9780470257616 - Lead Generation Approaches in Drug Discovery di Rankovic, Zoran; Morphy, Richard (26 risultati)

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Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

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Condizione: New. pp. xi + 295 Illus.

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Hardcover. Condizione: new. Hardcover. An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novodesigned molecules The impact of natural products on drug discovery, and potential of natural productlike compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery. This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Condizione: New. This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. Num Pages: 296 pages, Illustrations. BIC Classification: MBGR1. Category: (P) Professional & Vocational. Dimension: 243 x 163 x 22. Weight in Grams: 570. . 2010. 1st Edition. Hardcover. . . . .

Condizione: New. This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. Num Pages: 296 pages, Illustrations. BIC Classification: MBGR1. Category: (P) Professional & Vocational. Dimension: 243 x 163 x 22. Weight in Grams: 570. . 2010. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Hardcover. Condizione: new. Hardcover. An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novodesigned molecules The impact of natural products on drug discovery, and potential of natural productlike compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery. This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.

Gebunden. Condizione: New. ZORAN RANKOVIC is a Senior Research Fellow and Associate Director in Medicinal Chemistry at Schering-Plough Research Institute, UK. He received his PhD in organic chemistry from the University of Leeds (UK) before starting his medicinal chemistry career in .

Condizione: New. Brand New ! Fast Delivery "International Edition " and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 4-6 Working days .and we do have flat rate for up to 2LB. Extra shipping charges will be requested This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.

Hardcover. Condizione: new. Hardcover. An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novodesigned molecules The impact of natural products on drug discovery, and potential of natural productlike compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery. This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.