ISBN: 9786208491529 - novel acid-amine derivatives for their in-silico and in-vitro analysis (9 risultati)

Condizione: New.

Condizione: New.

PAP. Condizione: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 136 pp. Englisch.

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book explores the design, synthesis, spectroscopic characterisation, computational insights, and antimicrobial evaluation of novel acid-amine derivatives. It highlights the importance of amide-containing drugs, their synthesis through acid-amine coupling reactions, and the vital role of computational tools in modern drug discovery. The study utilised high-purity chemicals and advanced software to ensure reliable outcomes. Novel derivatives were successfully synthesised by coupling -COOH and -NH2 groups with reagents such as HATU, HBTU, SOCl2, and POCl , and characterised using H NMR, C NMR, UV, and mass spectrometry. Computational analysis provided insights into optimised geometries, Mulliken charge distribution, molecular electrostatic potential maps, and HOMO-LUMO energy gaps via DFT. Protein-ligand interaction studies using Schrödinger software revealed significant hydrogen bonding and hydrophobic contacts. Biological evaluation further demonstrated the antimicrobial potential of these derivatives, with certain compounds showing strong activity against both Gram-positive and Gram-negative bacterial strains, identifying them as promising leads for drug development.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book explores the design, synthesis, spectroscopic characterisation, computational insights, and antimicrobial evaluation of novel acid-amine derivatives. It highlights the importance of amide-containing drugs, their synthesis through acid-amine coupling reactions, and the vital role of computational tools in modern drug discovery. The study utilised high-purity chemicals and advanced software to ensure reliable outcomes. Novel derivatives were successfully synthesised by coupling -COOH and -NH¿ groups with reagents such as HATU, HBTU, SOCl¿, and POCl¿, and characterised using H NMR, C NMR, UV, and mass spectrometry. Computational analysis provided insights into optimised geometries, Mulliken charge distribution, molecular electrostatic potential maps, and HOMO-LUMO energy gaps via DFT. Protein-ligand interaction studies using Schrödinger software revealed significant hydrogen bonding and hydrophobic contacts. Biological evaluation further demonstrated the antimicrobial potential of these derivatives, with certain compounds showing strong activity against both Gram-positive and Gram-negative bacterial strains, identifying them as promising leads for drug development.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 136 pp. Englisch.…

Condizione: New. Print on Demand.

Condizione: New. PRINT ON DEMAND.