Isbn: 9786200471789 - solubility enhancement: development of extended release matrix pellets of water insoluble azilsartan medoxomil using with its solid dispersion (8 risultati)

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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets. 56 pp. Englisch.…

Condizione: New. Print on Demand.

Condizione: New. PRINT ON DEMAND.

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sanklecha VishalVishal Sanklecha completed Post Graduation in Pharmaceutics from Sanjivani College of Pharmaceutical Education & Research, Koprgaon. He currently works at Wockhardt Research Centre in Biotech Formulation & Development.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 56 pp. Englisch.…

Taschenbuch. Condizione: Neu. Solubility Enhancement | Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion | Vishal Sanklecha (u. a.) | Taschenbuch | Englisch | 2019 | LAP LAMBERT Academic Publishing | EAN 9786200471789 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand.…