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physiologically based pharmacokinetic modeling (93 risultati)
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling (Paperback or Softback)
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
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Physiologically Based Pharmacokinetic Modeling: Of Monoclonal Antibodies
Lingua: Inglese
Editore: LAP Lambert Academic Publishing, 2009
ISBN 10: 3838309707 ISBN 13: 9783838309705
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Physiologically Based Pharmacokinetic Modeling: Of Monoclonal Antibodies
Lingua: Inglese
Editore: LAP Lambert Academic Publishing 2009-08-26, 2009
ISBN 10: 3838309707 ISBN 13: 9783838309705
Da: Chiron Media, Wallingford, Regno Unito
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Aggiungi al carrelloCondizione: New. KlappentextrnrnA physiologically - based pharmacokinetic model has been developed to examine the effects of organophosphates on the levels of acetylcholine in different tissues throughout the mammalian body. Many organophosphate-like chemical an.
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
Da: Bay State Book Company, North Smithfield, RI, U.S.A.
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
Da: Alplaus Books, Alplaus, NY, U.S.A.
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hardcover. Condizione: Good. Hardcover. Pages unmarked, gentle cover wear.
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hardcover. Condizione: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
Lingua: Inglese
Editore: Creative Media Partners, LLC Mai 2025, 2025
ISBN 10: 1025097327 ISBN 13: 9781025097329
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Neuware - Novel properties of engineered nanoparticles that make them attractive may also present unique exposure risks. The traditional physiologically-based pharmacokinetic (PBPK) modeling assumption of instantaneous equilibration likely does not apply to nanoparticles. This simulation-based research begins with development of a model that includes di usion, active transport, and carrier mediated transport. Eigenvalue analysis was used to examine model behavior to focus future research. Results show that cellular transport processes greatly a ect biokinetics of nanoparticles. The new paradigm established by this research leverages traditional in vitro, in vivo, and PBPK modeling, but includes area under the curve to bridge animal testing results to humans. This allows assessment of risk and assists in setting appropriate exposure limits. The model provides critical understanding of nanoparticle biokinetics and allows estimation of total exposure. This e ort highlights future research needs and demonstrates how modeling can be used as a tool to advance nanoparticle risk assessment.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
Lingua: Inglese
Editore: British Library, Historical Print Editions Nov 2012, 2012
ISBN 10: 1288368801 ISBN 13: 9781288368808
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Neuware - A physiologically - based pharmacokinetic model has been developed to examine the effects of organophosphates on the levels of acetylcholine in different tissues throughout the mammalian body. Many organophosphate-like chemical and kinetic characteristics are tested without reference to a specific chemical. Characteristics include partition coefficients, metabolic constants, the inhibition coefficient, the aging rate, and the regeneration rate. Two separate exposure scenarios are tested and compared against a baseline. The baseline consists of a direct inhalation exposure. The first exposure scenario examines the effects of bronchial scrubbing (via inhalation) and the second scenario is a study of dermal exposures and compares the levels of ACh in the different tissues with those in the inhalation (baseline) tests. Organophosphates that are absorbed directly into the bronchial tissue exhibit little variation on the levels of ACh buildup in any of the tissue groups tested when compared to the inhalation exposures. No matter what the scrubbing coefficient used, or the combination of the parameters (partition coefficients, inhibition coefficient, aging rate, and regeneration rate) values, the change in ACh was minimal. The results showed different behavior between inhalation and dermal exposures. The dermal results suggest that an individual may have additional time to don protective equipment before the levels of ACh are high enough to render the person incapable of doing so.
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
Lingua: Inglese
Editore: Creative Media Partners, LLC Mai 2025, 2025
ISBN 10: 1025093011 ISBN 13: 9781025093017
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Aggiungi al carrelloBuch. Condizione: Neu. Neuware - Novel properties of engineered nanoparticles that make them attractive may also present unique exposure risks. The traditional physiologically-based pharmacokinetic (PBPK) modeling assumption of instantaneous equilibration likely does not apply to nanoparticles. This simulation-based research begins with development of a model that includes di usion, active transport, and carrier mediated transport. Eigenvalue analysis was used to examine model behavior to focus future research. Results show that cellular transport processes greatly a ect biokinetics of nanoparticles. The new paradigm established by this research leverages traditional in vitro, in vivo, and PBPK modeling, but includes area under the curve to bridge animal testing results to humans. This allows assessment of risk and assists in setting appropriate exposure limits. The model provides critical understanding of nanoparticle biokinetics and allows estimation of total exposure. This e ort highlights future research needs and demonstrates how modeling can be used as a tool to advance nanoparticle risk assessment.
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
Lingua: Inglese
Editore: Wiley-Interscience Publishing, 2005
ISBN 10: 0471478148 ISBN 13: 9780471478140
Da: Salish Sea Books, Bellingham, WA, U.S.A.
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Condizione: Good. Good; Hardcover; Covers are moderately shelfworn and edgeworn; Unblemished textblock edges; The endpapers and all text pages are clean and unmarked; Good binding; This book will be stored and delivered in a sturdy cardboard box with foam padding; Medium Format (8.5" - 9.75" tall); Dark blue and red covers with title in white lettering; 2005, Wiley-Interscience Publishing; 420 pages; "Physiologically Based Pharmacokinetic Modeling : Science and Applications," by Micaela Reddy, et al.
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Physiologically Based Pharmacokinetic Modeling | Of Monoclonal Antibodies
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838309707 ISBN 13: 9783838309705
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Physiologically Based Pharmacokinetic Modeling | Of Monoclonal Antibodies | Jasmine Davda | Taschenbuch | 112 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838309705 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.
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Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic Modeling
Lingua: Inglese
Editore: Creative Media Partners, LLC, 2025
ISBN 10: 1025097327 ISBN 13: 9781025097329
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Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
Lingua: Inglese
Editore: British Library, Historical Print Editions, 2012
ISBN 10: 1288368801 ISBN 13: 9781288368808
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations
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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry (eng)
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Physiologically Based Pharmacokinetic Modeling
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Physiologically Based Pharmacokinetic Modeling - Science and Applications (eng)
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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry
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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry
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