steinkopff feb 2012 (68 risultati)

Taschenbuch. Condizione: Neu. Neuware -This is the first book to present an overview of the exciting new cardiac imaging technique of tissue Doppler echocardiography (TDE). In order to understand the background of this technique, it is necessary to compare the physical properties of blood, which reflects ultrasound poorly but moves with high velocity (up to 150 cm/s) with those of the myocar dium, which reflects ultrasound strongly but moves with low velocity (less than 10 cm/s). In tissue Doppler imaging, existing Doppler technology has been modified to bypass the high-pass filter and enhance calculation of low velocities, thus enabling selective visualization of the myocardium rather than of the blood. Because the color Doppler tissue images are super imposed on the conventional two-dimensional ultrasound images, this technique is known as TDE. Following a brief introduction, the history of ultrasound and Doppler imaging is presented. It is now about 150 years since the death of Christian Doppler, who described the 'Doppler' effect, and more than 100 years since Pierre Curie discovered the piezoelectric effects of crystals. TDE was developed by Nobuo Yamazaki and Yoshitaka Mine at the Medi cal Engineering Laboratory, Toshiba Corporation, Tochigi, Japan. En gineers involved in the development of the technique have provided important technical information, which the reader will find an invaluable background to potential applications ofTDE.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 180 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -A vast literature has been concerned with arteriosclerosis and yet, many aspects of pathogenesis and of the mechanism of development of the arteriosclerotic vascular lesion remain only poorly understood. In recent years, our knowledge of the earliest stages of arteriosclerosis have greatly improved. By now, we have learned to relate morphologic changes to disturbances in function. It has been of particular impor tance that components of the arterial wall could be analyzed in regard to dysfunction, for example, in the endothelium or the vascular smooth muscle. The interaction of the different morphological components of the vascular wall could thus be much bet ter understood. Likewise, the interaction between the arterial wall and the flowing blood could be much better described, including the intimate relationship between platelets and the endothelium, the coagulation system and the endothelium, the granulocytes and the endothelial cell layer, as well as processes of migration of blood cells into the subendothelial space. The recognition of functional and morphological disturbance has attained clinical significance not only because the arteriosclerotic diseases have quantitatively reached the dimensions of an epidemic, that is, of a magnitude never been witnessed. It is also because of the development of new drugs that interfere with the atherogenic process and thereby prevent the development of the disease or halt its progression. It is also becoming increasingly possible to inhibit the occurrence of complications in existing arteriosclerotic lesions in manifest disease, i. e.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 216 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be tween 20-70% of the cell's metabolic energy is consumed for the pumping pro cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me tabolism. It is therefore understandable that special cellular demands are han dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun terpart in steroids from plant and toad origin which are generally known as 'car diac glycosides'. They are in medical use since at least 200 years in medicine in the treatment of heart diseases.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 932 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Alcohol consumption in all European countries is one of the leading causes for productivity loss, premature death, and accidents and is a hazard to health. Therefore, in order to monitor alcohol consumption in clinical as well as in forensic practice, occupational medicine, at court and for traffic safety and safety at workplaces, biological state markers of high sensitivity and specificity, capable of monitoring those in treatment for alcohol dependence or poly-drug-abusers as well as social drinkers in risky situations (driving, workplaces) are required. The markers known today can not be considered satisfying with regard to these parameters. Therefore the aim of this book is to contribute to improving the above mentioned issues by promoting knowledge on new, by far more accurate, and both disease and time independent alcohol intake markers.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 144 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -After decades of laboratory investigations mechanical circulatory support for the failing heart has entered the clinical arena. Today, a growing number of patients with progressive myocardial failure awaiting cardiac transplantation is successfully bridged to transplantation with ventricular assist devices. The proceedings of the 'Mechanical Circulatory Support'-meeting, held in Berlin, October 21-22, 1995, present new aspects of mechanical circulatory support, recent experience with MCS in newborns and children using specially developed small devices, and the results of long-term mechanical assistance. The ability of the myocardium to recover under pressure de-loading and reduced workload is discussed. All these topics open up new perspectives for the use of mechanical circulatory support, not only as a bridge to transplantation, but also as a definitive approach for treating patients with end-stage heart failure. Some of these concepts may even provide real alternatives to heart transplantation, these being sorely needed in light of the severe donor organ shortage. Regulatory as well as ethical aspects of the extended use of mechanical circulatory support systems and new technical developments in the field are discussed by internationally distinguished experts.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 236 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -In 1956, Bruno Kisch (90) discovered a special form of myocyte in the guinea pig heart atrium which contained peculiar, dense inclusions, but it was not before the early 1980s that cardiac hormones were isolated and characterized independently and almost simultaneously by several working groups. In 1964 Jamieson and Palade (84) were the first to postulate the secretory nature of the atrial myocytes and their specific granules. In 1976, Marie et al. (103) revealed the relation of the granular index of these atrial cells with the water- electrolyte balance of the body fluid. The biological effects of purified atrial extracts, i. e. , the diuretic and vasorelaxant effects, were detected in the early 1980s, (26,35,38,56). Now, a series of polypeptides, of the same family, and all derived from a homologous precursor in the different species are know to exert the diuretic and vasorelaxant effects. This development of the discovery of a peptide hormone is unparalleled in the sense that it was mostly morphologists who contributed to the final characterization of these cardiac hormones. Thus, it was a great honor for us to be given the opportunity on the occasion of the 8th European Anatomical Congress to organize a special satellite symposium on the rapidly growing field of research in cardiac endocrinology. The symposium 'Functional Endocrinology of the Endocrine Heart' was planned as an interdisciplinary meeting to enable anatomists to follow recent advances in cardiac endocrinology.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 260 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Among the greatest challenges in cardiovascular surgery today remain operations on aortic arch pathology, supraaortic vessels, and the protection of the brain from hypoxic or ischemic injury during these delicate operations. Since DeBakey's first successful repair of an aortic arch aneurysm in 1957, understanding of the aortic arch pathology, neuroprotective strategies, neuromonitoring and surgical technique have markedly improved. Although the specific surgical procedures have reached an advanced standard and general acceptance, many questions remain unanswered and have contributed to ongoing controversy.Cerebral Protection in Cerebrovascular and Aortic Surgery presents the current knowledge of understanding causes and pathogenesis of cerebral damage during surgery on the aortic arch and supraaortic vessels and prevention of brain damage by specific surgical therapy.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 292 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The measurement of cardio-circulatory and gas-exchange parameters during phy sical exercise - the so-called ergo spirometry or cardiopulmonary exercise testing (CPX) - as a basis of pathophysiological and clinical research has a long tradition in Cologne. Knipping and his coworkers, especially Hollmann, performed basic re search work in healthy subjects. In the area of sports medicine, bicycle or treadmill exercise testing with parallel serial lactate determinations has gained increasing im portance for the assessment of cardiac functional capacity. Also, in other medical disciplines, ergospirometry lost its importance. K. Wasserman in Los Angeles is to be credited for having further improved the method to its present standard, a computerized, on-line measuring and practicable cardiopulmonary exercise testing procedure. The prerequisites were technical innovations, such as continuously measuring gas analyzers and personal computers. Thereby, the knowledge about physiology, pathophysiology, and clinical circumstances of cardiocirculatory and re spiratory regulation during exercise were significantly extended. The working groups of W. Hollmann, Cologne, and K. Wasserman, Los Angeles, determined normal values for the gas-exchange parameters and derived values for healthy normals in large populations. Wasserman and coworkers were able to introduce a differential diagnostic concept for patients suffering from various cardiovascular and cardio pulmonary diseases. Many cardiologists, working, for example in myocardial failure or with rate-adaptive pacemakers, belong to those who recommended the modem, computerized ergo spirometry. Furthermore, this method is controversely discussed by colleagues working in sports medicine and pulmonary function.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 208 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Der vorliegende Band ist Bestandteil einer Buchreihe, die auBerdem die bereits vor liegenden Bande »Grundlagen der Lebensmittelmikrobiologie«( und »Mikrobiologie tierischer Lebensmittel«( umfaBt. Die Gliederung des recht heterogenen Gebietes der Mikrobiologie pflanzlicher Lebens mittel erfolgte nach Lebensmittelgruppen. Dabei wurde auch die direkte Verwertung von MikroorganismenzelIen als Lebens- und Futtermittel sowie die Nutzung von Mikroorganismen zur Herstellung von alkoholischen Getranken, organischen Sauren, Polysacchariden, Fetten, Aminosauren, Proteinen, Enzymen und Vitaminen ein bezogen. Wir gehen dabei von der Voraussetzung aus, daJ3 diese Produkte im wesent lichen aus Rohstoffen pflanzlicher Herkunft gewonnen werden. Damit ergibt sich ein fIieBender Dbergang zu den Zweigen der technischen Mikrobiologie. Da abge sehen von seltenen Ausnahmen aIle pflanzlichen Lebensmittel bei der Be- und Ver arbeitung mit Trinkwasser in Beriihrung kommen, wurde diesem lebensnotwendigen Lebensmittel ein eigenes Kapitel gewidmet. Es war naheliegend, auch die Mikro biologie der pflanzlichen GenuBmittel Kaffee, Tee und Tabak sowie der Gewiirze mit einzubeziehen. AusfUhrliche Darstellungen tiber die Verfahrensgrundlagen zur Erhaltung von Lebensmitteln, die mikrobiellen Lebensmittelvergiftungen sowie die allgemeine Mikrobiologie sind in dem Grundlagenband zu finden. Das vorliegende Werk ist in erster Linie als Lehrbuch fUr die Ausbildung von Fach und Hochschulingenieuren ftir die Lebensmittelindustrie gedacht. Um den Umfang in bestimmten Grenzen zu halten, wurden mikrobiologische Methoden der Lebens mitteluntersuchung prinzipielI nicht aufgenommen. Dagegen wurden notwendiger weise technologische Grundlagen beriicksichtigt, denn die Mikrobiologie pflanzlicherLebensmittel kann nur in Verbindung mit der entsprechenden Technologie gesehen werden. Um die dynamische Entwicklung des Wissensgebietes zu verdeutlichen, wurden historische Aspekte im begrenzten MaBe einbezogen.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 396 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Wie setzen sich ehemalige jüdische Lagerhäftlinge und Emigranten im Alter mit ihren Erinnerungen an Deportation, Lagerhaft und Vertreibung sowie mit vielfältigen anderen Verlusten auseinander, in einer Lebensphase, in der die Intensität dieser Erinnerungen wieder deutlich zunimmt Die Gesprächspartnerinnen und Gesprächspartner der Autoren leben heute in verschiedenen Ländern der Welt. Doch keinem ist Deutschland, seine Geschichte und Kultur gleichgültig. Auch jene, die sich entschieden haben, nie wieder nach Deutschland zurückzukehren, beschäftigen sich innerlich mit diesem Land. Ein Teil der befragten Personen ist im Alter wieder nach Deutschland zurückgekehrt. Wie haben diese Menschen versucht, sich hier wieder neu zu orientieren Das Buch bemüht sich auf solider wissenschaftlicher Grundlage, Antworten auf diese Fragen zu geben.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 300 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Mikrobiell verursachte Endokarditiden unterscheiden sich hinsichtlich der Klinik, der Prognose und der therapeutischen Erfordernisse von allen anderen Infektionserkrankungen. Die vorliegende Publikation ist das Resultat einer langjährigen klinischen und tierexperimentellen Beschäftigung mit diesem stets aktuellen Krankheitsbild. Es bietet rationale Handlungskonzepte für die häufigen Probleme der Diagnostik und Therapie. Die für den klinischen Alltag wichtigen konservativ-medikamentösen wie auch chirurgischen Therapiestrategien werden umfassend dargestellt. Dabei läßt die systematische Beobachtung einer großen Zahl von Endokarditispatienten über mehrere Jahrzehnte wichtige differentialtherapeutische Schlußfolgerungen zu.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 164 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Das 3. Symposium 'Phytopharmaka in Forschung und klinischer Anwendung' befaßt sich mit Toxikologie und Sicherheit von Phytopharmaka, Immunstimulation und der Bedeutung von pflanzlichen Arzneimitteln bei Erkältungen.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 228 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -'Wichtig zu lernen vor aHem ist Einverstiindnis. Viele sagenja, und doch ist da kein Einverstiindnis. Viele wer den nicht gefragt, und viele sind einverstanden mit Fal schem. Darum: Wichtig zu lernen vor aHem ist Einver stiindnis' Bertold Brecht Auch wenn beide Herausgeber unterschiedliche Ziele verfolgten, sollte man ihren Wunsch nach Einverstandnis nicht vergessen. Dem Pathologen lag es am Herzen, die Basisphanomene der entzundlichen Gelenkzerstorung von verschiedenen wissen schaftlichen Fachrichtungen beleuchtet zu sehen. Eine freimutige Diskussion ermog lichte es, 'viele' auszufragen, aber auch 'nein' zu sagen bei fehlendem Einverstand nis. Zum Einverstandensein mit Falschem wurde niemand gedrangt. DaB in vielen Fragen - noch kein Einverstandnis erreicht werden konnte, lag sicher nicht am Nichtfragen begrundet, sondern in der mangelnden Kenntnis uber Auslosung und Entwicklung der Krankheitsphanomene. Vnterschiedliche Herkunft und unterschiedliche Tatigkeiten der Herausgeber sind der Grund fUr das auch zwischen ihnen nicht immer vorhandene 'Einverstandnis'. DaB sich beim Partner aus der pharmazeutischen Industrie immer dann Hellhorig keit einstellte, wenn 'Einverstandnis' gegenuber therapeutischen MaBnahmen wahrnehmbar wurde, ist verstandlich; ein oft fehlendes 'Einverstandnis' sollte je doch Ansporn zur Suche nach mehr 'Einverstandnis' sein.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 232 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Nur höchst selten beobachtet man in der Medizin, daß eine längst bekannte Erkrankung bzw. Krankheitsgruppe durch die Entdeckung auf einem ganz an deren Gebiet eine so überraschende und befriedigende Erklärung findet, wie dieses bei der fötalen Erythroblastose durch die Auffindung des Rh-Faktors der Fall gewesen ist. Die Bilder des Hydrops foetus universalis, des Icterus gravis und auch der Neugeborenen-Anämie sind sehr lange bekannt. Aber erst v. GIERKE (1921) brachte sie auf einen Nenner, indem er das Gemeinsame mancher Veränderungen heraushob, ohne allerdings eine brauchbare Erklärung für die Pathogenese dieser sich so verschieden darbietenden Erscheinungen bringen zu können. Erst die neuen Entdeckungen, insbesondere amerikanischer Forscher, auf dem Gebiet der Blutgruppen brachten plötzlich Licht in das unklare Geschehen, für das so viele Theorien aufgestellt waren. Nachdem nuh die engen Zusammenhänge zwischen dem eigenartigen Verhal ten des Blutes der Eltern und der Erkrankung der Frucht einwandfrei festgelegt waren, zeigte sich überraschend die ungeheuere praktische Bedeutung und die zahlenmäßige Ausdehnung des ganzen Problems, aber auch manche Schwierigkeit in der Beweisführung. Während des Krieges sind diese Forschungen gerade in angelsächsischen Län dern schnell vorwärtsgetrieben worden, während sich in Deutschland nur ganz vereinzelte Autoren damit befaßten.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 188 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Die Borna'sche Krankheit ist schon lange bei Tieren, v.a. bei Pferden und Schafen, als eine sporadisch auftretende, progressiv verlaufende Encephalomyelitis bekannt und galt ausschließlich als tierpathogen. In Studien konnten Wissenschaftler BD-virusspezifische Antikörper auch in Liquores von Menschen mit psychiatrisch relevantem Krankheitsbild nachweisen, die die Erkenntnis brachten, daß der Mensch mit dem BD-Virus infizierbar ist. Der Autor führte dazu eine der weltweit größten Untersuchungen an über 10.000 Patienten durch und stellte fest, daß das BD-Virus bzw. eine seiner Varianten den Menschen nicht nur infizieren, sondern bei ihm auch zu psychischen Störungen führen können. Die vorliegende Monographie versucht eine Einordnung dieser Erkenntnisse in den derzeitigen Wissensstand zu Ätiologe und Pathogenese psychiatrischer Erkrankungen und bietet neuen Diskussionsstoff für Forschungsgruppen.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 188 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -In diesem Buch wird die gefährliche Sauerstoffunterversorgung des Fetus während der Geburt behandelt.Die verschiedenen Techniken der fetalen kontinuierlichen Erfasssung der Sauerstoffsättigung werden in diesem Buch dargelegt und die ersten klinischen Ergebnisse präsentiert. Neben der fetalen Pulsoxymetrie werden auch andere Techniken angeführt, die Rückschlüsse auf die fetale Sauerstoffversorgung gestatten, so beispielsweise die fetale EKG-Interpretation und die Near Infrared Spectroscopy.Ziel dieses Buches ist es, dem klinisch tätigen Geburtshelfer den derzeitigen Stand der fetalen Geburtsüberwachungsmethoden kritisch darzulegen und über zukünftig in der Klinik verfügbare Technologien zu informieren.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 256 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -Schwerpunkte des 4. Symposiums 'Phytopharmaka in Forschung und klinischer Anwendung' waren die - Qualität und Unbedenklichkeit von Phytopharmaka - Phytotherapie in der Pädiatrie - Verordnung und Anwendung von pflanzlichen ArzneimittelnSteinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 200 pp. Deutsch.

Taschenbuch. Condizione: Neu. Neuware -kleine, mittlere und groBe Hydrotherapie, be riicksichtigt im wesentlichen die Flachen- und Aufbauend auf den theoretischen Grundla z. T. die Zeitdosis. In Wirklichkeit bestehen gen, die das Lehrgebiet Reaktionslehre bietet, wechselseitige Beziehungen zwischen den verfolgt das Lehrgebiet Hydrotherapie das Reizfaktoren: 1st der Reizfaktor groB, sind Ziel, die Praxis ihrer Methoden zu beschrei zwangslaufig andere Reizfaktoren in der Dosis ben. zu reduzieren. Aufbau und Reihenfolge bei der Ausfiihrung der verschiedenen Hydrotherapieapplikatio Ais Hydrotherapie bezeichnen wir die nen entspringen nicht einem Schemadenken gezielte Anwendung des Wassers in seinen oder einer Pedanterie, sie sollen dem Behand Aggregatzustanden (Eis, Wasser, Dampf) ler auch keine Schablone aufzwingen. Einmal im Sinne der Krankheitsvorbeugung, der entsprechen die Regeln zur Ausfiihrung der Behandlung, Wiederherstellung und H ydrotherapieapplikationen ph ysiologischen Nachsorge im Krankheitsfall. Erfordernissen, zum anderen bedeutet jeder Behandlungsablauf einen Algorithmus, der Die Wasseranwendung zu hygienischen Zwek dem Behandler so gelaufig werden muB, daB er ken gilt nicht als Hydrotherapie. Die Hydro die Behandlung ohne nachzudenken absolvie therapie ist neben der Peloidtherapie, den Pa ren kann. Dabei darf keine Korperstelle ver raffinpackungen, der lnfrarot-Phototherapie, gessen werden. der Hochfrequenz-Elektrotherapie und der UI BewuBt sind lediglich diejenigen Stellen bei traschallbehandlung eine Form der Thermo Anwendungen mit dem Tuch und mit flieBen therapie. dem Wasser langer oder intensiver zu behan Dank ihrer Variabilitat und Individualisierbar deln, die dies individuell verlangen.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 332 pp. Deutsch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is the first book to present an overview of the exciting new cardiac imaging technique of tissue Doppler echocardiography (TDE). In order to understand the background of this technique, it is necessary to compare the physical properties of blood, which reflects ultrasound poorly but moves with high velocity (up to 150 cm/s) with those of the myocar dium, which reflects ultrasound strongly but moves with low velocity (less than 10 cm/s). In tissue Doppler imaging, existing Doppler technology has been modified to bypass the high-pass filter and enhance calculation of low velocities, thus enabling selective visualization of the myocardium rather than of the blood. Because the color Doppler tissue images are super imposed on the conventional two-dimensional ultrasound images, this technique is known as TDE. Following a brief introduction, the history of ultrasound and Doppler imaging is presented. It is now about 150 years since the death of Christian Doppler, who described the 'Doppler' effect, and more than 100 years since Pierre Curie discovered the piezoelectric effects of crystals. TDE was developed by Nobuo Yamazaki and Yoshitaka Mine at the Medi cal Engineering Laboratory, Toshiba Corporation, Tochigi, Japan. En gineers involved in the development of the technique have provided important technical information, which the reader will find an invaluable background to potential applications ofTDE. 180 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -After decades of laboratory investigations mechanical circulatory support for the failing heart has entered the clinical arena. Today, a growing number of patients with progressive myocardial failure awaiting cardiac transplantation is successfully bridged to transplantation with ventricular assist devices. The proceedings of the 'Mechanical Circulatory Support'-meeting, held in Berlin, October 21-22, 1995, present new aspects of mechanical circulatory support, recent experience with MCS in newborns and children using specially developed small devices, and the results of long-term mechanical assistance. The ability of the myocardium to recover under pressure de-loading and reduced workload is discussed. All these topics open up new perspectives for the use of mechanical circulatory support, not only as a bridge to transplantation, but also as a definitive approach for treating patients with end-stage heart failure. Some of these concepts may even provide real alternatives to heart transplantation, these being sorely needed in light of the severe donor organ shortage. Regulatory as well as ethical aspects of the extended use of mechanical circulatory support systems and new technical developments in the field are discussed by internationally distinguished experts. 236 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in heart surgical treatment have been impressive in the last 15 years. In end-stage heart disease, procedures are now performed routinely which were only experimental one or two decades ago. Heart transplantation has become a well-established procedure. According to the Gen eral Registry of the International Society of Heart and Lung Transplantation. 40,738 heart transplantations had been performed through the end of 1997 with survival rates of 78 % at one year, 65 % at five years, and 42 % at ten years. The progress in this field has been due to intense efforts in understanding and modulating immune responses to the trans planted heart, to elaborate therapeutic strategies to constrain infections, and to improved out-patient care. Accordingly, heart transplantation is integrated into the facilities of the health care systems, the routine of physicians, and the awareness of patients. The resulting increase in potential organ recipients has not been met, however, by an equivalent increase of available donor organs. This increasing discrepancy has forced the technical improvement and clinical evalua tion of mechanical circulatory support systems as an option for treatment of critically ill patients with a failing heart. Initially, these assist devices were only used to maintain sufficient circulation in post-cardiotomy heart failure until myocardial function had recov ered. Since the late 1980s, their primary use has been that of bridging patients with heart failure until a suitable organ is available so that heart transplantation can be performed. 132 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In 1956, Bruno Kisch (90) discovered a special form of myocyte in the guinea pig heart atrium which contained peculiar, dense inclusions, but it was not before the early 1980s that cardiac hormones were isolated and characterized independently and almost simultaneously by several working groups. In 1964 Jamieson and Palade (84) were the first to postulate the secretory nature of the atrial myocytes and their specific granules. In 1976, Marie et al. (103) revealed the relation of the granular index of these atrial cells with the water- electrolyte balance of the body fluid. The biological effects of purified atrial extracts, i. e. , the diuretic and vasorelaxant effects, were detected in the early 1980s, (26,35,38,56). Now, a series of polypeptides, of the same family, and all derived from a homologous precursor in the different species are know to exert the diuretic and vasorelaxant effects. This development of the discovery of a peptide hormone is unparalleled in the sense that it was mostly morphologists who contributed to the final characterization of these cardiac hormones. Thus, it was a great honor for us to be given the opportunity on the occasion of the 8th European Anatomical Congress to organize a special satellite symposium on the rapidly growing field of research in cardiac endocrinology. The symposium 'Functional Endocrinology of the Endocrine Heart' was planned as an interdisciplinary meeting to enable anatomists to follow recent advances in cardiac endocrinology. 260 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Alcohol consumption in all European countries is one of the leading causes for productivity loss, premature death, and accidents and is a hazard to health. Therefore, in order to monitor alcohol consumption in clinical as well as in forensic practice, occupational medicine, at court and for traffic safety and safety at workplaces, biological state markers of high sensitivity and specificity, capable of monitoring those in treatment for alcohol dependence or poly-drug-abusers as well as social drinkers in risky situations (driving, workplaces) are required. The markers known today can not be considered satisfying with regard to these parameters. Therefore the aim of this book is to contribute to improving the above mentioned issues by promoting knowledge on new, by far more accurate, and both disease and time independent alcohol intake markers. 144 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, we have witnessed a rapid expansion of our knowledge regarding the role of the endothelium in the control of vascular tone (and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealth of information on structure and function of this heretofore largely neglected 'organ'. Clinical medicine is now called upon to define the clinical significance of these observa tions that imply the mechanisms of blood coagulation, e.g., the interaction of throm bocytes with the endothelium, vasomotor control, and specifically, the regulation of smooth muscle tone with consequences for vascular resistance and conductance and organ blood flow. Finally, metabolism of lipids with the everlasting problem of athero sclerosis is an important aspect. In a second step, implications regarding the improvement of current therapeutic con cepts, as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endothelial Mechanisms of Vasomotor Control, clearly is of interest for both basic scientists and clinicians. It has been the aim of the organizers, the Society for Cooperation in Medical Science (SCMS) with this and the previous symposia to foster and support both basic science and clinical research. Research in medicine today shows two major directions of development: on the one hand, increasing involvement of the basic sciences and their methodology. On the other hand, statistical validation of concepts and therapeutic strategies in large scale population-and multicenter-studies. 256 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A vast literature has been concerned with arteriosclerosis and yet, many aspects of pathogenesis and of the mechanism of development of the arteriosclerotic vascular lesion remain only poorly understood. In recent years, our knowledge of the earliest stages of arteriosclerosis have greatly improved. By now, we have learned to relate morphologic changes to disturbances in function. It has been of particular impor tance that components of the arterial wall could be analyzed in regard to dysfunction, for example, in the endothelium or the vascular smooth muscle. The interaction of the different morphological components of the vascular wall could thus be much bet ter understood. Likewise, the interaction between the arterial wall and the flowing blood could be much better described, including the intimate relationship between platelets and the endothelium, the coagulation system and the endothelium, the granulocytes and the endothelial cell layer, as well as processes of migration of blood cells into the subendothelial space. The recognition of functional and morphological disturbance has attained clinical significance not only because the arteriosclerotic diseases have quantitatively reached the dimensions of an epidemic, that is, of a magnitude never been witnessed. It is also because of the development of new drugs that interfere with the atherogenic process and thereby prevent the development of the disease or halt its progression. It is also becoming increasingly possible to inhibit the occurrence of complications in existing arteriosclerotic lesions in manifest disease, i. e. 216 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be tween 20-70% of the cell's metabolic energy is consumed for the pumping pro cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me tabolism. It is therefore understandable that special cellular demands are han dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun terpart in steroids from plant and toad origin which are generally known as 'car diac glycosides'. They are in medical use since at least 200 years in medicine in the treatment of heart diseases. 932 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Among the greatest challenges in cardiovascular surgery today remain operations on aortic arch pathology, supraaortic vessels, and the protection of the brain from hypoxic or ischemic injury during these delicate operations. Since DeBakey's first successful repair of an aortic arch aneurysm in 1957, understanding of the aortic arch pathology, neuroprotective strategies, neuromonitoring and surgical technique have markedly improved. Although the specific surgical procedures have reached an advanced standard and general acceptance, many questions remain unanswered and have contributed to ongoing controversy.Cerebral Protection in Cerebrovascular and Aortic Surgery presents the current knowledge of understanding causes and pathogenesis of cerebral damage during surgery on the aortic arch and supraaortic vessels and prevention of brain damage by specific surgical therapy. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 296 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Advances in heart surgical treatment have been impressive in the last 15 years. In end-stage heart disease, procedures are now performed routinely which were only experimental one or two decades ago. Heart transplantation has become a well-established procedure. According to the Gen eral Registry of the International Society of Heart and Lung Transplantation. 40,738 heart transplantations had been performed through the end of 1997 with survival rates of 78 % at one year, 65 % at five years, and 42 % at ten years. The progress in this field has been due to intense efforts in understanding and modulating immune responses to the trans planted heart, to elaborate therapeutic strategies to constrain infections, and to improved out-patient care. Accordingly, heart transplantation is integrated into the facilities of the health care systems, the routine of physicians, and the awareness of patients. The resulting increase in potential organ recipients has not been met, however, by an equivalent increase of available donor organs. This increasing discrepancy has forced the technical improvement and clinical evalua tion of mechanical circulatory support systems as an option for treatment of critically ill patients with a failing heart. Initially, these assist devices were only used to maintain sufficient circulation in post-cardiotomy heart failure until myocardial function had recov ered. Since the late 1980s, their primary use has been that of bridging patients with heart failure until a suitable organ is available so that heart transplantation can be performed.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 132 pp. Englisch.