Isbn: 9783659280535 - reprogramming of human fibroblast into induced pluripotent stem cells: controlled expression of transcription factors: enhancing efficiency of reprogramming process (5 risultati)

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Taschenbuch. Condizione: Neu. Reprogramming of human Fibroblast into Induced Pluripotent Stem Cells | Controlled Expression of Transcription Factors: Enhancing Efficiency of Reprogramming Process | Ju-Sung Song | Taschenbuch | 52 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783659280535 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Human Embryonic stem cells (hESCs) represent a pluripotent cell population derived from the inner cell mass of the blastocyst stage of the developing embryo. Ethical concerns have been raised regarding the derivation process, as the procedure ultimately results in the destruction of the embryos. Recently, alternative approach has been devised that encompasses reprogramming of terminally differentiated cells into a hESC-like state. This process relies on the over-expression of four pluripotency-associated factors, and successfully reprogrammed cells are termed induced pluripotent stem cells. These cells hold great promise for the use in future cell-based therapeutics such as evaluating drug induced toxicity and developing personalized medicines. However, the intricacies of the reprogramming mechanism are not fully understood, mostly due to the random nature of the expression of the four transcription factors. In this study, a novel molecular switch, known as Rheostat system, was utilized in conjunction with the doxycycline system to regulate the expression of the transcription factors in a precise temporal manner and elucidate underlying mechanisms of the reprogramming process. 52 pp. Englisch.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Song Ju-SungJu-sung is in his third year in pharmacy school, actively completing his Doctor of Pharmacy at the University of Connecticut. He holds a Bachelor of Science degree in Pharmacy Studies with the recognition of magna cum lau.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Human Embryonic stem cells (hESCs) represent a pluripotent cell population derived from the inner cell mass of the blastocyst stage of the developing embryo. Ethical concerns have been raised regarding the derivation process, as the procedure ultimately results in the destruction of the embryos. Recently, alternative approach has been devised that encompasses reprogramming of terminally differentiated cells into a hESC-like state. This process relies on the over-expression of four pluripotency-associated factors, and successfully reprogrammed cells are termed induced pluripotent stem cells. These cells hold great promise for the use in future cell-based therapeutics such as evaluating drug induced toxicity and developing personalized medicines. However, the intricacies of the reprogramming mechanism are not fully understood, mostly due to the random nature of the expression of the four transcription factors. In this study, a novel molecular switch, known as Rheostat system, was utilized in conjunction with the doxycycline system to regulate the expression of the transcription factors in a precise temporal manner and elucidate underlying mechanisms of the reprogramming process.OmniScriptum SRL, Str. Armeneasca 28/1, office 1, 2012 Chisinau 52 pp. Englisch.…