ISBN: 9783659240973 - formulation and evaluation of cinnarizine floating tablets: a floating type approach of gastro - retentive tablet dosage form of cinnarizine, an anti histaminic drug (4 risultati)

Taschenbuch. Condizione: Neu. Formulation And Evaluation Of Cinnarizine Floating Tablets | A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug | Sumit Doshi (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659240973 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

Paperback. Condizione: Brand New. 144 pages. 8.66x5.91x0.33 inches. In Stock.

Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Doshi SumitBachelor of Pharmacy from J. S. S. College of Pharmacy, Ooty. Master of Pharmacy in Pharmaceutical Technology from Rajiv Gandhi University of Health Sciences, Karnataka. Pursuing Ph D from R. K. University, Rajkot. Attende.…

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr s index, Hausner s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was validated & optimized formulation was prepared as suggested by the software. All the predicted values of responses were found to be closed to the observed values.…