The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae

 
9780128033210: The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae

Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. * Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research * Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity * Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation * Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response * Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory * Contains color figures and tables that explain the field to newcomers

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Straub, Rainer
Editore: Elsevier Science Publishing Co Inc, United States (2015)
ISBN 10: 0128033215 ISBN 13: 9780128033210
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Descrizione libro Elsevier Science Publishing Co Inc, United States, 2015. Paperback. Condizione libro: New. 234 x 152 mm. Language: English . Brand New Book. Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. * Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research* Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity* Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation* Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response* Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory* Contains color figures and tables that explain the field to newcomers. Codice libro della libreria AAZ9780128033210

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Descrizione libro Elsevier Science Publishing Co Inc 2015-04-08, San Diego, 2015. paperback. Condizione libro: New. Codice libro della libreria 9780128033210

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Straub, Rainer
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Descrizione libro Elsevier Science Publishing Co Inc, United States, 2015. Paperback. Condizione libro: New. 234 x 152 mm. Language: English . Brand New Book. Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. * Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research* Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity* Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation* Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response* Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory* Contains color figures and tables that explain the field to newcomers. Codice libro della libreria AAZ9780128033210

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Descrizione libro Academic Press, 2015. Condizione libro: New. Num Pages: 390 pages. BIC Classification: MJCM. Category: (P) Professional & Vocational. Dimension: 229 x 152. . . 2015. 1st Edition. Paperback. . . . . . Codice libro della libreria V9780128033210

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Descrizione libro Elsevier Science Publishing Co Inc. Paperback. Condizione libro: new. BRAND NEW, The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae, Rainer Straub, Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. * Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research * Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity * Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation * Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response * Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory * Contains color figures and tables that explain the field to newcomers. Codice libro della libreria B9780128033210

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Descrizione libro Paperback. Condizione libro: New. Not Signed; Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. book. Codice libro della libreria ria9780128033210_rkm

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Descrizione libro Academic Press. Condizione libro: New. Num Pages: 390 pages. BIC Classification: MJCM. Category: (P) Professional & Vocational. Dimension: 229 x 152. . . 2015. 1st Edition. Paperback. . . . . Books ship from the US and Ireland. Codice libro della libreria V9780128033210

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Descrizione libro Academic Press, 2015. Paperback. Condizione libro: New. Brand New Book. Shipping: Once your order has been confirmed and payment received, your order will then be processed. The book will be located by our staff, packaged and despatched to you as quickly as possible. From time to time, items get mislaid en route. If your item fails to arrive, please contact us first. We will endeavour to trace the item for you and where necessary, replace or refund the item. Please do not leave negative feedback without contacting us first. All orders will be dispatched within two working days. If you have any quesions please contact us. Codice libro della libreria V9780128033210

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Descrizione libro Academic Press, 2015. Paperback. Condizione libro: NEW. 9780128033210 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Codice libro della libreria HTANDREE01200526

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Descrizione libro Academic Press, 2015. Paperback. Condizione libro: NEW. 9780128033210 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Codice libro della libreria HTANDREE0895999

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