9786200474414 - correlation of caveolin-1 with vegf in osteosarcoma: caveolin-1 expression together with vegf can be a predictor for lung metastasis and poor prognosis in osteosarcoma di khalil, elzahraa; mohamed, fatma el-zahraa; toni, nisreen (8 risultati)

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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis. Previous evidence demonstrated the positive role of Caveolin-1 in the regulation of endothelial cell differentiation and th…e involvement of Caveolin-1 in vascular endothelial growth factor (VEGF) mediated angiogenesis. The correlation of caveolin-1 expression and angiogenesis is not yet elucidated in osteosarcoma. This study included 66 formalin-fixed and paraffin embedded osteosarcoma tissue samples. The expression levels of Caveolin-1 and VEGF were assessed by immunohistochemistry. Then correlations with clinicopathological variables and the relationship between both markers were evaluated statistically. We also investigated the expression of Caveolin-1 and VEGF genes in Microarrays of osteosarcoma patients by using GEO data sets.Our results suggest that Caveolin-1 may act as a tumor suppressor in osteosarcoma and can be used as an indicator for poor prognosis. Also, overexpression of VEGF is a predictor of pulmonary metastasis and poor prognosis. Furthermore, there was a significant inverse correlation between Caveolin-1 and VEGF. 56 pp. Englisch.

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Da: Biblios, frankfurt am main, HESSE, GermaniaBiblios
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Khalil ElzahraaDemonstrator: From 3/4/2006, Pathology Department, Faculty of Medicine, Minia UniversityAssistant lecturer: From 3/4/2011, Pathology Department, Faculty of Medicine, Minia UniversityLect…urer: From 31/5/2016 till now, P.

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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis. Previous evidence demonstrated the positive role of Caveolin-1 in the regulation of endothelial cell differentiation and the in…volvement of Caveolin-1 in vascular endothelial growth factor (VEGF) mediated angiogenesis. The correlation of caveolin-1 expression and angiogenesis is not yet elucidated in osteosarcoma. This study included 66 formalin-fixed and paraffin embedded osteosarcoma tissue samples. The expression levels of Caveolin-1 and VEGF were assessed by immunohistochemistry. Then correlations with clinicopathological variables and the relationship between both markers were evaluated statistically. We also investigated the expression of Caveolin-1 and VEGF genes in Microarrays of osteosarcoma patients by using GEO data sets.Our results suggest that Caveolin-1 may act as a tumor suppressor in osteosarcoma and can be used as an indicator for poor prognosis. Also, overexpression of VEGF is a predictor of pulmonary metastasis and poor prognosis. Furthermore, there was a significant inverse correlation between Caveolin-1 and VEGF.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 56 pp. Englisch.

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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis. Previous evidence demonstrated the positive role of Caveolin-1 in the regulation of endothelial cell differentiation and the inv…olvement of Caveolin-1 in vascular endothelial growth factor (VEGF) mediated angiogenesis. The correlation of caveolin-1 expression and angiogenesis is not yet elucidated in osteosarcoma. This study included 66 formalin-fixed and paraffin embedded osteosarcoma tissue samples. The expression levels of Caveolin-1 and VEGF were assessed by immunohistochemistry. Then correlations with clinicopathological variables and the relationship between both markers were evaluated statistically. We also investigated the expression of Caveolin-1 and VEGF genes in Microarrays of osteosarcoma patients by using GEO data sets.Our results suggest that Caveolin-1 may act as a tumor suppressor in osteosarcoma and can be used as an indicator for poor prognosis. Also, overexpression of VEGF is a predictor of pulmonary metastasis and poor prognosis. Furthermore, there was a significant inverse correlation between Caveolin-1 and VEGF.

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Taschenbuch. Condizione: Neu. Correlation of Caveolin-1 with VEGF in Osteosarcoma | Caveolin-1 expression together with VEGF can be a predictor for lung metastasis and poor prognosis in Osteosarcoma | Elzahraa Khalil (u. a.) | Taschenbuch | Englisch | 2019 | LAP LAMBERT Academic Publishing | EAN 9786200474414 | Verantwortliche P…erson für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand.