Isbn: 9783642174254 - brain, behavior and epigenetics (12 risultati)

Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 336 | Sprache: Englisch | Produktart: Bücher | Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.…

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Hardcover. Condizione: Brand New. 1st edition. 317 pages. 9.50x6.25x0.75 inches. In Stock.

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical delopmental stage.Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals. Epigenetic mechanisms regulate the structure of the chromatin through post-translational modifications of histone proteins and covalent DNA modifications. Though the mechanisms through which these effects are achieved likely involve diverse cellular and molecular pathways, there is emerging evidence supporting the hypothesis that epigenetic changes, such as DNA methylation and histone modifications, may mediate the effects of early-life variations in the social interactions between mothers and infants.…

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Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Art Petronis and Jon Mill s research is dedicated to the understanding of the role of epigenetic risk factors in complex diseasesEpigenetic processes can explain some of the epidemiological associations between environmental exposure and disease..…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical delopmental stage.Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals. Epigenetic mechanisms regulate the structure of the chromatin through post-translational modifications of histone proteins and covalent DNA modifications. Though the mechanisms through which these effects are achieved likely involve diverse cellular and molecular pathways, there is emerging evidence supporting the hypothesis that epigenetic changes, such as DNA methylation and histone modifications, may mediate the effects of early-life variations in the social interactions between mothers and infants. 336 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.…

Condizione: New. Print on Demand pp. 336.

Condizione: New. PRINT ON DEMAND pp. 336.