9781631497902 - lithium: a doctor, a drug, and a breakthrough di brown, walter a. (36 risultati)

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Paperback. Condizione: New. From insulin comas and lobotomy to incarceration; those who suffered bipolar disorder endured dangerous, ineffective treatments for centuries until a breakthrough in the 1950s offered salvation. Lithium's efficacy at both ending and preventing manic depressive episodes was discovered by John Cade, who…se years running a psychiatric ward as a prisoner of war sparked a hunch that put him on the path to revelation. The miraculous metal has since salvaged an untold number of lives but even after its healing power was discovered, it was decades before the medical community could be convinced that lithium was not only safe but life-saving. Walter A. Brown reveals how close we came to missing out on this extraordinary drug and showcasing the possibilities of scientific curiosity.

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Condizione: New. 2020. paperback. . . . . .

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Paperback. Condizione: new. Paperback. The DNA double helix, penicillin, the X-ray, insulinthese are routinely cited as some of the most important medical discoveries of the twentieth century. And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most importantyet largely unsungbreakthroughs… of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization. From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade's Lithium Salts in the Treatment of Psychotic Excitement described, for the first time, lithium's astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented. With a vivid portrait of the story's unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade's laboratory was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical researchat least in Americahas transformed in such a way that serendipitous discoveries like Cade's are unlikely to occur ever again. Recently described by the New York Times as the Cinderella of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical historyrevealing just how close we came to passing over this extraordinary cure. In this incredible story of a miracle drug and the forgotten pioneer who discovered it, Lithium pays homage to. the renegade side of science (NPR). Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Paperback. Condizione: New. From insulin comas and lobotomy to incarceration; those who suffered bipolar disorder endured dangerous, ineffective treatments for centuries until a breakthrough in the 1950s offered salvation. Lithium's efficacy at both ending and preventing manic depressive episodes was discovered by John Cade, who…se years running a psychiatric ward as a prisoner of war sparked a hunch that put him on the path to revelation. The miraculous metal has since salvaged an untold number of lives but even after its healing power was discovered, it was decades before the medical community could be convinced that lithium was not only safe but life-saving. Walter A. Brown reveals how close we came to missing out on this extraordinary drug and showcasing the possibilities of scientific curiosity.

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Paperback. Condizione: new. Paperback. The DNA double helix, penicillin, the X-ray, insulinthese are routinely cited as some of the most important medical discoveries of the twentieth century. And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most importantyet largely unsungbreakthroughs… of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization. From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade's Lithium Salts in the Treatment of Psychotic Excitement described, for the first time, lithium's astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented. With a vivid portrait of the story's unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade's laboratory was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical researchat least in Americahas transformed in such a way that serendipitous discoveries like Cade's are unlikely to occur ever again. Recently described by the New York Times as the Cinderella of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical historyrevealing just how close we came to passing over this extraordinary cure. In this incredible story of a miracle drug and the forgotten pioneer who discovered it, Lithium pays homage to. the renegade side of science (NPR). Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.

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Paperback. Condizione: New. From insulin comas and lobotomy to incarceration; those who suffered bipolar disorder endured dangerous, ineffective treatments for centuries until a breakthrough in the 1950s offered salvation. Lithium's efficacy at both ending and preventing manic depressive episodes was discovered by John Cade, who…se years running a psychiatric ward as a prisoner of war sparked a hunch that put him on the path to revelation. The miraculous metal has since salvaged an untold number of lives but even after its healing power was discovered, it was decades before the medical community could be convinced that lithium was not only safe but life-saving. Walter A. Brown reveals how close we came to missing out on this extraordinary drug and showcasing the possibilities of scientific curiosity.