techniques.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book helps the reader gain more accurate results with contour mapping software and offers generic methods suitable for most commercial mapping and interactive or batch submitted jobs.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 334 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the past 25 years, the growing impor cardiovascular. We hope that by having this tance of genetic factors in the basic understand compilation of cardiovascular diseases in one ing of human cardiovascular disease has become source, it will be of value to all who are involved apparent. Prior to this time, there was an era in the care of patients with cardiovascular dis when cardiovascular disease was first viewed at ease or their families. the diagnostic level followed by an era when The first six chapters of this book delineate cardiovascular disease was viewed at a treatment conditions related to congenital cardiac mal level. The first era occurred at the turn of the formations. Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. The development of formations. The first chapter provides discus diagnostic methodology, such as radiographic sion of mechanisms of maldevelopment of the studies and electrocardiography, led to marked heart. We believe that these mechanisms pro changes in our understanding of cardiovascular vide a basis for understanding the genetic and disease. This era was followed by improved environmental factors which operate to produce methods of medical treatment, introduction congenital cardiac malformations. Chapter 2 describes the occurrence of con of medication such as antibiotics, and more genital cardiac malformations in families and sophisticated surgical techniques. 388 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 528 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts. 528 pp. Englisch.