9783642111822 - Laron Syndrome - From Man to Mouse: Lessons fron Clinical and Experimental Experience (6 risultati)

Condizione: New.

Hardcover. Condizione: new. Hardcover. Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions. Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Gebunden. Condizione: New. First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him)Describes the comprehensive pathophysiology of IGF-I deficiency and gives valuable advice for the IGF-I.

Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 428 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

Hardcover. Condizione: Brand New. 1st edition. 531 pages. 10.25x8.00x1.00 inches. In Stock.

Buch. Condizione: Neu. Neuware - Laron Syndrome covers the relationship between GH and IGFI and their phenotypic effects. These effects can generally be separated into growth and metabolic defects. In this unique book, the authors illustrate and demonstrate the interesting results of the short and long-term effects of the mutation and give valuable treatment advice. This book is a helpful resource for pediatricians, endocrinologists and internists as well as researcher in the field of genetics and biology.