9783642031021 - mirna regulation of the translational machinery: 50 (12 risultati)
Lingua: Inglese
Editore: Springer, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Condizione: New. pp. 128.
Lingua: Inglese
Editore: Springer Verlag, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Hardcover. Condizione: Brand New. 1st edition. 115 pages. 9.50x6.00x0.50 inches. In Stock.
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Lingua: Inglese
Editore: Springer Berlin Heidelberg, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
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Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways cul…minate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).
Lingua: Inglese
Editore: Springer Spektrum, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Da: Buchpark, Trebbin, GermaniaBuchpark
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Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | An odd and unexpected finding was reported by the laboratory of Richard Jorgensen in 1990: expression of extra copies of the gene encoding chalone synthase in petunias turned off the endogenous chalone synthase gene. An observation that appeared t…otally unrelated was made by the laboratory of Victor Ambrose in 1993: a gene in Caenorhabditis elegans, lin-4, controlled the timing of larval development but did not encode a protein. Rather, it expressed two small RNAs that were complementary to the 3¿-untranslated region of the lin-14 gene in a region that had previously been shown to repress expression of the LIN-14 protein. From another quarter, David Baulcombe¿s laboratory showed in 1997 that plant viruses could induce sequen- specific gene silencing. Then in a landmark paper, Andrew Fire and Craig Mello showed in 1998 that double-stranded RNA (dsRNA) triggers a gene-silencing mechanism that they dubbed RNA interference (RNAi), for which discovery they were awarded the Nobel Prize in Physiology or Medicine in 2006. These diverse findings have triggered an explosion of research around the world in both plants and animals to discover the mechanisms and broader ramifications of RNAi. We now know that there are both exogenous pathways involving formation of siRNA when dsRNA is introduced and endogenous pathways involving miRNA, piwiRNA, and rasiRNAs. All pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing.
Lingua: Inglese
Editore: Springer, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Lingua: Inglese
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Lingua: Inglese
Editore: Springer Berlin Heidelberg Nov 2009, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.
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Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multi…ple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1). 128 pp. Englisch.
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Lingua: Inglese
Editore: Springer Berlin Heidelberg, 2009
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Da: moluna, Greven, Germaniamoluna
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Up-to-day findings on influence of miRNAs on gene translationGives an overview on different microRNA types and functions in plants and animalsShows novel applications of microRNAsUnderstanding How miRNAs Post-Transcr…iptionally Regul.
Lingua: Inglese
Editore: Springer, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Condizione: New. Print on Demand pp. 128 23 Illus. (4 Col.).
Lingua: Inglese
Editore: Springer, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Da: Biblios, frankfurt am main, HESSE, GermaniaBiblios
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Condizione: New. PRINT ON DEMAND pp. 128.
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Lingua: Inglese
Editore: Springer, Springer Nov 2009, 2009
Serie: Libro 12 di 31 - Progress in Molecular and Subcellular Biology
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Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000
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Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression.- Translational Control of Endogenous MicroRNA Target Genes in.- Translational Inhibition by MicroRNAs in Plants.- Regulation of p27 mRNA Expression by MicroRNAs.- The I…nhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs.- MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System.- miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 128 pp. Englisch.
