Therapeutic Applications of Quadruplex Nucleic Acids - Brossura

Neidle, Stephen

Brossura

ISBN 10: 0128103728 ISBN 13: 9780128103722

Casa editrice: Academic Press, 2016

Riassunto

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligandsÿand the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Su questo libro

Informazioni sull?autore

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Dettagli dell'edizione

• Editore: Academic Press
• Data di pubblicazione: 2016
• Lingua: Inglese
• ISBN 10: 0128103728
• ISBN 13: 9780128103722
• Rilegatura: Copertina flessibile
• Numero di pagine: 208
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile