ISBN: 9783659579639 - degradation study of tenofovir disoproxil fumarate: rp-hplc method development (17 risultati)

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Taschenbuch. Condizione: Neu. Degradation Study Of Tenofovir Disoproxil Fumarate | RP-HPLC Method Development | Shubhangi Sutar (u. a.) | Taschenbuch | 68 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659579639 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu. …

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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stability indicating RP-HPLC method for estimation of Tenofovir Disoproxil Fumarate in the presence of its degradation products during conduction of stability studies on the pure drug which was carried out by using a mobile phase comprising ACN: Water (70:30 v/v), pH adjusted to 4.5with OPA, at flow rate of 1 ml/min. with UV detection at 260 nm. The concentration of TDF was found sufficient for obeying Beer's law over a range of 10-90mig/ml. In the present study, the drug was subjected to acid (0.1N HCl and 0.01N HCl), and alkaline (0.1N NaOH and 0.01N NaOH) hydrolysis. TDF was found to be more sensitive to alkaline hydrolysis and it was somewhat stable to acidic conditions. The degradation kinetic of Tenofovir Disoproxil Fumarate is governed by hydrolysis of the isopropyloxycarbonylmethyl moiety. Degraded product formed is monoester. The % degradation in both acidic and alkaline condition is calculated by UV-Spectrophotometric and RP-HPLC method. 68 pp. Englisch.…

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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Stability indicating RP-HPLC method for estimation of Tenofovir Disoproxil Fumarate in the presence of its degradation products during conduction of stability studies on the pure drug which was carried out by using a mobile phase comprising ACN: Water (70:30 v/v), pH adjusted to 4.5with OPA, at flow rate of 1 ml/min. with UV detection at 260 nm. The concentration of TDF was found sufficient for obeying Beer's law over a range of 10-90mig/ml. In the present study, the drug was subjected to acid (0.1N HCl and 0.01N HCl), and alkaline (0.1N NaOH and 0.01N NaOH) hydrolysis. TDF was found to be more sensitive to alkaline hydrolysis and it was somewhat stable to acidic conditions. The degradation kinetic of Tenofovir Disoproxil Fumarate is governed by hydrolysis of the isopropyloxycarbonylmethyl moiety. Degraded product formed is monoester. The % degradation in both acidic and alkaline condition is calculated by UV-Spectrophotometric and RP-HPLC method.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sutar ShubhangiMiss. Shubhangi V. Sutar is working as Assistant Professor of Department o Pharmaceutical Chemistry in Ashokrao Mane College of Pharmacy, Peth Vadgaon having 5 years Diploma Teaching and 3 years Degree Teaching Experie.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Stability indicating RP-HPLC method for estimation of Tenofovir Disoproxil Fumarate in the presence of its degradation products during conduction of stability studies on the pure drug which was carried out by using a mobile phase comprising ACN: Water (70:30 v/v), pH adjusted to 4.5with OPA, at flow rate of 1 ml/min. with UV detection at 260 nm. The concentration of TDF was found sufficient for obeying Beer's law over a range of 10-90¿g/ml. In the present study, the drug was subjected to acid (0.1N HCl and 0.01N HCl), and alkaline (0.1N NaOH and 0.01N NaOH) hydrolysis. TDF was found to be more sensitive to alkaline hydrolysis and it was somewhat stable to acidic conditions. The degradation kinetic of Tenofovir Disoproxil Fumarate is governed by hydrolysis of the isopropyloxycarbonylmethyl moiety. Degraded product formed is monoester. The % degradation in both acidic and alkaline condition is calculated by UV-Spectrophotometric and RP-HPLC method.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 68 pp. Englisch.…