Noradrenergic Signaling and Astroglia - Rilegato

Rilegato

ISBN 10: 0128050888 ISBN 13: 9780128050880

Casa editrice: Academic Pr, 2017

Riassunto

Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrenergic system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induced receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer’s disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences.

• Covers what is currently known about the role of astroglia in the noradrenergic system
• Provides biochemical and physiological mechanistic data to understand how noradrenergic signals acting on astroglia produce observed effects
• Includes figures and tables of structures, mechanisms and processes related to astroglia and noradrenergic signaling in CNS

Su questo libro

Informazioni sugli autori

Nina Vardjan, Ph.D., Assistant Professor of Biochemistry is Coordinating Director of the Neuroglia Projects, part of the National Programme of Cell Physiology (jointly carried out by the Laboratory of Neuroendocrinology-Molecular Cell Physiology at Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, and the Cell Engineering Laboratory at Celica Biomedical, Tech Park Ljubljana, Slovenia). Her fields of study include Biochemistry, Molecular Biology, Neuroscience, Cell Physiology, Neuroendocrinology and Biophysics. She obtained her B.Sc. in Microbiology at the Biotechnical Faculty, University of Ljubljana, Slovenia in 1999. In 2003 she received her Ph.D. in Biochemistry and Molecular Biology at the Post-graduate Study of Biomedicine, Faculty of Medicine, University of Ljubljana, Slovenia. During her Ph.D. she held the position of a Young Researcher and from 2003 to 2004 she was Associate Research Scientist at the Department of Biochemistry and Molecular Biology, Jožef Stefan Institute, Ljubljana, Slovenia. In 2002, she obtained a FEBS Fellowship for training in neuromuscular junction physiology at the Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, UK. Since 2004, she holds a Research Scientist position at the Celica Biomedical and the Faculty of Medicine, Ljubljana, Slovenia. From 2006, she is involved in teaching (General Physiology, Cell Physiology, Molecular Physiology, Cell Engineering) at the Faculty of Chemistry and Chemical Technology and Biotechnical Faculty, University of Ljubljana, Slovenia. She co-edited a special volume of the Annals of the New York Academy of Sciences “Mechanisms of Exocytosis” and co-organized the international meetings ISN Satellite Meeting: Glial Cells in (Patho)physiology (2011), FEPS 2009 (2009), and Mechanism(s) of Exocytosis (2008) and 15th Young Neuroscientists Meeting (2008).

Robert Zorec, Ph.D., Professor of Pathophysiology at the University of Ljubljana, Faculty of Medicine, a Full Member of Academia Europaea (London) and Slovenian Academy of Sciences and Arts (continuation of Academia Operosorum Labacensis from 1693), as well as a past Member of the Committee for Advanced Therapy at the European Medicines Agency (London). He received his Ph.D. from the University of Ljubljana in 1986 for his work conducted at the Newcastle Medical School and at the MRC Neuroendocrinology Unit in Newcastle upon Tyne, UK, in Dr. R.N. McBurney's laboratory studying single-channel chloride currents activated by GABA and glycine in spinal cord neurons. He introduced the patch-clamp technique in Ljubljana in 1985. Dr. Zorec’s post-doctoral experience was at Cambridge, UK, in Dr. W.T. Mason's laboratory. Independently of the laboratory of the Nobel Laureate, Erwin Neher, he developed his own membrane capacitance measurements (MCM) to monitor processes such as endo-and exocytosis in real time. In Prof. M. Berridge's laboratory at Cambridge University (UK), he studied cytosolic calcium homeostasis by imaging related to the MCM approach. In 1991, he conducted experiments on plant secretory cells at the University of Adelaide, Australia. He used his MCM technique to study regulated exocytosis in skeletal muscle, taste cells, neurons, and glia. Since 1991, he has been Head of the Laboratory of Neuroendocrinology-Molecular Cell Physiology and in 1997 he received the Republic of Slovenia Prize for Science. In 2000, he established the Cell Engineering Laboratory at Celica Biomedical, Ljubljana Tech Park (http://celicabiomedical.com/) where he has been a CEO since 2006 and the head of the Carl Zeiss Reference Center for Confocal Microscopy. Recently, his laboratory has developed research on astrocytes, the most heterogeneous neuroglial cells in the brain, to learn how vesicle traffic and regulated exocytosis are altered in these cells under pathologic conditions. In addition to MCM, super-resolution fluorescence microscopy has been developed in his laboratory to study subcellular vesicle traffic and more than 160 peer-reviewed papers have been published. He has lectured at over 100 distinguished universities, international meetings, and research institutions worldwide. He has been a reviewer for leading scientific journals including Nature, Science, PNAS, Neuron, Journal of Neuroscience, Journal of Physiology, Biophysical Journal, Brain Research, and others. In addition to basic research, the laboratory is also developing advanced cell-based medicines such as hybridoma cells to treat cancer; one product, HybriCure, is currently in phase 1/2 clinical trials.

Dalla quarta di copertina

Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the LC-noradrenergic system obtained in in vitro, ex vivo and in vivo models. It covers recent knowledge on molecular mechanisms underlying a- and ß-adrenergic receptor activation in astroglia with a focus on intracellular secondary messengers Ca²⁺- and cAMP and their downstream cellular targets. Norepinephrine-induced downstream cellular effects, astroglial cellular metabolism, and CNS energy provision are also discussed, as well as astroglial functions in signaling, norepinephrine release, gliotransmitter release, and neurotransmitter uptake. The book will lastly address the role of astroglial adrenergic receptor activation on neural activity in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer s diseases), neuroinflammation (multiple sclerosis), and neurodevelopmental disorders (intellectual deficiency). Noradrenergic Signaling and Astroglia provides an up-to-date view of the role of astroglia in the LC-noradrenergic system and is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, academics, and researchers in the fields of neuroscience, but also in biological, biomedical & life sciences.

Dettagli dell'edizione

• Editore: Academic Pr
• Data di pubblicazione: 2017
• Lingua: Inglese
• ISBN 10: 0128050888
• ISBN 13: 9780128050880
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 321
• Redattore: Vardjan Nina, Zorec Robert
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile