Isbn: 9780470848937 - model organisms in drug discovery (26 risultati)

Condizione: Fine. First edition. Hardback. Large octavo. xiv, 288pp. Slight bruising to extremities, otherwise a near fine, unread copy. No jacket as issued.

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Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

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Condizione: New. pp. xiii + 288.

Condizione: New. pp. xiii + 288 Illus.

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Condizione: New. pp. xiii + 288.

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Hardback. Condizione: New. Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer's disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.…

Condizione: New. Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. This book provides accounts of model organism research that have impacted on specific therapeutic areas. Editor(s): Carroll, Pamela M.; Fitzgerald, Kevin. Num Pages: 302 pages, Illustrations. BIC Classification: MMG; PSB; TDCW. Category: (P) Professional & Vocational. Dimension: 172 x 249 x 21. Weight in Grams: 650. . 2003. 1st Edition. Hardcover. . . . .…

Hardcover. Condizione: Brand New. 1st edition. 302 pages. 10.00x7.00x1.00 inches. In Stock.

Buch. Condizione: Neu. Neuware - Fruit flies are 'little people with wings' goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which 'define' humans are conserved in Drosophila, the common fruit fly.Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer's disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems.Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future.Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future.This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.…

Condizione: New. Fruit flies are little people with wings goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signa.

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Buch. Condizione: Neu. Model Organisms in Drug Discovery | Kevin Fitzgerald (u. a.) | Buch | List of contributorsAcknowledgments1. Introduction to Model Systems in Drug Discovery (Kevin Fitzgerald and Pamela M. Carroll).2. Growing Yeast for Fun and Profit: Use of Saccharomyces cerevisiae as a Model System in Drug Discovery (Petra Ross-Macdonald) | Englisch | 2003 | John Wiley & Sons Inc | EAN 9780470848937 | Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, 36244 Bad Hersfeld, gpsr[at]libri[dot]de | Anbieter: preigu.…

Hardback. Condizione: New. Modellorganismen sind sehr hilfreich bei einem systematischen Ansatz zur Klärung einer breiten Palette krankheitsbezogener Fragestellungen. Aufgrund fortgeschrittener Gentechniken für Modellorganismen und die Verfügbarkeit ihrer Genomsequenzen, können diese Organismen einen großen Einfluss auf die Wirkstoffentdeckung haben, insbesondere in dem kritischen Bereich der Targetvalidierung krankheitsrelevanter Proteine. Dieses topaktuelle Buch erläutert die neuesten Fortschritte in den Bereichen Bioinformatik, Proteomik, Genomik sowie Biochemische- und Automationstechnologien, soweit sie sich auf einfache Organismen beziehen, die in der Wirkstoffentdeckung eingesetzt werden. Führende Experten auf diesem Gebiet berichten hier umfassend über den Bereich der Erforschung von Modellorganismem, die einen großen Einfluss auf spezifische Therapiebereiche ausgeübt hat. Darüber hinaus analysieren sie topaktuelle Anwendungen von Modellsystemen, beschreiben Anwendungen in der Praxis und mögliche Zukunftsperspektiven. "Model Organisms in Drug Discovery" - eine nützliche Lektüre nicht nur für Fachleute in der Wirkstoffentdeckung, sondern für eine Vielzahl von Wissenschaftlern.…

Condizione: New. Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. This book provides accounts of model organism research that have impacted on specific therapeutic areas. Editor(s): Carroll, Pamela M.; Fitzgerald, Kevin. Num Pages: 302 pages, Illustrations. BIC Classification: MMG; PSB; TDCW. Category: (P) Professional & Vocational. Dimension: 172 x 249 x 21. Weight in Grams: 650. . 2003. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.…

Condizione: New. Brand New ! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…