ISBN: 9781439818602 - trp channels (1 risultati)

Hardback. Condizione: Fine. In excellent condition, No writing or highlighting, book is crisp and clean. inquire for photos or more details. 100% satisfaction guarantee. Shipped with care. --- A collection of laboratory methods for research on transient receptor potential (TRP) ion channels, edited by Michael X. Zhu. Most chapters are written as working protocols, and the volume covers mammalian, Drosophila and C. elegans channels across the TRPC, TRPV, TRPA, TRPM and TRPML subfamilies. It opens with cell-based high-throughput screening for TRPC channel ligands, including how stable cell lines are set up and how assays are developed. Later chapters deal with temperature-sensitive channels and their study, and with drug-discovery screening. One chapter on electrophysiology addresses gating, pore permeation and selectivity, fractional calcium currents and pore sizing. Another treats TRP channel function in sensory neurons, using DRG and trigeminal ganglion preparations.…