ISBN: 9783764389888 - epigenetics and disease: pharmaceutical opportunities: 67 (14 risultati)

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Condizione: New. Epigentic alterations, unlike genetic, are, in principle, amenable to pharmacological intervention, and a few of those drugs are currently undergoing clinical trial. This volume highlights the results of those studies. Editor(s): Gasser, Susan M.; Li, En. Series: Progress in Drug Research. Num Pages: 280 pages, biography. BIC Classification: MFN; MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 20. Weight in Grams: 635. . 2010. Hardback. . . . .…

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. …

Condizione: New. pp. 282.

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Condizione: New. Epigentic alterations, unlike genetic, are, in principle, amenable to pharmacological intervention, and a few of those drugs are currently undergoing clinical trial. This volume highlights the results of those studies. Editor(s): Gasser, Susan M.; Li, En. Series: Progress in Drug Research. Num Pages: 280 pages, biography. BIC Classification: MFN; MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 20. Weight in Grams: 635. . 2010. Hardback. . . . . Books ship from the US and Ireland.…

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Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Discusses new approaches to pharmaceutical interventionIncludes new findings from stem cell researchWith numerous illustrationsEpigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potent.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. 280 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 280 pp. Englisch.…

Condizione: New. Print on Demand pp. 282 Illus.

Condizione: New. PRINT ON DEMAND pp. 282.