9783659633980 - floating alginate microbeads of sumatriptan succinate: formulation, development, evaluation di jagdale, swati; patil, satej (14 risultati)

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Taschenbuch. Condizione: Neu. Floating Alginate Microbeads of Sumatriptan Succinate | Formulation, Development, Evaluation | Swati Jagdale (u. a.) | Taschenbuch | 120 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659633980 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 S…aarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.

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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Sumatriptan succinate is effective in -70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stom…ach and upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals. 120 pp. Englisch.

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Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Sumatriptan succinate is effective in ~70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stomach…and upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch.

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Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Sumatriptan succinate is effective in -70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stomach a…nd upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals.